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Reduced plasminogen activator inhibitor 1 activity

MedGen UID:
906749
Concept ID:
C4280700
Finding
HPO: HP:0040248

Definition

Reduced activity of plasminogen activator inhibitor 1. This protein down-regulates fibrinolysis in the circulation by inhibiting the two major plasminogen activators [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced plasminogen activator inhibitor 1 activity

Professional guidelines

PubMed

Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Das AK, Kalra S, Tiwaskar M, Bajaj S, Seshadri K, Chowdhury S, Sahay R, Indurkar S, Unnikrishnan AG, Phadke U, Pareek A, Purkait I
J Assoc Physicians India 2019 Dec;67(12):65-74. PMID: 31801334
Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN; Haemato-oncology Task Force of British Committee for Standards in Haematology; British Society for Blood and Marrow Transplantation
Br J Haematol 2013 Nov;163(4):444-57. Epub 2013 Sep 17 doi: 10.1111/bjh.12558. PMID: 24102514

Recent clinical studies

Etiology

Baumeier C, Escher F, Aleshcheva G, Pietsch H, Schultheiss HP
Basic Res Cardiol 2021 Jan 11;116(1):1. doi: 10.1007/s00395-020-00840-w. PMID: 33432417Free PMC Article
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Yasar Yildiz S, Kuru P, Toksoy Oner E, Agirbasli M
ScientificWorldJournal 2014;2014:858293. Epub 2014 Oct 15 doi: 10.1155/2014/858293. PMID: 25386620Free PMC Article
Yamamoto K, Takeshita K, Saito H
Semin Thromb Hemost 2014 Sep;40(6):652-9. Epub 2014 Aug 14 doi: 10.1055/s-0034-1384635. PMID: 25122500
Cho SH, Ryu CH, Oh CK
Exp Biol Med (Maywood) 2004 Feb;229(2):138-46. doi: 10.1177/153537020422900202. PMID: 14734792

Diagnosis

Wang X, Guo L, Huang J, Jiang S, Li N, Mu HH, Xu C
Int J Biol Sci 2023;19(7):2132-2149. Epub 2023 Apr 9 doi: 10.7150/ijbs.75890. PMID: 37151884Free PMC Article
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN; Haemato-oncology Task Force of British Committee for Standards in Haematology; British Society for Blood and Marrow Transplantation
Br J Haematol 2013 Nov;163(4):444-57. Epub 2013 Sep 17 doi: 10.1111/bjh.12558. PMID: 24102514
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166

Therapy

Altalhi R, Pechlivani N, Ajjan RA
Int J Mol Sci 2021 Mar 20;22(6) doi: 10.3390/ijms22063170. PMID: 33804680Free PMC Article
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Yasar Yildiz S, Kuru P, Toksoy Oner E, Agirbasli M
ScientificWorldJournal 2014;2014:858293. Epub 2014 Oct 15 doi: 10.1155/2014/858293. PMID: 25386620Free PMC Article
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Tsikouris JP, Suarez JA, Meyerrose GE
J Clin Pharmacol 2002 Nov;42(11):1187-99. doi: 10.1177/009127002762491271. PMID: 12412817

Prognosis

Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM
Eur Respir J 2021 May;57(5) Epub 2021 May 27 doi: 10.1183/13993003.02559-2020. PMID: 33214209Free PMC Article
Park HJ, Chi GY, Choi YH, Park SH
Biochem Biophys Res Commun 2020 Jul 5;527(4):889-895. Epub 2020 May 16 doi: 10.1016/j.bbrc.2020.04.160. PMID: 32430175
Alessi MC, Poggi M, Juhan-Vague I
Curr Opin Lipidol 2007 Jun;18(3):240-5. doi: 10.1097/MOL.0b013e32814e6d29. PMID: 17495595
Endemann DH, Schiffrin EL
J Am Soc Nephrol 2004 Aug;15(8):1983-92. doi: 10.1097/01.ASN.0000132474.50966.DA. PMID: 15284284

Clinical prediction guides

Guo JZ, Wu QJ, Liu FH, Gao C, Gong TT, Li G
Front Endocrinol (Lausanne) 2022;13:783150. Epub 2022 May 9 doi: 10.3389/fendo.2022.783150. PMID: 35615721Free PMC Article
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM
Eur Respir J 2021 May;57(5) Epub 2021 May 27 doi: 10.1183/13993003.02559-2020. PMID: 33214209Free PMC Article
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Alessi MC, Poggi M, Juhan-Vague I
Curr Opin Lipidol 2007 Jun;18(3):240-5. doi: 10.1097/MOL.0b013e32814e6d29. PMID: 17495595

Recent systematic reviews

Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Sahebkar A, Catena C, Ray KK, Vallejo-Vaz AJ, Reiner Ž, Sechi LA, Colussi G
Thromb Haemost 2016 Jul 4;116(1):162-71. Epub 2016 Mar 24 doi: 10.1160/TH15-10-0770. PMID: 27009446
Sahebkar A, Simental-Mendía LE, Watts GF, Golledge J
Atherosclerosis 2015 May;240(1):284-96. Epub 2015 Mar 16 doi: 10.1016/j.atherosclerosis.2015.03.016. PMID: 25828270
Allman-Farinelli MA
Semin Thromb Hemost 2011 Nov;37(8):903-7. Epub 2011 Dec 23 doi: 10.1055/s-0031-1297369. PMID: 22198855
Mitaka C, Tomita M
Shock 2011 Oct;36(4):332-8. doi: 10.1097/SHK.0b013e318225f839. PMID: 21654557

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