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Chalazion

MedGen UID:
869
•Concept ID:
C0007933
•
Disease or Syndrome
Synonyms: Chalazia; Cyst, Meibomian; Meibomian Cyst
SNOMED CT: Chalazion (1482004); Meibomian gland cyst (1482004); Tarsal cyst (1482004); Meibomian cyst (1482004); Cyst of meibomian gland (1482004)
 
HPO: HP:0010605
Monarch Initiative: MONDO:0005844

Definition

A chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland. A chalazion or meibomian cyst appears as a painless tuberous swelling in the upper lid without loss of eyelashes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChalazion

Professional guidelines

PubMed

Extralesional triamcinolone acetonide injection in the treatment of small chalazion.
Gan L, Liu Y, Zhou X, Xue K, Guo J, Qian J, Ren H
Indian J Ophthalmol 2023 Aug;71(8):2959-2961. doi: 10.4103/IJO.IJO_3186_22. PMID: 37530264Free PMC Article
Differential Diagnosis of the Swollen Red Eyelid.
Carlisle RT, Digiovanni J
Am Fam Physician 2015 Jul 15;92(2):106-12. PMID: 26176369
Chalazion treatment.
Unal M
Orbit 2008;27(6):397-8. doi: 10.1080/01676830802623174. PMID: 19085290

Recent clinical studies

Etiology

TearCare for the Treatment of Meibomian Gland Dysfunction in Adult Patients With Dry Eye Disease: A Masked Randomized Controlled Trial.
Gupta PK, Holland EJ, Hovanesian J, Loh J, Jackson MA, Karpecki PM, Dhamdhere K
Cornea 2022 Apr 1;41(4):417-426. doi: 10.1097/ICO.0000000000002837. PMID: 34581297Free PMC Article
Chalazion: racial risk factors for formation, recurrence, and surgical intervention.
Evans J, Vo KBH, Schmitt M
Can J Ophthalmol 2022 Aug;57(4):242-246. Epub 2021 May 30 doi: 10.1016/j.jcjo.2021.04.023. PMID: 34062122Free PMC Article
Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study.
Li J, Li D, Zhou N, Qi M, Luo Y, Wang Y
BMC Ophthalmol 2020 Jul 11;20(1):278. doi: 10.1186/s12886-020-01557-z. PMID: 32652956Free PMC Article
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Blepharitis.
Bernardes TF, Bonfioli AA
Semin Ophthalmol 2010 May;25(3):79-83. doi: 10.3109/08820538.2010.488562. PMID: 20590417

Diagnosis

Chalazion: racial risk factors for formation, recurrence, and surgical intervention.
Evans J, Vo KBH, Schmitt M
Can J Ophthalmol 2022 Aug;57(4):242-246. Epub 2021 May 30 doi: 10.1016/j.jcjo.2021.04.023. PMID: 34062122Free PMC Article
Common inflammatory and infectious conditions of the eyelid.
Gordon AA, Danek DJ, Phelps PO
Dis Mon 2020 Oct;66(10):101042. Epub 2020 Jul 1 doi: 10.1016/j.disamonth.2020.101042. PMID: 32622681
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article
Differential Diagnosis of the Swollen Red Eyelid.
Carlisle RT, Digiovanni J
Am Fam Physician 2015 Jul 15;92(2):106-12. PMID: 26176369
Blepharitis.
Bernardes TF, Bonfioli AA
Semin Ophthalmol 2010 May;25(3):79-83. doi: 10.3109/08820538.2010.488562. PMID: 20590417

Therapy

Hordeolum and chalazion.
Rupani SR
JAAPA 2023 Jun 1;36(6):43-44. doi: 10.1097/01.JAA.0000931468.68794.aa. PMID: 37229584
TearCare for the Treatment of Meibomian Gland Dysfunction in Adult Patients With Dry Eye Disease: A Masked Randomized Controlled Trial.
Gupta PK, Holland EJ, Hovanesian J, Loh J, Jackson MA, Karpecki PM, Dhamdhere K
Cornea 2022 Apr 1;41(4):417-426. doi: 10.1097/ICO.0000000000002837. PMID: 34581297Free PMC Article
Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study.
Li J, Li D, Zhou N, Qi M, Luo Y, Wang Y
BMC Ophthalmol 2020 Jul 11;20(1):278. doi: 10.1186/s12886-020-01557-z. PMID: 32652956Free PMC Article
Common inflammatory and infectious conditions of the eyelid.
Gordon AA, Danek DJ, Phelps PO
Dis Mon 2020 Oct;66(10):101042. Epub 2020 Jul 1 doi: 10.1016/j.disamonth.2020.101042. PMID: 32622681
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article

Prognosis

TearCare for the Treatment of Meibomian Gland Dysfunction in Adult Patients With Dry Eye Disease: A Masked Randomized Controlled Trial.
Gupta PK, Holland EJ, Hovanesian J, Loh J, Jackson MA, Karpecki PM, Dhamdhere K
Cornea 2022 Apr 1;41(4):417-426. doi: 10.1097/ICO.0000000000002837. PMID: 34581297Free PMC Article
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Ocular infection and inflammation.
Mueller JB, McStay CM
Emerg Med Clin North Am 2008 Feb;26(1):57-72, vi. doi: 10.1016/j.emc.2007.10.004. PMID: 18249257
Sebaceous carcinoma of the eyelids: personal experience with 60 cases.
Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL
Ophthalmology 2004 Dec;111(12):2151-7. doi: 10.1016/j.ophtha.2004.07.031. PMID: 15582067
Pyogenic granulomas.
Jennings BJ
J Am Optom Assoc 1987 Aug;58(8):664-73. PMID: 3624762

Clinical prediction guides

Focus on Ophthalmopathology - Orbital Infections from Hordeolum to Necrotizing Fasciitis.
Weller JM, Messmer E
Klin Monbl Augenheilkd 2022 Jul;239(7):886-893. Epub 2022 Jul 20 doi: 10.1055/a-1709-6152. PMID: 35858598
TearCare for the Treatment of Meibomian Gland Dysfunction in Adult Patients With Dry Eye Disease: A Masked Randomized Controlled Trial.
Gupta PK, Holland EJ, Hovanesian J, Loh J, Jackson MA, Karpecki PM, Dhamdhere K
Cornea 2022 Apr 1;41(4):417-426. doi: 10.1097/ICO.0000000000002837. PMID: 34581297Free PMC Article
Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study.
Li J, Li D, Zhou N, Qi M, Luo Y, Wang Y
BMC Ophthalmol 2020 Jul 11;20(1):278. doi: 10.1186/s12886-020-01557-z. PMID: 32652956Free PMC Article
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article
Associated morbidity of chalazia.
Nemet AY, Vinker S, Kaiserman I
Cornea 2011 Dec;30(12):1376-81. doi: 10.1097/ICO.0b013e31821de36f. PMID: 21993469

Recent systematic reviews

Clinical trials targeting the gut-microbiome to effect ocular health: a systematic review.
Russell MW, Muste JC, Kuo BL, Wu AK, Singh RP
Eye (Lond) 2023 Oct;37(14):2877-2885. Epub 2023 Mar 14 doi: 10.1038/s41433-023-02462-7. PMID: 36918627Free PMC Article
Acupuncture for acute hordeolum.
Cheng K, Law A, Guo M, Wieland LS, Shen X, Lao L
Cochrane Database Syst Rev 2017 Feb 9;2(2):CD011075. doi: 10.1002/14651858.CD011075.pub2. PMID: 28181687Free PMC Article
Non-surgical interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2017 Jan 9;1(1):CD007742. doi: 10.1002/14651858.CD007742.pub4. PMID: 28068454Free PMC Article
Interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2013 Apr 30;4(4):CD007742. doi: 10.1002/14651858.CD007742.pub3. PMID: 23633345Free PMC Article
Interventions for acute internal hordeolum.
Lindsley K, Nichols JJ, Dickersin K
Cochrane Database Syst Rev 2010 Sep 8;(9):CD007742. doi: 10.1002/14651858.CD007742.pub2. PMID: 20824865Free PMC Article

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