U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7

MedGen UID:
881978
•Concept ID:
C4055249
•
Neoplastic Process

Definition

A rare acute myeloid leukemia that occurs in childhood and is characterized by deletion of chromosome 7. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7

Recent clinical studies

Etiology

Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine.
Hama A, Takahashi Y, Muramatsu H, Ito M, Narita A, Kosaka Y, Tsuchida M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S
Haematologica 2015 Nov;100(11):1426-33. Epub 2015 Aug 13 doi: 10.3324/haematol.2015.128553. PMID: 26273061Free PMC Article
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group.
Heerema NA, Nachman JB, Sather HN, La MK, Hutchinson R, Lange BJ, Bostrom B, Steinherz PG, Gaynon PS, Uckun FM; Children's Cancer Group
Leukemia 2004 May;18(5):939-47. doi: 10.1038/sj.leu.2403327. PMID: 14999294
Childhood myeloid leukaemias.
Hall GW
Best Pract Res Clin Haematol 2001 Sep;14(3):573-91. doi: 10.1053/beha.2001.0155. PMID: 11640870
t(7;12)(q36;p13) and t(7;12)(q32;p13)--translocations involving ETV6 in children 18 months of age or younger with myeloid disorders.
Slater RM, von Drunen E, Kroes WG, Weghuis DO, van den Berg E, Smit EM, van der Does-van den Berg A, van Wering E, Hählen K, Carroll AJ, Raimondi SC, Beverloo HB
Leukemia 2001 Jun;15(6):915-20. doi: 10.1038/sj.leu.2402121. PMID: 11417477

Diagnosis

Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
Childhood myeloid leukaemias.
Hall GW
Best Pract Res Clin Haematol 2001 Sep;14(3):573-91. doi: 10.1053/beha.2001.0155. PMID: 11640870
Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7. European Working Group on MDS in Childhood (EWOG-MDS).
Hasle H, Aricò M, Basso G, Biondi A, Cantù Rajnoldi A, Creutzig U, Fenu S, Fonatsch C, Haas OA, Harbott J, Kardos G, Kerndrup G, Mann G, Niemeyer CM, Ptoszkova H, Ritter J, Slater R, Starý J, Stollmann-Gibbels B, Testi AM, van Wering ER, Zimmermann M
Leukemia 1999 Mar;13(3):376-85. doi: 10.1038/sj.leu.2401342. PMID: 10086728
Analysis of ras gene mutations in childhood myeloid leukaemia.
Farr C, Gill R, Katz F, Gibbons B, Marshall CJ
Br J Haematol 1991 Mar;77(3):323-7. doi: 10.1111/j.1365-2141.1991.tb08578.x. PMID: 2012756
Atypical (7;19) translocation in acute myelomonocytic leukemia.
Sherer ME, Shekhter-Levin S, Krause JR, Joyce RA, Gollin SM
Cancer Genet Cytogenet 1991 Dec;57(2):169-73. doi: 10.1016/0165-4608(91)90148-n. PMID: 1756494

Therapy

Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine.
Hama A, Takahashi Y, Muramatsu H, Ito M, Narita A, Kosaka Y, Tsuchida M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S
Haematologica 2015 Nov;100(11):1426-33. Epub 2015 Aug 13 doi: 10.3324/haematol.2015.128553. PMID: 26273061Free PMC Article
MRC trials in childhood acute myeloid leukaemia.
Hann IM, Webb DK, Gibson BE, Harrison CJ
Ann Hematol 2004;83 Suppl 1:S108-12. doi: 10.1007/s00277-004-0850-2. PMID: 15124698
Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children.
Kojima S, Ohara A, Tsuchida M, Kudoh T, Hanada R, Okimoto Y, Kaneko T, Takano T, Ikuta K, Tsukimoto I; Japan Childhood Aplastic Anemia Study Group
Blood 2002 Aug 1;100(3):786-90. doi: 10.1182/blood.v100.3.786. PMID: 12130487
Secondary myelodysplasia with monosomy 7 arising after treatment for acute lymphoblastic leukemia in childhood.
Aquino VM, Schneider NR, Sandler ES
J Pediatr Hematol Oncol 2001 Jan;23(1):48-50. doi: 10.1097/00043426-200101000-00011. PMID: 11196270
Secondary acute non-lymphocytic leukemia with monosomy 7 arising 9 years after acute lymphoblastic leukemia in childhood.
Lewis ME, Solh H, Poon A, Dubé ID
Cancer Genet Cytogenet 1991 Aug;55(1):85-8. doi: 10.1016/0165-4608(91)90239-q. PMID: 1913612

Prognosis

Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine.
Hama A, Takahashi Y, Muramatsu H, Ito M, Narita A, Kosaka Y, Tsuchida M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S
Haematologica 2015 Nov;100(11):1426-33. Epub 2015 Aug 13 doi: 10.3324/haematol.2015.128553. PMID: 26273061Free PMC Article
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
MRC trials in childhood acute myeloid leukaemia.
Hann IM, Webb DK, Gibson BE, Harrison CJ
Ann Hematol 2004;83 Suppl 1:S108-12. doi: 10.1007/s00277-004-0850-2. PMID: 15124698
Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group.
Heerema NA, Nachman JB, Sather HN, La MK, Hutchinson R, Lange BJ, Bostrom B, Steinherz PG, Gaynon PS, Uckun FM; Children's Cancer Group
Leukemia 2004 May;18(5):939-47. doi: 10.1038/sj.leu.2403327. PMID: 14999294
Childhood myeloid leukaemias.
Hall GW
Best Pract Res Clin Haematol 2001 Sep;14(3):573-91. doi: 10.1053/beha.2001.0155. PMID: 11640870

Clinical prediction guides

Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine.
Hama A, Takahashi Y, Muramatsu H, Ito M, Narita A, Kosaka Y, Tsuchida M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S
Haematologica 2015 Nov;100(11):1426-33. Epub 2015 Aug 13 doi: 10.3324/haematol.2015.128553. PMID: 26273061Free PMC Article
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
MRC trials in childhood acute myeloid leukaemia.
Hann IM, Webb DK, Gibson BE, Harrison CJ
Ann Hematol 2004;83 Suppl 1:S108-12. doi: 10.1007/s00277-004-0850-2. PMID: 15124698
Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7. European Working Group on MDS in Childhood (EWOG-MDS).
Hasle H, Aricò M, Basso G, Biondi A, Cantù Rajnoldi A, Creutzig U, Fenu S, Fonatsch C, Haas OA, Harbott J, Kardos G, Kerndrup G, Mann G, Niemeyer CM, Ptoszkova H, Ritter J, Slater R, Starý J, Stollmann-Gibbels B, Testi AM, van Wering ER, Zimmermann M
Leukemia 1999 Mar;13(3):376-85. doi: 10.1038/sj.leu.2401342. PMID: 10086728
Analysis of ras gene mutations in childhood myeloid leukaemia.
Farr C, Gill R, Katz F, Gibbons B, Marshall CJ
Br J Haematol 1991 Mar;77(3):323-7. doi: 10.1111/j.1365-2141.1991.tb08578.x. PMID: 2012756

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...