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Childhood acute myeloid leukemia

MedGen UID:: 65075
•Concept ID:: C0220621
•: Neoplastic Process

Synonyms:	acute myeloid leukaemia of childhood; acute myeloid leukemia of childhood; childhood acute granulocytic leukaemia; childhood acute granulocytic leukemia; childhood acute myeloblastic leukaemia; Childhood Acute Myeloblastic Leukemia; childhood acute myeloblastic leukemia; childhood acute myelocytic leukaemia; childhood acute myelocytic leukemia; childhood acute myelogenous leukaemia; Childhood Acute Myelogenous Leukemia; childhood acute myelogenous leukemia; Childhood Acute Myeloid Leukemia; childhood acute myeloid leukemia; Childhood AML; childhood AML; paediatric acute myeloblastic leukaemia; paediatric acute myelocytic leukaemia; paediatric acute myelogenous leukaemia; paediatric acute myeloid leukaemia; paediatric AML; Pediatric Acute Myeloblastic Leukemia; pediatric acute myeloblastic leukemia; pediatric acute myelocytic leukemia; Pediatric Acute Myelogenous Leukemia; pediatric acute myelogenous leukemia; Pediatric Acute Myeloid Leukemia; pediatric acute myeloid leukemia; Pediatric AML; pediatric AML

Monarch Initiative:	MONDO:0004996

Definition

Acute myeloid leukemia occurring in childhood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChildhood acute myeloid leukemia

Hematopoietic and Lymphoid System Disorder
- Hematologic disorder
  - Hematologic neoplasm
    - Leukemia
      - Acute leukemia
        Acute myeloid leukemia
        Childhood acute myeloid leukemia
        Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2
        Acute Myeloid Leukemia with RAM Immunophenotype
        Acute Myeloid Leukemia with t(10;11)(p12;q23); MLLT10-MLL
        Acute Myeloid Leukemia with t(6;11)(q27;q23); MLLT4-MLL
        Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6
        Childhood Acute Myeloid Leukemia Not Otherwise Specified
        Childhood Acute Basophilic Leukemia
        Childhood Acute Erythroid Leukemia
        Childhood acute megakaryoblastic leukemia
        Childhood Acute Monoblastic and Monocytic Leukemia
        Childhood Acute Monoblastic Leukemia
        Childhood Acute Monocytic Leukemia
        Childhood Acute Myeloid Leukemia with Maturation
        Childhood Acute Myeloid Leukemia with Minimal Differentiation
        Childhood Acute Myeloid Leukemia without Maturation
        Childhood Acute Myelomonocytic Leukemia
        Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7
        Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q
        Childhood Acute Myeloid Leukemia with NUP98 Rearrangement
        Acute Megakaryoblastic Leukemia with NUP98-KDM5A
        Acute Myeloid Leukemia with t(11;15)(p15;q35); NUP98-JARID1A
        Acute Myeloid Leukemia with t(5;11)(q35;p15); NUP98-NSD1
        Childhood Acute Promyelocytic Leukemia with PML-RARA
        Recurrent Childhood Acute Myeloid Leukemia

Professional guidelines

PubMed

Current and emerging pharmacotherapy for the treatment of childhood acute myeloid leukemia.

Cuglievan B, McCall D, Robusto L, Mireles ME, Gettys SC
Expert Opin Pharmacother 2022 Dec;23(17):1915-1925. Epub 2022 Nov 13 doi: 10.1080/14656566.2022.2145186. PMID: 36346029

Treatment of Childhood Acute Myeloid Leukemia in Bulgaria.

Burnusuzov HA, Yordanova MN, Avramova BE, Yurukova NN, Bachvarov KN, Muchinova AB, Vlahova IH, Stoyanova AA, Mumdzhiev IN, Ivanova LR, Spasov NY, Peteva ET, Belcheva MI, Hristozova H, Spasova MI, Kaleva VI, Bobev D, Konstantinov DN
Folia Med (Plovdiv) 2018 Jun 1;60(2):234-240. doi: 10.1515/folmed-2017-0090. PMID: 30355812

Current Management of Childhood Acute Myeloid Leukemia.

Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777

See all (18)

Recent clinical studies

Etiology

Acute kidney injury and childhood acute myeloid leukemia.

Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241

Current Management of Childhood Acute Myeloid Leukemia.

Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777

Global characteristics of childhood acute promyelocytic leukemia.

Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717 Free PMC Article

Epidemiology of childhood acute myeloid leukemia.

Puumala SE, Ross JA, Aplenc R, Spector LG
Pediatr Blood Cancer 2013 May;60(5):728-33. Epub 2013 Jan 9 doi: 10.1002/pbc.24464. PMID: 23303597 Free PMC Article

Childhood acute myeloid leukemia.

Rubnitz JE
Curr Treat Options Oncol 2008 Feb;9(1):95-105. Epub 2008 May 28 doi: 10.1007/s11864-008-0059-z. PMID: 18506629

See all (177)

Diagnosis

Neurocognitive deficits in survivors of childhood acute myeloid leukemia.

Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905 Free PMC Article

Acute kidney injury and childhood acute myeloid leukemia.

Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241

Treatment of Childhood Acute Myeloid Leukemia in Bulgaria.

Global characteristics of childhood acute promyelocytic leukemia.

Epidemiology of childhood acute myeloid leukemia.

Puumala SE, Ross JA, Aplenc R, Spector LG
Pediatr Blood Cancer 2013 May;60(5):728-33. Epub 2013 Jan 9 doi: 10.1002/pbc.24464. PMID: 23303597 Free PMC Article

See all (148)

Therapy

Current and emerging pharmacotherapy for the treatment of childhood acute myeloid leukemia.

Cuglievan B, McCall D, Robusto L, Mireles ME, Gettys SC
Expert Opin Pharmacother 2022 Dec;23(17):1915-1925. Epub 2022 Nov 13 doi: 10.1080/14656566.2022.2145186. PMID: 36346029

Treatment of Childhood Acute Myeloid Leukemia in Bulgaria.

Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia.

Laing AA, Harrison CJ, Gibson BES, Keeshan K
Exp Hematol 2017 Oct;54:40-50. Epub 2017 Jun 28 doi: 10.1016/j.exphem.2017.06.007. PMID: 28668350

Current Management of Childhood Acute Myeloid Leukemia.

Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777

Global characteristics of childhood acute promyelocytic leukemia.

See all (127)

Prognosis

Relapsed Childhood Acute Myeloid Leukemia: Experience from a Single Tertiary Center in Thailand.

Songthawee N, Sripornsawan P, Chavananon S, McNeil EB, Chotsampancharoen T
Asian Pac J Cancer Prev 2022 Dec 1;23(12):4079-4084. doi: 10.31557/APJCP.2022.23.12.4079. PMID: 36579988 Free PMC Article

Neurocognitive deficits in survivors of childhood acute myeloid leukemia.

Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905 Free PMC Article

Treatment of Childhood Acute Myeloid Leukemia in Bulgaria.

Current Management of Childhood Acute Myeloid Leukemia.

Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777

Global characteristics of childhood acute promyelocytic leukemia.

See all (172)

Clinical prediction guides

The Role of Gender-Related Immune Genes in Childhood Acute Myeloid Leukemia.

Hao L, Chen Q, Chen X, Zhou Q
Biomed Res Int 2022;2022:3235238. Epub 2022 Sep 23 doi: 10.1155/2022/3235238. PMID: 36193320 Free PMC Article

Neurocognitive deficits in survivors of childhood acute myeloid leukemia.

Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905 Free PMC Article

Abandonment and Outcome of Childhood Acute Myeloid Leukemia in A Tertiary Level Hospital.

Begum M, Islam A, Rahman AA, Akter M, Alam ST, Tasmeen R
Mymensingh Med J 2018 Jan;27(1):95-102. PMID: 29459598

Global characteristics of childhood acute promyelocytic leukemia.

Chromosomal rearrangements in childhood acute myeloid leukemia and myelodysplastic syndromes.

Martinez-Climent JA, García-Conde J
J Pediatr Hematol Oncol 1999 Mar-Apr;21(2):91-102. doi: 10.1097/00043426-199903000-00004. PMID: 10206454

See all (89)

Recent systematic reviews

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis.

Karalexi MA, Dessypris N, Skalkidou A, Biniaris-Georgallis S-, Kalogirou ΕΙ, Thomopoulos TP, Herlenius E, Spector LG, Loutradis D, Chrousos GP, Petridou ET
Cancer Causes Control 2017 Jun;28(6):599-624. Epub 2017 Apr 11 doi: 10.1007/s10552-017-0890-2. PMID: 28401353

Maternal alcohol consumption during pregnancy and risk of childhood leukemia: systematic review and meta-analysis.

Latino-Martel P, Chan DS, Druesne-Pecollo N, Barrandon E, Hercberg S, Norat T
Cancer Epidemiol Biomarkers Prev 2010 May;19(5):1238-60. doi: 10.1158/1055-9965.EPI-09-1110. PMID: 20447918

See all (2)

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Childhood acute myeloid leukemia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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