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Childhood acute myeloid leukemia

MedGen UID:
65075
•Concept ID:
C0220621
•
Neoplastic Process
Synonyms: acute myeloid leukaemia of childhood; acute myeloid leukemia of childhood; childhood acute granulocytic leukaemia; childhood acute granulocytic leukemia; childhood acute myeloblastic leukaemia; Childhood Acute Myeloblastic Leukemia; childhood acute myeloblastic leukemia; childhood acute myelocytic leukaemia; childhood acute myelocytic leukemia; childhood acute myelogenous leukaemia; Childhood Acute Myelogenous Leukemia; childhood acute myelogenous leukemia; Childhood Acute Myeloid Leukemia; childhood acute myeloid leukemia; Childhood AML; childhood AML; paediatric acute myeloblastic leukaemia; paediatric acute myelocytic leukaemia; paediatric acute myelogenous leukaemia; paediatric acute myeloid leukaemia; paediatric AML; Pediatric Acute Myeloblastic Leukemia; pediatric acute myeloblastic leukemia; pediatric acute myelocytic leukemia; Pediatric Acute Myelogenous Leukemia; pediatric acute myelogenous leukemia; Pediatric Acute Myeloid Leukemia; pediatric acute myeloid leukemia; Pediatric AML; pediatric AML
 
Monarch Initiative: MONDO:0004996

Definition

Acute myeloid leukemia occurring in childhood. [from NCI]

Professional guidelines

PubMed

Current and emerging pharmacotherapy for the treatment of childhood acute myeloid leukemia.
Cuglievan B, McCall D, Robusto L, Mireles ME, Gettys SC
Expert Opin Pharmacother 2022 Dec;23(17):1915-1925. Epub 2022 Nov 13 doi: 10.1080/14656566.2022.2145186. PMID: 36346029
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Treatment of childhood acute myeloid leukemia.
ter Bals E, Kaspers GJ
Expert Rev Anticancer Ther 2005 Oct;5(5):917-29. doi: 10.1586/14737140.5.5.917. PMID: 16221060

Recent clinical studies

Etiology

Acute kidney injury and childhood acute myeloid leukemia.
Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Epidemiology of childhood acute myeloid leukemia.
Puumala SE, Ross JA, Aplenc R, Spector LG
Pediatr Blood Cancer 2013 May;60(5):728-33. Epub 2013 Jan 9 doi: 10.1002/pbc.24464. PMID: 23303597Free PMC Article
Childhood acute myeloid leukemia.
Rubnitz JE
Curr Treat Options Oncol 2008 Feb;9(1):95-105. Epub 2008 May 28 doi: 10.1007/s11864-008-0059-z. PMID: 18506629

Diagnosis

Acute kidney injury and childhood acute myeloid leukemia.
Limratchapong C, Sophark P, Vachvanichsanong P, McNeil EB, Chotsampancharoen T
Pediatr Nephrol 2022 Nov;37(11):2765-2770. Epub 2022 Mar 7 doi: 10.1007/s00467-022-05506-4. PMID: 35257241
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Epidemiology of childhood acute myeloid leukemia.
Puumala SE, Ross JA, Aplenc R, Spector LG
Pediatr Blood Cancer 2013 May;60(5):728-33. Epub 2013 Jan 9 doi: 10.1002/pbc.24464. PMID: 23303597Free PMC Article
Treatment of childhood acute myeloid leukemia.
ter Bals E, Kaspers GJ
Expert Rev Anticancer Ther 2005 Oct;5(5):917-29. doi: 10.1586/14737140.5.5.917. PMID: 16221060
Diagnosis of childhood acute myeloid leukemia.
Behm FG
Clin Lab Med 1999 Mar;19(1):187-237, vii. PMID: 10403081

Therapy

Current and emerging pharmacotherapy for the treatment of childhood acute myeloid leukemia.
Cuglievan B, McCall D, Robusto L, Mireles ME, Gettys SC
Expert Opin Pharmacother 2022 Dec;23(17):1915-1925. Epub 2022 Nov 13 doi: 10.1080/14656566.2022.2145186. PMID: 36346029
Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia.
Laing AA, Harrison CJ, Gibson BES, Keeshan K
Exp Hematol 2017 Oct;54:40-50. Epub 2017 Jun 28 doi: 10.1016/j.exphem.2017.06.007. PMID: 28668350
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article

Prognosis

Neurocognitive deficits in survivors of childhood acute myeloid leukemia.
Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905Free PMC Article
Current Management of Childhood Acute Myeloid Leukemia.
Rubnitz JE
Paediatr Drugs 2017 Feb;19(1):1-10. doi: 10.1007/s40272-016-0200-6. PMID: 27785777
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Treatment of childhood acute myeloid leukemia.
ter Bals E, Kaspers GJ
Expert Rev Anticancer Ther 2005 Oct;5(5):917-29. doi: 10.1586/14737140.5.5.917. PMID: 16221060

Clinical prediction guides

Neurocognitive deficits in survivors of childhood acute myeloid leukemia.
Takahashi S, Sato S, Igarashi S, Dairoku H, Takiguchi Y, Takimoto T
BMC Pediatr 2022 May 21;22(1):298. doi: 10.1186/s12887-022-03369-0. PMID: 35597905Free PMC Article
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article
Acute myeloid leukemia in children and adolescents: identification of new molecular targets brings promise of new therapies.
Kolb EA, Meshinchi S
Hematology Am Soc Hematol Educ Program 2015;2015:507-13. doi: 10.1182/asheducation-2015.1.507. PMID: 26637766
Global characteristics of childhood acute promyelocytic leukemia.
Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C
Blood Rev 2015 Mar;29(2):101-25. Epub 2014 Sep 30 doi: 10.1016/j.blre.2014.09.013. PMID: 25445717Free PMC Article
Chromosomal rearrangements in childhood acute myeloid leukemia and myelodysplastic syndromes.
Martinez-Climent JA, García-Conde J
J Pediatr Hematol Oncol 1999 Mar-Apr;21(2):91-102. doi: 10.1097/00043426-199903000-00004. PMID: 10206454

Recent systematic reviews

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Skalkidou A, Biniaris-Georgallis S-, Kalogirou ΕΙ, Thomopoulos TP, Herlenius E, Spector LG, Loutradis D, Chrousos GP, Petridou ET
Cancer Causes Control 2017 Jun;28(6):599-624. Epub 2017 Apr 11 doi: 10.1007/s10552-017-0890-2. PMID: 28401353
Maternal alcohol consumption during pregnancy and risk of childhood leukemia: systematic review and meta-analysis.
Latino-Martel P, Chan DS, Druesne-Pecollo N, Barrandon E, Hercberg S, Norat T
Cancer Epidemiol Biomarkers Prev 2010 May;19(5):1238-60. doi: 10.1158/1055-9965.EPI-09-1110. PMID: 20447918

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