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Acantholytic squamous cell skin carcinoma

MedGen UID:
91065
Concept ID:
C0345979
Neoplastic Process
Synonyms: Acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of Skin; acantholytic squamous cell carcinoma of skin; Acantholytic Squamous Cell Carcinoma of the Skin; acantholytic squamous cell carcinoma of the skin; acantholytic squamous cell skin carcinoma; Skin Acantholytic Squamous Cell Carcinoma; Skin Adenoid Squamous Cell Carcinoma; Skin Pseudoglandular Squamous Cell Carcinoma
SNOMED CT: Acantholytic squamous cell carcinoma of skin (254654004)
 
Monarch Initiative: MONDO:0004316

Definition

A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcantholytic squamous cell skin carcinoma

Professional guidelines

Recent clinical studies

Etiology

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Franceschi N, Gašić A, Šitum M, Majda V, Kolić M
Acta Dermatovenerol Croat 2022 Nov;30(3):201-202. PMID: 36812285
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Duray PH, Merino MJ, Axiotis C
Int J Gynecol Pathol 1983;2(3):286-93. doi: 10.1097/00004347-198303000-00006. PMID: 6642851

Diagnosis

Franceschi N, Gašić A, Šitum M, Majda V, Kolić M
Acta Dermatovenerol Croat 2022 Nov;30(3):201-202. PMID: 36812285
Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Allon I, Buchner A
J Oral Pathol Med 2012 Mar;41(3):261-7. Epub 2011 Sep 21 doi: 10.1111/j.1600-0714.2011.01082.x. PMID: 21936875
Duray PH, Merino MJ, Axiotis C
Int J Gynecol Pathol 1983;2(3):286-93. doi: 10.1097/00004347-198303000-00006. PMID: 6642851

Therapy

Chen WS, Tetzlaff MT, Diwan H, Jahan-Tigh R, Diab A, Nelson K, Glitza IC, Kaunitz GJ, Johnson D, Torres-Cabala C, Pacha O, Taube JM, Maloney K, Prieto VG, Curry JL
J Cutan Pathol 2018 Oct;45(10):764-773. Epub 2018 Jul 24 doi: 10.1111/cup.13312. PMID: 29943453
Mohammad M, Wilcox R
Ann N Y Acad Sci 2018 Dec;1434(1):102-108. Epub 2018 May 9 doi: 10.1111/nyas.13675. PMID: 29744885
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Chu EY, Wanat KA, Miller CJ, Amaravadi RK, Fecher LA, Brose MS, McGettigan S, Giles LR, Schuchter LM, Seykora JT, Rosenbach M
J Am Acad Dermatol 2012 Dec;67(6):1265-72. Epub 2012 May 18 doi: 10.1016/j.jaad.2012.04.008. PMID: 22609219Free PMC Article
Kane CL, Keehn CA, Smithberger E, Glass LF
Semin Cutan Med Surg 2004 Mar;23(1):54-61. doi: 10.1016/s1085-5629(03)00088-9. PMID: 15095916

Prognosis

Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Allon I, Buchner A
J Oral Pathol Med 2012 Mar;41(3):261-7. Epub 2011 Sep 21 doi: 10.1111/j.1600-0714.2011.01082.x. PMID: 21936875
Garcia C, Crowson AN
Dermatol Surg 2011 Mar;37(3):353-6. doi: 10.1111/j.1524-4725.2011.01886.x. PMID: 21410819
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Apr;33(4):261-79. doi: 10.1111/j.0303-6987.2006.00516.x. PMID: 16630176
Duray PH, Merino MJ, Axiotis C
Int J Gynecol Pathol 1983;2(3):286-93. doi: 10.1097/00004347-198303000-00006. PMID: 6642851

Clinical prediction guides

Kanitakis J
Am J Dermatopathol 2023 Sep 1;45(9):639-641. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002499. PMID: 37506275
Franceschi N, Gašić A, Šitum M, Majda V, Kolić M
Acta Dermatovenerol Croat 2022 Nov;30(3):201-202. PMID: 36812285
Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, Revelles-Peñas L, Revilla-Nebreda D, Becerril-Andrés S, Román-Curto C, Cañueto J
J Cutan Pathol 2022 Feb;49(2):133-138. Epub 2021 Aug 25 doi: 10.1111/cup.14116. PMID: 34363705
Moreno-Maldonado R, Ramírez A, Navarro M, Fernández-Aceñero MJ, Villanueva C, Page A, Jorcano JL, Bravo A, Llanos Casanova M
Cell Cycle 2008 Jul 1;7(13):2021-9. Epub 2008 Apr 11 doi: 10.4161/cc.7.13.6147. PMID: 18604171
Furukawa F, Takigawa M, Matsuyoshi N, Shirahama S, Wakita H, Fujita M, Horiguchi Y, Imamura S
J Dermatol 1994 Nov;21(11):802-13. doi: 10.1111/j.1346-8138.1994.tb03294.x. PMID: 7852640

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