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Borderline Ovarian Mucinous Tumor/Atypical Proliferative Ovarian Mucinous Tumor

MedGen UID:
883431
•Concept ID:
C4053516
•
Neoplastic Process

Definition

A non-invasive neoplasm that arises from the ovary and is composed of gastrointestinal-type, mucin-containing epithelial cells. It shows greater cellular proliferation and cytologic atypia as compared to benign ovarian mucinous tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Ovarian Mucinous Tumor/Atypical Proliferative Ovarian Mucinous Tumor

Professional guidelines

PubMed

Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior.
Ronnett BM, Kajdacsy-Balla A, Gilks CB, Merino MJ, Silva E, Werness BA, Young RH
Hum Pathol 2004 Aug;35(8):949-60. doi: 10.1016/j.humpath.2004.03.006. PMID: 15297962
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
Refined diagnostic criteria for implants associated with ovarian atypical proliferative serous tumors (borderline) and micropapillary serous carcinomas.
Bell KA, Smith Sehdev AE, Kurman RJ
Am J Surg Pathol 2001 Apr;25(4):419-32. doi: 10.1097/00000478-200104000-00001. PMID: 11257616

Recent clinical studies

Etiology

Assessing the landscape of ovarian serous borderline tumors.
Messini I, Doulgeraki T, Chrysanthakis D, Yiannou P, Gavresea T, Papadimitriou C, Panoskaltsis T, Voulgaris Z, Vlachos A, Pavlakis K
Int J Gynecol Cancer 2019 Mar;29(3):572-578. Epub 2019 Jan 18 doi: 10.1136/ijgc-2018-000086. PMID: 30659030
Seromucinous Tumors of the Ovary. What's in a Name?
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2016 Jan;35(1):78-81. doi: 10.1097/PGP.0000000000000266. PMID: 26598986Free PMC Article
The relationship between papillary infarction and microinvasion in ovarian atypical proliferative ("borderline") serous and seromucinous tumors.
Kraus JA, Seidman JD
Int J Gynecol Pathol 2010 Jul;29(4):303-9. doi: 10.1097/PGP.0b013e3181cc824f. PMID: 20567140
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848

Diagnosis

Ovarian seromucinous tumors: clinicopathological features of 10 cases with a detailed review of the literature.
Idrees R, Din NU, Siddique S, Fatima S, Abdul-Ghafar J, Ahmad Z
J Ovarian Res 2021 Mar 18;14(1):47. doi: 10.1186/s13048-021-00796-y. PMID: 33736662Free PMC Article
Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature.
Salibay CJ, Zanfagnin V, Miller H, Walia S, Brunette LL, Wang T
Int J Surg Pathol 2021 Oct;29(7):788-793. Epub 2021 Feb 26 doi: 10.1177/1066896921999459. PMID: 33635096
Ovarian Seromucinous Borderline Tumors Are Histologically Different from Mucinous Borderline Tumors.
Hada T, Miyamoto M, Ishibashi H, Kawauchi H, Soyama H, Matsuura H, Sakamoto T, Kakimoto S, Aoyama T, Iwahashi H, Suzuki R, Tsuda H, Takano M
In Vivo 2020 May-Jun;34(3):1341-1346. doi: 10.21873/invivo.11911. PMID: 32354928Free PMC Article
Assessing the landscape of ovarian serous borderline tumors.
Messini I, Doulgeraki T, Chrysanthakis D, Yiannou P, Gavresea T, Papadimitriou C, Panoskaltsis T, Voulgaris Z, Vlachos A, Pavlakis K
Int J Gynecol Cancer 2019 Mar;29(3):572-578. Epub 2019 Jan 18 doi: 10.1136/ijgc-2018-000086. PMID: 30659030
Low-grade serous tumors of ovary.
Bell DA
Int J Gynecol Pathol 2014 Jul;33(4):348-56. doi: 10.1097/PGP.0000000000000135. PMID: 24901394

Therapy

Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.
Seidman JD, Kurman RJ
Hum Pathol 2000 May;31(5):539-57. doi: 10.1053/hp.2000.8048. PMID: 10836293

Prognosis

Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature.
Salibay CJ, Zanfagnin V, Miller H, Walia S, Brunette LL, Wang T
Int J Surg Pathol 2021 Oct;29(7):788-793. Epub 2021 Feb 26 doi: 10.1177/1066896921999459. PMID: 33635096
Ovarian Seromucinous Borderline Tumors Are Histologically Different from Mucinous Borderline Tumors.
Hada T, Miyamoto M, Ishibashi H, Kawauchi H, Soyama H, Matsuura H, Sakamoto T, Kakimoto S, Aoyama T, Iwahashi H, Suzuki R, Tsuda H, Takano M
In Vivo 2020 May-Jun;34(3):1341-1346. doi: 10.21873/invivo.11911. PMID: 32354928Free PMC Article
Assessing the landscape of ovarian serous borderline tumors.
Messini I, Doulgeraki T, Chrysanthakis D, Yiannou P, Gavresea T, Papadimitriou C, Panoskaltsis T, Voulgaris Z, Vlachos A, Pavlakis K
Int J Gynecol Cancer 2019 Mar;29(3):572-578. Epub 2019 Jan 18 doi: 10.1136/ijgc-2018-000086. PMID: 30659030
Low-grade serous tumors of ovary.
Bell DA
Int J Gynecol Pathol 2014 Jul;33(4):348-56. doi: 10.1097/PGP.0000000000000135. PMID: 24901394
Serous borderline (low malignant potential, atypical proliferative) ovarian tumors: workshop perspectives.
Bell DA, Longacre TA, Prat J, Kohn EC, Soslow RA, Ellenson LH, Malpica A, Stoler MH, Kurman RJ
Hum Pathol 2004 Aug;35(8):934-48. doi: 10.1016/j.humpath.2004.03.005. PMID: 15297961

Clinical prediction guides

Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A.
Wu CH, Mao TL, Vang R, Ayhan A, Wang TL, Kurman RJ, Shih IeM
Int J Gynecol Pathol 2012 Jul;31(4):297-303. doi: 10.1097/PGP.0b013e31823f8482. PMID: 22653341Free PMC Article
Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion.
Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S
Int J Gynecol Pathol 2011 May;30(3):218-30. doi: 10.1097/PGP.0b013e3181fcf01a. PMID: 21464732
The relationship between papillary infarction and microinvasion in ovarian atypical proliferative ("borderline") serous and seromucinous tumors.
Kraus JA, Seidman JD
Int J Gynecol Pathol 2010 Jul;29(4):303-9. doi: 10.1097/PGP.0b013e3181cc824f. PMID: 20567140
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848
Metallothionein expression and nuclear size in benign, borderline, and malignant serous ovarian tumours.
Tan Y, Sinniah R, Bay BH, Singh G
J Pathol 1999 Sep;189(1):60-5. doi: 10.1002/(SICI)1096-9896(199909)189:1<60::AID-PATH387>3.0.CO;2-J. PMID: 10451489

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