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Acantholytic squamous cell skin carcinoma

MedGen UID:
91065
Concept ID:
C0345979
Neoplastic Process
Synonyms: Acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of Skin; acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of the Skin; acantholytic squamous cell carcinoma of the skin; acantholytic squamous cell skin carcinoma; Skin Acantholytic Squamous Cell Carcinoma; Skin Adenoid Squamous Cell Carcinoma; Skin Pseudoglandular Squamous Cell Carcinoma
SNOMED CT: Acantholytic squamous cell carcinoma of skin (254654004)
 
Monarch Initiative: MONDO:0004316

Definition

A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcantholytic squamous cell skin carcinoma

Professional guidelines

Recent clinical studies

Etiology

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
O'Shea C, Fitzpatrick JE, Koch PJ
J Cutan Pathol 2014 Nov;41(11):873-9. Epub 2014 Nov 4 doi: 10.1111/cup.12390. PMID: 25264142Free PMC Article
Sajin M, Hodorogea Prisăcaru A, Luchian MC, Pătraşcu OM, Dumitru A, Costache D, Dumitrescu D, Vrînceanu D, Voinea LM, Simionescu O, Costache M
Rom J Morphol Embryol 2014;55(2):279-83. PMID: 24969975

Diagnosis

Shetty D, Suresh A, Acharya S, Desai A, Anehosur V, Kumar N
Stomatologija 2022;24(1):26-32. PMID: 36321707
Dang LT, Terrell JR, Konia T, Fung MA, McPherson JD, Kiuru M
J Cutan Pathol 2022 May;49(5):500-503. Epub 2022 Feb 20 doi: 10.1111/cup.14210. PMID: 35118708Free PMC Article
Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Satter EK
Am J Dermatopathol 2007 Oct;29(5):486-9. doi: 10.1097/DAD.0b013e318156d756. PMID: 17890923

Therapy

Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Resnik KS, DiLeonardo M
Am J Dermatopathol 2007 Jun;29(3):264-9. doi: 10.1097/DAD.0b013e3180465860. PMID: 17519624
Kane CL, Keehn CA, Smithberger E, Glass LF
Semin Cutan Med Surg 2004 Mar;23(1):54-61. doi: 10.1016/s1085-5629(03)00088-9. PMID: 15095916
Leshin B, White WL, Koufman JA
Arch Dermatol 1990 Jul;126(7):931-4. PMID: 2360842

Prognosis

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Kiyohara T, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K, Tanimura H
J Dermatol 2018 Dec;45(12):1448-1451. Epub 2018 Sep 11 doi: 10.1111/1346-8138.14640. PMID: 30204258
Garcia C, Crowson AN
Dermatol Surg 2011 Mar;37(3):353-6. doi: 10.1111/j.1524-4725.2011.01886.x. PMID: 21410819
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Apr;33(4):261-79. doi: 10.1111/j.0303-6987.2006.00516.x. PMID: 16630176
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Mar;33(3):191-206. doi: 10.1111/j.0303-6987.2006.00516_1.x. PMID: 16466506

Clinical prediction guides

Kanitakis J
Am J Dermatopathol 2023 Sep 1;45(9):639-641. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002499. PMID: 37506275
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Kiyohara T, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K, Tanimura H
J Dermatol 2018 Dec;45(12):1448-1451. Epub 2018 Sep 11 doi: 10.1111/1346-8138.14640. PMID: 30204258
Furukawa F, Fujii K, Horiguchi Y, Matsuyoshi N, Fujita M, Toda K, Imamura S, Wakita H, Shirahama S, Takigawa M
Microsc Res Tech 1997 Aug 15;38(4):343-52. doi: 10.1002/(SICI)1097-0029(19970815)38:4<343::AID-JEMT2>3.0.CO;2-K. PMID: 9297684
Furukawa F, Takigawa M, Matsuyoshi N, Shirahama S, Wakita H, Fujita M, Horiguchi Y, Imamura S
J Dermatol 1994 Nov;21(11):802-13. doi: 10.1111/j.1346-8138.1994.tb03294.x. PMID: 7852640

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