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Eosinophilic inflammation

MedGen UID:
923781
•Concept ID:
C3687252
•
Finding
Synonym: Eosinophilic infiltration
SNOMED CT: Eosinophilic inflammation (767256007); Eosinophilic infiltration (767256007)

Definition

An inflammatory infiltrate composed exclusively or predominantly of eosinophils. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEosinophilic inflammation

Professional guidelines

PubMed

Dietary Management of Eosinophilic Esophagitis.
Lucendo A, Groetch M, Gonsalves N
Immunol Allergy Clin North Am 2024 May;44(2):223-244. Epub 2024 Feb 16 doi: 10.1016/j.iac.2023.12.009. PMID: 38575220
International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature.
Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS
Clin Gastroenterol Hepatol 2022 Nov;20(11):2474-2484.e3. Epub 2022 Feb 16 doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570Free PMC Article
Near fatal asthma: treatment and prevention.
D'Amato G, Vitale C, Lanza M, Sanduzzi A, Molino A, Mormile M, Vatrella A, Bilò MB, Antonicelli L, Bresciani M, Micheletto C, Vaghi A, D'Amato M
Eur Ann Allergy Clin Immunol 2016 Jul;48(4):116-22. PMID: 27425166

Recent clinical studies

Etiology

The emerging role of IL-23 in asthma and its clinical implications.
Wu AY, Peebles RS
Expert Rev Clin Immunol 2023 Jan;19(1):1-5. Epub 2022 Sep 20 doi: 10.1080/1744666X.2023.2125380. PMID: 36106675Free PMC Article
The different phenotypes of COPD.
Yousuf A, McAuley H, Elneima O, Brightling CE
Br Med Bull 2021 Mar 25;137(1):82-97. doi: 10.1093/bmb/ldaa043. PMID: 33693527
Airway inflammation in COPD: progress to precision medicine.
Brightling C, Greening N
Eur Respir J 2019 Aug;54(2) Epub 2019 Aug 1 doi: 10.1183/13993003.00651-2019. PMID: 31073084
Chronic obstructive pulmonary disease.
Barnes PJ, Burney PG, Silverman EK, Celli BR, Vestbo J, Wedzicha JA, Wouters EF
Nat Rev Dis Primers 2015 Dec 3;1:15076. doi: 10.1038/nrdp.2015.76. PMID: 27189863
Severe/fatal asthma.
Wenzel S
Chest 2003 Mar;123(3 Suppl):405S-10S. doi: 10.1378/chest.123.3_suppl.405s-a. PMID: 12629003

Diagnosis

Eosinophilic esophagitis in the era of biologics.
Rossi CM, Santacroce G, Lenti MV, di Sabatino A
Expert Rev Gastroenterol Hepatol 2024 Jun;18(6):271-281. Epub 2024 Jul 1 doi: 10.1080/17474124.2024.2374471. PMID: 38940016
Dietary Management of Eosinophilic Esophagitis.
Lucendo A, Groetch M, Gonsalves N
Immunol Allergy Clin North Am 2024 May;44(2):223-244. Epub 2024 Feb 16 doi: 10.1016/j.iac.2023.12.009. PMID: 38575220
ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics.
Piga MA, Fraticelli P, Antonicelli L, Garritani MS, Ghirelli G, Martini M, Di Vincenzo A, Danieli MG, Moroncini G, Bilò MB
Front Immunol 2023;14:1325299. Epub 2023 Nov 27 doi: 10.3389/fimmu.2023.1325299. PMID: 38090592Free PMC Article
Genetics of eosinophilic esophagitis.
Sherrill JD, Blanchard C
Dig Dis 2014;32(1-2):22-9. Epub 2014 Feb 28 doi: 10.1159/000357005. PMID: 24603376
Adult-onset food allergy.
Kivity S
Isr Med Assoc J 2012 Jan;14(1):70-2. PMID: 22624448

Therapy

Eosinophilic esophagitis in the era of biologics.
Rossi CM, Santacroce G, Lenti MV, di Sabatino A
Expert Rev Gastroenterol Hepatol 2024 Jun;18(6):271-281. Epub 2024 Jul 1 doi: 10.1080/17474124.2024.2374471. PMID: 38940016
Taking the red out of eosinophilic inflammation in COPD.
Bush RK
J Allergy Clin Immunol 2020 Aug;146(2):278-279. Epub 2020 Jun 2 doi: 10.1016/j.jaci.2020.05.028. PMID: 32502512
Airway inflammation in COPD: progress to precision medicine.
Brightling C, Greening N
Eur Respir J 2019 Aug;54(2) Epub 2019 Aug 1 doi: 10.1183/13993003.00651-2019. PMID: 31073084
Chronic obstructive pulmonary disease.
Barnes PJ, Burney PG, Silverman EK, Celli BR, Vestbo J, Wedzicha JA, Wouters EF
Nat Rev Dis Primers 2015 Dec 3;1:15076. doi: 10.1038/nrdp.2015.76. PMID: 27189863
The immunology of asthma.
Lambrecht BN, Hammad H
Nat Immunol 2015 Jan;16(1):45-56. doi: 10.1038/ni.3049. PMID: 25521684

Prognosis

Predicting the course of asthma from childhood until early adulthood.
Koefoed HJL, Vonk JM, Koppelman GH
Curr Opin Allergy Clin Immunol 2022 Apr 1;22(2):115-122. doi: 10.1097/ACI.0000000000000810. PMID: 35197433Free PMC Article
The different phenotypes of COPD.
Yousuf A, McAuley H, Elneima O, Brightling CE
Br Med Bull 2021 Mar 25;137(1):82-97. doi: 10.1093/bmb/ldaa043. PMID: 33693527
Chronic obstructive pulmonary disease.
Barnes PJ, Burney PG, Silverman EK, Celli BR, Vestbo J, Wedzicha JA, Wouters EF
Nat Rev Dis Primers 2015 Dec 3;1:15076. doi: 10.1038/nrdp.2015.76. PMID: 27189863
Eosinophilic gastroenteritis: an update.
Lucendo AJ, Arias A
Expert Rev Gastroenterol Hepatol 2012 Sep;6(5):591-601. doi: 10.1586/egh.12.42. PMID: 23061710
Eosinophilic esophagitis.
Franciosi JP, Liacouras CA
Immunol Allergy Clin North Am 2009 Feb;29(1):19-27, viii. doi: 10.1016/j.iac.2008.09.001. PMID: 19141338

Clinical prediction guides

Exploring novel perspectives on eosinophilic inflammation in severe asthma.
Candia C, Ambrosino P, D'Anna SE, Motta A, Maniscalco M
Biomark Med 2024;18(8):357-361. Epub 2024 Apr 16 doi: 10.2217/bmm-2023-0801. PMID: 38623926Free PMC Article
ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics.
Piga MA, Fraticelli P, Antonicelli L, Garritani MS, Ghirelli G, Martini M, Di Vincenzo A, Danieli MG, Moroncini G, Bilò MB
Front Immunol 2023;14:1325299. Epub 2023 Nov 27 doi: 10.3389/fimmu.2023.1325299. PMID: 38090592Free PMC Article
Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials.
Gevaert P, Omachi TA, Corren J, Mullol J, Han J, Lee SE, Kaufman D, Ligueros-Saylan M, Howard M, Zhu R, Owen R, Wong K, Islam L, Bachert C
J Allergy Clin Immunol 2020 Sep;146(3):595-605. Epub 2020 Jun 7 doi: 10.1016/j.jaci.2020.05.032. PMID: 32524991
Airway inflammation in COPD: progress to precision medicine.
Brightling C, Greening N
Eur Respir J 2019 Aug;54(2) Epub 2019 Aug 1 doi: 10.1183/13993003.00651-2019. PMID: 31073084
Mepolizumab treatment in patients with severe eosinophilic asthma.
Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, Chanez P; MENSA Investigators
N Engl J Med 2014 Sep 25;371(13):1198-207. Epub 2014 Sep 8 doi: 10.1056/NEJMoa1403290. PMID: 25199059

Recent systematic reviews

Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis.
Mao D, He Z, Li L, Lei Y, Xiao M, Zhang H, Zhang F
J Healthc Eng 2022;2022:3594210. Epub 2022 Apr 11 doi: 10.1155/2022/3594210. PMID: 35444784Free PMC Article
Clinical Evidence of Type 2 Inflammation in Non-allergic Rhinitis with Eosinophilia Syndrome: a Systematic Review.
De Corso E, Seccia V, Ottaviano G, Cantone E, Lucidi D, Settimi S, Di Cesare T, Galli J
Curr Allergy Asthma Rep 2022 Apr;22(4):29-42. Epub 2022 Feb 9 doi: 10.1007/s11882-022-01027-0. PMID: 35141844
Systematic review and meta-regressions: management of eosinophilic esophagitis requires histologic assessment.
Chang JW, Yeow RY, Waljee AK, Rubenstein JH
Dis Esophagus 2018 Aug 1;31(8) doi: 10.1093/dote/doy049. PMID: 29893826Free PMC Article
The relationship between inflammation and remodeling in childhood asthma: A systematic review.
Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, Oyarzun MA, Fleming L, Bush A
Pediatr Pulmonol 2018 Jun;53(6):824-835. Epub 2018 Feb 22 doi: 10.1002/ppul.23968. PMID: 29469196
Macrolides for chronic asthma.
Richeldi L, Ferrara G, Fabbri LM, Gibson PG
Cochrane Database Syst Rev 2002;(1):CD002997. doi: 10.1002/14651858.CD002997. PMID: 11869648

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