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Reduced plasminogen activator inhibitor 1 activity

MedGen UID:
906749
•Concept ID:
C4280700
•
Finding
HPO: HP:0040248

Definition

Reduced activity of plasminogen activator inhibitor 1. This protein down-regulates fibrinolysis in the circulation by inhibiting the two major plasminogen activators [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced plasminogen activator inhibitor 1 activity

Professional guidelines

PubMed

Specific inhibition on PAI-1 reduces the dose of Alteplase for ischemic stroke treatment.
Xu Y, Hu Y, Wu G, Niu L, Fang C, Li Y, Jiang L, Yuan C, Huang M
Int J Biol Macromol 2024 Feb;257(Pt 2):128618. Epub 2023 Dec 8 doi: 10.1016/j.ijbiomac.2023.128618. PMID: 38070813
BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation.
Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN; Haemato-oncology Task Force of British Committee for Standards in Haematology; British Society for Blood and Marrow Transplantation
Br J Haematol 2013 Nov;163(4):444-57. Epub 2013 Sep 17 doi: 10.1111/bjh.12558. PMID: 24102514
Selection criteria for epirubicin-based adjuvant chemotherapy in node-negative breast cancer.
Jänicke F
Clin Breast Cancer 2000 Sep;1 Suppl 1:S57-61. doi: 10.3816/cbc.2000.s.011. PMID: 11970751

Recent clinical studies

Therapy

The Antiobesity Effects and Potential Mechanisms of Theaflavins.
Fang Y, Wang J, Cao Y, Liu W, Duan L, Hu J, Peng J
J Med Food 2024 Jan;27(1):1-11. Epub 2023 Dec 7 doi: 10.1089/jmf.2023.K.0180. PMID: 38060708
Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury.
Das DN, Puthusseri B, Gopu V, Krishnan V, Bhagavath AK, Bolla S, Saini Y, Criner GJ, Marchetti N, Tang H, Konduru NV, Fan L, Shetty S
Am J Physiol Lung Cell Mol Physiol 2023 Nov 1;325(5):L689-L708. Epub 2023 Aug 29 doi: 10.1152/ajplung.00178.2022. PMID: 37642665Free PMC Article
PAI-1 in Diabetes: Pathophysiology and Role as a Therapeutic Target.
Altalhi R, Pechlivani N, Ajjan RA
Int J Mol Sci 2021 Mar 20;22(6) doi: 10.3390/ijms22063170. PMID: 33804680Free PMC Article
Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease.
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Functional stability of plasminogen activator inhibitor-1.
Yasar Yildiz S, Kuru P, Toksoy Oner E, Agirbasli M
ScientificWorldJournal 2014;2014:858293. Epub 2014 Oct 15 doi: 10.1155/2014/858293. PMID: 25386620Free PMC Article

Prognosis

Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM
Eur Respir J 2021 May;57(5) Epub 2021 May 27 doi: 10.1183/13993003.02559-2020. PMID: 33214209Free PMC Article
Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease.
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Plasminogen activator inhibitor-1 in kidney pathology (Review).
Małgorzewicz S, Skrzypczak-Jankun E, Jankun J
Int J Mol Med 2013 Mar;31(3):503-10. Epub 2013 Jan 10 doi: 10.3892/ijmm.2013.1234. PMID: 23314920
Endothelial dysfunction.
Endemann DH, Schiffrin EL
J Am Soc Nephrol 2004 Aug;15(8):1983-92. doi: 10.1097/01.ASN.0000132474.50966.DA. PMID: 15284284

Clinical prediction guides

Review of Mendelian Randomization Studies on Endometrial Cancer.
Guo JZ, Wu QJ, Liu FH, Gao C, Gong TT, Li G
Front Endocrinol (Lausanne) 2022;13:783150. Epub 2022 May 9 doi: 10.3389/fendo.2022.783150. PMID: 35615721Free PMC Article
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM
Eur Respir J 2021 May;57(5) Epub 2021 May 27 doi: 10.1183/13993003.02559-2020. PMID: 33214209Free PMC Article
Biomarkers of Cancer-Associated Thromboembolism.
Mahajan A, Wun T
Cancer Treat Res 2019;179:69-85. doi: 10.1007/978-3-030-20315-3_5. PMID: 31317481
Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease.
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article

Recent systematic reviews

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease.
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Impact of statin therapy on plasma levels of plasminogen activator inhibitor-1. A systematic review and meta-analysis of randomised controlled trials.
Sahebkar A, Catena C, Ray KK, Vallejo-Vaz AJ, Reiner Ž, Sechi LA, Colussi G
Thromb Haemost 2016 Jul 4;116(1):162-71. Epub 2016 Mar 24 doi: 10.1160/TH15-10-0770. PMID: 27009446
Impact of fibrate therapy on plasma plasminogen activator inhibitor-1: a systematic review and meta-analysis of randomized controlled trials.
Sahebkar A, Simental-Mendía LE, Watts GF, Golledge J
Atherosclerosis 2015 May;240(1):284-96. Epub 2015 Mar 16 doi: 10.1016/j.atherosclerosis.2015.03.016. PMID: 25828270
Obesity and venous thrombosis: a review.
Allman-Farinelli MA
Semin Thromb Hemost 2011 Nov;37(8):903-7. Epub 2011 Dec 23 doi: 10.1055/s-0031-1297369. PMID: 22198855
Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Mitaka C, Tomita M
Shock 2011 Oct;36(4):332-8. doi: 10.1097/SHK.0b013e318225f839. PMID: 21654557

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