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Chalazion

MedGen UID:
869
•Concept ID:
C0007933
•
Disease or Syndrome
Synonyms: Chalazia; Cyst, Meibomian; Meibomian Cyst
SNOMED CT: Chalazion (1482004); Meibomian gland cyst (1482004); Tarsal cyst (1482004); Meibomian cyst (1482004); Cyst of meibomian gland (1482004)
 
HPO: HP:0010605
Monarch Initiative: MONDO:0005844

Definition

A chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland. A chalazion or meibomian cyst appears as a painless tuberous swelling in the upper lid without loss of eyelashes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChalazion

Conditions with this feature

Chromosome 17q23.1-q23.2 deletion syndrome
MedGen UID:
461957
•Concept ID:
C3150607
•
Disease or Syndrome
17q23.1q23.2 microdeletion syndrome is a recently described syndrome characterized by developmental delay, microcephaly, short stature, heart defects and limb abnormalities.
See: Condition Record
Chromosome 17q23.1-q23.2 deletion syndrome

Professional guidelines

PubMed

Novel treatment of chalazion using light-guided-tip intense pulsed light.
Zhu Y, Zhao H, Huang X, Lin L, Huo Y, Qin Z, Lu J, Jin X
Sci Rep 2023 Jul 31;13(1):12393. doi: 10.1038/s41598-023-39332-x. PMID: 37524772Free PMC Article
Differential Diagnosis of the Swollen Red Eyelid.
Carlisle RT, Digiovanni J
Am Fam Physician 2015 Jul 15;92(2):106-12. PMID: 26176369
Chalazion treatment.
Unal M
Orbit 2008;27(6):397-8. doi: 10.1080/01676830802623174. PMID: 19085290

Recent clinical studies

Etiology

Novel treatment of chalazion using light-guided-tip intense pulsed light.
Zhu Y, Zhao H, Huang X, Lin L, Huo Y, Qin Z, Lu J, Jin X
Sci Rep 2023 Jul 31;13(1):12393. doi: 10.1038/s41598-023-39332-x. PMID: 37524772Free PMC Article
Prevalence of Demodex folliculorum and Demodex brevis in patients with blepharitis and chalazion.
Akkucuk S, Kaya OM, Aslan L, Ozdemir T, Uslu U
Int Ophthalmol 2023 Apr;43(4):1249-1259. Epub 2022 Oct 18 doi: 10.1007/s10792-022-02523-y. PMID: 36255613
Chalazion: racial risk factors for formation, recurrence, and surgical intervention.
Evans J, Vo KBH, Schmitt M
Can J Ophthalmol 2022 Aug;57(4):242-246. Epub 2021 May 30 doi: 10.1016/j.jcjo.2021.04.023. PMID: 34062122Free PMC Article
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Blepharitis.
Bernardes TF, Bonfioli AA
Semin Ophthalmol 2010 May;25(3):79-83. doi: 10.3109/08820538.2010.488562. PMID: 20590417

Diagnosis

The lowly chalazion.
Kim ES, Afshin EE, Elahi E
Surv Ophthalmol 2023 Jul-Aug;68(4):784-793. Epub 2022 Nov 15 doi: 10.1016/j.survophthal.2022.11.002. PMID: 36395826
When Is a Chalazion Not a Chalazion?
Wagner RS
J Pediatr Ophthalmol Strabismus 2016 Jul 1;53(4):205. doi: 10.3928/01913913-20160510-01. PMID: 27428621
Differential Diagnosis of the Swollen Red Eyelid.
Carlisle RT, Digiovanni J
Am Fam Physician 2015 Jul 15;92(2):106-12. PMID: 26176369
Blepharitis.
Bernardes TF, Bonfioli AA
Semin Ophthalmol 2010 May;25(3):79-83. doi: 10.3109/08820538.2010.488562. PMID: 20590417
Blepharitis.
Raskin EM, Speaker MG, Laibson PR
Infect Dis Clin North Am 1992 Dec;6(4):777-87. PMID: 1460262

Therapy

Hordeolum and chalazion.
Rupani SR
JAAPA 2023 Jun 1;36(6):43-44. doi: 10.1097/01.JAA.0000931468.68794.aa. PMID: 37229584
Adult Eye Conditions: Common Eye Conditions.
McGinley TC Jr
FP Essent 2022 Aug;519:11-18. PMID: 35947131
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Chalazion treatment.
Unal M
Orbit 2008;27(6):397-8. doi: 10.1080/01676830802623174. PMID: 19085290
Ocular infection and inflammation.
Mueller JB, McStay CM
Emerg Med Clin North Am 2008 Feb;26(1):57-72, vi. doi: 10.1016/j.emc.2007.10.004. PMID: 18249257

Prognosis

Incidence of Adverse Events Induced by Atropine in Myopic Children: A Meta-Analysis.
Sun H, Bu F, Xin X, Yan J
J Clin Pharmacol 2023 Dec;63(12):1377-1386. Epub 2023 Aug 9 doi: 10.1002/jcph.2320. PMID: 37492894
Prevalence and risk factors for chalazion in an older veteran population.
Patel S, Tohme N, Gorrin E, Kumar N, Goldhagen B, Galor A
Br J Ophthalmol 2022 Sep;106(9):1200-1205. Epub 2021 Mar 31 doi: 10.1136/bjophthalmol-2020-318420. PMID: 33789846Free PMC Article
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Ocular infection and inflammation.
Mueller JB, McStay CM
Emerg Med Clin North Am 2008 Feb;26(1):57-72, vi. doi: 10.1016/j.emc.2007.10.004. PMID: 18249257
Sebaceous carcinoma of the eyelids: personal experience with 60 cases.
Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL
Ophthalmology 2004 Dec;111(12):2151-7. doi: 10.1016/j.ophtha.2004.07.031. PMID: 15582067

Clinical prediction guides

Focus on Ophthalmopathology - Orbital Infections from Hordeolum to Necrotizing Fasciitis.
Weller JM, Messmer E
Klin Monbl Augenheilkd 2022 Jul;239(7):886-893. Epub 2022 Jul 20 doi: 10.1055/a-1709-6152. PMID: 35858598
Plug-related canaliculitis: a rare or underdiagnosed disease?
Yeh TC, Hou TY, Huang YY, Yu WK, Tsai CC
Clin Exp Optom 2022 May;105(4):385-391. Epub 2021 Jun 17 doi: 10.1080/08164622.2021.1927675. PMID: 34139956
Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study.
Li J, Li D, Zhou N, Qi M, Luo Y, Wang Y
BMC Ophthalmol 2020 Jul 11;20(1):278. doi: 10.1186/s12886-020-01557-z. PMID: 32652956Free PMC Article
Acupuncture for acute hordeolum.
Cheng K, Law A, Guo M, Wieland LS, Shen X, Lao L
Cochrane Database Syst Rev 2017 Feb 9;2(2):CD011075. doi: 10.1002/14651858.CD011075.pub2. PMID: 28181687Free PMC Article
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article

Recent systematic reviews

Incidence of Adverse Events Induced by Atropine in Myopic Children: A Meta-Analysis.
Sun H, Bu F, Xin X, Yan J
J Clin Pharmacol 2023 Dec;63(12):1377-1386. Epub 2023 Aug 9 doi: 10.1002/jcph.2320. PMID: 37492894
Clinical trials targeting the gut-microbiome to effect ocular health: a systematic review.
Russell MW, Muste JC, Kuo BL, Wu AK, Singh RP
Eye (Lond) 2023 Oct;37(14):2877-2885. Epub 2023 Mar 14 doi: 10.1038/s41433-023-02462-7. PMID: 36918627Free PMC Article
Acupuncture for acute hordeolum.
Cheng K, Law A, Guo M, Wieland LS, Shen X, Lao L
Cochrane Database Syst Rev 2017 Feb 9;2(2):CD011075. doi: 10.1002/14651858.CD011075.pub2. PMID: 28181687Free PMC Article
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article
Interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2013 Apr 30;4(4):CD007742. doi: 10.1002/14651858.CD007742.pub3. PMID: 23633345Free PMC Article

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