U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Allergy, Milk

MedGen UID:
86965
•Concept ID:
C0079840
•
Pathologic Function
Synonyms: Hypersensitivity, Milk; Milk Allergies; Milk Allergy; Milk Hypersensitivities; Milk Hypersensitivity

Definition

Allergic reaction to milk (usually cow''s milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergy, Milk

Professional guidelines

PubMed

Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.
Burris AD, Burris J, Järvinen KM
Neoreviews 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795. PMID: 33262206
Food Allergy Prevention and Treatment by Targeted Nutrition.
Heine RG
Ann Nutr Metab 2018;72 Suppl 3:33-45. Epub 2018 Apr 9 doi: 10.1159/000487380. PMID: 29631274
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA
J Allergy Clin Immunol 2014 Feb;133(2):291-307; quiz 308. Epub 2013 Dec 31 doi: 10.1016/j.jaci.2013.11.020. PMID: 24388012

Recent clinical studies

Etiology

Missed Diagnosis of Anaphylaxis in Patients With Pediatric Urticaria in the Emergency Department.
Jung WS, Kim SH, Lee H
Pediatr Emerg Care 2021 Apr 1;37(4):199-203. doi: 10.1097/PEC.0000000000001617. PMID: 30281553
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article
Therapeutic modalities for cow's milk allergy.
Seidman EG, Singer S
Ann Allergy Asthma Immunol 2003 Jun;90(6 Suppl 3):104-11. doi: 10.1016/s1081-1206(10)61670-5. PMID: 12839123
Fatty acids in breast milk of allergic and non-allergic mothers: The PIAMA birth cohort study.
Wijga A, Houwelingen AC, Smit HA, Kerkhof M, Vos AP, Neijens HJ, Brunekreef B; PIAMA Birth Cohort Study
Pediatr Allergy Immunol 2003 Jun;14(3):156-62. doi: 10.1034/j.1399-3038.2003.00022.x. PMID: 12787293
Cow's milk allergy in the first year of life. An Italian Collaborative Study.
Acta Paediatr Scand Suppl 1988;348:1-14. PMID: 3071078

Diagnosis

Missed Diagnosis of Anaphylaxis in Patients With Pediatric Urticaria in the Emergency Department.
Jung WS, Kim SH, Lee H
Pediatr Emerg Care 2021 Apr 1;37(4):199-203. doi: 10.1097/PEC.0000000000001617. PMID: 30281553
Component resolved diagnostic study of cow's milk allergy in infants and young children in northern China.
Li J, Zhang J, Qiong C, She T, Bian Y, Lin S, Li H
Int Immunopharmacol 2018 Aug;61:126-131. Epub 2018 May 30 doi: 10.1016/j.intimp.2018.05.027. PMID: 29859469
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article
Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age.
Bezrodnik L, Raccio AC, Canil LM, Rey MA, Carabajal PC, Fossati CA, Docena GH
Immunology 2007 Sep;122(1):140-6. Epub 2007 May 11 doi: 10.1111/j.1365-2567.2007.02628.x. PMID: 17498216Free PMC Article
Therapeutic modalities for cow's milk allergy.
Seidman EG, Singer S
Ann Allergy Asthma Immunol 2003 Jun;90(6 Suppl 3):104-11. doi: 10.1016/s1081-1206(10)61670-5. PMID: 12839123

Therapy

The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article
Beef, pork, and milk allergy (cross reactivity with each other and pet allergies).
Mamikoglu B
Otolaryngol Head Neck Surg 2005 Oct;133(4):534-7. doi: 10.1016/j.otohns.2005.07.016. PMID: 16213925
Therapeutic modalities for cow's milk allergy.
Seidman EG, Singer S
Ann Allergy Asthma Immunol 2003 Jun;90(6 Suppl 3):104-11. doi: 10.1016/s1081-1206(10)61670-5. PMID: 12839123
Cow's milk allergy in the first year of life. An Italian Collaborative Study.
Acta Paediatr Scand Suppl 1988;348:1-14. PMID: 3071078

Prognosis

Component resolved diagnostic study of cow's milk allergy in infants and young children in northern China.
Li J, Zhang J, Qiong C, She T, Bian Y, Lin S, Li H
Int Immunopharmacol 2018 Aug;61:126-131. Epub 2018 May 30 doi: 10.1016/j.intimp.2018.05.027. PMID: 29859469
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article

Clinical prediction guides

Component resolved diagnostic study of cow's milk allergy in infants and young children in northern China.
Li J, Zhang J, Qiong C, She T, Bian Y, Lin S, Li H
Int Immunopharmacol 2018 Aug;61:126-131. Epub 2018 May 30 doi: 10.1016/j.intimp.2018.05.027. PMID: 29859469
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article
Fatty acids in breast milk of allergic and non-allergic mothers: The PIAMA birth cohort study.
Wijga A, Houwelingen AC, Smit HA, Kerkhof M, Vos AP, Neijens HJ, Brunekreef B; PIAMA Birth Cohort Study
Pediatr Allergy Immunol 2003 Jun;14(3):156-62. doi: 10.1034/j.1399-3038.2003.00022.x. PMID: 12787293

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...