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Gastric fundus carcinoma

MedGen UID:
87514
•Concept ID:
C0345799
•
Neoplastic Process
Synonyms: Cancer of Fundus of Stomach; Cancer of Gastric Fundus; Cancer of the Fundus of the Stomach; Cancer of the Gastric Fundus; Carcinoma of fundus of stomach; Carcinoma of Fundus of Stomach; carcinoma of fundus of stomach; Carcinoma of Gastric Fundus; carcinoma of gastric fundus; Carcinoma of the Fundus of the Stomach; carcinoma of the fundus of the stomach; Carcinoma of the Gastric Fundus; carcinoma of the gastric fundus; fundus of stomach carcinoma; Gastric Fundus Cancer; gastric fundus cancer; Gastric Fundus Carcinoma; gastric fundus carcinoma
SNOMED CT: Carcinoma of fundus of stomach (254555008)
 
Monarch Initiative: MONDO:0003970

Definition

A carcinoma that arises from the fundus of the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric fundus carcinoma

Professional guidelines

PubMed

Emerging evidence supports grouping by location of early gastric carcinoma for appropriate clinical management in Chinese patients.
Huang Q, Li R, Xu GF, Zhou D, Fan XS, Zou XP
J Dig Dis 2018 Dec;19(12):730-736. Epub 2018 Nov 14 doi: 10.1111/1751-2980.12674. PMID: 30270559
Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor.
Zhang L, Ozao J, Warner R, Divino C
World J Surg 2011 Aug;35(8):1879-86. doi: 10.1007/s00268-011-1137-0. PMID: 21559999
Surgical treatment of oesophageal cancer.
Hartel M, Wente MN, Büchler MW, Friess H
Dig Dis 2004;22(2):213-20. doi: 10.1159/000080322. PMID: 15383764

Recent clinical studies

Etiology

Twenty cases of gastric adenocarcinoma of the fundic gland type.
Yang M, Sun X, Chen Y, Yang P
Scand J Gastroenterol 2023 Jul;58(7):744-750. Epub 2023 Jan 5 doi: 10.1080/00365521.2022.2164213. PMID: 36604805
Neoplastic Lesions of Gastric Adenocarcinoma and Proximal Polyposis Syndrome (GAPPS) Are Gastric Phenotype.
de Boer WB, Ee H, Kumarasinghe MP
Am J Surg Pathol 2018 Jan;42(1):1-8. doi: 10.1097/PAS.0000000000000924. PMID: 29112017
Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis.
Tran-Duy A, Spaetgens B, Hoes AW, de Wit NJ, Stehouwer CD
Clin Gastroenterol Hepatol 2016 Dec;14(12):1706-1719.e5. Epub 2016 May 20 doi: 10.1016/j.cgh.2016.05.018. PMID: 27211501
Helicobacter pylori and gastroesophageal reflux disease.
Kandulski A, Malfertheiner P
Curr Opin Gastroenterol 2014 Jul;30(4):402-7. doi: 10.1097/MOG.0000000000000085. PMID: 24848647
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347

Diagnosis

Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Neoplastic Lesions of Gastric Adenocarcinoma and Proximal Polyposis Syndrome (GAPPS) Are Gastric Phenotype.
de Boer WB, Ee H, Kumarasinghe MP
Am J Surg Pathol 2018 Jan;42(1):1-8. doi: 10.1097/PAS.0000000000000924. PMID: 29112017
Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor.
Zhang L, Ozao J, Warner R, Divino C
World J Surg 2011 Aug;35(8):1879-86. doi: 10.1007/s00268-011-1137-0. PMID: 21559999
Gastritis in the elderly.
Green LK, Graham DY
Gastroenterol Clin North Am 1990 Jun;19(2):273-92. PMID: 2194946

Therapy

Delayed diaphragmatic hernia and gastric fundus incarceration: a rare complication after transarterial chemoembolization.
Goh SK, Naazar A, Issa M, Starkey G, Ranatunga D, Lee E
ANZ J Surg 2022 Jul;92(7-8):1882-1884. Epub 2021 Oct 17 doi: 10.1111/ans.17295. PMID: 34657385
Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis.
Tran-Duy A, Spaetgens B, Hoes AW, de Wit NJ, Stehouwer CD
Clin Gastroenterol Hepatol 2016 Dec;14(12):1706-1719.e5. Epub 2016 May 20 doi: 10.1016/j.cgh.2016.05.018. PMID: 27211501
Surgical treatment of oesophageal cancer.
Hartel M, Wente MN, Büchler MW, Friess H
Dig Dis 2004;22(2):213-20. doi: 10.1159/000080322. PMID: 15383764
Gastritis in the elderly.
Green LK, Graham DY
Gastroenterol Clin North Am 1990 Jun;19(2):273-92. PMID: 2194946
Diffuse varioliform gastritis.
Lambert R, André C, Moulinier B, Bugnon B
Digestion 1978;17(2):159-67. doi: 10.1159/000198106. PMID: 414953

Prognosis

Twenty cases of gastric adenocarcinoma of the fundic gland type.
Yang M, Sun X, Chen Y, Yang P
Scand J Gastroenterol 2023 Jul;58(7):744-750. Epub 2023 Jan 5 doi: 10.1080/00365521.2022.2164213. PMID: 36604805
Clinicopathological characteristics and prognosis of 232 patients with poorly differentiated gastric neuroendocrine neoplasms.
Han D, Li YL, Zhou ZW, Yin F, Chen J, Liu F, Shi YF, Wang W, Zhang Y, Yu XJ, Xu JM, Yang RX, Tian C, Luo J, Tan HY
World J Gastroenterol 2021 Jun 7;27(21):2895-2909. doi: 10.3748/wjg.v27.i21.2895. PMID: 34135560Free PMC Article
Mucosal microbial microenvironment in early gastric neoplasia and non-neoplastic gastric disease.
Li F, Zhu H, Tao K, Xia Y, Liu M, Wang Y, Sun Y, Cao T, Chai J, Ni F, Shi B, Xu H
J Gastroenterol Hepatol 2021 Nov;36(11):3092-3101. Epub 2021 Jun 29 doi: 10.1111/jgh.15565. PMID: 34089623
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Clinical Characteristics and Prognostic Analysis of Patients With Signet Ring Cell Gastric Carcinoma.
Yu JM, Zhan ZW, Zhen JX, Wang XJ, Chen Y, Lin J, Chen L, Chen LZ, Huang YF, Guo ZQ
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820983812. doi: 10.1177/1533033820983812. PMID: 33371800Free PMC Article

Clinical prediction guides

Mucosal microbial microenvironment in early gastric neoplasia and non-neoplastic gastric disease.
Li F, Zhu H, Tao K, Xia Y, Liu M, Wang Y, Sun Y, Cao T, Chai J, Ni F, Shi B, Xu H
J Gastroenterol Hepatol 2021 Nov;36(11):3092-3101. Epub 2021 Jun 29 doi: 10.1111/jgh.15565. PMID: 34089623
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Clinicopathologic Features of Gastric and Gastrooesophageal Junction Adenocarcinoma.
Rima FA, Hussain M, Dewan RK, Haque MN, Sultana T, Chowdhury F, Aminullah M, Ferdous JN
Mymensingh Med J 2020 Jan;29(1):195-201. PMID: 31915358
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Neuroendocrine carcinoma of the stomach: clinical features and CT findings.
Liang P, Wang YX, Ren XC, Gao JB
Abdom Radiol (NY) 2016 Jan;41(1):19-24. doi: 10.1007/s00261-015-0593-7. PMID: 26830607

Recent systematic reviews

Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis.
Tran-Duy A, Spaetgens B, Hoes AW, de Wit NJ, Stehouwer CD
Clin Gastroenterol Hepatol 2016 Dec;14(12):1706-1719.e5. Epub 2016 May 20 doi: 10.1016/j.cgh.2016.05.018. PMID: 27211501

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