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Chalazion

MedGen UID:
869
•Concept ID:
C0007933
•
Disease or Syndrome
Synonyms: Chalazia; Cyst, Meibomian; Meibomian Cyst
SNOMED CT: Chalazion (1482004); Meibomian gland cyst (1482004); Tarsal cyst (1482004); Meibomian cyst (1482004); Cyst of meibomian gland (1482004)
 
HPO: HP:0010605
Monarch Initiative: MONDO:0005844

Definition

A chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland. A chalazion or meibomian cyst appears as a painless tuberous swelling in the upper lid without loss of eyelashes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChalazion

Conditions with this feature

Chromosome 17q23.1-q23.2 deletion syndrome
MedGen UID:
461957
•Concept ID:
C3150607
•
Disease or Syndrome
17q23.1q23.2 microdeletion syndrome is a recently described syndrome characterized by developmental delay, microcephaly, short stature, heart defects and limb abnormalities.
See: Condition Record
Immunoskeletal dysplasia with neurodevelopmental abnormalities
MedGen UID:
1381460
•Concept ID:
C4479452
•
Disease or Syndrome
See: Condition Record
Chromosome 17q23.1-q23.2 deletion syndrome
Immunoskeletal dysplasia with neurodevelopmental abnormalities

Professional guidelines

PubMed

Chalazion Treatment: A Concise Review of Clinical Trials.
Tashbayev B, Chen X, Utheim TP
Curr Eye Res 2024 Feb;49(2):109-118. Epub 2024 Jan 18 doi: 10.1080/02713683.2023.2279014. PMID: 37937798
Differential Diagnosis of the Swollen Red Eyelid.
Carlisle RT, Digiovanni J
Am Fam Physician 2015 Jul 15;92(2):106-12. PMID: 26176369
Chalazion treatment.
Unal M
Orbit 2008;27(6):397-8. doi: 10.1080/01676830802623174. PMID: 19085290

Recent clinical studies

Etiology

Chalazion Treatment: A Concise Review of Clinical Trials.
Tashbayev B, Chen X, Utheim TP
Curr Eye Res 2024 Feb;49(2):109-118. Epub 2024 Jan 18 doi: 10.1080/02713683.2023.2279014. PMID: 37937798
Chalazion: racial risk factors for formation, recurrence, and surgical intervention.
Evans J, Vo KBH, Schmitt M
Can J Ophthalmol 2022 Aug;57(4):242-246. Epub 2021 May 30 doi: 10.1016/j.jcjo.2021.04.023. PMID: 34062122Free PMC Article
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Acupuncture for acute hordeolum.
Cheng K, Law A, Guo M, Wieland LS, Shen X, Lao L
Cochrane Database Syst Rev 2017 Feb 9;2(2):CD011075. doi: 10.1002/14651858.CD011075.pub2. PMID: 28181687Free PMC Article
Blepharitis.
Bernardes TF, Bonfioli AA
Semin Ophthalmol 2010 May;25(3):79-83. doi: 10.3109/08820538.2010.488562. PMID: 20590417

Diagnosis

The lowly chalazion.
Kim ES, Afshin EE, Elahi E
Surv Ophthalmol 2023 Jul-Aug;68(4):784-793. Epub 2022 Nov 15 doi: 10.1016/j.survophthal.2022.11.002. PMID: 36395826
When Is a Chalazion Not a Chalazion?
Wagner RS
J Pediatr Ophthalmol Strabismus 2016 Jul 1;53(4):205. doi: 10.3928/01913913-20160510-01. PMID: 27428621
Differential Diagnosis of the Swollen Red Eyelid.
Carlisle RT, Digiovanni J
Am Fam Physician 2015 Jul 15;92(2):106-12. PMID: 26176369
Blepharitis.
Bernardes TF, Bonfioli AA
Semin Ophthalmol 2010 May;25(3):79-83. doi: 10.3109/08820538.2010.488562. PMID: 20590417
Blepharitis.
Raskin EM, Speaker MG, Laibson PR
Infect Dis Clin North Am 1992 Dec;6(4):777-87. PMID: 1460262

Therapy

Chalazion Treatment: A Concise Review of Clinical Trials.
Tashbayev B, Chen X, Utheim TP
Curr Eye Res 2024 Feb;49(2):109-118. Epub 2024 Jan 18 doi: 10.1080/02713683.2023.2279014. PMID: 37937798
Hordeolum and chalazion.
Rupani SR
JAAPA 2023 Jun 1;36(6):43-44. doi: 10.1097/01.JAA.0000931468.68794.aa. PMID: 37229584
Common inflammatory and infectious conditions of the eyelid.
Gordon AA, Danek DJ, Phelps PO
Dis Mon 2020 Oct;66(10):101042. Epub 2020 Jul 1 doi: 10.1016/j.disamonth.2020.101042. PMID: 32622681
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Chalazion treatment.
Unal M
Orbit 2008;27(6):397-8. doi: 10.1080/01676830802623174. PMID: 19085290

Prognosis

Incidence of Adverse Events Induced by Atropine in Myopic Children: A Meta-Analysis.
Sun H, Bu F, Xin X, Yan J
J Clin Pharmacol 2023 Dec;63(12):1377-1386. Epub 2023 Aug 9 doi: 10.1002/jcph.2320. PMID: 37492894
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Ocular infection and inflammation.
Mueller JB, McStay CM
Emerg Med Clin North Am 2008 Feb;26(1):57-72, vi. doi: 10.1016/j.emc.2007.10.004. PMID: 18249257
Cytopathology of chalazia.
Dhaliwal U, Arora VK, Singh N, Bhatia A
Diagn Cytopathol 2004 Aug;31(2):118-22. doi: 10.1002/dc.20092. PMID: 15282726
Sebaceous carcinoma of the ocular adnexa.
Kass LG, Hornblass A
Surv Ophthalmol 1989 May-Jun;33(6):477-90. doi: 10.1016/0039-6257(89)90049-0. PMID: 2658172

Clinical prediction guides

Focus on Ophthalmopathology - Orbital Infections from Hordeolum to Necrotizing Fasciitis.
Weller JM, Messmer E
Klin Monbl Augenheilkd 2022 Jul;239(7):886-893. Epub 2022 Jul 20 doi: 10.1055/a-1709-6152. PMID: 35858598
Plug-related canaliculitis: a rare or underdiagnosed disease?
Yeh TC, Hou TY, Huang YY, Yu WK, Tsai CC
Clin Exp Optom 2022 May;105(4):385-391. Epub 2021 Jun 17 doi: 10.1080/08164622.2021.1927675. PMID: 34139956
Acupuncture for acute hordeolum.
Cheng K, Law A, Guo M, Wieland LS, Shen X, Lao L
Cochrane Database Syst Rev 2017 Feb 9;2(2):CD011075. doi: 10.1002/14651858.CD011075.pub2. PMID: 28181687Free PMC Article
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article
Associated morbidity of chalazia.
Nemet AY, Vinker S, Kaiserman I
Cornea 2011 Dec;30(12):1376-81. doi: 10.1097/ICO.0b013e31821de36f. PMID: 21993469

Recent systematic reviews

Incidence of Adverse Events Induced by Atropine in Myopic Children: A Meta-Analysis.
Sun H, Bu F, Xin X, Yan J
J Clin Pharmacol 2023 Dec;63(12):1377-1386. Epub 2023 Aug 9 doi: 10.1002/jcph.2320. PMID: 37492894
Acupuncture for acute hordeolum.
Cheng K, Law A, Guo M, Wieland LS, Shen X, Lao L
Cochrane Database Syst Rev 2017 Feb 9;2(2):CD011075. doi: 10.1002/14651858.CD011075.pub2. PMID: 28181687Free PMC Article
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article
Interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2013 Apr 30;4(4):CD007742. doi: 10.1002/14651858.CD007742.pub3. PMID: 23633345Free PMC Article
Interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2010 Sep 8;(9):CD007742. doi: 10.1002/14651858.CD007742.pub2. PMID: 20824865Free PMC Article

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