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Abnormal circulating alanine concentration

MedGen UID:
869231
•Concept ID:
C4023654
•
Finding
Synonym: Abnormality of alanine metabolism
 
HPO: HP:0010916

Definition

An abnormality of an alanine metabolic process. [from HPO]

Professional guidelines

PubMed

Twenty-four hour hormonal and metabolic profiles in uraemic patients before and during treatment with continuous ambulatory peritoneal dialysis.
Heaton A, Johnston DG, Haigh JW, Ward MK, Alberti KG, Kerr DN
Clin Sci (Lond) 1985 Oct;69(4):449-57. doi: 10.1042/cs0690449. PMID: 4042546

Recent clinical studies

Etiology

Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
Splanchnic circulation and metabolism in patients with acute liver failure.
Clemmesen O
Dan Med Bull 2002 Aug;49(3):177-93. PMID: 12238280
Role of bile acid measurement in pregnancy.
Walker IA, Nelson-Piercy C, Williamson C
Ann Clin Biochem 2002 Mar;39(Pt 2):105-13. doi: 10.1258/0004563021901856. PMID: 11928758
Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography.
Camici P, Ferrannini E, Opie LH
Prog Cardiovasc Dis 1989 Nov-Dec;32(3):217-38. doi: 10.1016/0033-0620(89)90027-3. PMID: 2682779

Diagnosis

Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
Role of bile acid measurement in pregnancy.
Walker IA, Nelson-Piercy C, Williamson C
Ann Clin Biochem 2002 Mar;39(Pt 2):105-13. doi: 10.1258/0004563021901856. PMID: 11928758
Control of glycaemia.
Gerich JE
Baillieres Clin Endocrinol Metab 1993 Jul;7(3):551-86. doi: 10.1016/s0950-351x(05)80207-1. PMID: 8379904
Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.
Johnston DG, Haigh J, Prescott RW, Heaton A, Kendall-Taylor P, Baylis P, Alberti KG, Rowe R, Friesen H, Cook D
Clin Endocrinol (Oxf) 1985 May;22(5):661-78. doi: 10.1111/j.1365-2265.1985.tb03003.x. PMID: 3928210

Therapy

Safety and efficacy of REP 2139 and pegylated interferon alfa-2a for treatment-naive patients with chronic hepatitis B virus and hepatitis D virus co-infection (REP 301 and REP 301-LTF): a non-randomised, open-label, phase 2 trial.
Bazinet M, Pântea V, Cebotarescu V, Cojuhari L, Jimbei P, Albrecht J, Schmid P, Le Gal F, Gordien E, Krawczyk A, Mijočević H, Karimzadeh H, Roggendorf M, Vaillant A
Lancet Gastroenterol Hepatol 2017 Dec;2(12):877-889. Epub 2017 Sep 28 doi: 10.1016/S2468-1253(17)30288-1. PMID: 28964701
Persistent inflammation and immune activation contribute to cholestasis in patients receiving home parenteral nutrition.
Reimund JM, Duclos B, Arondel Y, Baumann R
Nutrition 2001 Apr;17(4):300-4. doi: 10.1016/s0899-9007(00)00583-9. PMID: 11369168
Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload.
McNamara L, MacPhail AP, Mandishona E, Bloom P, Paterson AC, Rouault TA, Gordeuk VR
J Gastroenterol Hepatol 1999 Feb;14(2):126-32. doi: 10.1046/j.1440-1746.1999.01830.x. PMID: 10029292
Dichloroacetate.
Stacpoole PW, Greene YJ
Diabetes Care 1992 Jun;15(6):785-91. doi: 10.2337/diacare.15.6.785. PMID: 1600837
Trauma metabolism and the heart. Uptake of substrates and effects of insulin early after cardiac operations.
Svensson S, Svedjeholm R, Ekroth R, Milocco I, Nilsson F, Sabel KG, William-Olsson G
J Thorac Cardiovasc Surg 1990 Jun;99(6):1063-73. PMID: 2193199

Prognosis

Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
The involvement of nitric oxide in the physiopathology of hepatoportal sclerosis.
Purnak T, Beyazit Y, Ibis M, Koklu S, Efe C, Ozaslan E, Ciftci A, Tenlik I
Clin Biochem 2012 Nov;45(16-17):1450-4. Epub 2012 Jul 20 doi: 10.1016/j.clinbiochem.2012.07.091. PMID: 22820432
Correlation of circulating endoglin with clinical outcome in biliary atresia.
Preativatanyou K, Honsawek S, Chongsrisawat V, Vejchapipat P, Theamboonlers A, Poovorawan Y
Eur J Pediatr Surg 2010 Jul;20(4):237-41. Epub 2010 Apr 9 doi: 10.1055/s-0030-1249695. PMID: 20383820
Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation.
Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA
Eur J Appl Physiol Occup Physiol 1997;75(1):47-53. doi: 10.1007/s004210050125. PMID: 9007457

Clinical prediction guides

Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Changes Over Time in Hepatic Markers Predict Changes in Insulin Sensitivity, β-Cell Function, and Glycemia.
Pinnaduwage L, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R
J Clin Endocrinol Metab 2018 Jul 1;103(7):2651-2659. doi: 10.1210/jc.2018-00306. PMID: 29897453
Splanchnic circulation and metabolism in patients with acute liver failure.
Clemmesen O
Dan Med Bull 2002 Aug;49(3):177-93. PMID: 12238280
Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography.
Camici P, Ferrannini E, Opie LH
Prog Cardiovasc Dis 1989 Nov-Dec;32(3):217-38. doi: 10.1016/0033-0620(89)90027-3. PMID: 2682779
Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.
Johnston DG, Haigh J, Prescott RW, Heaton A, Kendall-Taylor P, Baylis P, Alberti KG, Rowe R, Friesen H, Cook D
Clin Endocrinol (Oxf) 1985 May;22(5):661-78. doi: 10.1111/j.1365-2265.1985.tb03003.x. PMID: 3928210

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