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Abnormal circulating threonine concentration

MedGen UID:
869243
•Concept ID:
C4023666
•
Finding
Synonym: Abnormality of threonine metabolism
 
HPO: HP:0010900

Definition

Any deviation from the normal concentration of threonine in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy.
He J, Liu B, Du X, Wei Y, Kong D, Feng B, Guo R, Asiamah EA, Griffin MD, Hynes SO, Shen S, Liu Y, Cui H, Ma J, O'Brien T
Stem Cell Res Ther 2024 Mar 5;15(1):66. doi: 10.1186/s13287-024-03647-x. PMID: 38443965Free PMC Article
Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle.
Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep 2020 Jun 2;10(1):8930. doi: 10.1038/s41598-020-65852-x. PMID: 32488174Free PMC Article
Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Hoegh SV, Lindegaard HM, Sorensen GL, Høj A, Bendixen C, Junker P, Holmskov U
Scand J Immunol 2008 Jan;67(1):71-6. doi: 10.1111/j.1365-3083.2007.02039.x. PMID: 18052966

Diagnosis

Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Hoegh SV, Lindegaard HM, Sorensen GL, Høj A, Bendixen C, Junker P, Holmskov U
Scand J Immunol 2008 Jan;67(1):71-6. doi: 10.1111/j.1365-3083.2007.02039.x. PMID: 18052966

Therapy

Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle.
Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep 2020 Jun 2;10(1):8930. doi: 10.1038/s41598-020-65852-x. PMID: 32488174Free PMC Article
Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts.
Euceda LR, Hill DK, Stokke E, Hatem R, El Botty R, Bièche I, Marangoni E, Bathen TF, Moestue SA
J Proteome Res 2017 May 5;16(5):1868-1879. Epub 2017 Apr 3 doi: 10.1021/acs.jproteome.6b00918. PMID: 28290700

Prognosis

Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts.
Euceda LR, Hill DK, Stokke E, Hatem R, El Botty R, Bièche I, Marangoni E, Bathen TF, Moestue SA
J Proteome Res 2017 May 5;16(5):1868-1879. Epub 2017 Apr 3 doi: 10.1021/acs.jproteome.6b00918. PMID: 28290700
Abnormal expression of Endoglin and its receptor complex (TGF-β1 and TGF-β receptor II) as early angiogenic switch indicator in premalignant lesions of the colon mucosa.
Bellone G, Gramigni C, Vizio B, Mauri FA, Prati A, Solerio D, Dughera L, Ruffini E, Gasparri G, Camandona M
Int J Oncol 2010 Nov;37(5):1153-65. doi: 10.3892/ijo_00000767. PMID: 20878063
Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Hoegh SV, Lindegaard HM, Sorensen GL, Høj A, Bendixen C, Junker P, Holmskov U
Scand J Immunol 2008 Jan;67(1):71-6. doi: 10.1111/j.1365-3083.2007.02039.x. PMID: 18052966
Gamma371 Thr-->Ile substitution in the fibrinogen gammaD domain causes hypofibrinogenaemia.
Brennan SO, Wyatt JM, Fellowes AP, Dlott JS, Triplett DA, George PM
Biochim Biophys Acta 2001 Dec 17;1550(2):183-8. doi: 10.1016/s0167-4838(01)00280-1. PMID: 11755207

Clinical prediction guides

Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts.
Euceda LR, Hill DK, Stokke E, Hatem R, El Botty R, Bièche I, Marangoni E, Bathen TF, Moestue SA
J Proteome Res 2017 May 5;16(5):1868-1879. Epub 2017 Apr 3 doi: 10.1021/acs.jproteome.6b00918. PMID: 28290700
Gamma371 Thr-->Ile substitution in the fibrinogen gammaD domain causes hypofibrinogenaemia.
Brennan SO, Wyatt JM, Fellowes AP, Dlott JS, Triplett DA, George PM
Biochim Biophys Acta 2001 Dec 17;1550(2):183-8. doi: 10.1016/s0167-4838(01)00280-1. PMID: 11755207

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