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Abnormal adipose tissue morphology

MedGen UID:
867166
•Concept ID:
C4021524
•
Anatomical Abnormality
Synonym: Abnormality of adipose tissue
 
HPO: HP:0009124

Definition

An abnormality of adipose tissue, which is loose connective tissue composed of adipocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal adipose tissue morphology

Professional guidelines

PubMed

Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans.
Pafili K, Roden M
Mol Metab 2021 Aug;50:101122. Epub 2020 Nov 19 doi: 10.1016/j.molmet.2020.101122. PMID: 33220492Free PMC Article
Diagnosis and treatment of lipodystrophy: a step-by-step approach.
Araújo-Vilar D, Santini F
J Endocrinol Invest 2019 Jan;42(1):61-73. Epub 2018 Apr 27 doi: 10.1007/s40618-018-0887-z. PMID: 29704234Free PMC Article
Evaluation and treatment of disorders of the infrapatellar fat pad.
Dragoo JL, Johnson C, McConnell J
Sports Med 2012 Jan 1;42(1):51-67. doi: 10.2165/11595680-000000000-00000. PMID: 22149697

Recent clinical studies

Etiology

Obesity, Diabetes, and Increased Cancer Progression.
Kim DS, Scherer PE
Diabetes Metab J 2021 Nov;45(6):799-812. Epub 2021 Nov 22 doi: 10.4093/dmj.2021.0077. PMID: 34847640Free PMC Article
Obesity, Adipose Tissue and Vascular Dysfunction.
Koenen M, Hill MA, Cohen P, Sowers JR
Circ Res 2021 Apr 2;128(7):951-968. Epub 2021 Apr 1 doi: 10.1161/CIRCRESAHA.121.318093. PMID: 33793327Free PMC Article
Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance.
Kojta I, Chacińska M, Błachnio-Zabielska A
Nutrients 2020 May 3;12(5) doi: 10.3390/nu12051305. PMID: 32375231Free PMC Article
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications.
Longo M, Zatterale F, Naderi J, Parrillo L, Formisano P, Raciti GA, Beguinot F, Miele C
Int J Mol Sci 2019 May 13;20(9) doi: 10.3390/ijms20092358. PMID: 31085992Free PMC Article
Obesity, male infertility, and the sperm epigenome.
Craig JR, Jenkins TG, Carrell DT, Hotaling JM
Fertil Steril 2017 Apr;107(4):848-859. doi: 10.1016/j.fertnstert.2017.02.115. PMID: 28366411

Diagnosis

Brown adipose tissue and alzheimer's disease.
Tayanloo-Beik A, Nikkhah A, Alaei S, Goodarzi P, Rezaei-Tavirani M, Mafi AR, Larijani B, Shouroki FF, Arjmand B
Metab Brain Dis 2023 Jan;38(1):91-107. Epub 2022 Nov 2 doi: 10.1007/s11011-022-01097-z. PMID: 36322277
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J
Int J Mol Sci 2020 Apr 10;21(7) doi: 10.3390/ijms21072632. PMID: 32290082Free PMC Article
Diagnosis and treatment of lipodystrophy: a step-by-step approach.
Araújo-Vilar D, Santini F
J Endocrinol Invest 2019 Jan;42(1):61-73. Epub 2018 Apr 27 doi: 10.1007/s40618-018-0887-z. PMID: 29704234Free PMC Article
Polycystic Ovary Syndrome.
Azziz R
Obstet Gynecol 2018 Aug;132(2):321-336. doi: 10.1097/AOG.0000000000002698. PMID: 29995717
Evaluation and treatment of disorders of the infrapatellar fat pad.
Dragoo JL, Johnson C, McConnell J
Sports Med 2012 Jan 1;42(1):51-67. doi: 10.2165/11595680-000000000-00000. PMID: 22149697

Therapy

Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammation and inducing browning of white adipose tissue†.
Zhang Y, Lin Y, Li G, Yuan Y, Wang X, Li N, Xiong C, Yang Y, Ma Y, Zhang Z, Ding X
Biol Reprod 2023 Jun 9;108(6):945-959. doi: 10.1093/biolre/ioad032. PMID: 36930063Free PMC Article
Diagnosis and treatment of lipodystrophy: a step-by-step approach.
Araújo-Vilar D, Santini F
J Endocrinol Invest 2019 Jan;42(1):61-73. Epub 2018 Apr 27 doi: 10.1007/s40618-018-0887-z. PMID: 29704234Free PMC Article
Adipose tissue dysfunction and its effects on tumor metabolism.
Diedrich J, Gusky HC, Podgorski I
Horm Mol Biol Clin Investig 2015 Jan;21(1):17-41. doi: 10.1515/hmbci-2014-0045. PMID: 25781550Free PMC Article
Panniculitis in children.
Grassi S, Borroni RG, Brazzelli V
G Ital Dermatol Venereol 2013 Aug;148(4):371-85. PMID: 23900159
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J
Cell Metab 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. PMID: 22682224Free PMC Article

Prognosis

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Obesity and Adipose Tissue-derived Cytokines in the Pathogenesis of Multiple Sclerosis.
Daryabor G, Amirghofran Z, Gholijani N, Bemani P
Endocr Metab Immune Disord Drug Targets 2022;22(12):1217-1231. doi: 10.2174/1871530322666220215110041. PMID: 35168514
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J
Int J Mol Sci 2020 Apr 10;21(7) doi: 10.3390/ijms21072632. PMID: 32290082Free PMC Article
Inflammation and metabolic cardiomyopathy.
Nishida K, Otsu K
Cardiovasc Res 2017 Mar 15;113(4):389-398. doi: 10.1093/cvr/cvx012. PMID: 28395010
Panniculitis in children.
Grassi S, Borroni RG, Brazzelli V
G Ital Dermatol Venereol 2013 Aug;148(4):371-85. PMID: 23900159

Clinical prediction guides

Obesity and Adipose Tissue-derived Cytokines in the Pathogenesis of Multiple Sclerosis.
Daryabor G, Amirghofran Z, Gholijani N, Bemani P
Endocr Metab Immune Disord Drug Targets 2022;22(12):1217-1231. doi: 10.2174/1871530322666220215110041. PMID: 35168514
Obesity, Diabetes, and Increased Cancer Progression.
Kim DS, Scherer PE
Diabetes Metab J 2021 Nov;45(6):799-812. Epub 2021 Nov 22 doi: 10.4093/dmj.2021.0077. PMID: 34847640Free PMC Article
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J
Int J Mol Sci 2020 Apr 10;21(7) doi: 10.3390/ijms21072632. PMID: 32290082Free PMC Article
Adrenal myelolipoma: a comprehensive review.
Decmann Á, Perge P, Tóth M, Igaz P
Endocrine 2018 Jan;59(1):7-15. Epub 2017 Nov 21 doi: 10.1007/s12020-017-1473-4. PMID: 29164520
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies.
Auer-Grumbach M, Toegel S, Schabhüttl M, Weinmann D, Chiari C, Bennett DLH, Beetz C, Klein D, Andersen PM, Böhme I, Fink-Puches R, Gonzalez M, Harms MB, Motley W, Reilly MM, Renner W, Rudnik-Schöneborn S, Schlotter-Weigel B, Themistocleous AC, Weishaupt JH, Ludolph AC, Wieland T, Tao F, Abreu L, Windhager R, Zitzelsberger M, Strom TM, Walther T, Scherer SS, Züchner S, Martini R, Senderek J
Am J Hum Genet 2016 Sep 1;99(3):607-623. doi: 10.1016/j.ajhg.2016.07.008. PMID: 27588448Free PMC Article

Recent systematic reviews

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Alvaro AI, Willet JW, Dounas GD, Jeeves A, Lodge M, Javed MU
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The biology of human overfeeding: A systematic review.
Bray GA, Bouchard C
Obes Rev 2020 Sep;21(9):e13040. Epub 2020 Jun 8 doi: 10.1111/obr.13040. PMID: 32515127
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article
Cartilage Regeneration in Human with Adipose Tissue-Derived Stem Cells: Current Status in Clinical Implications.
Pak J, Lee JH, Kartolo WA, Lee SH
Biomed Res Int 2016;2016:4702674. Epub 2016 Jan 6 doi: 10.1155/2016/4702674. PMID: 26881220Free PMC Article
"Is obesity linked to aging?": adipose tissue and the role of telomeres.
Tzanetakou IP, Katsilambros NL, Benetos A, Mikhailidis DP, Perrea DN
Ageing Res Rev 2012 Apr;11(2):220-9. Epub 2011 Dec 13 doi: 10.1016/j.arr.2011.12.003. PMID: 22186032

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