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Spinal cord astrocytoma

MedGen UID:
91152
•Concept ID:
C0349540
•
Neoplastic Process
Synonyms: Astrocytic tumor of spinal cord; astrocytoma (excluding glioblastoma) of spinal cord; Astrocytoma of spinal cord; Astrocytoma of Spinal Cord; astrocytoma of spinal cord; Astrocytoma of the Spinal Cord; astrocytoma of the spinal cord; Spinal Astrocytoma; spinal astrocytoma; Spinal Cord Astrocytoma; spinal cord astrocytoma; spinal cord astrocytoma (excluding glioblastoma)
SNOMED CT: Astrocytoma of spinal cord (254948003); Astrocytic tumor of spinal cord (254948003)
 
Monarch Initiative: MONDO:0003174

Definition

A low or high grade astrocytoma that arises in the spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinal cord astrocytoma

Professional guidelines

PubMed

Treatment of childhood astrocytomas with irinotecan and cisplatin.
Mora J, Perez-Jaume S, Cruz O
Clin Transl Oncol 2018 Apr;20(4):500-507. Epub 2017 Aug 21 doi: 10.1007/s12094-017-1741-z. PMID: 28828715
Prognosis and treatment of spinal cord astrocytoma.
Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP
Int J Radiat Oncol Biol Phys 2009 Mar 1;73(3):727-33. Epub 2008 Aug 5 doi: 10.1016/j.ijrobp.2008.04.060. PMID: 18687533
Spinal cord astrocytoma: pathological and treatment considerations.
Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM
J Neurosurg 1995 Oct;83(4):590-5. doi: 10.3171/jns.1995.83.4.0590. PMID: 7674006

Recent clinical studies

Etiology

Mutational landscape of primary spinal cord astrocytoma.
Cheng L, Zhang F, Zhao X, Wang L, Duan W, Guan J, Wang K, Liu Z, Wang X, Wang Z, Wu H, Chen Z, Teng L, Li Y, Xiao F, Fan T, Jian F
J Pathol 2023 Jul;260(3):317-328. Epub 2023 Apr 28 doi: 10.1002/path.6084. PMID: 37114614
Primary Spinal Cord Astrocytomas: Two-Center Clinical Experience of Low- and High-Grade Lesions.
Snyder MH, Yu-Der Wang A, Ampie L, Sarathy D, Chatrath A, Asthagiri AR, Shaffrey CI, Smith JS, Shaffrey ME, Yen CP, Buchholz AL, Syed HR, Kryzanski J, Wu JK, Heilman CB
World Neurosurg 2022 Nov;167:e1006-e1016. Epub 2022 Sep 5 doi: 10.1016/j.wneu.2022.08.130. PMID: 36064118
Clinical outcomes and a therapeutic indication of intramedullary spinal cord astrocytoma.
Nagoshi N, Tsuji O, Suzuki S, Nori S, Yagi M, Okada E, Okita H, Fujita N, Ishii K, Matsumoto M, Nakamura M, Watanabe K
Spinal Cord 2022 Mar;60(3):216-222. Epub 2021 Jul 26 doi: 10.1038/s41393-021-00676-8. PMID: 34312493
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Prognosis and treatment of spinal cord astrocytoma.
Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP
Int J Radiat Oncol Biol Phys 2009 Mar 1;73(3):727-33. Epub 2008 Aug 5 doi: 10.1016/j.ijrobp.2008.04.060. PMID: 18687533

Diagnosis

Genomic profiling and prognostic factors of H3 K27M-mutant spinal cord diffuse glioma.
Chai RC, Yan H, An SY, Pang B, Chen HY, Mu QH, Zhang KN, Zhang YW, Liu YQ, Liu X, Zhao Z, Jiang T, Wang YZ, Jia WQ
Brain Pathol 2023 Jul;33(4):e13153. Epub 2023 Feb 7 doi: 10.1111/bpa.13153. PMID: 36751054Free PMC Article
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies.
Teng YD, Abd-El-Barr M, Wang L, Hajiali H, Wu L, Zafonte RD
Exp Neurol 2019 Jan;311:135-147. Epub 2018 Sep 21 doi: 10.1016/j.expneurol.2018.09.010. PMID: 30243796
Multicentric Spinal Cord Glioblastoma.
Cabrera-Aldana EE, De la Garza Ramos R, Pichardo-Bahena R
World Neurosurg 2017 Apr;100:707.e11. Epub 2017 Jan 13 doi: 10.1016/j.wneu.2017.01.006. PMID: 28089804
Prognosis and treatment of spinal cord astrocytoma.
Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP
Int J Radiat Oncol Biol Phys 2009 Mar 1;73(3):727-33. Epub 2008 Aug 5 doi: 10.1016/j.ijrobp.2008.04.060. PMID: 18687533

Therapy

Treatment of childhood astrocytomas with irinotecan and cisplatin.
Mora J, Perez-Jaume S, Cruz O
Clin Transl Oncol 2018 Apr;20(4):500-507. Epub 2017 Aug 21 doi: 10.1007/s12094-017-1741-z. PMID: 28828715
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation.
Takai K, Tanaka S, Sota T, Mukasa A, Komori T, Taniguchi M
World Neurosurg 2017 Dec;108:991.e13-991.e16. Epub 2017 Sep 1 doi: 10.1016/j.wneu.2017.08.142. PMID: 28866063
Differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis.
Seki M, Suzuki S, Ishii K, Izawa Y, Takahashi S, Toyama Y, Nakamura M, Suzuki N
Intern Med 2012;51(3):321-4. Epub 2012 Feb 1 doi: 10.2169/internalmedicine.51.5568. PMID: 22293811
Spinal cord astrocytoma: multidisciplinary experience.
Tovar Martín MI, López Ramírez E, Saura Rojas E, Arregui Castillo G, Zurita Herrera M
Clin Transl Oncol 2011 Mar;13(3):185-8. doi: 10.1007/s12094-011-0638-5. PMID: 21421463
Prognostic factors in pediatric spinal cord astrocytoma.
Bouffet E, Pierre-Kahn A, Marchal JC, Jouvet A, Kalifa C, Choux M, Dhellemmes P, Guérin J, Tremoulet M, Mottolese C
Cancer 1998 Dec 1;83(11):2391-9. doi: 10.1002/(sici)1097-0142(19981201)83:11<2391::aid-cncr20>3.0.co;2-0. PMID: 9840540

Prognosis

Mutational landscape of primary spinal cord astrocytoma.
Cheng L, Zhang F, Zhao X, Wang L, Duan W, Guan J, Wang K, Liu Z, Wang X, Wang Z, Wu H, Chen Z, Teng L, Li Y, Xiao F, Fan T, Jian F
J Pathol 2023 Jul;260(3):317-328. Epub 2023 Apr 28 doi: 10.1002/path.6084. PMID: 37114614
Genomic profiling and prognostic factors of H3 K27M-mutant spinal cord diffuse glioma.
Chai RC, Yan H, An SY, Pang B, Chen HY, Mu QH, Zhang KN, Zhang YW, Liu YQ, Liu X, Zhao Z, Jiang T, Wang YZ, Jia WQ
Brain Pathol 2023 Jul;33(4):e13153. Epub 2023 Feb 7 doi: 10.1111/bpa.13153. PMID: 36751054Free PMC Article
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
MICROSURGICAL MANAGEMENT OF LOW-GRADE SPINAL CORD ASTROCYTOMA IN ADULTS: A PERSONAL CASE SERIES REPORT AND BRIEF LITERATURE REVIEW.
Pojskić M, Rotim K, Splavski B, Arnautović KI
Acta Clin Croat 2020 Sep;59(3):505-512. doi: 10.20471/acc.2020.59.03.15. PMID: 34177061Free PMC Article
Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies.
Teng YD, Abd-El-Barr M, Wang L, Hajiali H, Wu L, Zafonte RD
Exp Neurol 2019 Jan;311:135-147. Epub 2018 Sep 21 doi: 10.1016/j.expneurol.2018.09.010. PMID: 30243796

Clinical prediction guides

Mutational landscape of primary spinal cord astrocytoma.
Cheng L, Zhang F, Zhao X, Wang L, Duan W, Guan J, Wang K, Liu Z, Wang X, Wang Z, Wu H, Chen Z, Teng L, Li Y, Xiao F, Fan T, Jian F
J Pathol 2023 Jul;260(3):317-328. Epub 2023 Apr 28 doi: 10.1002/path.6084. PMID: 37114614
Clinical outcomes and a therapeutic indication of intramedullary spinal cord astrocytoma.
Nagoshi N, Tsuji O, Suzuki S, Nori S, Yagi M, Okada E, Okita H, Fujita N, Ishii K, Matsumoto M, Nakamura M, Watanabe K
Spinal Cord 2022 Mar;60(3):216-222. Epub 2021 Jul 26 doi: 10.1038/s41393-021-00676-8. PMID: 34312493
MRI characteristics and resectability in spinal cord glioma.
Seaman SC, Bathla G, Park BJ, Woodroffe RW, Smith M, Menezes AH, Noeller J, Yamaguchi S, Hitchon PW
Clin Neurol Neurosurg 2021 Jan;200:106321. Epub 2020 Oct 19 doi: 10.1016/j.clineuro.2020.106321. PMID: 33268194
Prognosis and treatment of spinal cord astrocytoma.
Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP
Int J Radiat Oncol Biol Phys 2009 Mar 1;73(3):727-33. Epub 2008 Aug 5 doi: 10.1016/j.ijrobp.2008.04.060. PMID: 18687533
Spinal cord astrocytoma: pathological and treatment considerations.
Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM
J Neurosurg 1995 Oct;83(4):590-5. doi: 10.3171/jns.1995.83.4.0590. PMID: 7674006

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