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Non-Functioning Pituitary Neuroendocrine Tumor/Microadenoma

MedGen UID:
886514
•Concept ID:
C4053795
•
Neoplastic Process
Synonyms: Non-Functioning PitNET/Microadenoma; Non-Functioning Pituitary Gland Microadenoma; Nonfunctional Pituitary Gland Microadenoma; Nonfunctioning Pituitary Gland Microadenoma

Definition

A pituitary neuroendocrine tumor/microadenoma not associated with a hormonal syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Functioning Pituitary Neuroendocrine Tumor/Microadenoma

Professional guidelines

PubMed

Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
MANAGEMENT OF ENDOCRINE DISEASE: Pituitary 'incidentaloma': neuroradiological assessment and differential diagnosis.
Vasilev V, Rostomyan L, Daly AF, Potorac I, Zacharieva S, Bonneville JF, Beckers A
Eur J Endocrinol 2016 Oct;175(4):R171-84. Epub 2016 Apr 11 doi: 10.1530/EJE-15-1272. PMID: 27068689
Contemporary issues in the evaluation and management of pituitary adenomas.
Pekic S, Stojanovic M, Popovic V
Minerva Endocrinol 2015 Dec;40(4):307-19. Epub 2015 Apr 22 PMID: 25900682

Recent clinical studies

Etiology

Natural History of Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis.
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Natural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.
Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
Non-functioning pituitary tumors: 2012 update.
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732
Pituitary tumours: pituitary incidentalomas.
Molitch ME
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):667-75. doi: 10.1016/j.beem.2009.05.001. PMID: 19945030

Diagnosis

Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
Clinically non-functioning pituitary adenomas: Pathogenic, diagnostic and therapeutic aspects.
Mercado M, Melgar V, Salame L, Cuenca D
Endocrinol Diabetes Nutr 2017 Aug-Sep;64(7):384-395. Epub 2017 Jul 4 doi: 10.1016/j.endinu.2017.05.009. PMID: 28745610
Non-functioning pituitary tumors: 2012 update.
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732
Pituitary tumours: pituitary incidentalomas.
Molitch ME
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):667-75. doi: 10.1016/j.beem.2009.05.001. PMID: 19945030
Clinically non-functioning pituitary adenoma.
Jaffe CA
Pituitary 2006;9(4):317-21. doi: 10.1007/s11102-006-0412-9. PMID: 17082898

Therapy

Natural History of Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis.
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Is pituitary MRI screening necessary in cluster headache?
Grangeon L, O'Connor E, Danno D, Ngoc TMP, Cheema S, Tronvik E, Davagnanam I, Matharu M
Cephalalgia 2021 Jun;41(7):779-788. Epub 2021 Jan 6 doi: 10.1177/0333102420983303. PMID: 33406848Free PMC Article
Clinically non-functioning pituitary adenomas: Pathogenic, diagnostic and therapeutic aspects.
Mercado M, Melgar V, Salame L, Cuenca D
Endocrinol Diabetes Nutr 2017 Aug-Sep;64(7):384-395. Epub 2017 Jul 4 doi: 10.1016/j.endinu.2017.05.009. PMID: 28745610
Immediate and delayed postoperative morbidity in functional and non-functioning pituitary adenomas.
Aulinas A, Colom C, Ybarra J, Muñoz F, Tresserras P, Resmini E, Webb SM
Pituitary 2012 Sep;15(3):380-5. doi: 10.1007/s11102-011-0331-2. PMID: 21833618
Diagnosis and treatment of pituitary microadenoma: report of 80 cases.
Zhang HW, Sun W, Yang J, Yan CX, Yu CJ
Neurol Res 2008 Jul;30(6):587-93. doi: 10.1179/174313208X310287. PMID: 18647498

Prognosis

Natural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.
Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Non-functioning pituitary microadenoma in children and adolescents: Is follow-up with diagnostic imaging necessary?
Borghammar C, Tamaddon A, Erfurth EM, Sundgren PC, Siesjö P, Elfving M, Nilsson M
Endocrine 2023 Jan;79(1):152-160. Epub 2022 Oct 17 doi: 10.1007/s12020-022-03212-7. PMID: 36251115Free PMC Article
Contemporary issues in the evaluation and management of pituitary adenomas.
Pekic S, Stojanovic M, Popovic V
Minerva Endocrinol 2015 Dec;40(4):307-19. Epub 2015 Apr 22 PMID: 25900682
Non-functioning pituitary tumors: 2012 update.
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732
Pituitary tumours: pituitary incidentalomas.
Molitch ME
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):667-75. doi: 10.1016/j.beem.2009.05.001. PMID: 19945030

Clinical prediction guides

Natural History of Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis.
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Natural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.
Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Symptoms at presentation in conservatively managed patients with non-functioning pituitary adenomas.
Han AJ, Fleseriu M, Varlamov EV
Hormones (Athens) 2023 Jun;22(2):305-309. Epub 2023 Mar 11 doi: 10.1007/s42000-023-00444-8. PMID: 36905572
Functioning gonadotroph adenomas in premenopausal women: clinical and molecular characterization and review of the literature.
Wang L, Liang H, Deng C, Yu Q, Gong F, Feng F, You H, Liang Z, Chen B, Deng K, Ma J, Wang R, Yao Y, Zhu H
Pituitary 2022 Jun;25(3):454-467. Epub 2022 Feb 9 doi: 10.1007/s11102-021-01205-9. PMID: 35138520
Non-functioning pituitary tumors: 2012 update.
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732

Recent systematic reviews

Natural History of Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis.
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Fluorescence-guided detection of pituitary neuroendocrine tumor (PitNET) tissue during endoscopic transsphenoidal surgery available agents, their potential, and technical aspects.
Vergeer RA, Theunissen REP, van Elk T, Schmidt I, Postma MR, Tamasi K, van Dijk JMC, Kuijlen JMA
Rev Endocr Metab Disord 2022 Jun;23(3):647-657. Epub 2022 Mar 28 doi: 10.1007/s11154-022-09718-9. PMID: 35344185Free PMC Article

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