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Abnormal curvature of the vertebral column

MedGen UID:
869321
Concept ID:
C4023747
Anatomical Abnormality
Synonyms: Abnormal curve of the backbone; Abnormal curve of the spine; Abnormal curving of the spine; Abnormality of the curvature of the vertebral column; Curvature of spine; Curved spine
 
HPO: HP:0010674

Definition

The presence of an abnormal curvature of the vertebral column. [from HPO]

Conditions with this feature

Developmental delay, impaired speech, and behavioral abnormalities
MedGen UID:
1794167
Concept ID:
C5561957
Disease or Syndrome
Developmental delay, impaired speech, and behavioral abnormalities (DDISBA) is characterized by global developmental delay apparent from early childhood. Intellectual disability can range from mild to severe. Additional variable features may include dysmorphic facial features, seizures, hypotonia, motor abnormalities such as Tourette syndrome or dystonia, and hearing loss (summary by Cousin et al., 2021).

Professional guidelines

PubMed

Mackel CE, Jada A, Samdani AF, Stephen JH, Bennett JT, Baaj AA, Hwang SW
Childs Nerv Syst 2018 Nov;34(11):2155-2171. Epub 2018 Aug 4 doi: 10.1007/s00381-018-3915-6. PMID: 30078055
Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JC 3rd, Bonfield CM
J Neurosurg Pediatr 2017 Jul;20(1):99-108. Epub 2017 Apr 28 doi: 10.3171/2017.2.PEDS16641. PMID: 28452655
Margraf NG, Wrede A, Deuschl G, Schulz-Schaeffer WJ
J Parkinsons Dis 2016 Jun 16;6(3):485-501. doi: 10.3233/JPD-160836. PMID: 27314757Free PMC Article

Recent clinical studies

Etiology

Diebo BG, Shah NV, Boachie-Adjei O, Zhu F, Rothenfluh DA, Paulino CB, Schwab FJ, Lafage V
Lancet 2019 Jul 13;394(10193):160-172. Epub 2019 Jul 11 doi: 10.1016/S0140-6736(19)31125-0. PMID: 31305254
Barrey CY, Le Huec JC; French Society for Spine Surgery
Orthop Traumatol Surg Res 2019 Apr;105(2):339-346. Epub 2019 Feb 18 doi: 10.1016/j.otsr.2018.11.021. PMID: 30792166
Mancarella C, Delfini R, Landi A
Acta Neurochir Suppl 2019;125:89-95. doi: 10.1007/978-3-319-62515-7_13. PMID: 30610307
Mackel CE, Jada A, Samdani AF, Stephen JH, Bennett JT, Baaj AA, Hwang SW
Childs Nerv Syst 2018 Nov;34(11):2155-2171. Epub 2018 Aug 4 doi: 10.1007/s00381-018-3915-6. PMID: 30078055
Reamy BV, Slakey JB
Am Fam Physician 2001 Jul 1;64(1):111-6. PMID: 11456428

Diagnosis

Mesiti BL
Radiol Technol 2021 Sep;93(1):55-72. PMID: 34588279
Kuznia AL, Hernandez AK, Lee LU
Am Fam Physician 2020 Jan 1;101(1):19-23. PMID: 31894928
Mancarella C, Delfini R, Landi A
Acta Neurochir Suppl 2019;125:89-95. doi: 10.1007/978-3-319-62515-7_13. PMID: 30610307
Mackel CE, Jada A, Samdani AF, Stephen JH, Bennett JT, Baaj AA, Hwang SW
Childs Nerv Syst 2018 Nov;34(11):2155-2171. Epub 2018 Aug 4 doi: 10.1007/s00381-018-3915-6. PMID: 30078055
Reamy BV, Slakey JB
Am Fam Physician 2001 Jul 1;64(1):111-6. PMID: 11456428

Therapy

Nouri F, Ghasemi SH, Lee JY
BMC Musculoskelet Disord 2020 Mar 31;21(1):199. doi: 10.1186/s12891-020-03230-4. PMID: 32234029Free PMC Article
Compton J, Voort WV, Weinstein S
Spine (Phila Pa 1976) 2020 Mar 15;45(6):378-380. doi: 10.1097/BRS.0000000000002731. PMID: 29952884
Ridderbusch K, Spiro AS, Kunkel P, Grolle B, Stücker R, Rupprecht M
Dtsch Arztebl Int 2018 Jun 1;115(22):371-376. doi: 10.3238/arztebl.2018.0371. PMID: 29932047Free PMC Article
Joaquim AF, Riew KD
Neurosurg Focus 2015 Aug;39(2):E13. doi: 10.3171/2015.5.FOCUS15134. PMID: 26235011
Hensinger RN
Spine (Phila Pa 1976) 2009 Aug 1;34(17):1745-50. doi: 10.1097/BRS.0b013e3181abf69e. PMID: 19602997

Prognosis

Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JC 3rd, Bonfield CM
J Neurosurg Pediatr 2017 Jul;20(1):99-108. Epub 2017 Apr 28 doi: 10.3171/2017.2.PEDS16641. PMID: 28452655
Lombardi G, Akoume MY, Colombini A, Moreau A, Banfi G
Adv Clin Chem 2011;54:165-82. doi: 10.1016/b978-0-12-387025-4.00007-8. PMID: 21874761
Melamed E, Djaldetti R
J Neurol 2006 Dec;253 Suppl 7:VII14-16. doi: 10.1007/s00415-006-7004-5. PMID: 17131221
Reamy BV, Slakey JB
Am Fam Physician 2001 Jul 1;64(1):111-6. PMID: 11456428
Gay RE
J Manipulative Physiol Ther 1993 Nov-Dec;16(9):591-4. PMID: 8133194

Clinical prediction guides

Lahmar S, Kessabi K, Messaoudi I
Spine Deform 2021 Jul;9(4):883-892. Epub 2021 Jan 29 doi: 10.1007/s43390-021-00291-w. PMID: 33512704
Kuznia AL, Hernandez AK, Lee LU
Am Fam Physician 2020 Jan 1;101(1):19-23. PMID: 31894928
Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JC 3rd, Bonfield CM
J Neurosurg Pediatr 2017 Jul;20(1):99-108. Epub 2017 Apr 28 doi: 10.3171/2017.2.PEDS16641. PMID: 28452655
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article
Arlet V, Odent T, Aebi M
Eur Spine J 2003 Oct;12(5):456-63. Epub 2003 Jun 14 doi: 10.1007/s00586-003-0555-6. PMID: 14618384Free PMC Article

Recent systematic reviews

Spindler P, Alzoobi Y, Kühn AA, Faust K, Schneider GH, Vajkoczy P
Neurosurg Rev 2022 Oct;45(5):3083-3092. Epub 2022 Jul 5 doi: 10.1007/s10143-022-01830-3. PMID: 35790655Free PMC Article
Zwierzchowska A, Gaweł E, Maszczyk A, Roczniok R
Sci Rep 2022 May 25;12(1):8808. doi: 10.1038/s41598-022-12979-8. PMID: 35614193Free PMC Article
Chan AK, Chan AY, Lau D, Durcanova B, Miller CA, Larson PS, Starr PA, Mummaneni PV
J Neurosurg 2018 Sep 14;131(2):368-375. doi: 10.3171/2018.4.JNS173032. PMID: 30215560
Hedequist DJ
Spine (Phila Pa 1976) 2009 Aug 1;34(17):1783-90. doi: 10.1097/BRS.0b013e3181ab62b3. PMID: 19644329

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