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Recurrent gram-negative bacterial infections

MedGen UID:
870743
Concept ID:
C4025198
Finding
HPO: HP:0005420

Definition

Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents. [from HPO]

Conditions with this feature

Leukocyte adhesion deficiency 1
MedGen UID:
98310
Concept ID:
C0398738
Disease or Syndrome
Leukocyte adhesion deficiency (LAD) is an autosomal recessive disorder of neutrophil function resulting from a deficiency of the beta-2 integrin subunit of the leukocyte cell adhesion molecule. The leukocyte cell adhesion molecule is present on the surface of peripheral blood mononuclear leukocytes and granulocytes and mediates cell-cell and cell-extracellular matrix adhesion. LAD is characterized by recurrent bacterial infections; impaired pus formation and wound healing; abnormalities of a wide variety of adhesion-dependent functions of granulocytes, monocytes, and lymphocytes; and a lack of beta-2/alpha-L, beta-2/alpha-M, and beta-2/alpha-X expression. Genetic Heterogeneity of Leukocyte Adhesion Deficiency Also see LAD2 (266265), caused by mutation in the SLC35C1 gene (605881), and LAD3 (612840), caused by mutation in the FERMT3 gene (607901).

Professional guidelines

PubMed

Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
Wagenlehner FME, Bjerklund Johansen TE, Cai T, Koves B, Kranz J, Pilatz A, Tandogdu Z
Nat Rev Urol 2020 Oct;17(10):586-600. Epub 2020 Aug 25 doi: 10.1038/s41585-020-0362-4. PMID: 32843751
Workowski KA, Bolan GA; Centers for Disease Control and Prevention
MMWR Recomm Rep 2015 Jun 5;64(RR-03):1-137. PMID: 26042815Free PMC Article

Recent clinical studies

Etiology

McAteer J, Lee JH, Cosgrove SE, Dzintars K, Fiawoo S, Heil EL, Kendall RE, Louie T, Malani AN, Nori P, Percival KM, Tamma PD
Clin Infect Dis 2023 May 3;76(9):1604-1612. doi: 10.1093/cid/ciad009. PMID: 36633559Free PMC Article
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
von Dach E, Albrich WC, Brunel AS, Prendki V, Cuvelier C, Flury D, Gayet-Ageron A, Huttner B, Kohler P, Lemmenmeier E, McCallin S, Rossel A, Harbarth S, Kaiser L, Bochud PY, Huttner A
JAMA 2020 Jun 2;323(21):2160-2169. doi: 10.1001/jama.2020.6348. PMID: 32484534Free PMC Article
Sun Y, Zhang J
J Cell Mol Med 2019 Dec;23(12):7919-7925. Epub 2019 Sep 19 doi: 10.1111/jcmm.14682. PMID: 31536675Free PMC Article
Kutob LF, Justo JA, Bookstaver PB, Kohn J, Albrecht H, Al-Hasan MN
Int J Antimicrob Agents 2016 Nov;48(5):498-503. Epub 2016 Aug 20 doi: 10.1016/j.ijantimicag.2016.07.013. PMID: 27590704

Diagnosis

Bock A, Hanson BM, Ruffin F, Parsons JB, Park LP, Sharma-Kuinkel B, Mohnasky M, Arias CA, Fowler VG, Thaden JT
Clin Infect Dis 2023 Feb 8;76(3):e1285-e1293. doi: 10.1093/cid/ciac638. PMID: 35929656Free PMC Article
Coombe RF, Hamed H
Br J Hosp Med (Lond) 2021 May 2;82(5):1-7. Epub 2021 May 7 doi: 10.12968/hmed.2020.0718. PMID: 34076525
Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez-Monfort M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C
Am J Obstet Gynecol 2018 Jun;218(6):602.e1-602.e16. Epub 2018 Feb 23 doi: 10.1016/j.ajog.2018.02.012. PMID: 29477653
Weidner T, Tittelbach J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2018 Jan;32(1):39-47. Epub 2017 Nov 7 doi: 10.1111/jdv.14644. PMID: 29055132
Mousa HA
East Mediterr Health J 2003 Jan-Mar;9(1-2):208-14. PMID: 15562753

Therapy

Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
von Dach E, Albrich WC, Brunel AS, Prendki V, Cuvelier C, Flury D, Gayet-Ageron A, Huttner B, Kohler P, Lemmenmeier E, McCallin S, Rossel A, Harbarth S, Kaiser L, Bochud PY, Huttner A
JAMA 2020 Jun 2;323(21):2160-2169. doi: 10.1001/jama.2020.6348. PMID: 32484534Free PMC Article
Ackley R, Roshdy D, Meredith J, Minor S, Anderson WE, Capraro GA, Polk C
Antimicrob Agents Chemother 2020 Apr 21;64(5) doi: 10.1128/AAC.02313-19. PMID: 32094128Free PMC Article
Umphress B, Raparia K
Arch Pathol Lab Med 2018 Dec;142(12):1533-1536. Epub 2018 Aug 31 doi: 10.5858/arpa.2018-0073-RA. PMID: 30168726
Kutob LF, Justo JA, Bookstaver PB, Kohn J, Albrecht H, Al-Hasan MN
Int J Antimicrob Agents 2016 Nov;48(5):498-503. Epub 2016 Aug 20 doi: 10.1016/j.ijantimicag.2016.07.013. PMID: 27590704

Prognosis

De Waele JJ, Martin-Loeches I
Curr Opin Infect Dis 2018 Dec;31(6):606-611. doi: 10.1097/QCO.0000000000000491. PMID: 30382951
Gomes CC, Gomez RS, Zina LG, Amaral FR
Med Oral Patol Oral Cir Bucal 2016 Mar 1;21(2):e187-91. doi: 10.4317/medoral.20872. PMID: 26827061Free PMC Article
Kaye R, Kaye A, Sueke H, Neal T, Winstanley C, Horsburgh M, Kaye S
Invest Ophthalmol Vis Sci 2013 Jun 14;54(6):4136-9. doi: 10.1167/iovs.13-12130. PMID: 23696605
Mousa HA
East Mediterr Health J 2003 Jan-Mar;9(1-2):208-14. PMID: 15562753
Garcia-Tsao G
Gastroenterol Clin North Am 1992 Mar;21(1):257-75. PMID: 1568776

Clinical prediction guides

McAteer J, Lee JH, Cosgrove SE, Dzintars K, Fiawoo S, Heil EL, Kendall RE, Louie T, Malani AN, Nori P, Percival KM, Tamma PD
Clin Infect Dis 2023 May 3;76(9):1604-1612. doi: 10.1093/cid/ciad009. PMID: 36633559Free PMC Article
Stracy M, Snitser O, Yelin I, Amer Y, Parizade M, Katz R, Rimler G, Wolf T, Herzel E, Koren G, Kuint J, Foxman B, Chodick G, Shalev V, Kishony R
Science 2022 Feb 25;375(6583):889-894. Epub 2022 Feb 24 doi: 10.1126/science.abg9868. PMID: 35201862Free PMC Article
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
Kobayashi T, Ikeda M, Okada Y, Higurashi Y, Okugawa S, Moriya K
Microbiol Spectr 2021 Dec 22;9(3):e0139921. Epub 2021 Dec 8 doi: 10.1128/Spectrum.01399-21. PMID: 34878318Free PMC Article
von Dach E, Albrich WC, Brunel AS, Prendki V, Cuvelier C, Flury D, Gayet-Ageron A, Huttner B, Kohler P, Lemmenmeier E, McCallin S, Rossel A, Harbarth S, Kaiser L, Bochud PY, Huttner A
JAMA 2020 Jun 2;323(21):2160-2169. doi: 10.1001/jama.2020.6348. PMID: 32484534Free PMC Article

Recent systematic reviews

Kuehn R, Stoesser N, Eyre D, Darton TC, Basnyat B, Parry CM
Cochrane Database Syst Rev 2022 Nov 24;11(11):CD010452. doi: 10.1002/14651858.CD010452.pub2. PMID: 36420914Free PMC Article
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
Goodlet KJ, Benhalima FZ, Nailor MD
Antimicrob Agents Chemother 2019 Jan;63(1) Epub 2018 Dec 21 doi: 10.1128/AAC.02165-18. PMID: 30397061Free PMC Article
Best LM, Takwoingi Y, Siddique S, Selladurai A, Gandhi A, Low B, Yaghoobi M, Gurusamy KS
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD012080. doi: 10.1002/14651858.CD012080.pub2. PMID: 29543326Free PMC Article
Canavan TN, Mathes EF, Frieden I, Shinkai K
J Am Acad Dermatol 2015 Feb;72(2):239-45. doi: 10.1016/j.jaad.2014.06.026. PMID: 25592340

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