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Motor neuron atrophy

MedGen UID:
870450
Concept ID:
C4024896
Disease or Syndrome
Synonym: Motor neuron degeneration
 
HPO: HP:0007373

Definition

Wasting involving the motor neuron. [from HPO]

Professional guidelines

PubMed

Nishio H, Niba ETE, Saito T, Okamoto K, Takeshima Y, Awano H
Int J Mol Sci 2023 Jul 26;24(15) doi: 10.3390/ijms241511939. PMID: 37569314Free PMC Article
Mercuri E, Finkel RS, Muntoni F, Wirth B, Montes J, Main M, Mazzone ES, Vitale M, Snyder B, Quijano-Roy S, Bertini E, Davis RH, Meyer OH, Simonds AK, Schroth MK, Graham RJ, Kirschner J, Iannaccone ST, Crawford TO, Woods S, Qian Y, Sejersen T; SMA Care Group
Neuromuscul Disord 2018 Feb;28(2):103-115. Epub 2017 Nov 23 doi: 10.1016/j.nmd.2017.11.005. PMID: 29290580
Mary P, Servais L, Vialle R
Orthop Traumatol Surg Res 2018 Feb;104(1S):S89-S95. Epub 2017 Nov 28 doi: 10.1016/j.otsr.2017.04.019. PMID: 29196274

Recent clinical studies

Etiology

Almaguer-Mederos LE, Jorge-Sainz Y, Almaguer-Gotay D, Aguilera-Rodríguez R, Rodríguez-Labrada R, Velázquez-Pérez L, González-Zaldívar Y, Cuello-Almarales D, Vázquez-Mojena Y, Canales-Ochoa N, Aguiar-Santiago J, Auburger G, MacLeod P
J Neurol Sci 2020 Feb 15;409:116586. Epub 2019 Nov 22 doi: 10.1016/j.jns.2019.116586. PMID: 31812845

Diagnosis

Almaguer-Mederos LE, Jorge-Sainz Y, Almaguer-Gotay D, Aguilera-Rodríguez R, Rodríguez-Labrada R, Velázquez-Pérez L, González-Zaldívar Y, Cuello-Almarales D, Vázquez-Mojena Y, Canales-Ochoa N, Aguiar-Santiago J, Auburger G, MacLeod P
J Neurol Sci 2020 Feb 15;409:116586. Epub 2019 Nov 22 doi: 10.1016/j.jns.2019.116586. PMID: 31812845
Gelernter J, Van Dyck C, van Kammen DP, Malison R, Price LH, Cubells JF, Berman R, Charney DS, Heninger G
Am J Med Genet 1997 Sep 19;74(5):497-500. PMID: 9342199

Therapy

Hefti F
J Neurobiol 1994 Nov;25(11):1418-35. doi: 10.1002/neu.480251109. PMID: 7852995

Clinical prediction guides

Almaguer-Mederos LE, Jorge-Sainz Y, Almaguer-Gotay D, Aguilera-Rodríguez R, Rodríguez-Labrada R, Velázquez-Pérez L, González-Zaldívar Y, Cuello-Almarales D, Vázquez-Mojena Y, Canales-Ochoa N, Aguiar-Santiago J, Auburger G, MacLeod P
J Neurol Sci 2020 Feb 15;409:116586. Epub 2019 Nov 22 doi: 10.1016/j.jns.2019.116586. PMID: 31812845
Gelernter J, Van Dyck C, van Kammen DP, Malison R, Price LH, Cubells JF, Berman R, Charney DS, Heninger G
Am J Med Genet 1997 Sep 19;74(5):497-500. PMID: 9342199

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