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Moderate glandular cell atypia

MedGen UID:
90726
•Concept ID:
C0333882
•
Cell or Molecular Dysfunction
Synonym: Moderate Glandular Cell Atypia
SNOMED CT: Moderate glandular cell atypia (55160006)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate glandular cell atypia

Professional guidelines

PubMed

Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions.
Hayes MM, Matisic JP, Chen CJ, Mohamed A, Anderson GH, LeRiche JC, Amy R
Cytopathology 1997 Dec;8(6):397-408. doi: 10.1111/j.1365-2303.1997.tb00570.x. PMID: 9439892

Recent clinical studies

Etiology

Clear cell adenocarcinoma of the cervix and its mimickers - A series of 19 cases from a tertiary care referral centre in India.
Thomas A, Menon S, Rekhi B, Mittal N, Deodhar K
Indian J Pathol Microbiol 2024 Jul 1;67(3):619-623. Epub 2024 Jun 4 doi: 10.4103/ijpm.ijpm_518_23. PMID: 38847204
Gastric-type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature.
Greenland NY, Wolsky RJ, Darragh TM, Vohra P
Cytopathology 2021 Jan;32(1):75-83. Epub 2020 Oct 5 doi: 10.1111/cyt.12907. PMID: 32851700
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Microcystic adenoma of the pancreas: clinical, radiologic, and cytologic features.
Lal A, Bourtsos EP, DeFrias DV, Nemcek AA, Nayar R
Cancer 2004 Oct 25;102(5):288-94. doi: 10.1002/cncr.20487. PMID: 15559952
Endocervical glandular atypia: does a preneoplastic lesion of adenocarcinoma in situ exist?
Goldstein NS, Ahmad E, Hussain M, Hankin RC, Perez-Reyes N
Am J Clin Pathol 1998 Aug;110(2):200-9. doi: 10.1093/ajcp/110.2.200. PMID: 9704619

Diagnosis

Pancreatic acinar cell carcinoma with pleomorphic and spindle cells: An autopsy-proven case.
Uruga H, Tamura T, Miura Y, Itonaga J, Koyama R, Imamura T, Takazawa Y
Pathol Int 2023 Jun;73(6):255-260. Epub 2023 May 3 doi: 10.1111/pin.13326. PMID: 37133201
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.
Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi: 10.1097/PGP.0000000000000491. PMID: 30550483Free PMC Article
Cytological features of atypical polypoid adenomyoma of the endometrium: A case report with literature review.
Ebisu Y, Arimoto T, Ishida M, Miyasaka C, Uemura Y, Okada H, Tsuta K
Diagn Cytopathol 2017 Apr;45(4):345-349. Epub 2017 Feb 4 doi: 10.1002/dc.23665. PMID: 28160434
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
The cytodynamics of endometrial hyperplasia and carcinoma. A review.
Ferenczy A, Gelfand MM, Tzipris F
Ann Pathol 1983 Sep;3(3):189-201. PMID: 6354201

Therapy

Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin.
Simpson S, Simoni M, Hui P, Taylor HS, Buza N
Int J Gynecol Pathol 2020 May;39(3):247-253. doi: 10.1097/PGP.0000000000000601. PMID: 31033797
Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial.
Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A
J Thorac Oncol 2009 Jan;4(1):49-54. doi: 10.1097/JTO.0b013e3181914506. PMID: 19096306Free PMC Article
Pseudoinfiltrative tubal metaplasia of the endocervix: a potential form of in utero diethylstilbestrol exposure-related adenosis simulating minimal deviation adenocarcinoma.
Vang R, Vinh TN, Burks RT, Barner R, Kurman RJ, Ronnett BM
Int J Gynecol Pathol 2005 Oct;24(4):391-8. doi: 10.1097/01.pgp.0000170064.95465.5c. PMID: 16175088

Prognosis

Gastric-type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature.
Greenland NY, Wolsky RJ, Darragh TM, Vohra P
Cytopathology 2021 Jan;32(1):75-83. Epub 2020 Oct 5 doi: 10.1111/cyt.12907. PMID: 32851700
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Cutaneous digital papillary adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations.
Suchak R, Wang WL, Prieto VG, Ivan D, Lazar AJ, Brenn T, Calonje E
Am J Surg Pathol 2012 Dec;36(12):1883-91. doi: 10.1097/PAS.0b013e31826320ec. PMID: 23026931
Cytological findings of mixed squamous cell and glandular papilloma in the lung.
Kadota K, Haba R, Katsuki N, Hayashi T, Miyai Y, Bando K, Shibuya S, Kushida Y
Diagn Cytopathol 2010 Dec;38(12):913-7. doi: 10.1002/dc.21334. PMID: 20301213
Prostate carcinoma with squamous differentiation: an analysis of 33 cases.
Parwani AV, Kronz JD, Genega EM, Gaudin P, Chang S, Epstein JI
Am J Surg Pathol 2004 May;28(5):651-7. doi: 10.1097/00000478-200405000-00014. PMID: 15105655

Clinical prediction guides

Pancreatic acinar cell carcinoma with pleomorphic and spindle cells: An autopsy-proven case.
Uruga H, Tamura T, Miura Y, Itonaga J, Koyama R, Imamura T, Takazawa Y
Pathol Int 2023 Jun;73(6):255-260. Epub 2023 May 3 doi: 10.1111/pin.13326. PMID: 37133201
Goblet cell carcinoid of the appendix - An interobserver variability study using two proposed classification systems.
Maedler C, Arnason T, Dorreen A, Sapp H, Castonguay M, Murphy J, Selegean S, Huang WY
Ann Diagn Pathol 2018 Feb;32:51-55. Epub 2017 Nov 7 doi: 10.1016/j.anndiagpath.2017.11.001. PMID: 29414399
Cytological features of atypical polypoid adenomyoma of the endometrium: A case report with literature review.
Ebisu Y, Arimoto T, Ishida M, Miyasaka C, Uemura Y, Okada H, Tsuta K
Diagn Cytopathol 2017 Apr;45(4):345-349. Epub 2017 Feb 4 doi: 10.1002/dc.23665. PMID: 28160434
Expression of immunoreactivity and genetic mutation in eosinophilic and ciliated metaplastic changes of endometrial glandular and stromal breakdown: cytodiagnostic implications.
Shimizu K, Norimatsu Y, Kobayashi TK, Sakurai M, Ogura S, Yoshizawa A, Miyamoto T, Miyake Y, Aratake Y, Sakaguchi T, Ohno E
Ann Diagn Pathol 2009 Apr;13(2):89-95. doi: 10.1016/j.anndiagpath.2008.12.007. PMID: 19302956
Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial.
Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A
J Thorac Oncol 2009 Jan;4(1):49-54. doi: 10.1097/JTO.0b013e3181914506. PMID: 19096306Free PMC Article

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