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Juvenile aseptic necrosis

MedGen UID:
892393
•Concept ID:
C4022146
•
Disease or Syndrome
Synonym: Aseptic epiphyseal necrosis
 
HPO: HP:0100323

Definition

Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers. [from HPO]

Professional guidelines

PubMed

Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
A classification-based treatment algorithm for Kienböck disease: current and future considerations.
Saunders BM, Lichtman D
Tech Hand Up Extrem Surg 2011 Mar;15(1):38-40. doi: 10.1097/BTH.0b013e31820e82d2. PMID: 21358524
Differential diagnosis and management of hip pain in childhood.
Hollingworth P
Br J Rheumatol 1995 Jan;34(1):78-82. doi: 10.1093/rheumatology/34.1.78. PMID: 7881844

Recent clinical studies

Etiology

The pediatric glucocorticoid toxicity index.
Brogan P, Naden R, Ardoin SP, Cooper JC, De Benedetti F, Dicaire JF, Eleftheriou D, Feldman B, Goldin J, Karol SE, Price-Kuehne F, Skuse D, Stratakis CA, Webb N, Stone JH
Semin Arthritis Rheum 2022 Oct;56:152068. Epub 2022 Jul 14 doi: 10.1016/j.semarthrit.2022.152068. PMID: 35917759
Kienböck Disease in the Skeletally Immature Patient.
Afshar A
J Hand Surg Am 2018 May;43(5):465-469. Epub 2018 Mar 21 doi: 10.1016/j.jhsa.2018.02.029. PMID: 29573896
The orthopedic diseases of ancient Egypt.
Fritsch KO, Hamoud H, Allam AH, Grossmann A, Nur El-Din AH, Abdel-Maksoud G, Soliman MA, Badr I, Sutherland JD, Sutherland ML, Akl M, Finch CE, Thomas GS, Wann LS, Thompson RC
Anat Rec (Hoboken) 2015 Jun;298(6):1036-46. doi: 10.1002/ar.23136. PMID: 25998638
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Bisphosphonate use in conditions other than osteoporosis.
Silverman SL
Ann N Y Acad Sci 2011 Feb;1218:33-7. Epub 2010 Sep 28 doi: 10.1111/j.1749-6632.2010.05769.x. PMID: 20946575

Diagnosis

Osteochondritis Dissecans: Etiology, Pathology, and Imaging with a Special Focus on the Knee Joint.
Bruns J, Werner M, Habermann C
Cartilage 2018 Oct;9(4):346-362. Epub 2017 Jun 22 doi: 10.1177/1947603517715736. PMID: 28639852Free PMC Article
Evaluating the Limping Child: A Rheumatology Perspective.
Syed R
Mo Med 2016 Mar-Apr;113(2):131-5. PMID: 27311224Free PMC Article
Pediatric hip: pearls and pitfalls.
Gill KG
Semin Musculoskelet Radiol 2013 Jul;17(3):328-38. Epub 2013 Jun 20 doi: 10.1055/s-0033-1348099. PMID: 23787987
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Arthritis in children.
Wilkinson RH, Weissman BN
Radiol Clin North Am 1988 Nov;26(6):1247-65. PMID: 3051095

Therapy

The pediatric glucocorticoid toxicity index.
Brogan P, Naden R, Ardoin SP, Cooper JC, De Benedetti F, Dicaire JF, Eleftheriou D, Feldman B, Goldin J, Karol SE, Price-Kuehne F, Skuse D, Stratakis CA, Webb N, Stone JH
Semin Arthritis Rheum 2022 Oct;56:152068. Epub 2022 Jul 14 doi: 10.1016/j.semarthrit.2022.152068. PMID: 35917759
Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats.
Sommer NG, Hirzberger D, Paar L, Berger L, Ćwieka H, Schwarze UY, Herber V, Okutan B, Bodey AJ, Willumeit-Römer R, Zeller-Plumhoff B, Löffler JF, Weinberg AM
Acta Biomater 2022 Jul 15;147:427-438. Epub 2022 May 27 doi: 10.1016/j.actbio.2022.05.041. PMID: 35644328
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.
Young ML, Little DG, Kim HK
Clin Orthop Relat Res 2012 Sep;470(9):2462-75. doi: 10.1007/s11999-011-2240-0. PMID: 22270467Free PMC Article
Bisphosphonate use in conditions other than osteoporosis.
Silverman SL
Ann N Y Acad Sci 2011 Feb;1218:33-7. Epub 2010 Sep 28 doi: 10.1111/j.1749-6632.2010.05769.x. PMID: 20946575

Prognosis

The pediatric glucocorticoid toxicity index.
Brogan P, Naden R, Ardoin SP, Cooper JC, De Benedetti F, Dicaire JF, Eleftheriou D, Feldman B, Goldin J, Karol SE, Price-Kuehne F, Skuse D, Stratakis CA, Webb N, Stone JH
Semin Arthritis Rheum 2022 Oct;56:152068. Epub 2022 Jul 14 doi: 10.1016/j.semarthrit.2022.152068. PMID: 35917759
High Satisfaction and Activity Levels After Total Hip Arthroplasty in Patients Under Age 21.
Kahlenberg CA, Garvey MD, Blevins JL, Sculco TP, Sculco PK, Figgie MP
J Arthroplasty 2021 Oct;36(10):3485-3489. Epub 2021 May 21 doi: 10.1016/j.arth.2021.05.020. PMID: 34092468
Unravelling the enigma of Perthes disease.
Perry DC
Ann R Coll Surg Engl 2013 Jul;95(5):311-6. doi: 10.1308/003588413X13629960046192. PMID: 23838491Free PMC Article
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Infantile and juvenile lunatomalacia.
Irisarri C, Kalb K, Ribak S
J Hand Surg Eur Vol 2010 Sep;35(7):544-8. Epub 2010 Mar 17 doi: 10.1177/1753193410364913. PMID: 20237187

Clinical prediction guides

Outcome measures and survivorship following total hip arthroplasty in adolescent population.
Fernandez-Fernandez R, Moraleda-Novo L, De Armas JN, Cruz-Pardos A
Int Orthop 2022 Dec;46(12):2785-2791. Epub 2022 Aug 9 doi: 10.1007/s00264-022-05536-5. PMID: 35945465
The pediatric glucocorticoid toxicity index.
Brogan P, Naden R, Ardoin SP, Cooper JC, De Benedetti F, Dicaire JF, Eleftheriou D, Feldman B, Goldin J, Karol SE, Price-Kuehne F, Skuse D, Stratakis CA, Webb N, Stone JH
Semin Arthritis Rheum 2022 Oct;56:152068. Epub 2022 Jul 14 doi: 10.1016/j.semarthrit.2022.152068. PMID: 35917759
Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats.
Sommer NG, Hirzberger D, Paar L, Berger L, Ćwieka H, Schwarze UY, Herber V, Okutan B, Bodey AJ, Willumeit-Römer R, Zeller-Plumhoff B, Löffler JF, Weinberg AM
Acta Biomater 2022 Jul 15;147:427-438. Epub 2022 May 27 doi: 10.1016/j.actbio.2022.05.041. PMID: 35644328
High Satisfaction and Activity Levels After Total Hip Arthroplasty in Patients Under Age 21.
Kahlenberg CA, Garvey MD, Blevins JL, Sculco TP, Sculco PK, Figgie MP
J Arthroplasty 2021 Oct;36(10):3485-3489. Epub 2021 May 21 doi: 10.1016/j.arth.2021.05.020. PMID: 34092468
Unravelling the enigma of Perthes disease.
Perry DC
Ann R Coll Surg Engl 2013 Jul;95(5):311-6. doi: 10.1308/003588413X13629960046192. PMID: 23838491Free PMC Article

Recent systematic reviews

Do Bisphosphonates Alleviate Pain in Children? A Systematic Review.
Celin MR, Simon JC, Krzak JJ, Fial AV, Kruger KM, Smith PA, Harris GF
Curr Osteoporos Rep 2020 Oct;18(5):486-504. doi: 10.1007/s11914-020-00621-3. PMID: 32960409
Effects of the use of growth hormone in children and adolescents with juvenile idiopathic arthritis: a systematic review.
Frittoli RB, Longhi BS, Silva AM, Filho AAB, Monteiro MÂRG, Appenzeller S
Rev Bras Reumatol Engl Ed 2017 Mar-Apr;57(2):100-106. Epub 2016 Oct 24 doi: 10.1016/j.rbre.2016.07.009. PMID: 28343613
Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.
Young ML, Little DG, Kim HK
Clin Orthop Relat Res 2012 Sep;470(9):2462-75. doi: 10.1007/s11999-011-2240-0. PMID: 22270467Free PMC Article

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