U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign neoplasm of gallbladder

MedGen UID:
87524
•Concept ID:
C0345912
•
Neoplastic Process
Synonyms: Benign Gallbladder Neoplasm; benign gallbladder neoplasm; Benign Gallbladder Tumor; benign gallbladder tumor; benign gallbladder tumour; Benign Neoplasm of Gallbladder; benign neoplasm of gallbladder; Benign Neoplasm of the Gallbladder; benign neoplasm of the gallbladder; Benign tumor of gallbladder; Benign Tumor of Gallbladder; benign tumor of gallbladder; Benign Tumor of the Gallbladder; benign tumor of the gallbladder; benign tumour of gallbladder; benign tumour of the gallbladder; gall bladder benign neoplasm; Gallbladder Benign Neoplasm; gallbladder benign neoplasm; Gallbladder Benign Tumor; gallbladder benign tumor; gallbladder benign tumour
SNOMED CT: Benign tumor of gallbladder (92117002); Benign neoplasm of gallbladder (92117002)
 
Monarch Initiative: MONDO:0021503

Definition

A neoplasm that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Management of Incidentally Detected Gallbladder Polyps: Society of Radiologists in Ultrasound Consensus Conference Recommendations.
Kamaya A, Fung C, Szpakowski JL, Fetzer DT, Walsh AJ, Alimi Y, Bingham DB, Corwin MT, Dahiya N, Gabriel H, Park WG, Porembka MR, Rodgers SK, Tublin ME, Yuan X, Zhang Y, Middleton WD
Radiology 2022 Nov;305(2):277-289. Epub 2022 Jul 5 doi: 10.1148/radiol.213079. PMID: 35787200
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131

Recent clinical studies

Etiology

Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Safety of Semaglutide.
Smits MM, Van Raalte DH
Front Endocrinol (Lausanne) 2021;12:645563. Epub 2021 Jul 7 doi: 10.3389/fendo.2021.645563. PMID: 34305810Free PMC Article
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
Current practices and future prospects for the management of gallbladder polyps: A topical review.
McCain RS, Diamond A, Jones C, Coleman HG
World J Gastroenterol 2018 Jul 14;24(26):2844-2852. doi: 10.3748/wjg.v24.i26.2844. PMID: 30018479Free PMC Article
Imaging and Screening of Cancer of the Gallbladder and Bile Ducts.
Sandrasegaran K, Menias CO
Radiol Clin North Am 2017 Nov;55(6):1211-1222. doi: 10.1016/j.rcl.2017.06.005. PMID: 28991561

Diagnosis

Gallbladder Disorders: A Comprehensive Review.
Lam R, Zakko A, Petrov JC, Kumar P, Duffy AJ, Muniraj T
Dis Mon 2021 Jul;67(7):101130. Epub 2021 Jan 18 doi: 10.1016/j.disamonth.2021.101130. PMID: 33478678
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases.
Yu MH, Kim YJ, Park HS, Jung SI
World J Gastroenterol 2020 Jun 14;26(22):2967-2986. doi: 10.3748/wjg.v26.i22.2967. PMID: 32587442Free PMC Article
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
Current practices and future prospects for the management of gallbladder polyps: A topical review.
McCain RS, Diamond A, Jones C, Coleman HG
World J Gastroenterol 2018 Jul 14;24(26):2844-2852. doi: 10.3748/wjg.v24.i26.2844. PMID: 30018479Free PMC Article
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Therapy

Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial.
Nakachi K, Ikeda M, Konishi M, Nomura S, Katayama H, Kataoka T, Todaka A, Yanagimoto H, Morinaga S, Kobayashi S, Shimada K, Takahashi Y, Nakagohri T, Gotoh K, Kamata K, Shimizu Y, Ueno M, Ishii H, Okusaka T, Furuse J; Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG)
Lancet 2023 Jan 21;401(10372):195-203. doi: 10.1016/S0140-6736(22)02038-4. PMID: 36681415
Safety of Semaglutide.
Smits MM, Van Raalte DH
Front Endocrinol (Lausanne) 2021;12:645563. Epub 2021 Jul 7 doi: 10.3389/fendo.2021.645563. PMID: 34305810Free PMC Article
Molecular targeted therapies: Ready for "prime time" in biliary tract cancer.
Lamarca A, Barriuso J, McNamara MG, Valle JW
J Hepatol 2020 Jul;73(1):170-185. Epub 2020 Mar 12 doi: 10.1016/j.jhep.2020.03.007. PMID: 32171892
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article

Prognosis

Gallbladder polyps and adenomyomatosis.
Riddell ZC, Corallo C, Albazaz R, Foley KG
Br J Radiol 2023 Feb;96(1142):20220115. Epub 2022 Jul 1 doi: 10.1259/bjr.20220115. PMID: 35731858Free PMC Article
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-َAnalysis.
Soteriades ES, Kim J, Christophi CA, Kales SN
Asian Pac J Cancer Prev 2019 Nov 1;20(11):3221-3231. doi: 10.31557/APJCP.2019.20.11.3221. PMID: 31759344Free PMC Article
Current practices and future prospects for the management of gallbladder polyps: A topical review.
McCain RS, Diamond A, Jones C, Coleman HG
World J Gastroenterol 2018 Jul 14;24(26):2844-2852. doi: 10.3748/wjg.v24.i26.2844. PMID: 30018479Free PMC Article

Clinical prediction guides

Value of prediction model in distinguishing gallbladder adenoma from cholesterol polyp.
Liu J, Qian Y, Yang F, Huang S, Chen G, Yu J, Jiang S, Huang G
J Gastroenterol Hepatol 2022 Oct;37(10):1893-1900. Epub 2022 Jul 22 doi: 10.1111/jgh.15928. PMID: 35750491
Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
Treatment of advanced gallbladder cancer: A SEER-based study.
Mao W, Deng F, Wang D, Gao L, Shi X
Cancer Med 2020 Jan;9(1):141-150. Epub 2019 Nov 13 doi: 10.1002/cam4.2679. PMID: 31721465Free PMC Article
Significance of HER2 and Ki-67 in Preneoplastic Lesions and Carcinoma of Gallbladder.
Halder S, Kundu S, Chakraborty J, Chakrabarti S
J Gastrointest Cancer 2019 Dec;50(4):848-854. doi: 10.1007/s12029-018-0162-8. PMID: 30155833
Gallbladder tumor and pseudotumor: Diagnosis and management.
Zemour J, Marty M, Lapuyade B, Collet D, Chiche L
J Visc Surg 2014 Sep;151(4):289-300. Epub 2014 Jun 12 doi: 10.1016/j.jviscsurg.2014.05.003. PMID: 24930718

Recent systematic reviews

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Wogonin and its analogs for the prevention and treatment of cancer: A systematic review.
Banik K, Khatoon E, Harsha C, Rana V, Parama D, Thakur KK, Bishayee A, Kunnumakkara AB
Phytother Res 2022 May;36(5):1854-1883. Epub 2022 Jan 31 doi: 10.1002/ptr.7386. PMID: 35102626
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article
The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.
Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH
BMC Public Health 2009 Mar 25;9:88. doi: 10.1186/1471-2458-9-88. PMID: 19320986Free PMC Article
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...