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Abnormal circulating homocysteine concentration

MedGen UID:
869228
•Concept ID:
C4023651
•
Finding
Synonym: Abnormality of homocysteine metabolism
 
HPO: HP:0010919

Definition

An abnormality of a homocysteine metabolic process. [from HPO]

Recent clinical studies

Etiology

RBC Folate and Serum Folate, Vitamin B-12, and Homocysteine in Chinese Couples Prepregnancy in the Shanghai Preconception Cohort.
Li M, Chen X, Zhang Y, Chen H, Wang D, Cao C, Jiang Y, Huang X, Dou Y, Wang Y, Ma X, Sheng W, Yan W, Huang G; Birth Defect Prevention Group
J Nutr 2022 Jun 9;152(6):1496-1506. doi: 10.1093/jn/nxac050. PMID: 35259272
Homocysteine, intracellular signaling and thrombotic disorders.
Dionisio N, Jardín I, Salido GM, Rosado JA
Curr Med Chem 2010;17(27):3109-19. doi: 10.2174/092986710791959783. PMID: 20629621
Effect of food fortification on folic acid intake in the United States.
Quinlivan EP, Gregory JF 3rd
Am J Clin Nutr 2003 Jan;77(1):221-5. doi: 10.1093/ajcn/77.1.221. PMID: 12499345
Malabsorption syndrome associated with ulceration of the stomach and small bowel caused by chronic intestinal ischemia in a patient with hyperhomocysteinemia.
Bakker RC, Brandjes DP, Snel P, Lawson JA, Lindeman J, Batchelor D
Mayo Clin Proc 1997 Jun;72(6):546-50. doi: 10.4065/72.6.546. PMID: 9179139
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910

Diagnosis

Lipid Risk Factors in Vitiligo: Homocysteine the Connecting Link?
Taneja K, Taneja J, Kaur C, Patel S, Haldar D
Clin Lab 2020 Oct 1;66(10) doi: 10.7754/Clin.Lab.2020.200120. PMID: 33073941
Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency.
Di Minno A, Anesi A, Chiesa M, Cirillo F, Colombo GI, Orsini RC, Capasso F, Morisco F, Fiorelli S, Eligini S, Cavalca V, Tremoli E, Porro B, Di Minno MND
Nutr Metab Cardiovasc Dis 2020 Nov 27;30(12):2286-2295. Epub 2020 Jul 23 doi: 10.1016/j.numecd.2020.07.019. PMID: 32912785
Uterine artery Doppler and mid-trimester maternal plasma homocysteine in subsequent pre-eclampsia.
Yu CK, Lakasing L, Papageorghiou AT, Spencer K, Nicolaides KH
J Matern Fetal Neonatal Med 2004 Aug;16(2):134-9. doi: 10.1080/14767050400009287. PMID: 15512726
Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population.
Nilsson K, Gustafson L, Hultberg B
Dement Geriatr Cogn Disord 1999 Nov-Dec;10(6):476-82. doi: 10.1159/000017193. PMID: 10559563
Is an elevated circulating maternal homocysteine concentration a risk factor for neural tube defects?
Ubbink JB
Nutr Rev 1995 Jun;53(6):173-5. doi: 10.1111/j.1753-4887.1995.tb01546.x. PMID: 7478313

Therapy

Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes.
Mangoni AA, Sherwood RA, Asonganyi B, Swift CG, Thomas S, Jackson SH
Am J Hypertens 2005 Feb;18(2 Pt 1):220-6. doi: 10.1016/j.amjhyper.2004.08.036. PMID: 15752950
Effect of homocysteine-lowering treatment with folic acid plus vitamin B on cerebrovascular atherosclerosis and white matter abnormalities as determined by MRA and MRI: a placebo-controlled, randomized trial.
Vermeulen EG, Stehouwer CD, Valk J, van der Knaap M, van den Berg M, Twisk JW, Prevoo W, Rauwerda JA
Eur J Clin Invest 2004 Apr;34(4):256-61. doi: 10.1111/j.1365-2362.2004.01332.x. PMID: 15086356
Effect of food fortification on folic acid intake in the United States.
Quinlivan EP, Gregory JF 3rd
Am J Clin Nutr 2003 Jan;77(1):221-5. doi: 10.1093/ajcn/77.1.221. PMID: 12499345
Homocysteine, coagulation, platelet function, and thrombosis.
Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G
Semin Thromb Hemost 2000;26(3):243-54. doi: 10.1055/s-2000-8469. PMID: 11011842
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910

Prognosis

Lipid Risk Factors in Vitiligo: Homocysteine the Connecting Link?
Taneja K, Taneja J, Kaur C, Patel S, Haldar D
Clin Lab 2020 Oct 1;66(10) doi: 10.7754/Clin.Lab.2020.200120. PMID: 33073941
Oxidative stress and cardiovascular complications in polycystic ovarian syndrome.
Hyderali BN, Mala K
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:15-22. Epub 2015 Jun 2 doi: 10.1016/j.ejogrb.2015.05.005. PMID: 26066290
Uterine artery Doppler and mid-trimester maternal plasma homocysteine in subsequent pre-eclampsia.
Yu CK, Lakasing L, Papageorghiou AT, Spencer K, Nicolaides KH
J Matern Fetal Neonatal Med 2004 Aug;16(2):134-9. doi: 10.1080/14767050400009287. PMID: 15512726
Effect of food fortification on folic acid intake in the United States.
Quinlivan EP, Gregory JF 3rd
Am J Clin Nutr 2003 Jan;77(1):221-5. doi: 10.1093/ajcn/77.1.221. PMID: 12499345
Methods for measuring sulfur amino acid metabolism.
Hoffer LJ
Curr Opin Clin Nutr Metab Care 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. PMID: 12172474

Clinical prediction guides

Lipid Risk Factors in Vitiligo: Homocysteine the Connecting Link?
Taneja K, Taneja J, Kaur C, Patel S, Haldar D
Clin Lab 2020 Oct 1;66(10) doi: 10.7754/Clin.Lab.2020.200120. PMID: 33073941
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
Homocysteine and metalloprotease-3 and -9 in patients with ascending aorta aneurysms.
Tsarouhas K, Tsitsimpikou C, Apostolakis S, Haliassos A, Tzardi M, Panagiotou M, Tsatsakis A, Spandidos DA
Thromb Res 2011 Nov;128(5):e95-9. Epub 2011 Jul 29 doi: 10.1016/j.thromres.2011.07.008. PMID: 21802713
Effect of food fortification on folic acid intake in the United States.
Quinlivan EP, Gregory JF 3rd
Am J Clin Nutr 2003 Jan;77(1):221-5. doi: 10.1093/ajcn/77.1.221. PMID: 12499345
Increased membrane-protein methylation in hereditary spherocytosis. A marker of cytoskeletal disarray.
Ingrosso D, D'Angelo S, Perna AF, Iolascon A, Miraglia del Giudice E, Perrotta S, Zappia V, Galletti P
Eur J Biochem 1995 Mar 15;228(3):894-8. doi: 10.1111/j.1432-1033.1995.tb20337.x. PMID: 7737191

Recent systematic reviews

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.
Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
Hum Reprod Update 2013 May-Jun;19(3):268-88. Epub 2013 Jan 9 doi: 10.1093/humupd/dms059. PMID: 23303572

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