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Acantholytic squamous cell skin carcinoma

MedGen UID:
91065
•Concept ID:
C0345979
•
Neoplastic Process
Synonyms: Acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of Skin; acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of the Skin; acantholytic squamous cell carcinoma of the skin; acantholytic squamous cell skin carcinoma; Skin Acantholytic Squamous Cell Carcinoma; Skin Adenoid Squamous Cell Carcinoma; Skin Pseudoglandular Squamous Cell Carcinoma
SNOMED CT: Acantholytic squamous cell carcinoma of skin (254654004)
 
Monarch Initiative: MONDO:0004316

Definition

A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcantholytic squamous cell skin carcinoma

Professional guidelines

PubMed

Acantholytic squamous cell carcinoma is usually associated with hair follicles, not acantholytic actinic keratosis, and is not "high risk": Diagnosis, management, and clinical outcomes in a series of 115 cases.
Ogawa T, Kiuru M, Konia TH, Fung MA
J Am Acad Dermatol 2017 Feb;76(2):327-333. Epub 2016 Nov 23 doi: 10.1016/j.jaad.2016.09.024. PMID: 27889291Free PMC Article

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case-control study.
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Histopathology of cutaneous squamous cell carcinoma and its variants.
Kane CL, Keehn CA, Smithberger E, Glass LF
Semin Cutan Med Surg 2004 Mar;23(1):54-61. doi: 10.1016/s1085-5629(03)00088-9. PMID: 15095916

Diagnosis

Acantholytic variant of squamous cell carcinoma in the mandible: A rare entity and a brief review.
Shetty D, Suresh A, Acharya S, Desai A, Anehosur V, Kumar N
Stomatologija 2022;24(1):26-32. PMID: 36321707
Pseudovascular squamous cell carcinoma: A review of the published work and reassessment of prognosis.
Kiyohara T, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K, Tanimura H
J Dermatol 2018 Dec;45(12):1448-1451. Epub 2018 Sep 11 doi: 10.1111/1346-8138.14640. PMID: 30204258
Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review.
Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Mar;33(3):191-206. doi: 10.1111/j.0303-6987.2006.00516_1.x. PMID: 16466506

Therapy

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature.
Sheldon JD, Buckley K, Ulman C, Chung CG
J Cutan Pathol 2021 Aug;48(8):1075-1079. Epub 2021 May 13 doi: 10.1111/cup.14029. PMID: 33893742
Morphologic mimicry: acantholytic squamous cell carcinoma in nondermal locations-a literature review.
Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Histopathology of cutaneous squamous cell carcinoma and its variants.
Kane CL, Keehn CA, Smithberger E, Glass LF
Semin Cutan Med Surg 2004 Mar;23(1):54-61. doi: 10.1016/s1085-5629(03)00088-9. PMID: 15095916
Radiation-induced squamous sialometaplasia.
Leshin B, White WL, Koufman JA
Arch Dermatol 1990 Jul;126(7):931-4. PMID: 2360842

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case-control study.
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Pseudovascular squamous cell carcinoma: A review of the published work and reassessment of prognosis.
Kiyohara T, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K, Tanimura H
J Dermatol 2018 Dec;45(12):1448-1451. Epub 2018 Sep 11 doi: 10.1111/1346-8138.14640. PMID: 30204258
Acantholytic squamous cell carcinoma: is it really a more-aggressive tumor?
Garcia C, Crowson AN
Dermatol Surg 2011 Mar;37(3):353-6. doi: 10.1111/j.1524-4725.2011.01886.x. PMID: 21410819
Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Mar;33(3):191-206. doi: 10.1111/j.0303-6987.2006.00516_1.x. PMID: 16466506

Clinical prediction guides

Acantholytic Nodular Basal Cell Carcinoma.
Kanitakis J
Am J Dermatopathol 2023 Sep 1;45(9):639-641. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002499. PMID: 37506275
Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case-control study.
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Pseudovascular squamous cell carcinoma: A review of the published work and reassessment of prognosis.
Kiyohara T, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K, Tanimura H
J Dermatol 2018 Dec;45(12):1448-1451. Epub 2018 Sep 11 doi: 10.1111/1346-8138.14640. PMID: 30204258
Roles of E- and P-cadherin in the human skin.
Furukawa F, Fujii K, Horiguchi Y, Matsuyoshi N, Fujita M, Toda K, Imamura S, Wakita H, Shirahama S, Takigawa M
Microsc Res Tech 1997 Aug 15;38(4):343-52. doi: 10.1002/(SICI)1097-0029(19970815)38:4<343::AID-JEMT2>3.0.CO;2-K. PMID: 9297684
Cadherins in cutaneous biology.
Furukawa F, Takigawa M, Matsuyoshi N, Shirahama S, Wakita H, Fujita M, Horiguchi Y, Imamura S
J Dermatol 1994 Nov;21(11):802-13. doi: 10.1111/j.1346-8138.1994.tb03294.x. PMID: 7852640

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