U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Extra-Adrenal Paraganglioma

MedGen UID:
87237
Concept ID:
C0334418
Neoplastic Process
Synonyms: Extra-adrenal paraganglioma, malignant; Malignant extra-adrenal paraganglioma; Malignant Extra-Adrenal Paraganglioma; Malignant non-chromaffin paraganglioma; Nonchromaffin paraganglioma, malignant
SNOMED CT: Malignant non-chromaffin paraganglioma (32512003); Malignant extra-adrenal paraganglioma (32512003); Extra-adrenal paraganglioma, malignant (32512003); Nonchromaffin paraganglioma, malignant (32512003)

Definition

An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic sites. Common sites of metastasis include the lymph nodes, lungs, bones, and liver. [from NCI]

Professional guidelines

PubMed

De Filpo G, Cantini G, Rastrelli G, Vannini G, Ercolino T, Luconi M, Mannelli M, Maggi M, Canu L
J Endocrinol Invest 2022 Jan;45(1):149-157. Epub 2021 Jul 5 doi: 10.1007/s40618-021-01629-x. PMID: 34227051Free PMC Article
Peng S, Zhang J, Tan X, Huang Y, Xu J, Silk N, Zhang D, Liu Q, Jiang J
Front Endocrinol (Lausanne) 2020;11:586857. Epub 2020 Nov 24 doi: 10.3389/fendo.2020.586857. PMID: 33329393Free PMC Article
Tanabe A, Naruse M
Hypertens Res 2020 Nov;43(11):1141-1151. Epub 2020 Aug 11 doi: 10.1038/s41440-020-0531-0. PMID: 32778780

Recent clinical studies

Etiology

Eisenhofer G, Pamporaki C, Lenders JWM
Endocr Rev 2023 Sep 15;44(5):862-909. doi: 10.1210/endrev/bnad011. PMID: 36996131
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Chan EY, Ali A, Umana JP, Nguyen DT, Hamilton DJ, Graviss EA, Ravi V, MacGillivray TE, Reardon MJ
J Thorac Cardiovasc Surg 2022 Jul;164(1):158-166.e1. Epub 2020 Oct 3 doi: 10.1016/j.jtcvs.2020.09.100. PMID: 33148444
Wachtel H, Hutchens T, Baraban E, Schwartz LE, Montone K, Baloch Z, LiVolsi V, Krumeich L, Fraker DL, Nathanson KL, Cohen DL, Fishbein L
J Clin Endocrinol Metab 2020 Dec 1;105(12):e4661-70. doi: 10.1210/clinem/dgaa608. PMID: 32877928Free PMC Article
Fishbein L
Curr Cardiol Rep 2019 Jul 31;21(9):104. doi: 10.1007/s11886-019-1184-y. PMID: 31367972

Diagnosis

Eisenhofer G, Pamporaki C, Lenders JWM
Endocr Rev 2023 Sep 15;44(5):862-909. doi: 10.1210/endrev/bnad011. PMID: 36996131
Harmsworth D, Mallia A, DeGaetano J, Cassar PJ
BMJ Case Rep 2023 Jan 17;16(1) doi: 10.1136/bcr-2022-252449. PMID: 36653043Free PMC Article
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Wachtel H, Hutchens T, Baraban E, Schwartz LE, Montone K, Baloch Z, LiVolsi V, Krumeich L, Fraker DL, Nathanson KL, Cohen DL, Fishbein L
J Clin Endocrinol Metab 2020 Dec 1;105(12):e4661-70. doi: 10.1210/clinem/dgaa608. PMID: 32877928Free PMC Article

Therapy

Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Jungels C, Karfis I
Curr Opin Oncol 2021 Jan;33(1):33-39. doi: 10.1097/CCO.0000000000000691. PMID: 33093336
Peng S, Zhang J, Tan X, Huang Y, Xu J, Silk N, Zhang D, Liu Q, Jiang J
Front Endocrinol (Lausanne) 2020;11:586857. Epub 2020 Nov 24 doi: 10.3389/fendo.2020.586857. PMID: 33329393Free PMC Article
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Ghazi AA, Amirbaigloo A, Dezfooli AA, Saadat N, Ghazi S, Pourafkari M, Tirgari F, Dhall D, Bannykh S, Melmed S, Cooper O
Endocrine 2013 Apr;43(2):293-302. Epub 2012 Sep 15 doi: 10.1007/s12020-012-9790-0. PMID: 22983831Free PMC Article

Prognosis

Nikiforchin A, Baron E, Wernberg JA, Sharma R
Ann Surg Oncol 2024 Jul;31(7):4197-4198. Epub 2024 Apr 13 doi: 10.1245/s10434-024-15267-z. PMID: 38615151
Martinelli S, Amore F, Canu L, Maggi M, Rapizzi E
Front Endocrinol (Lausanne) 2023;14:1137456. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1137456. PMID: 37033265Free PMC Article
Juhlin CC, Mete O
Adv Anat Pathol 2023 Jan 1;30(1):47-57. Epub 2022 Sep 23 doi: 10.1097/PAP.0000000000000365. PMID: 36136370
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Wachtel H, Hutchens T, Baraban E, Schwartz LE, Montone K, Baloch Z, LiVolsi V, Krumeich L, Fraker DL, Nathanson KL, Cohen DL, Fishbein L
J Clin Endocrinol Metab 2020 Dec 1;105(12):e4661-70. doi: 10.1210/clinem/dgaa608. PMID: 32877928Free PMC Article

Clinical prediction guides

Park SS, Ahn CH, Lee S, Lee W, Kim WW, Lee YM, Kim SJ, Sung TY, Lee KE, Kim JH, Lee SH, Koh JM
J Intern Med 2024 Jul;296(1):68-79. Epub 2024 Apr 24 doi: 10.1111/joim.13791. PMID: 38659304
Kuo MJM, Nazari MA, Jha A, Pacak K
Front Endocrinol (Lausanne) 2022;13:936178. Epub 2022 Jul 12 doi: 10.3389/fendo.2022.936178. PMID: 35903274Free PMC Article
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Wachtel H, Hutchens T, Baraban E, Schwartz LE, Montone K, Baloch Z, LiVolsi V, Krumeich L, Fraker DL, Nathanson KL, Cohen DL, Fishbein L
J Clin Endocrinol Metab 2020 Dec 1;105(12):e4661-70. doi: 10.1210/clinem/dgaa608. PMID: 32877928Free PMC Article
Thomas AJ, Wiggins RH 3rd, Gurgel RK
Otolaryngol Clin North Am 2015 Apr;48(2):343-59. Epub 2015 Feb 4 doi: 10.1016/j.otc.2014.12.008. PMID: 25659512

Recent systematic reviews

Kakodkar P, Houlihan LM, Preul M, Bermingham N, Lim C
Br J Neurosurg 2023 Oct;37(5):967-975. Epub 2021 Mar 19 doi: 10.1080/02688697.2021.1902477. PMID: 33739182
Prado-Wohlwend S, Del Olmo-García MI, Bello-Arques P, Merino-Torres JF
Front Endocrinol (Lausanne) 2022;13:957172. Epub 2022 Oct 20 doi: 10.3389/fendo.2022.957172. PMID: 36339441Free PMC Article
Shtaya A, Iorga R, Hettige S, Bridges LR, Stapleton S, Johnston FG
Neurosurg Rev 2022 Feb;45(1):103-118. Epub 2021 May 21 doi: 10.1007/s10143-021-01565-7. PMID: 34021421Free PMC Article
Brito JP, Asi N, Gionfriddo MR, Norman C, Leppin AL, Zeballos-Palacios C, Undavalli C, Wang Z, Domecq JP, Prustsky G, Elraiyah TA, Prokop LJ, Montori VM, Murad MH
Endocrine 2015 Sep;50(1):176-86. Epub 2015 Feb 6 doi: 10.1007/s12020-015-0544-7. PMID: 25663601
Rufini V, Treglia G, Castaldi P, Perotti G, Giordano A
Q J Nucl Med Mol Imaging 2013 Jun;57(2):122-33. PMID: 23822989

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...