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Unresectable Esophageal Carcinoma

MedGen UID:
922955
•Concept ID:
C0743568
•
Neoplastic Process
Synonyms: Esophageal Cancer Unresectable; Esophageal Carcinoma Unresectable; Unresectable Cancer of Esophagus; Unresectable Cancer of the Esophagus; Unresectable Esophageal Cancer

Definition

A carcinoma that arises from the esophagus and is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Recent progress in multidisciplinary treatment for patients with esophageal cancer.
Watanabe M, Otake R, Kozuki R, Toihata T, Takahashi K, Okamura A, Imamura Y
Surg Today 2020 Jan;50(1):12-20. Epub 2019 Sep 18 doi: 10.1007/s00595-019-01878-7. PMID: 31535225Free PMC Article

Recent clinical studies

Etiology

Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database.
Xie L, Zhang Z
Front Immunol 2024;15:1334992. Epub 2024 Jan 16 doi: 10.3389/fimmu.2024.1334992. PMID: 38292873Free PMC Article
Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis.
Ma N, Ming X, Chen J, Wu KL, Lu J, Jiang G, Mao J
Radiat Oncol 2023 Dec 1;18(1):195. doi: 10.1186/s13014-023-02371-9. PMID: 38041122Free PMC Article
Tolerance and efficacy of dose escalation using IMRT combined with chemotherapy for unresectable esophageal carcinoma: Long-term results of 51 patients.
Modesto A, Dalmasso C, Lusque A, Vieillevigne L, Izar F, Moyal E, Carrère N, Guimbaud R, Rives M
Cancer Radiother 2020 Apr;24(2):88-92. Epub 2020 Mar 7 doi: 10.1016/j.canrad.2020.01.006. PMID: 32156457
Double stents: airway stenting after esophageal-stent implantation for esophageal cancer.
Oida T, Mimatsu K, Kano H, Kawasaki A, Kuboi Y, Fukino N, Kida K, Amano S
Hepatogastroenterology 2011 Nov-Dec;58(112):1985-8. doi: 10.5754/hge09484. PMID: 22234065
Celestin tube use: radiographic manifestations of associated complications.
Haynes JW, Miller PR, Steiger Z, Leichman LP, Kling GA
Radiology 1984 Jan;150(1):41-4. doi: 10.1148/radiology.150.1.6196808. PMID: 6196808

Diagnosis

Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database.
Xie L, Zhang Z
Front Immunol 2024;15:1334992. Epub 2024 Jan 16 doi: 10.3389/fimmu.2024.1334992. PMID: 38292873Free PMC Article
Tolerance and efficacy of dose escalation using IMRT combined with chemotherapy for unresectable esophageal carcinoma: Long-term results of 51 patients.
Modesto A, Dalmasso C, Lusque A, Vieillevigne L, Izar F, Moyal E, Carrère N, Guimbaud R, Rives M
Cancer Radiother 2020 Apr;24(2):88-92. Epub 2020 Mar 7 doi: 10.1016/j.canrad.2020.01.006. PMID: 32156457
Palliative therapy for patients with unresectable esophageal carcinoma.
Freeman RK, Ascioti AJ, Mahidhara RJ
Surg Clin North Am 2012 Oct;92(5):1337-51. Epub 2012 Aug 11 doi: 10.1016/j.suc.2012.07.004. PMID: 23026285
Fragmentation of a Celestin tube causing intestinal obstruction. Case report and review of the literature.
Palafox BA, Lifschutz H, Juler G, Stemmer E, Mason GR
J Thorac Cardiovasc Surg 1984 May;87(5):698-701. PMID: 6201682

Therapy

Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis.
Ma N, Ming X, Chen J, Wu KL, Lu J, Jiang G, Mao J
Radiat Oncol 2023 Dec 1;18(1):195. doi: 10.1186/s13014-023-02371-9. PMID: 38041122Free PMC Article
Phase III study of tri-modality combination therapy with induction docetaxel plus cisplatin and 5-fluorouracil versus definitive chemoradiotherapy for locally advanced unresectable squamous-cell carcinoma of the thoracic esophagus (JCOG1510: TRIANgLE).
Terada M, Hara H, Daiko H, Mizusawa J, Kadota T, Hori K, Ogawa H, Ogata T, Sakanaka K, Sakamoto T, Kato K, Kitagawa Y
Jpn J Clin Oncol 2019 Dec 18;49(11):1055-1060. doi: 10.1093/jjco/hyz112. PMID: 31411696
A rare life-threatening complication of migrated nitinol self-expanding metallic stent (Ultraflex).
Ho HS, Ong HS
Surg Endosc 2004 Feb;18(2):347. doi: 10.1007/s00464-003-4248-3. PMID: 15106627
Endoscopic palliation of esophageal carcinoma.
Reed CE
Chest Surg Clin N Am 1994 Feb;4(1):155-72. PMID: 7519958
Celestin tube use: radiographic manifestations of associated complications.
Haynes JW, Miller PR, Steiger Z, Leichman LP, Kling GA
Radiology 1984 Jan;150(1):41-4. doi: 10.1148/radiology.150.1.6196808. PMID: 6196808

Prognosis

Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database.
Xie L, Zhang Z
Front Immunol 2024;15:1334992. Epub 2024 Jan 16 doi: 10.3389/fimmu.2024.1334992. PMID: 38292873Free PMC Article
Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer: a pilot study.
Ortner MA, Taha AA, Schreiber S, Wirth J, Weber-Eibl J, Ernst H, Lochs H
Endoscopy 2004 May;36(5):421-5. doi: 10.1055/s-2004-814327. PMID: 15100951
Palliation of malignant dysphagia by laser therapy.
Savage AP, Baigrie RJ, Cobb RA, Barr H, Kettlewell MG
Dis Esophagus 1997 Oct;10(4):243-6. doi: 10.1093/dote/10.4.243. PMID: 9455650
Fragmentation of a Celestin tube causing intestinal obstruction. Case report and review of the literature.
Palafox BA, Lifschutz H, Juler G, Stemmer E, Mason GR
J Thorac Cardiovasc Surg 1984 May;87(5):698-701. PMID: 6201682
Celestin tube palliation of unresectable esophageal carcinoma.
Kairaluoma MI, Jokinen K, Kärkölä P, Larmi TK
J Thorac Cardiovasc Surg 1977 May;73(5):783-6. PMID: 66421

Clinical prediction guides

Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database.
Xie L, Zhang Z
Front Immunol 2024;15:1334992. Epub 2024 Jan 16 doi: 10.3389/fimmu.2024.1334992. PMID: 38292873Free PMC Article
Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis.
Ma N, Ming X, Chen J, Wu KL, Lu J, Jiang G, Mao J
Radiat Oncol 2023 Dec 1;18(1):195. doi: 10.1186/s13014-023-02371-9. PMID: 38041122Free PMC Article
A randomized prospective comparison of self-expandable plastic stents and partially covered self-expandable metal stents in the palliation of malignant esophageal dysphagia.
Conio M, Repici A, Battaglia G, De Pretis G, Ghezzo L, Bittinger M, Messmann H, Demarquay JF, Blanchi S, Togni M, Conigliaro R, Filiberti R
Am J Gastroenterol 2007 Dec;102(12):2667-77. doi: 10.1111/j.1572-0241.2007.01565.x. PMID: 18042102
Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer: a pilot study.
Ortner MA, Taha AA, Schreiber S, Wirth J, Weber-Eibl J, Ernst H, Lochs H
Endoscopy 2004 May;36(5):421-5. doi: 10.1055/s-2004-814327. PMID: 15100951
A pilot study of irinotecan (CPT-11) as single-agent therapy in patients with locally advanced or metastatic esophageal carcinoma.
Mühr-Wilkenshoff F, Hinkelbein W, Ohnesorge I, Wolf KJ, Riecken EO, Zeitz M, Scherübl H
Int J Colorectal Dis 2003 Jul;18(4):330-4. Epub 2003 Feb 1 doi: 10.1007/s00384-002-0464-x. PMID: 12774248

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