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Giant Cell Lesion of Small Bones

MedGen UID:
890148
•Concept ID:
C4049867
•
Neoplastic Process
Synonym: Giant Cell Reparative Granuloma

Definition

A rare tumor-like lesion of the hands and feet characterized by the presence of hemorrhagic fibrous tissue, hemosiderin deposition, osteoclast-like giant cells which are irregularly distributed, and reactive bone formation. Pain and swelling are the most frequent symptoms. It may recur following curettage, but is usually cured after a second procedure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant Cell Lesion of Small Bones

Professional guidelines

PubMed

Cryotherapy efficacy and safety as local therapy in surgical treatment of musculoskeletal tumours. A retrospective case series of 143 patients.
Colangeli S, Parchi P, Andreani L, Beltrami G, Scoccianti G, Sacchetti F, Ceccoli M, Totti F, Campanacci DA, Capanna R
J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):65-70. PMID: 30644284
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA.
VandenBussche CJ, Sathiyamoorthy S, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2016 Jul;124(7):493-500. Epub 2016 Mar 21 doi: 10.1002/cncy.21715. PMID: 26999748
Orbitofrontal cholesterol granuloma: distinct diagnostic features and management.
Arat YO, Chaudhry IA, Boniuk M
Ophthalmic Plast Reconstr Surg 2003 Sep;19(5):382-7. doi: 10.1097/01.IOP.0000083644.62765.70. PMID: 14506423

Recent clinical studies

Etiology

Multiple versus solitary giant cell lesions of the jaw: Similar or distinct entities?
Schreuder WH, van der Wal JE, de Lange J, van den Berg H
Bone 2021 Aug;149:115935. Epub 2021 Mar 24 doi: 10.1016/j.bone.2021.115935. PMID: 33771761
Giant cell reparative granuloma of the scapula: report of a case and literature review.
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Giant cell tumor of the small bones of the foot.
Co HL, Wang EH
J Orthop Surg (Hong Kong) 2018 May-Aug;26(3):2309499018801168. doi: 10.1177/2309499018801168. PMID: 30270796
Clinical characteristics and prognoses of six patients with multicentric giant cell tumor of the bone.
Liu C, Tang Y, Li M, Jiao Q, Zhang H, Yang Q, Yao W
Oncotarget 2016 Dec 13;7(50):83795-83805. doi: 10.18632/oncotarget.13057. PMID: 27823978Free PMC Article
Giant cell tumor of the small bones of the hands and feet.
Wold LE, Swee RG
Semin Diagn Pathol 1984 Aug;1(3):173-84. PMID: 6599927

Diagnosis

Molecular and immunohistochemical testing of bone tumours: review and update.
Kovacs SK, Manassaporn A, Nielsen GP, Hung YP
Histopathology 2023 May;82(6):794-811. Epub 2022 Dec 16 doi: 10.1111/his.14845. PMID: 36424903
Utility of P63 in Differentiating Giant Cell Tumor from Other Giant Cell-Containing Lesions.
Hui M, Uppin SG, Kumar KK, Radhika S, Chandrasekhar P, Rao KN
Turk Patoloji Derg 2022;38(1):9-15. doi: 10.5146/tjpath.2021.01538. PMID: 34514571Free PMC Article
Multiple versus solitary giant cell lesions of the jaw: Similar or distinct entities?
Schreuder WH, van der Wal JE, de Lange J, van den Berg H
Bone 2021 Aug;149:115935. Epub 2021 Mar 24 doi: 10.1016/j.bone.2021.115935. PMID: 33771761
Giant cell tumor of the small bones of the foot.
Co HL, Wang EH
J Orthop Surg (Hong Kong) 2018 May-Aug;26(3):2309499018801168. doi: 10.1177/2309499018801168. PMID: 30270796
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595

Therapy

Is a Short-course of Preoperative Denosumab as Effective as Prolonged Therapy for Giant Cell Tumor of Bone?
Hindiskere S, Errani C, Doddarangappa S, Ramaswamy V, Rai M, Chinder PS
Clin Orthop Relat Res 2020 Nov;478(11):2522-2533. doi: 10.1097/CORR.0000000000001285. PMID: 32401001Free PMC Article
Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature.
Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
Clinical characteristics and prognoses of six patients with multicentric giant cell tumor of the bone.
Liu C, Tang Y, Li M, Jiao Q, Zhang H, Yang Q, Yao W
Oncotarget 2016 Dec 13;7(50):83795-83805. doi: 10.18632/oncotarget.13057. PMID: 27823978Free PMC Article
The clinical approach toward giant cell tumor of bone.
van der Heijden L, Dijkstra PD, van de Sande MA, Kroep JR, Nout RA, van Rijswijk CS, Bovée JV, Hogendoorn PC, Gelderblom H
Oncologist 2014 May;19(5):550-61. Epub 2014 Apr 9 doi: 10.1634/theoncologist.2013-0432. PMID: 24718514Free PMC Article
Radiosurgery and radiotherapy for sacral tumors.
Gibbs IC, Chang SD
Neurosurg Focus 2003 Aug 15;15(2):E8. doi: 10.3171/foc.2003.15.2.8. PMID: 15350039

Prognosis

Update of pediatric bone tumors-other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone.
Wang A, Maloney E, Al-Dasuqi K, Irshaid L, Ahmed A, Haims A, Porrino J
Skeletal Radiol 2023 Aug;52(8):1443-1463. Epub 2023 Jan 19 doi: 10.1007/s00256-023-04286-8. PMID: 36656343
Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature.
Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
A clinicopathological study of giant cell tumor of small bones.
Yanagisawa M, Okada K, Tajino T, Torigoe T, Kawai A, Nishida J
Ups J Med Sci 2011 Nov;116(4):265-8. Epub 2011 Sep 16 doi: 10.3109/03009734.2011.596290. PMID: 21919814Free PMC Article
The pathology of pulmonary sarcoidosis: update.
Ma Y, Gal A, Koss MN
Semin Diagn Pathol 2007 Aug;24(3):150-61. doi: 10.1053/j.semdp.2007.06.002. PMID: 17882899
Aneurysmal bone cyst and giant cell tumor of the foot.
Casadei R, Ruggieri P, Moscato M, Ferraro A, Picci P
Foot Ankle Int 1996 Aug;17(8):487-95. doi: 10.1177/107110079601700810. PMID: 8863029

Clinical prediction guides

Giant cell reparative granuloma of the scapula: report of a case and literature review.
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature.
Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
Giant cell tumours of the small bones of the hands and feet: long-term results of 30 patients and a systematic literature review.
Oliveira VC, van der Heijden L, van der Geest IC, Campanacci DA, Gibbons CL, van de Sande MA, Dijkstra PD
Bone Joint J 2013 Jun;95-B(6):838-45. doi: 10.1302/0301-620X.95B6.30876. PMID: 23723282
A clinicopathological study of giant cell tumor of small bones.
Yanagisawa M, Okada K, Tajino T, Torigoe T, Kawai A, Nishida J
Ups J Med Sci 2011 Nov;116(4):265-8. Epub 2011 Sep 16 doi: 10.3109/03009734.2011.596290. PMID: 21919814Free PMC Article
Aneurysmal bone cyst and giant cell tumor of the foot.
Casadei R, Ruggieri P, Moscato M, Ferraro A, Picci P
Foot Ankle Int 1996 Aug;17(8):487-95. doi: 10.1177/107110079601700810. PMID: 8863029

Recent systematic reviews

Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature.
Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
Giant cell tumours of the small bones of the hands and feet: long-term results of 30 patients and a systematic literature review.
Oliveira VC, van der Heijden L, van der Geest IC, Campanacci DA, Gibbons CL, van de Sande MA, Dijkstra PD
Bone Joint J 2013 Jun;95-B(6):838-45. doi: 10.1302/0301-620X.95B6.30876. PMID: 23723282

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