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Moderate dysplasia

MedGen UID:
87192
•Concept ID:
C0334047
•
Finding
Synonym: Moderate Dysplasia
SNOMED CT: Moderate dysplasia (57045007)

Definition

A morphologic finding indicating the presence of moderate cellular atypia associated with moderate architectural changes in a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate dysplasia

Professional guidelines

PubMed

Management of Laryngeal Dysplasia and Early Invasive Cancer.
Hrelec C
Curr Treat Options Oncol 2021 Aug 23;22(10):90. doi: 10.1007/s11864-021-00881-w. PMID: 34424405
Conjunctival Squamous Neoplasia: Staging and Initial Treatment.
Bellerive C, Berry JL, Polski A, Singh AD
Cornea 2018 Oct;37(10):1287-1291. doi: 10.1097/ICO.0000000000001651. PMID: 29863543Free PMC Article
Laryngeal dysplasia: epidemiology and treatment outcome.
Blackwell KE, Calcaterra TC, Fu YS
Ann Otol Rhinol Laryngol 1995 Aug;104(8):596-602. doi: 10.1177/000348949510400802. PMID: 7639467

Recent clinical studies

Etiology

Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study.
Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, Lingen MW, Silverberg MJ
J Natl Cancer Inst 2020 Oct 1;112(10):1047-1054. doi: 10.1093/jnci/djz238. PMID: 31860085Free PMC Article
Endoluminal loco-regional resection by TEM after R1 endoscopic removal or recurrence of rectal tumors.
Quaresima S, Balla A, D'Ambrosio G, Bruzzone P, Ursi P, Lezoche E, Paganini AM
Minim Invasive Ther Allied Technol 2016;25(3):134-40. Epub 2016 Feb 16 doi: 10.3109/13645706.2016.1145125. PMID: 26882538
The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients.
Mogedas-Vegara A, Hueto-Madrid JA, Chimenos-Küstner E, Bescós-Atín C
J Craniomaxillofac Surg 2015 Jun;43(5):677-81. Epub 2015 Mar 26 doi: 10.1016/j.jcms.2015.03.011. PMID: 25913630
Pouch adenomas in Familial Adenomatous Polyposis after restorative proctocolectomy.
Zahid A, Kumar S, Koorey D, Young CJ
Int J Surg 2015 Jan;13:133-136. Epub 2014 Dec 10 doi: 10.1016/j.ijsu.2014.11.048. PMID: 25498488
Fate of the rectum after colectomy with ileorectal anastomosis in ulcerative colitis.
Lepistö A, Järvinen HJ
Scand J Surg 2005;94(1):40-2. doi: 10.1177/145749690509400110. PMID: 15865115

Diagnosis

Computational Modelling for Electrical Impedance Spectroscopy-Based Diagnosis of Oral Potential Malignant Disorders (OPMD).
Heath JP, Hunter KD, Murdoch C, Walker DC
Sensors (Basel) 2022 Aug 8;22(15) doi: 10.3390/s22155913. PMID: 35957472Free PMC Article
Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study.
Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, Lingen MW, Silverberg MJ
J Natl Cancer Inst 2020 Oct 1;112(10):1047-1054. doi: 10.1093/jnci/djz238. PMID: 31860085Free PMC Article
Endoluminal loco-regional resection by TEM after R1 endoscopic removal or recurrence of rectal tumors.
Quaresima S, Balla A, D'Ambrosio G, Bruzzone P, Ursi P, Lezoche E, Paganini AM
Minim Invasive Ther Allied Technol 2016;25(3):134-40. Epub 2016 Feb 16 doi: 10.3109/13645706.2016.1145125. PMID: 26882538
Familial intraductal papillary mucinous neoplasms of the pancreas.
Rebours V, Couvelard A, Peyroux JL, Sauvanet A, Hammel P, Ruszniewski P, Lévy P
Dig Liver Dis 2012 May;44(5):442-6. Epub 2011 Aug 6 doi: 10.1016/j.dld.2011.07.003. PMID: 21824831
Cryotherapy of the cervix.
Hurt WG
J Fam Pract 1979 Jul;9(1):109-11. PMID: 448310

Therapy

Prediction of recurrence-free survival and risk factors of sinonasal inverted papilloma after surgery by machine learning models.
Miao S, Cheng Y, Li Y, Chen X, Chen F, Zha D, Xue T
Eur J Med Res 2024 Nov 4;29(1):528. doi: 10.1186/s40001-024-02099-6. PMID: 39497172Free PMC Article
Prospective Evaluation of Multimodal Optical Imaging with Automated Image Analysis to Detect Oral Neoplasia In Vivo.
Quang T, Tran EQ, Schwarz RA, Williams MD, Vigneswaran N, Gillenwater AM, Richards-Kortum R
Cancer Prev Res (Phila) 2017 Oct;10(10):563-570. Epub 2017 Aug 1 doi: 10.1158/1940-6207.CAPR-17-0054. PMID: 28765195Free PMC Article
The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients.
Mogedas-Vegara A, Hueto-Madrid JA, Chimenos-Küstner E, Bescós-Atín C
J Craniomaxillofac Surg 2015 Jun;43(5):677-81. Epub 2015 Mar 26 doi: 10.1016/j.jcms.2015.03.011. PMID: 25913630
Obstetric and neonatal outcome after surgical treatment of cervical dysplasia.
Van Hentenryck M, Noel JC, Simon P
Eur J Obstet Gynecol Reprod Biol 2012 May;162(1):16-20. Epub 2012 Feb 27 doi: 10.1016/j.ejogrb.2012.01.019. PMID: 22377225
Prevention of cervical intraepithelial neoplasia and cervical cancer.
Meyskens FL Jr, Manetta A
Am J Clin Nutr 1995 Dec;62(6 Suppl):1417S-1419S. doi: 10.1093/ajcn/62.6.1417S. PMID: 7495240

Prognosis

Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study.
Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, Lingen MW, Silverberg MJ
J Natl Cancer Inst 2020 Oct 1;112(10):1047-1054. doi: 10.1093/jnci/djz238. PMID: 31860085Free PMC Article
Microinvasion: A Clinical Dilemma.
Regmee P , Rimal J , Maharjan IK , Shrestha A , Niroula D , Luitel A , Chaudhary SK
Kathmandu Univ Med J (KUMJ) 2019 Jan.-Mar;17(65):70-72. PMID: 31734683
Endoluminal loco-regional resection by TEM after R1 endoscopic removal or recurrence of rectal tumors.
Quaresima S, Balla A, D'Ambrosio G, Bruzzone P, Ursi P, Lezoche E, Paganini AM
Minim Invasive Ther Allied Technol 2016;25(3):134-40. Epub 2016 Feb 16 doi: 10.3109/13645706.2016.1145125. PMID: 26882538
The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients.
Mogedas-Vegara A, Hueto-Madrid JA, Chimenos-Küstner E, Bescós-Atín C
J Craniomaxillofac Surg 2015 Jun;43(5):677-81. Epub 2015 Mar 26 doi: 10.1016/j.jcms.2015.03.011. PMID: 25913630
Pouch adenomas in Familial Adenomatous Polyposis after restorative proctocolectomy.
Zahid A, Kumar S, Koorey D, Young CJ
Int J Surg 2015 Jan;13:133-136. Epub 2014 Dec 10 doi: 10.1016/j.ijsu.2014.11.048. PMID: 25498488

Clinical prediction guides

Isolated keratinising corneal ocular surface squamous neoplasia with multifocal recurrence.
Singh S, Jakati S, Pasari A, Basu S
BMJ Case Rep 2021 Jul 12;14(7) doi: 10.1136/bcr-2021-243925. PMID: 34253530Free PMC Article
Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study.
Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, Lingen MW, Silverberg MJ
J Natl Cancer Inst 2020 Oct 1;112(10):1047-1054. doi: 10.1093/jnci/djz238. PMID: 31860085Free PMC Article
Obstetric and neonatal outcome after surgical treatment of cervical dysplasia.
Van Hentenryck M, Noel JC, Simon P
Eur J Obstet Gynecol Reprod Biol 2012 May;162(1):16-20. Epub 2012 Feb 27 doi: 10.1016/j.ejogrb.2012.01.019. PMID: 22377225
Cervical dysplasia in the postmenopausal female: diagnosis and treatment.
Teaff NL, Malone JM Jr, Ginsburg KA, Bartles LW, Haigler BB
Int J Gynaecol Obstet 1991 Feb;34(2):145-9. doi: 10.1016/0020-7292(91)90229-x. PMID: 1671369
Local morphologic changes related to laryngeal carcinoma.
Resta L, Santangelo A, Caruso G, Buonomo C
Tumori 1985 Feb 28;71(1):19-24. doi: 10.1177/030089168507100103. PMID: 3984044

Recent systematic reviews

Inconsistent repeatability of the Dejour classification of trochlear dysplasia due to the variability of imaging modalities: a systematic review.
Pineda T; ReSurg, Dejour D
Knee Surg Sports Traumatol Arthrosc 2023 Dec;31(12):5707-5720. Epub 2023 Nov 2 doi: 10.1007/s00167-023-07612-8. PMID: 37919443
Alternative Colposcopy Techniques: A Systematic Review and Meta-analysis.
Hermens M, Ebisch RMF, Galaal K, Bekkers RLM
Obstet Gynecol 2016 Oct;128(4):795-803. doi: 10.1097/AOG.0000000000001613. PMID: 27607860
Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions.
van Hulst AM, Kroon W, van der Linden ES, Nagtzaam L, Ottenhof SR, Wegner I, Gunning AC, Grolman W, Braunius W
Head Neck 2016 Apr;38 Suppl 1:E2284-90. Epub 2015 Aug 13 doi: 10.1002/hed.24185. PMID: 26268427
The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis.
Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM
Clin Otolaryngol 2010 Oct;35(5):364-72. doi: 10.1111/j.1749-4486.2010.02181.x. PMID: 21108746

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