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Adipocyte hypertrophy

MedGen UID:
907421
•Concept ID:
C4280781
•
Finding
Synonym: Fat cell hypertrophy
 
HPO: HP:0030759

Definition

An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdipocyte hypertrophy

Professional guidelines

PubMed

Albumin-fused long-acting FGF21 analogue for the treatment of non-alcoholic fatty liver disease.
Chikamatsu M, Watanabe H, Shintani Y, Murata R, Miyahisa M, Nishinoiri A, Imafuku T, Takano M, Arimura N, Yamada K, Kamimura M, Mukai B, Satoh T, Maeda H, Maruyama T
J Control Release 2023 Mar;355:42-53. Epub 2023 Feb 1 doi: 10.1016/j.jconrel.2023.01.039. PMID: 36690035
Treatment with Soluble Activin Type IIB Receptor Ameliorates Ovariectomy-Induced Bone Loss and Fat Gain in Mice.
Puolakkainen T, Rummukainen P, Pihala-Nieminen V, Ritvos O, Savontaus E, Kiviranta R
Calcif Tissue Int 2022 Apr;110(4):504-517. Epub 2022 Jan 13 doi: 10.1007/s00223-021-00934-0. PMID: 35024891Free PMC Article
Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management.
van de Woestijne AP, Monajemi H, Kalkhoven E, Visseren FL
Obes Rev 2011 Oct;12(10):829-40. Epub 2011 Jul 12 doi: 10.1111/j.1467-789X.2011.00900.x. PMID: 21749607

Recent clinical studies

Etiology

Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.
Adam RC, Pryce DS, Lee JS, Zhao Y, Mintah IJ, Min S, Halasz G, Mastaitis J, Atwal GS, Aykul S, Idone V, Economides AN, Lotta LA, Murphy AJ, Yancopoulos GD, Sleeman MW, Gusarova V
Proc Natl Acad Sci U S A 2023 Aug 8;120(32):e2309967120. Epub 2023 Jul 31 doi: 10.1073/pnas.2309967120. PMID: 37523551Free PMC Article
Contribution of adipogenesis to healthy adipose tissue expansion in obesity.
Vishvanath L, Gupta RK
J Clin Invest 2019 Oct 1;129(10):4022-4031. doi: 10.1172/JCI129191. PMID: 31573549Free PMC Article
Adipokine dysregulation and adipose tissue inflammation in human obesity.
Unamuno X, Gómez-Ambrosi J, Rodríguez A, Becerril S, Frühbeck G, Catalán V
Eur J Clin Invest 2018 Sep;48(9):e12997. Epub 2018 Aug 3 doi: 10.1111/eci.12997. PMID: 29995306
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function.
Goossens GH
Obes Facts 2017;10(3):207-215. Epub 2017 Jun 1 doi: 10.1159/000471488. PMID: 28564650Free PMC Article
Obesogens.
Grün F
Curr Opin Endocrinol Diabetes Obes 2010 Oct;17(5):453-9. doi: 10.1097/MED.0b013e32833ddea0. PMID: 20689419

Diagnosis

Adipose Signals Regulating Distal Organ Health and Disease.
Gilani A, Stoll L, Homan EA, Lo JC
Diabetes 2024 Feb 1;73(2):169-177. doi: 10.2337/dbi23-0005. PMID: 38241508Free PMC Article
Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue.
Honecker J, Ruschke S, Seeliger C, Laber S, Strobel S, Pröll P, Nellaker C, Lindgren CM, Kulozik U, Ecker J, Karampinos DC, Claussnitzer M, Hauner H
EBioMedicine 2022 May;79:104020. Epub 2022 Apr 29 doi: 10.1016/j.ebiom.2022.104020. PMID: 35490555Free PMC Article
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function.
Goossens GH
Obes Facts 2017;10(3):207-215. Epub 2017 Jun 1 doi: 10.1159/000471488. PMID: 28564650Free PMC Article
Dietary cholesterol effects on adipose tissue inflammation.
Chung S, Parks JS
Curr Opin Lipidol 2016 Feb;27(1):19-25. doi: 10.1097/MOL.0000000000000260. PMID: 26655292Free PMC Article
Adipocyte dysfunction, inflammation and metabolic syndrome.
Klöting N, Blüher M
Rev Endocr Metab Disord 2014 Dec;15(4):277-87. doi: 10.1007/s11154-014-9301-0. PMID: 25344447

Therapy

Bisphenol A substitutes and obesity: a review of the epidemiology and pathophysiology.
Varghese SV, Hall JM
Front Endocrinol (Lausanne) 2023;14:1155694. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1155694. PMID: 37529602Free PMC Article
Fine particulate matter induces adipose tissue expansion and weight gain: Pathophysiology.
Della Guardia L, Wang L
Obes Rev 2023 Apr;24(4):e13552. Epub 2023 Jan 26 doi: 10.1111/obr.13552. PMID: 36700515
Adipogenesis and therapeutic potentials of antiobesogenic phytochemicals: Insights from preclinical studies.
Murugan DD, Balan D, Wong PF
Phytother Res 2021 Nov;35(11):5936-5960. Epub 2021 Jul 4 doi: 10.1002/ptr.7205. PMID: 34219306
Carotenoids in Adipose Tissue Biology and Obesity.
Bonet ML, Canas JA, Ribot J, Palou A
Subcell Biochem 2016;79:377-414. doi: 10.1007/978-3-319-39126-7_15. PMID: 27485231
Obesogens.
Grün F
Curr Opin Endocrinol Diabetes Obes 2010 Oct;17(5):453-9. doi: 10.1097/MED.0b013e32833ddea0. PMID: 20689419

Prognosis

Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.
Zheng R, Shen H, Li J, Zhao J, Lu L, Hu M, Lin Z, Ma H, Tan H, Hu M, Li J
J Ethnopharmacol 2023 Jan 30;301:115824. Epub 2022 Oct 20 doi: 10.1016/j.jep.2022.115824. PMID: 36273747
Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue.
Honecker J, Ruschke S, Seeliger C, Laber S, Strobel S, Pröll P, Nellaker C, Lindgren CM, Kulozik U, Ecker J, Karampinos DC, Claussnitzer M, Hauner H
EBioMedicine 2022 May;79:104020. Epub 2022 Apr 29 doi: 10.1016/j.ebiom.2022.104020. PMID: 35490555Free PMC Article
Adipose morphology and metabolic disease.
Tandon P, Wafer R, Minchin JEN
J Exp Biol 2018 Mar 7;221(Pt Suppl 1) doi: 10.1242/jeb.164970. PMID: 29514883
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function.
Goossens GH
Obes Facts 2017;10(3):207-215. Epub 2017 Jun 1 doi: 10.1159/000471488. PMID: 28564650Free PMC Article
Adipocyte dysfunction, inflammation and metabolic syndrome.
Klöting N, Blüher M
Rev Endocr Metab Disord 2014 Dec;15(4):277-87. doi: 10.1007/s11154-014-9301-0. PMID: 25344447

Clinical prediction guides

Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.
Zheng R, Shen H, Li J, Zhao J, Lu L, Hu M, Lin Z, Ma H, Tan H, Hu M, Li J
J Ethnopharmacol 2023 Jan 30;301:115824. Epub 2022 Oct 20 doi: 10.1016/j.jep.2022.115824. PMID: 36273747
Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue.
Honecker J, Ruschke S, Seeliger C, Laber S, Strobel S, Pröll P, Nellaker C, Lindgren CM, Kulozik U, Ecker J, Karampinos DC, Claussnitzer M, Hauner H
EBioMedicine 2022 May;79:104020. Epub 2022 Apr 29 doi: 10.1016/j.ebiom.2022.104020. PMID: 35490555Free PMC Article
Contribution of adipogenesis to healthy adipose tissue expansion in obesity.
Vishvanath L, Gupta RK
J Clin Invest 2019 Oct 1;129(10):4022-4031. doi: 10.1172/JCI129191. PMID: 31573549Free PMC Article
Adipose morphology and metabolic disease.
Tandon P, Wafer R, Minchin JEN
J Exp Biol 2018 Mar 7;221(Pt Suppl 1) doi: 10.1242/jeb.164970. PMID: 29514883
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function.
Goossens GH
Obes Facts 2017;10(3):207-215. Epub 2017 Jun 1 doi: 10.1159/000471488. PMID: 28564650Free PMC Article

Recent systematic reviews

Effects of a maternal high-fat diet on adipose tissue in murine offspring: A systematic review and meta-analysis.
Saullo C, Cruz LLD, Damasceno DC, Volpato GT, Sinzato YK, Karki B, Gallego FQ, Vesentini G
Biochimie 2022 Oct;201:18-32. Epub 2022 Jun 30 doi: 10.1016/j.biochi.2022.06.009. PMID: 35779649
Fat Cell Size: Measurement Methods, Pathophysiological Origins, and Relationships With Metabolic Dysregulations.
Ye RZ, Richard G, Gévry N, Tchernof A, Carpentier AC
Endocr Rev 2022 Jan 12;43(1):35-60. doi: 10.1210/endrev/bnab018. PMID: 34100954Free PMC Article
The role of cathepsin B in autophagy during obesity: A systematic review.
Araujo TF, Cordeiro AV, Vasconcelos DAA, Vitzel KF, Silva VRR
Life Sci 2018 Sep 15;209:274-281. Epub 2018 Aug 11 doi: 10.1016/j.lfs.2018.08.024. PMID: 30107168

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