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Abnormal curvature of the vertebral column

MedGen UID:
869321
•Concept ID:
C4023747
•
Anatomical Abnormality
Synonyms: Abnormal curve of the backbone; Abnormal curve of the spine; Abnormal curving of the spine; Abnormality of the curvature of the vertebral column; Curvature of spine; Curved spine
 
HPO: HP:0010674

Definition

The presence of an abnormal curvature of the vertebral column. [from HPO]

Conditions with this feature

Developmental delay, impaired speech, and behavioral abnormalities
MedGen UID:
1794167
•Concept ID:
C5561957
•
Disease or Syndrome
Developmental delay, impaired speech, and behavioral abnormalities (DDISBA) is characterized by global developmental delay apparent from early childhood. Intellectual disability can range from mild to severe. Additional variable features may include dysmorphic facial features, seizures, hypotonia, motor abnormalities such as Tourette syndrome or dystonia, and hearing loss (summary by Cousin et al., 2021).
See: Condition Record
Developmental delay, impaired speech, and behavioral abnormalities

Professional guidelines

PubMed

A comprehensive review of the diagnosis and management of congenital scoliosis.
Mackel CE, Jada A, Samdani AF, Stephen JH, Bennett JT, Baaj AA, Hwang SW
Childs Nerv Syst 2018 Nov;34(11):2155-2171. Epub 2018 Aug 4 doi: 10.1007/s00381-018-3915-6. PMID: 30078055
Scoliosis in myelomeningocele: epidemiology, management, and functional outcome.
Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JC 3rd, Bonfield CM
J Neurosurg Pediatr 2017 Jul;20(1):99-108. Epub 2017 Apr 28 doi: 10.3171/2017.2.PEDS16641. PMID: 28452655
Pathophysiological Concepts and Treatment of Camptocormia.
Margraf NG, Wrede A, Deuschl G, Schulz-Schaeffer WJ
J Parkinsons Dis 2016 Jun 16;6(3):485-501. doi: 10.3233/JPD-160836. PMID: 27314757Free PMC Article

Recent clinical studies

Etiology

Adult spinal deformity.
Diebo BG, Shah NV, Boachie-Adjei O, Zhu F, Rothenfluh DA, Paulino CB, Schwab FJ, Lafage V
Lancet 2019 Jul 13;394(10193):160-172. Epub 2019 Jul 11 doi: 10.1016/S0140-6736(19)31125-0. PMID: 31305254
Chronic low back pain: Relevance of a new classification based on the injury pattern.
Barrey CY, Le Huec JC; French Society for Spine Surgery
Orthop Traumatol Surg Res 2019 Apr;105(2):339-346. Epub 2019 Feb 18 doi: 10.1016/j.otsr.2018.11.021. PMID: 30792166
Chiari Malformations.
Mancarella C, Delfini R, Landi A
Acta Neurochir Suppl 2019;125:89-95. doi: 10.1007/978-3-319-62515-7_13. PMID: 30610307
A comprehensive review of the diagnosis and management of congenital scoliosis.
Mackel CE, Jada A, Samdani AF, Stephen JH, Bennett JT, Baaj AA, Hwang SW
Childs Nerv Syst 2018 Nov;34(11):2155-2171. Epub 2018 Aug 4 doi: 10.1007/s00381-018-3915-6. PMID: 30078055
Adolescent idiopathic scoliosis: review and current concepts.
Reamy BV, Slakey JB
Am Fam Physician 2001 Jul 1;64(1):111-6. PMID: 11456428

Diagnosis

Scoliosis: An Overview.
Mesiti BL
Radiol Technol 2021 Sep;93(1):55-72. PMID: 34588279
Adolescent Idiopathic Scoliosis: Common Questions and Answers.
Kuznia AL, Hernandez AK, Lee LU
Am Fam Physician 2020 Jan 1;101(1):19-23. PMID: 31894928
Chiari Malformations.
Mancarella C, Delfini R, Landi A
Acta Neurochir Suppl 2019;125:89-95. doi: 10.1007/978-3-319-62515-7_13. PMID: 30610307
A comprehensive review of the diagnosis and management of congenital scoliosis.
Mackel CE, Jada A, Samdani AF, Stephen JH, Bennett JT, Baaj AA, Hwang SW
Childs Nerv Syst 2018 Nov;34(11):2155-2171. Epub 2018 Aug 4 doi: 10.1007/s00381-018-3915-6. PMID: 30078055
Adolescent idiopathic scoliosis: review and current concepts.
Reamy BV, Slakey JB
Am Fam Physician 2001 Jul 1;64(1):111-6. PMID: 11456428

Therapy

Scoliosis Curvature Follows Thoracic Organ Orientation.
Compton J, Voort WV, Weinstein S
Spine (Phila Pa 1976) 2020 Mar 15;45(6):378-380. doi: 10.1097/BRS.0000000000002731. PMID: 29952884
Strategies for Treating Scoliosis in Early Childhood.
Ridderbusch K, Spiro AS, Kunkel P, Grolle B, Stücker R, Rupprecht M
Dtsch Arztebl Int 2018 Jun 1;115(22):371-376. doi: 10.3238/arztebl.2018.0371. PMID: 29932047Free PMC Article
Camptocormia in Parkinson's disease: definition, epidemiology, pathogenesis and treatment modalities.
Srivanitchapoom P, Hallett M
J Neurol Neurosurg Psychiatry 2016 Jan;87(1):75-85. Epub 2015 Apr 20 doi: 10.1136/jnnp-2014-310049. PMID: 25896683Free PMC Article
Management of cervical spine deformity after intradural tumor resection.
Joaquim AF, Riew KD
Neurosurg Focus 2015 Aug;39(2):E13. doi: 10.3171/2015.5.FOCUS15134. PMID: 26235011
Congenital scoliosis: etiology and associations.
Hensinger RN
Spine (Phila Pa 1976) 2009 Aug 1;34(17):1745-50. doi: 10.1097/BRS.0b013e3181abf69e. PMID: 19602997

Prognosis

Scoliosis in myelomeningocele: epidemiology, management, and functional outcome.
Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JC 3rd, Bonfield CM
J Neurosurg Pediatr 2017 Jul;20(1):99-108. Epub 2017 Apr 28 doi: 10.3171/2017.2.PEDS16641. PMID: 28452655
Biochemistry of adolescent idiopathic scoliosis.
Lombardi G, Akoume MY, Colombini A, Moreau A, Banfi G
Adv Clin Chem 2011;54:165-82. doi: 10.1016/b978-0-12-387025-4.00007-8. PMID: 21874761
Camptocormia in Parkinson's disease.
Melamed E, Djaldetti R
J Neurol 2006 Dec;253 Suppl 7:VII14-16. doi: 10.1007/s00415-006-7004-5. PMID: 17131221
Adolescent idiopathic scoliosis: review and current concepts.
Reamy BV, Slakey JB
Am Fam Physician 2001 Jul 1;64(1):111-6. PMID: 11456428
The curve of the cervical spine: variations and significance.
Gay RE
J Manipulative Physiol Ther 1993 Nov-Dec;16(9):591-4. PMID: 8133194

Clinical prediction guides

Aphanius fasciatus: a molecular model of scoliosis?
Lahmar S, Kessabi K, Messaoudi I
Spine Deform 2021 Jul;9(4):883-892. Epub 2021 Jan 29 doi: 10.1007/s43390-021-00291-w. PMID: 33512704
Adolescent Idiopathic Scoliosis: Common Questions and Answers.
Kuznia AL, Hernandez AK, Lee LU
Am Fam Physician 2020 Jan 1;101(1):19-23. PMID: 31894928
Scoliosis in myelomeningocele: epidemiology, management, and functional outcome.
Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JC 3rd, Bonfield CM
J Neurosurg Pediatr 2017 Jul;20(1):99-108. Epub 2017 Apr 28 doi: 10.3171/2017.2.PEDS16641. PMID: 28452655
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article
Congenital scoliosis.
Arlet V, Odent T, Aebi M
Eur Spine J 2003 Oct;12(5):456-63. Epub 2003 Jun 14 doi: 10.1007/s00586-003-0555-6. PMID: 14618384Free PMC Article

Recent systematic reviews

Deep brain stimulation for Parkinson's disease-related postural abnormalities: a systematic review and meta-analysis.
Spindler P, Alzoobi Y, Kühn AA, Faust K, Schneider GH, Vajkoczy P
Neurosurg Rev 2022 Oct;45(5):3083-3092. Epub 2022 Jul 5 doi: 10.1007/s10143-022-01830-3. PMID: 35790655Free PMC Article
The importance of extrinsic and intrinsic compensatory mechanisms to body posture of competitive athletes a systematic review and meta-analysis.
Zwierzchowska A, Gaweł E, Maszczyk A, Roczniok R
Sci Rep 2022 May 25;12(1):8808. doi: 10.1038/s41598-022-12979-8. PMID: 35614193Free PMC Article
Surgical management of camptocormia in Parkinson's disease: systematic review and meta-analysis.
Chan AK, Chan AY, Lau D, Durcanova B, Miller CA, Larson PS, Starr PA, Mummaneni PV
J Neurosurg 2019 Aug 1;131(2):368-375. Epub 2018 Sep 14 doi: 10.3171/2018.4.JNS173032. PMID: 30215560
Instrumentation and fusion for congenital spine deformities.
Hedequist DJ
Spine (Phila Pa 1976) 2009 Aug 1;34(17):1783-90. doi: 10.1097/BRS.0b013e3181ab62b3. PMID: 19644329

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