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Ocular dyssynergia

MedGen UID:
869256
•Concept ID:
C4023680
•
Disease or Syndrome
HPO: HP:0010868

Definition

A type of dyssynergia affecting eye movements and characterized by the inability to smoothly follow a visual target across the visual field. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular dyssynergia

Professional guidelines

PubMed

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients.
Le Roux M, Barth M, Gueden S, Desbordes de Cepoy P, Aeby A, Vilain C, Hirsch E, de Saint Martin A, Portes VD, Lesca G, Riquet A, Chaton L, Villeneuve N, Villard L, Cances C, Valton L, Renaldo F, Vermersch AI, Altuzarra C, Nguyen-Morel MA, Van Gils J, Angelini C, Biraben A, Arnaud L, Riant F, Van Bogaert P
Eur J Paediatr Neurol 2021 Jul;33:75-85. Epub 2021 May 26 doi: 10.1016/j.ejpn.2021.05.010. PMID: 34102571
Cerebellar Dizziness and Vertigo: Etiologies, Diagnostic Assessment, and Treatment.
Zwergal A, Feil K, Schniepp R, Strupp M
Semin Neurol 2020 Feb;40(1):87-96. Epub 2019 Dec 30 doi: 10.1055/s-0039-3400315. PMID: 31887755

Recent clinical studies

Etiology

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Cerebellar Dizziness and Vertigo: Etiologies, Diagnostic Assessment, and Treatment.
Zwergal A, Feil K, Schniepp R, Strupp M
Semin Neurol 2020 Feb;40(1):87-96. Epub 2019 Dec 30 doi: 10.1055/s-0039-3400315. PMID: 31887755
Aminoglycoside Vestibulotoxicity.
Rutka J
Adv Otorhinolaryngol 2019;82:101-110. Epub 2019 Jan 15 doi: 10.1159/000490277. PMID: 30947191
Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.
Bodranghien F, Bastian A, Casali C, Hallett M, Louis ED, Manto M, Mariën P, Nowak DA, Schmahmann JD, Serrao M, Steiner KM, Strupp M, Tilikete C, Timmann D, van Dun K
Cerebellum 2016 Jun;15(3):369-91. doi: 10.1007/s12311-015-0687-3. PMID: 26105056Free PMC Article
Thiamin in Clinical Practice.
Frank LL
JPEN J Parenter Enteral Nutr 2015 Jul;39(5):503-20. Epub 2015 Jan 6 doi: 10.1177/0148607114565245. PMID: 25564426

Diagnosis

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS): genetic and clinical aspects.
Cortese A, Curro' R, Vegezzi E, Yau WY, Houlden H, Reilly MM
Pract Neurol 2022 Feb;22(1):14-18. Epub 2021 Aug 13 doi: 10.1136/practneurol-2020-002822. PMID: 34389644
Opsoclonus-myoclonus-ataxia syndrome in children.
Bhatia P, Heim J, Cornejo P, Kane L, Santiago J, Kruer MC
J Neurol 2022 Feb;269(2):750-757. Epub 2021 Mar 29 doi: 10.1007/s00415-021-10536-3. PMID: 33779841
Cerebellar Dizziness and Vertigo: Etiologies, Diagnostic Assessment, and Treatment.
Zwergal A, Feil K, Schniepp R, Strupp M
Semin Neurol 2020 Feb;40(1):87-96. Epub 2019 Dec 30 doi: 10.1055/s-0039-3400315. PMID: 31887755
Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.
Bodranghien F, Bastian A, Casali C, Hallett M, Louis ED, Manto M, Mariën P, Nowak DA, Schmahmann JD, Serrao M, Steiner KM, Strupp M, Tilikete C, Timmann D, van Dun K
Cerebellum 2016 Jun;15(3):369-91. doi: 10.1007/s12311-015-0687-3. PMID: 26105056Free PMC Article

Therapy

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.
Bland P, Saville H, Wai PT, Curnow L, Muirhead G, Nieminuszczy J, Ravindran N, John MB, Hedayat S, Barker HE, Wright J, Yu L, Mavrommati I, Read A, Peck B, Allen M, Gazinska P, Pemberton HN, Gulati A, Nash S, Noor F, Guppy N, Roxanis I, Pratt G, Oldreive C, Stankovic T, Barlow S, Kalirai H, Coupland SE, Broderick R, Alsafadi S, Houy A, Stern MH, Pettit S, Choudhary JS, Haider S, Niedzwiedz W, Lord CJ, Natrajan R
Nat Genet 2023 Aug;55(8):1311-1323. Epub 2023 Jul 31 doi: 10.1038/s41588-023-01460-5. PMID: 37524790Free PMC Article
CANOMAD: a neurological monoclonal gammopathy of clinical significance that benefits from B-cell-targeted therapies.
Le Cann M, Bouhour F, Viala K, Simon L, Tard C, Rossi C, Morel G, Lagrange E, Magy L, Créange A, Michaud M, Franques J, Echaniz-Laguna A, Antoine JC, Baron M, Arnulf B, Puma A, Delmont E, Maisonobe T, Leblond V, Roos-Weil D
Blood 2020 Nov 19;136(21):2428-2436. doi: 10.1182/blood.2020007092. PMID: 32959046
Autoimmune Vestibulocerebellar Syndromes.
Narayan RN, McKeon A, Fife TD
Semin Neurol 2020 Feb;40(1):97-115. Epub 2020 Jan 20 doi: 10.1055/s-0039-3402061. PMID: 31958862
Aminoglycoside Vestibulotoxicity.
Rutka J
Adv Otorhinolaryngol 2019;82:101-110. Epub 2019 Jan 15 doi: 10.1159/000490277. PMID: 30947191
Thiamin in Clinical Practice.
Frank LL
JPEN J Parenter Enteral Nutr 2015 Jul;39(5):503-20. Epub 2015 Jan 6 doi: 10.1177/0148607114565245. PMID: 25564426

Prognosis

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.
Bland P, Saville H, Wai PT, Curnow L, Muirhead G, Nieminuszczy J, Ravindran N, John MB, Hedayat S, Barker HE, Wright J, Yu L, Mavrommati I, Read A, Peck B, Allen M, Gazinska P, Pemberton HN, Gulati A, Nash S, Noor F, Guppy N, Roxanis I, Pratt G, Oldreive C, Stankovic T, Barlow S, Kalirai H, Coupland SE, Broderick R, Alsafadi S, Houy A, Stern MH, Pettit S, Choudhary JS, Haider S, Niedzwiedz W, Lord CJ, Natrajan R
Nat Genet 2023 Aug;55(8):1311-1323. Epub 2023 Jul 31 doi: 10.1038/s41588-023-01460-5. PMID: 37524790Free PMC Article
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Autoimmune Vestibulocerebellar Syndromes.
Narayan RN, McKeon A, Fife TD
Semin Neurol 2020 Feb;40(1):97-115. Epub 2020 Jan 20 doi: 10.1055/s-0039-3402061. PMID: 31958862
Nonprogressive congenital ataxias.
Bertini E, Zanni G, Boltshauser E
Handb Clin Neurol 2018;155:91-103. doi: 10.1016/B978-0-444-64189-2.00006-8. PMID: 29891079
Bilateral vestibulopathy.
Strupp M, Feil K, Dieterich M, Brandt T
Handb Clin Neurol 2016;137:235-40. doi: 10.1016/B978-0-444-63437-5.00017-0. PMID: 27638075

Clinical prediction guides

APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors.
Zong C, Zhang Z, Gao L, He J, Wang Y, Li Q, Liu X, Yang J, Chen D, Huang R, Zheng G, Jin X, Wei W, Jia R, Shen J
Cell Death Dis 2023 Jun 3;14(6):348. doi: 10.1038/s41419-023-05867-0. PMID: 37270643Free PMC Article
Update on Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS).
Dupré M, Hermann R, Froment Tilikete C
Cerebellum 2021 Oct;20(5):687-700. Epub 2020 Oct 4 doi: 10.1007/s12311-020-01192-w. PMID: 33011895Free PMC Article
CANOMAD: a neurological monoclonal gammopathy of clinical significance that benefits from B-cell-targeted therapies.
Le Cann M, Bouhour F, Viala K, Simon L, Tard C, Rossi C, Morel G, Lagrange E, Magy L, Créange A, Michaud M, Franques J, Echaniz-Laguna A, Antoine JC, Baron M, Arnulf B, Puma A, Delmont E, Maisonobe T, Leblond V, Roos-Weil D
Blood 2020 Nov 19;136(21):2428-2436. doi: 10.1182/blood.2020007092. PMID: 32959046
Aminoglycoside Vestibulotoxicity.
Rutka J
Adv Otorhinolaryngol 2019;82:101-110. Epub 2019 Jan 15 doi: 10.1159/000490277. PMID: 30947191
Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.
Bodranghien F, Bastian A, Casali C, Hallett M, Louis ED, Manto M, Mariën P, Nowak DA, Schmahmann JD, Serrao M, Steiner KM, Strupp M, Tilikete C, Timmann D, van Dun K
Cerebellum 2016 Jun;15(3):369-91. doi: 10.1007/s12311-015-0687-3. PMID: 26105056Free PMC Article

Recent systematic reviews

When time is brain: a systematic review about Wernicke encephalopathy as a dramatic consequence of thiamin deficiency in hyperemesis gravidarum.
Fiorentini M, Nedu B, Dapoto F, Brunelli E, Pilu G, Youssef A
J Matern Fetal Neonatal Med 2023 Dec;36(2):2223678. doi: 10.1080/14767058.2023.2223678. PMID: 37322816
Wernicke Encephalopathy in schizophrenia: a systematic review.
Oudman E, Wijnia JW, Oey MJ, van Dam MJ, Postma A
Int J Psychiatry Clin Pract 2021 Sep;25(3):233-237. Epub 2020 Sep 21 doi: 10.1080/13651501.2020.1819333. PMID: 32957818
Acute vestibular syndrome associated with anti-GQ1b antibody.
Lee SU, Kim HJ, Choi JY, Kim JK, Kim JS
Neurology 2019 Sep 10;93(11):e1085-e1092. Epub 2019 Aug 9 doi: 10.1212/WNL.0000000000008107. PMID: 31399495
Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review.
Oudman E, Wijnia JW, Oey MJ, van Dam MJ, Postma A
Psychiatry Clin Neurosci 2018 Oct;72(10):774-779. Epub 2018 Jul 31 doi: 10.1111/pcn.12735. PMID: 29984541
Interventions for eye movement disorders due to acquired brain injury.
Rowe FJ, Hanna K, Evans JR, Noonan CP, Garcia-Finana M, Dodridge CS, Howard C, Jarvis KA, MacDiarmid SL, Maan T, North L, Rodgers H
Cochrane Database Syst Rev 2018 Mar 5;3(3):CD011290. doi: 10.1002/14651858.CD011290.pub2. PMID: 29505103Free PMC Article

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