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Giant Cell Lesion of Small Bones

MedGen UID:
890148
Concept ID:
C4049867
Neoplastic Process
Synonym: Giant Cell Reparative Granuloma

Definition

A rare tumor-like lesion of the hands and feet characterized by the presence of hemorrhagic fibrous tissue, hemosiderin deposition, osteoclast-like giant cells which are irregularly distributed, and reactive bone formation. Pain and swelling are the most frequent symptoms. It may recur following curettage, but is usually cured after a second procedure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant Cell Lesion of Small Bones

Professional guidelines

PubMed

Colangeli S, Parchi P, Andreani L, Beltrami G, Scoccianti G, Sacchetti F, Ceccoli M, Totti F, Campanacci DA, Capanna R
J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):65-70. PMID: 30644284
VandenBussche CJ, Sathiyamoorthy S, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2016 Jul;124(7):493-500. Epub 2016 Mar 21 doi: 10.1002/cncy.21715. PMID: 26999748
Arat YO, Chaudhry IA, Boniuk M
Ophthalmic Plast Reconstr Surg 2003 Sep;19(5):382-7. doi: 10.1097/01.IOP.0000083644.62765.70. PMID: 14506423

Recent clinical studies

Etiology

Schreuder WH, van der Wal JE, de Lange J, van den Berg H
Bone 2021 Aug;149:115935. Epub 2021 Mar 24 doi: 10.1016/j.bone.2021.115935. PMID: 33771761
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Co HL, Wang EH
J Orthop Surg (Hong Kong) 2018 May-Aug;26(3):2309499018801168. doi: 10.1177/2309499018801168. PMID: 30270796
Bertoni F, Unni KK, McLeod RA, Sim FH
Am J Clin Pathol 1988 Oct;90(4):377-84. doi: 10.1093/ajcp/90.4.377. PMID: 3140652
Wold LE, Swee RG
Semin Diagn Pathol 1984 Aug;1(3):173-84. PMID: 6599927

Diagnosis

Kovacs SK, Manassaporn A, Nielsen GP, Hung YP
Histopathology 2023 May;82(6):794-811. Epub 2022 Dec 16 doi: 10.1111/his.14845. PMID: 36424903
Schreuder WH, van der Wal JE, de Lange J, van den Berg H
Bone 2021 Aug;149:115935. Epub 2021 Mar 24 doi: 10.1016/j.bone.2021.115935. PMID: 33771761
Co HL, Wang EH
J Orthop Surg (Hong Kong) 2018 May-Aug;26(3):2309499018801168. doi: 10.1177/2309499018801168. PMID: 30270796
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Bertoni F, Unni KK, McLeod RA, Sim FH
Am J Clin Pathol 1988 Oct;90(4):377-84. doi: 10.1093/ajcp/90.4.377. PMID: 3140652

Therapy

Del Sindaco G, Berlanga P, Brugières L, Thebault E, Mantovani G, Wicart P, Linglart A
Front Endocrinol (Lausanne) 2021;12:698963. Epub 2021 Jul 16 doi: 10.3389/fendo.2021.698963. PMID: 34335473Free PMC Article
Hindiskere S, Errani C, Doddarangappa S, Ramaswamy V, Rai M, Chinder PS
Clin Orthop Relat Res 2020 Nov;478(11):2522-2533. doi: 10.1097/CORR.0000000000001285. PMID: 32401001Free PMC Article
Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
Liu C, Tang Y, Li M, Jiao Q, Zhang H, Yang Q, Yao W
Oncotarget 2016 Dec 13;7(50):83795-83805. doi: 10.18632/oncotarget.13057. PMID: 27823978Free PMC Article
van der Heijden L, Dijkstra PD, van de Sande MA, Kroep JR, Nout RA, van Rijswijk CS, Bovée JV, Hogendoorn PC, Gelderblom H
Oncologist 2014 May;19(5):550-61. Epub 2014 Apr 9 doi: 10.1634/theoncologist.2013-0432. PMID: 24718514Free PMC Article

Prognosis

Wang A, Maloney E, Al-Dasuqi K, Irshaid L, Ahmed A, Haims A, Porrino J
Skeletal Radiol 2023 Aug;52(8):1443-1463. Epub 2023 Jan 19 doi: 10.1007/s00256-023-04286-8. PMID: 36656343
Yanagisawa M, Okada K, Tajino T, Torigoe T, Kawai A, Nishida J
Ups J Med Sci 2011 Nov;116(4):265-8. Epub 2011 Sep 16 doi: 10.3109/03009734.2011.596290. PMID: 21919814Free PMC Article
Ma Y, Gal A, Koss MN
Semin Diagn Pathol 2007 Aug;24(3):150-61. doi: 10.1053/j.semdp.2007.06.002. PMID: 17882899
Casadei R, Ruggieri P, Moscato M, Ferraro A, Picci P
Foot Ankle Int 1996 Aug;17(8):487-95. doi: 10.1177/107110079601700810. PMID: 8863029
Bertoni F, Unni KK, McLeod RA, Sim FH
Am J Clin Pathol 1988 Oct;90(4):377-84. doi: 10.1093/ajcp/90.4.377. PMID: 3140652

Clinical prediction guides

Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
Oliveira VC, van der Heijden L, van der Geest IC, Campanacci DA, Gibbons CL, van de Sande MA, Dijkstra PD
Bone Joint J 2013 Jun;95-B(6):838-45. doi: 10.1302/0301-620X.95B6.30876. PMID: 23723282
Yanagisawa M, Okada K, Tajino T, Torigoe T, Kawai A, Nishida J
Ups J Med Sci 2011 Nov;116(4):265-8. Epub 2011 Sep 16 doi: 10.3109/03009734.2011.596290. PMID: 21919814Free PMC Article
Casadei R, Ruggieri P, Moscato M, Ferraro A, Picci P
Foot Ankle Int 1996 Aug;17(8):487-95. doi: 10.1177/107110079601700810. PMID: 8863029

Recent systematic reviews

Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
Oliveira VC, van der Heijden L, van der Geest IC, Campanacci DA, Gibbons CL, van de Sande MA, Dijkstra PD
Bone Joint J 2013 Jun;95-B(6):838-45. doi: 10.1302/0301-620X.95B6.30876. PMID: 23723282

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