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Skin infiltrative basal cell carcinoma

MedGen UID:
87201
Concept ID:
C0334257
Neoplastic Process
Synonyms: Basal cell carcinoma, desmoplastic type; Infiltrating Basal Cell Carcinoma; Infiltrating basal cell carcinoma; infiltrating basal cell carcinoma; Infiltrating basal cell carcinoma, non-sclerosing; Infiltrating basal cell carcinoma, sclerosing; infiltrative basal cell carcinoma; Skin Infiltrating Basal Cell Carcinoma; skin infiltrating basal cell carcinoma; skin infiltrative basal cell carcinoma
SNOMED CT: Infiltrating basal cell carcinoma, sclerosing (56665009); Infiltrating basal cell carcinoma, non-sclerosing (56665009); Basal cell carcinoma, desmoplastic type (56665009); Infiltrating basal cell carcinoma (56665009)
 
Monarch Initiative: MONDO:0002953

Definition

A variant of basal cell carcinoma presenting as a pale, indurated plaque, usually in the upper trunk or face. Morphologically, it is characterized by the presence of strands, cords, and columns of basaloid cells infiltrating the dermis. Perineural invasion may be present and the basaloid cell infiltrate may extend into deeper tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin infiltrative basal cell carcinoma

Professional guidelines

PubMed

Bernardini N, Skroza N, Zuber S, Tolino E, Balduzzi V, Mambrin A, Marchesiello A, Anzalone A, Colapietra D, Proietti I, Potenza C
Acta Dermatovenerol Croat 2019 Mar;27(1):22-27. PMID: 31032787
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Sun MT, Wu A, Figueira E, Huilgol S, Selva D
Future Oncol 2015 Nov;11(22):3003-10. Epub 2015 Oct 5 doi: 10.2217/fon.15.190. PMID: 26437207

Recent clinical studies

Etiology

Riihilä P, Nissinen L, Kähäri VM
Exp Dermatol 2021 Jan;30(1):50-61. Epub 2020 Sep 17 doi: 10.1111/exd.14183. PMID: 32869366Free PMC Article
Bernardini N, Skroza N, Zuber S, Tolino E, Balduzzi V, Mambrin A, Marchesiello A, Anzalone A, Colapietra D, Proietti I, Potenza C
Acta Dermatovenerol Croat 2019 Mar;27(1):22-27. PMID: 31032787
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Yesudian PD, Sugunendran H, Bates CM, O'Mahony C
Int J STD AIDS 2005 Jul;16(7):465-73, test 474. doi: 10.1258/0956462054308440. PMID: 16004624

Diagnosis

Bernardini N, Skroza N, Zuber S, Tolino E, Balduzzi V, Mambrin A, Marchesiello A, Anzalone A, Colapietra D, Proietti I, Potenza C
Acta Dermatovenerol Croat 2019 Mar;27(1):22-27. PMID: 31032787
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Alter M, Hillen U, Leiter U, Sachse M, Gutzmer R
J Dtsch Dermatol Ges 2015 Sep;13(9):863-74; quiz 875. doi: 10.1111/ddg.12798. PMID: 26882375
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364

Therapy

Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Alter M, Hillen U, Leiter U, Sachse M, Gutzmer R
J Dtsch Dermatol Ges 2015 Sep;13(9):863-74; quiz 875. doi: 10.1111/ddg.12798. PMID: 26882375
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555

Prognosis

Deutsch JS, Lai J, Schenk KM, Soni A, Will EM, Engle LL, Xu H, Ogurtsova A, Madan V, Chong JK, Wang D, Green BF, Nguyen P, Schollenberger MD, Lipson EJ, Taube JM
J Immunother Cancer 2023 Dec 14;11(12) doi: 10.1136/jitc-2023-007463. PMID: 38101862Free PMC Article
Bashline B
FP Essent 2019 Jun;481:17-22. PMID: 31188548
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Yesudian PD, Sugunendran H, Bates CM, O'Mahony C
Int J STD AIDS 2005 Jul;16(7):465-73, test 474. doi: 10.1258/0956462054308440. PMID: 16004624

Clinical prediction guides

Berl A, Shir-Az O, Genish I, Biran H, Mann D, Singh A, Wise J, Kravtsov V, Kidron D, Golberg A, Vitkin E, Yakhini Z, Shalom A
PLoS One 2023;18(11):e0293744. Epub 2023 Nov 10 doi: 10.1371/journal.pone.0293744. PMID: 37948379Free PMC Article
Goto K, Oishi T, Yoshikawa S
Int J Surg Pathol 2023 Dec;31(8):1466-1472. Epub 2023 Feb 27 doi: 10.1177/10668969231157781. PMID: 36843540
Requena C, Serra-Guillén C, Sanmartín O
Actas Dermosifiliogr 2022 Jun;113(6):575-582. Epub 2022 Feb 12 doi: 10.1016/j.ad.2022.01.026. PMID: 35339267
Bartos V, Pokorny D, Zacharova O, Kullova M, Adamicova K, Pec M
Bratisl Lek Listy 2012;113(10):624-7. doi: 10.4149/bll_2012_142. PMID: 23094905
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364

Recent systematic reviews

Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Ferrante di Ruffano L, Dinnes J, Deeks JJ, Chuchu N, Bayliss SE, Davenport C, Takwoingi Y, Godfrey K, O'Sullivan C, Matin RN, Tehrani H, Williams HC; Cochrane Skin Cancer Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD013189. doi: 10.1002/14651858.CD013189. PMID: 30521690Free PMC Article
Ferrante di Ruffano L, Dinnes J, Chuchu N, Bayliss SE, Takwoingi Y, Davenport C, Matin RN, O'Sullivan C, Roskell D, Deeks JJ, Williams HC; Cochrane Skin Cancer Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD013187. doi: 10.1002/14651858.CD013187. PMID: 30521689Free PMC Article
Ang JM, Riaz IB, Kamal MU, Paragh G, Zeitouni NC
Photodiagnosis Photodyn Ther 2017 Sep;19:308-344. Epub 2017 Jul 15 doi: 10.1016/j.pdpdt.2017.07.002. PMID: 28716738
Love WE, Bernhard JD, Bordeaux JS
Arch Dermatol 2009 Dec;145(12):1431-8. doi: 10.1001/archdermatol.2009.291. PMID: 20026854

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