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Adipocyte hypertrophy

MedGen UID:
907421
Concept ID:
C4280781
Finding
Synonym: Fat cell hypertrophy
 
HPO: HP:0030759

Definition

An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdipocyte hypertrophy

Professional guidelines

PubMed

Liang Y, Kaushal D, Wilson RB
Int J Mol Sci 2024 Jul 20;25(14) doi: 10.3390/ijms25147943. PMID: 39063184Free PMC Article
Bays HE, Toth PP, Kris-Etherton PM, Abate N, Aronne LJ, Brown WV, Gonzalez-Campoy JM, Jones SR, Kumar R, La Forge R, Samuel VT
J Clin Lipidol 2013 Jul-Aug;7(4):304-83. Epub 2013 May 31 doi: 10.1016/j.jacl.2013.04.001. PMID: 23890517
van de Woestijne AP, Monajemi H, Kalkhoven E, Visseren FL
Obes Rev 2011 Oct;12(10):829-40. Epub 2011 Jul 12 doi: 10.1111/j.1467-789X.2011.00900.x. PMID: 21749607

Recent clinical studies

Etiology

Guo G, Wang W, Tu M, Zhao B, Han J, Li J, Pan Y, Zhou J, Ma W, Liu Y, Sun T, Han X, An Y
Dev Dyn 2024 Nov;253(11):956-997. Epub 2024 Mar 22 doi: 10.1002/dvdy.708. PMID: 38516819
Dowsett L, Duluc L, Higgins E, Alghamdi F, Fast W, Salt IP, Leiper J
Cell Signal 2023 Jul;107:110676. Epub 2023 Apr 5 doi: 10.1016/j.cellsig.2023.110676. PMID: 37028778
Zatterale F, Raciti GA, Prevenzano I, Leone A, Campitelli M, De Rosa V, Beguinot F, Parrillo L
Biomolecules 2022 Jul 14;12(7) doi: 10.3390/biom12070982. PMID: 35883538Free PMC Article
Naimo GD, Gelsomino L, Catalano S, Mauro L, Andò S
Front Endocrinol (Lausanne) 2020;11:66. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00066. PMID: 32132979Free PMC Article
Vishvanath L, Gupta RK
J Clin Invest 2019 Oct 1;129(10):4022-4031. doi: 10.1172/JCI129191. PMID: 31573549Free PMC Article

Diagnosis

Dowsett L, Duluc L, Higgins E, Alghamdi F, Fast W, Salt IP, Leiper J
Cell Signal 2023 Jul;107:110676. Epub 2023 Apr 5 doi: 10.1016/j.cellsig.2023.110676. PMID: 37028778
Vorotnikov AV, Stafeev IS, Menshikov MY, Shestakova MV, Parfyonova YV
Biochemistry (Mosc) 2019 Nov;84(11):1329-1345. doi: 10.1134/S0006297919110099. PMID: 31760921
Goossens GH
Obes Facts 2017;10(3):207-215. Epub 2017 Jun 1 doi: 10.1159/000471488. PMID: 28564650Free PMC Article
Patel P, Abate N
J Obes 2013;2013:489187. Epub 2013 Apr 4 doi: 10.1155/2013/489187. PMID: 23691287Free PMC Article
Kadowaki T, Hara K, Yamauchi T, Terauchi Y, Tobe K, Nagai R
Exp Biol Med (Maywood) 2003 Nov;228(10):1111-7. doi: 10.1177/153537020322801003. PMID: 14610248

Therapy

Ralston JC, Mitchelson KAJ, Lynch GM, Tran TTT, Wang H, Strain CR, Lenighan YM, Kennedy EB, Stanton C, McGillicuddy FC, Su Q, O'Toole PW, Roche HM
Mol Nutr Food Res 2021 Jan;65(1):e2000202. Epub 2020 Jul 12 doi: 10.1002/mnfr.202000202. PMID: 32558187
Li S, Li J, Mao G, Wu T, Lin D, Hu Y, Ye X, Tian D, Chai W, Linhardt RJ, Chen S
Int J Biol Macromol 2019 Mar 1;124:377-388. Epub 2018 Nov 19 doi: 10.1016/j.ijbiomac.2018.11.167. PMID: 30465844
Gourronc FA, Robertson LW, Klingelhutz AJ
Environ Sci Pollut Res Int 2018 Jun;25(17):16481-16492. Epub 2017 Jul 11 doi: 10.1007/s11356-017-9676-z. PMID: 28699004Free PMC Article
Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T
Sci Rep 2016 Aug 8;6:31268. doi: 10.1038/srep31268. PMID: 27499372Free PMC Article
Grün F
Curr Opin Endocrinol Diabetes Obes 2010 Oct;17(5):453-9. doi: 10.1097/MED.0b013e32833ddea0. PMID: 20689419

Prognosis

Zheng R, Shen H, Li J, Zhao J, Lu L, Hu M, Lin Z, Ma H, Tan H, Hu M, Li J
J Ethnopharmacol 2023 Jan 30;301:115824. Epub 2022 Oct 20 doi: 10.1016/j.jep.2022.115824. PMID: 36273747
Lecoutre S, Lambert M, Drygalski K, Dugail I, Maqdasy S, Hautefeuille M, Clément K
Cells 2022 Jul 27;11(15) doi: 10.3390/cells11152310. PMID: 35954152Free PMC Article
Goossens GH
Obes Facts 2017;10(3):207-215. Epub 2017 Jun 1 doi: 10.1159/000471488. PMID: 28564650Free PMC Article
Muir LA, Baker NA, Washabaugh AR, Neeley CK, Flesher CG, DelProposto JB, Geletka LM, Ghaferi AA, Finks JF, Singer K, Varban OA, Lumeng CN, O'Rourke RW
Adipocyte 2017 Apr 3;6(2):134-140. Epub 2017 Jan 27 doi: 10.1080/21623945.2017.1287639. PMID: 28425841Free PMC Article
Suganami T, Ogawa Y
J Leukoc Biol 2010 Jul;88(1):33-9. Epub 2010 Apr 1 doi: 10.1189/jlb.0210072. PMID: 20360405

Clinical prediction guides

Naimo GD, Gelsomino L, Catalano S, Mauro L, Andò S
Front Endocrinol (Lausanne) 2020;11:66. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00066. PMID: 32132979Free PMC Article
Vishvanath L, Gupta RK
J Clin Invest 2019 Oct 1;129(10):4022-4031. doi: 10.1172/JCI129191. PMID: 31573549Free PMC Article
Jiang N, Li Y, Shu T, Wang J
Front Med 2019 Jun;13(3):314-329. Epub 2019 Jun 11 doi: 10.1007/s11684-018-0625-0. PMID: 30066061
Goossens GH
Obes Facts 2017;10(3):207-215. Epub 2017 Jun 1 doi: 10.1159/000471488. PMID: 28564650Free PMC Article
Cusi K
Curr Diab Rep 2010 Aug;10(4):306-15. doi: 10.1007/s11892-010-0122-6. PMID: 20556549

Recent systematic reviews

Saullo C, Cruz LLD, Damasceno DC, Volpato GT, Sinzato YK, Karki B, Gallego FQ, Vesentini G
Biochimie 2022 Oct;201:18-32. Epub 2022 Jun 30 doi: 10.1016/j.biochi.2022.06.009. PMID: 35779649
Ye RZ, Richard G, Gévry N, Tchernof A, Carpentier AC
Endocr Rev 2022 Jan 12;43(1):35-60. doi: 10.1210/endrev/bnab018. PMID: 34100954Free PMC Article
Araujo TF, Cordeiro AV, Vasconcelos DAA, Vitzel KF, Silva VRR
Life Sci 2018 Sep 15;209:274-281. Epub 2018 Aug 11 doi: 10.1016/j.lfs.2018.08.024. PMID: 30107168

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