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Malignant spindle cell neoplasm

MedGen UID:
90746
•Concept ID:
C0334230
•
Neoplastic Process
Synonyms: Malignant Spindle Cell Neoplasm; malignant spindle cell neoplasm; Malignant Spindle Cell Tumor; malignant spindle cell tumor; malignant spindle cell tumour; Malignant tumor - fusiform cell type; Malignant tumor - spindle cell type; Malignant tumor, fusiform cell type; Malignant tumor, spindle cell type; Spindle Cell Cancer; spindle cell cancer
SNOMED CT: Malignant tumor - spindle cell type (88897007); Malignant tumor - fusiform cell type (88897007); Malignant tumor, fusiform cell type (88897007); Malignant tumor, spindle cell type (88897007)
 
Monarch Initiative: MONDO:0020663

Definition

A malignant neoplasm characterized by the presence of atypical spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant spindle cell neoplasm

Professional guidelines

PubMed

Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
Challenges in the differential diagnosis of interdigitating dendritic cell sarcoma of intraparotid lymph node vs. metastatic malignant melanoma with unknown primary site.
Galli F, Petraitiene V, Muthu SK, James S, Koppana VR, Arya A
Int J Surg Pathol 2015 May;23(3):248-52. Epub 2015 Feb 26 doi: 10.1177/1066896914567333. PMID: 25722315
Malignant solitary fibrous tumor: cytopathologic findings and differential diagnosis.
Bishop JA, Rekhtman N, Chun J, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2010 Apr 25;118(2):83-9. doi: 10.1002/cncy.20069. PMID: 20209623

Recent clinical studies

Etiology

Vascular interventions in head and neck cancer patients as a marker of poor survival.
Krol E, Brandt CT, Blakeslee-Carter J, Ahanchi SS, Dexter DJ, Karakla D, Panneton JM
J Vasc Surg 2019 Jan;69(1):181-189. doi: 10.1016/j.jvs.2018.04.058. PMID: 30579444
Death from a malignant cerebellopontine angle triton tumor despite stereotactic radiosurgery. Case report.
Comey CH, McLaughlin MR, Jho HD, Martinez AJ, Lunsford LD
J Neurosurg 1998 Oct;89(4):653-8. doi: 10.3171/jns.1998.89.4.0653. PMID: 9761063
Periorbital melanocytic lesions: excision and reconstruction in 40 patients.
Glat PM, Longaker MT, Jelks EB, Spector JA, Roses DF, Shapiro RA, Zide BM, Jelks GW
Plast Reconstr Surg 1998 Jul;102(1):19-27. doi: 10.1097/00006534-199807000-00003. PMID: 9655402
Inflammatory myofibroblastic tumor of the larynx. A clinicopathologic study of eight cases simulating a malignant spindle cell neoplasm.
Wenig BM, Devaney K, Bisceglia M
Cancer 1995 Dec 1;76(11):2217-29. doi: 10.1002/1097-0142(19951201)76:11<2217::aid-cncr2820761107>3.0.co;2-n. PMID: 8635024
Angiotropic metastatic malignant melanoma.
Shea CR, Kline MA, Lugo J, McNutt NS
Am J Dermatopathol 1995 Feb;17(1):58-62. doi: 10.1097/00000372-199502000-00011. PMID: 7695012

Diagnosis

Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
Follicular dendritic cell sarcoma of the thigh: a clinicopathological report and management approach.
Rajan R, Roshni DG, Mathew SM, Jojo A, Nair HM, Kottarathil VD
BMJ Case Rep 2022 Apr 26;15(4) doi: 10.1136/bcr-2021-244812. PMID: 35473698Free PMC Article
Glioblastoma of the cerebellopontine angle and internal auditory canal mimicking a peripheral nerve sheath tumor: case report.
Takami H, Prummer CM, Graffeo CS, Peris-Celda M, Giannini C, Driscoll CL, Link MJ
J Neurosurg 2018 Dec 21;131(6):1835-1839. doi: 10.3171/2018.8.JNS181702. PMID: 30579279
A de novo unclassified malignant spindle cell neoplasm of liver allograft.
Clevenger JA, Saxena R, Idrees MT
Arch Pathol Lab Med 2014 Feb;138(2):274-7. doi: 10.5858/arpa.2012-0480-CR. PMID: 24476524
Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature.
Gavino AC, Spears MD, Peng Y
Int J Surg Pathol 2010 Oct;18(5):394-7. Epub 2008 Nov 17 doi: 10.1177/1066896908327166. PMID: 19017660

Therapy

Undifferentiated Sarcoma as Intermediate Step in Rhabdomyosarcomatous Transformation of a Metastatic Malignant Melanoma Resistant to Anti-BRAF Therapy: A Phenomenon Associated With Significant Diagnostic and Therapeutic Pitfalls.
Tran TAN
Int J Surg Pathol 2019 Sep;27(6):669-677. Epub 2019 Apr 3 doi: 10.1177/1066896919839143. PMID: 30942107
Vascular interventions in head and neck cancer patients as a marker of poor survival.
Krol E, Brandt CT, Blakeslee-Carter J, Ahanchi SS, Dexter DJ, Karakla D, Panneton JM
J Vasc Surg 2019 Jan;69(1):181-189. doi: 10.1016/j.jvs.2018.04.058. PMID: 30579444
A de novo unclassified malignant spindle cell neoplasm of liver allograft.
Clevenger JA, Saxena R, Idrees MT
Arch Pathol Lab Med 2014 Feb;138(2):274-7. doi: 10.5858/arpa.2012-0480-CR. PMID: 24476524
Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein.
Subbiah V, Westin SN, Wang K, Araujo D, Wang WL, Miller VA, Ross JS, Stephens PJ, Palmer GA, Ali SM
J Hematol Oncol 2014 Jan 14;7:8. doi: 10.1186/1756-8722-7-8. PMID: 24422672Free PMC Article
Pleomorphic leiomyosarcoma of the adrenal gland: case report and review of the literature.
Mohanty SK, Balani JP, Parwani AV
Urology 2007 Sep;70(3):591.e5-7. doi: 10.1016/j.urology.2007.07.029. PMID: 17905130

Prognosis

Spindle cell variant of papillary thyroid carcinoma: A diagnostic challenge - A rare case report with brief review of literature.
Khan S, Hassan MJ, Hameed S, Jetley S
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S881-S885. Epub 2023 Dec 15 doi: 10.4103/jcrt.jcrt_66_23. PMID: 38102908
Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.
Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715Free PMC Article
Glioblastoma of the cerebellopontine angle and internal auditory canal mimicking a peripheral nerve sheath tumor: case report.
Takami H, Prummer CM, Graffeo CS, Peris-Celda M, Giannini C, Driscoll CL, Link MJ
J Neurosurg 2018 Dec 21;131(6):1835-1839. doi: 10.3171/2018.8.JNS181702. PMID: 30579279
A de novo unclassified malignant spindle cell neoplasm of liver allograft.
Clevenger JA, Saxena R, Idrees MT
Arch Pathol Lab Med 2014 Feb;138(2):274-7. doi: 10.5858/arpa.2012-0480-CR. PMID: 24476524
Dedifferentiated chondrosarcoma of the larynx.
Rinaggio J, Duffey D, McGuff HS
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004 Mar;97(3):369-75. doi: 10.1016/j.tripleo.2003.09.015. PMID: 15024362

Clinical prediction guides

Multifaceted Spindle Cell/Sclerosing Rhabdomyosarcoma With Role of Immunohistochemistry in Avoiding Misdiagnosis: A Multi-Institutional Study of 45 Distinct Tumors.
Jain E, Munjal G, Sharma S, Brar Z, Bhardwaj N, Dewan A, Jain D, Jha S, Lobo A, Malik V, Arora S, Varshney J, Beg A, Sampat NY, Parwani AV, Balzer B, Varma M, Yadav BS, Sharma SK, Singh HP, Gogoi K, Kumar D, Bhandari V, Fulara LM, Kumar A, Singh H, Bhattacharya M, Dixit M, Mohanty SK
Int J Surg Pathol 2024 May;32(3):496-506. Epub 2023 Jul 25 doi: 10.1177/10668969231188422. PMID: 37489265

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