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Elevated alkaline phosphatase of hepatic origin

MedGen UID:
869338
•Concept ID:
C4023764
•
Finding
Synonym: Elevated ALP of hepatic origin
 
HPO: HP:0010638

Definition

An abnormally increased level of liver isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood. [from HPO]

Professional guidelines

PubMed

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
Kwo PY, Cohen SM, Lim JK
Am J Gastroenterol 2017 Jan;112(1):18-35. Epub 2016 Dec 20 doi: 10.1038/ajg.2016.517. PMID: 27995906
Surgical and nonsurgical management of primary and metastatic liver tumors.
Zibari GB, Riche A, Zizzi HC, McMillan RW, Aultman DF, Boykin KN, Gonzalez E, Nandy I, Dies DF, Gholson CF, Holcombe RF, McDonald JC
Am Surg 1998 Mar;64(3):211-20; discussion 220-1. PMID: 9520809

Recent clinical studies

Etiology

Risk factors of hepatic function alterations in hospitalized adult patients treated with short-term parenteral nutrition receiving the same lipid composition at the same dose.
Llop-Talaveron J, Badia-Tahull MB, Lozano-Andreu T, Suarez-Lledo A, Leiva-Badosa E
Lipids Health Dis 2018 Nov 24;17(1):267. doi: 10.1186/s12944-018-0912-4. PMID: 30474548Free PMC Article
Elevated Alkaline Phosphatase in Infants With Parenteral Nutrition-Associated Liver Disease Reflects Bone Rather Than Liver Disease.
Nandivada P, Potemkin AK, Carlson SJ, Chang MI, Cowan E, O'Loughlin AA, Gura KM, Puder M
JPEN J Parenter Enteral Nutr 2015 Nov;39(8):973-6. Epub 2014 Aug 8 doi: 10.1177/0148607114545995. PMID: 25106918
Surgical and nonsurgical management of primary and metastatic liver tumors.
Zibari GB, Riche A, Zizzi HC, McMillan RW, Aultman DF, Boykin KN, Gonzalez E, Nandy I, Dies DF, Gholson CF, Holcombe RF, McDonald JC
Am Surg 1998 Mar;64(3):211-20; discussion 220-1. PMID: 9520809
Hepatic peripheral T-cell lymphoma: a spectrum of liver pathology and clinical correlation.
Mitarnun W, Kietthubthew S, Suwiwat S
J Med Assoc Thai 1997 Apr;80(4):219-32. PMID: 9175391
Hepatic incidentaloma: a modern problem.
Little JM, Kenny J, Hollands MJ
World J Surg 1990 Jul-Aug;14(4):448-51. doi: 10.1007/BF01658665. PMID: 2166378

Diagnosis

Atypical Large Vessel Vasculitis Presenting With Cholestatic Liver Abnormalities: Case-Based Review.
Sangha S, Lenert A, Dawoud S, Kaur A, Yazan H, Voigt MD, Lenert P
J Clin Rheumatol 2021 Dec 1;27(8):e561-e567. doi: 10.1097/RHU.0000000000001596. PMID: 33065628
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
Kwo PY, Cohen SM, Lim JK
Am J Gastroenterol 2017 Jan;112(1):18-35. Epub 2016 Dec 20 doi: 10.1038/ajg.2016.517. PMID: 27995906
Elevated Alkaline Phosphatase in Infants With Parenteral Nutrition-Associated Liver Disease Reflects Bone Rather Than Liver Disease.
Nandivada P, Potemkin AK, Carlson SJ, Chang MI, Cowan E, O'Loughlin AA, Gura KM, Puder M
JPEN J Parenter Enteral Nutr 2015 Nov;39(8):973-6. Epub 2014 Aug 8 doi: 10.1177/0148607114545995. PMID: 25106918
Clinical associations between thyroid and liver diseases.
Huang MJ, Liaw YF
J Gastroenterol Hepatol 1995 May-Jun;10(3):344-50. doi: 10.1111/j.1440-1746.1995.tb01106.x. PMID: 7548816
Significance of elevated liver alkaline phosphatase in serum.
Brensilver HL, Kaplan MM
Gastroenterology 1975 Jun;68(6):1556-62. PMID: 1093921

Therapy

Elevated Alkaline Phosphatase in Infants With Parenteral Nutrition-Associated Liver Disease Reflects Bone Rather Than Liver Disease.
Nandivada P, Potemkin AK, Carlson SJ, Chang MI, Cowan E, O'Loughlin AA, Gura KM, Puder M
JPEN J Parenter Enteral Nutr 2015 Nov;39(8):973-6. Epub 2014 Aug 8 doi: 10.1177/0148607114545995. PMID: 25106918
Hepatic peripheral T-cell lymphoma: a spectrum of liver pathology and clinical correlation.
Mitarnun W, Kietthubthew S, Suwiwat S
J Med Assoc Thai 1997 Apr;80(4):219-32. PMID: 9175391
Clinical associations between thyroid and liver diseases.
Huang MJ, Liaw YF
J Gastroenterol Hepatol 1995 May-Jun;10(3):344-50. doi: 10.1111/j.1440-1746.1995.tb01106.x. PMID: 7548816
Hepatic incidentaloma: a modern problem.
Little JM, Kenny J, Hollands MJ
World J Surg 1990 Jul-Aug;14(4):448-51. doi: 10.1007/BF01658665. PMID: 2166378
Significance of elevated liver alkaline phosphatase in serum.
Brensilver HL, Kaplan MM
Gastroenterology 1975 Jun;68(6):1556-62. PMID: 1093921

Prognosis

Atypical Large Vessel Vasculitis Presenting With Cholestatic Liver Abnormalities: Case-Based Review.
Sangha S, Lenert A, Dawoud S, Kaur A, Yazan H, Voigt MD, Lenert P
J Clin Rheumatol 2021 Dec 1;27(8):e561-e567. doi: 10.1097/RHU.0000000000001596. PMID: 33065628
Surgical and nonsurgical management of primary and metastatic liver tumors.
Zibari GB, Riche A, Zizzi HC, McMillan RW, Aultman DF, Boykin KN, Gonzalez E, Nandy I, Dies DF, Gholson CF, Holcombe RF, McDonald JC
Am Surg 1998 Mar;64(3):211-20; discussion 220-1. PMID: 9520809
Hepatic peripheral T-cell lymphoma: a spectrum of liver pathology and clinical correlation.
Mitarnun W, Kietthubthew S, Suwiwat S
J Med Assoc Thai 1997 Apr;80(4):219-32. PMID: 9175391
Malignant lymphoma imitating hepatitis.
Harris AC, Kornstein MJ
Cancer 1993 Apr 15;71(8):2639-46. doi: 10.1002/1097-0142(19930415)71:8<2639::aid-cncr2820710832>3.0.co;2-q. PMID: 8453587
Hepatic incidentaloma: a modern problem.
Little JM, Kenny J, Hollands MJ
World J Surg 1990 Jul-Aug;14(4):448-51. doi: 10.1007/BF01658665. PMID: 2166378

Clinical prediction guides

Atypical Large Vessel Vasculitis Presenting With Cholestatic Liver Abnormalities: Case-Based Review.
Sangha S, Lenert A, Dawoud S, Kaur A, Yazan H, Voigt MD, Lenert P
J Clin Rheumatol 2021 Dec 1;27(8):e561-e567. doi: 10.1097/RHU.0000000000001596. PMID: 33065628
Elevated Alkaline Phosphatase in Infants With Parenteral Nutrition-Associated Liver Disease Reflects Bone Rather Than Liver Disease.
Nandivada P, Potemkin AK, Carlson SJ, Chang MI, Cowan E, O'Loughlin AA, Gura KM, Puder M
JPEN J Parenter Enteral Nutr 2015 Nov;39(8):973-6. Epub 2014 Aug 8 doi: 10.1177/0148607114545995. PMID: 25106918
Undifferentiated embryonal sarcoma of the liver: case report and literature survey.
Pachera S, Nishio H, Takahashi Y, Yokoyama Y, Oda K, Ebata T, Igami T, Nagino M
J Hepatobiliary Pancreat Surg 2008;15(5):536-44. Epub 2008 Oct 4 doi: 10.1007/s00534-007-1265-y. PMID: 18836810
Surgical and nonsurgical management of primary and metastatic liver tumors.
Zibari GB, Riche A, Zizzi HC, McMillan RW, Aultman DF, Boykin KN, Gonzalez E, Nandy I, Dies DF, Gholson CF, Holcombe RF, McDonald JC
Am Surg 1998 Mar;64(3):211-20; discussion 220-1. PMID: 9520809
How does liver dysfunction influence serum CA 19-9 in pancreatic cancer?
Basso D, Fabris C, Del Favero G, Piccoli A, Angonese C, Pasquali C, Castoro C, Plebani M, Leandro G, Burlina A
Ital J Gastroenterol 1990 Feb;22(1):1-6. PMID: 2131920

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