U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anaplastic pleomorphic xanthoastrocytoma

MedGen UID:
924393
Concept ID:
C4283858
Neoplastic Process
Synonyms: Anaplastic Pleomorphic Xanthoastrocytoma; anaplastic pleomorphic xanthoastrocytoma; WHO Grade 3 Pleomorphic Xanthoastrocytoma; WHO Grade III Pleomorphic Xanthoastrocytoma
SNOMED CT: Anaplastic pleomorphic xanthoastrocytoma (733848006)
 
Monarch Initiative: MONDO:0850312

Definition

A WHO grade 3 pleomorphic xanthoastrocytoma characterized by the presence of five or more mitoses per 10 high-power fields. Necrosis may be present. Patients have shorter survival rates when compared to those with WHO grade 2 pleomorphic xanthoastrocytoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic pleomorphic xanthoastrocytoma

Professional guidelines

PubMed

Scarpelli DB, Yu Y, Tep AC, Bergue B, Degnin C, Chen Y, McClelland S 3rd, Jaboin JJ
Cancer Rep (Hoboken) 2021 Dec;4(6):e1415. Epub 2021 May 8 doi: 10.1002/cnr2.1415. PMID: 33963808Free PMC Article

Recent clinical studies

Etiology

Huang W, Cai J, Lin N, Xu Y, Wang H, Wu Z, Kang D
AJNR Am J Neuroradiol 2021 Dec;42(12):2152-2159. Epub 2021 Nov 1 doi: 10.3174/ajnr.A7324. PMID: 34725042Free PMC Article
She D, Liu J, Xing Z, Zhang Y, Cao D, Zhang Z
AJNR Am J Neuroradiol 2018 Aug;39(8):1446-1452. Epub 2018 Jun 14 doi: 10.3174/ajnr.A5701. PMID: 29903923Free PMC Article
Wesseling P, Capper D
Neuropathol Appl Neurobiol 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. PMID: 28815663
Vaubel RA, Caron AA, Yamada S, Decker PA, Eckel Passow JE, Rodriguez FJ, Nageswara Rao AA, Lachance D, Parney I, Jenkins R, Giannini C
Brain Pathol 2018 Mar;28(2):172-182. Epub 2017 Apr 2 doi: 10.1111/bpa.12495. PMID: 28181325Free PMC Article
Martínez R, Carmona FJ, Vizoso M, Rohde V, Kirsch M, Schackert G, Ropero S, Paulus W, Barrantes A, Gomez A, Esteller M
BMC Cancer 2014 Mar 20;14:213. doi: 10.1186/1471-2407-14-213. PMID: 24650279Free PMC Article

Diagnosis

Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM
Lancet Child Adolesc Health 2023 Jul;7(7):471-478. Epub 2023 Mar 30 doi: 10.1016/S2352-4642(23)00031-7. PMID: 37004712Free PMC Article
Lin Z, Yang R, Zheng H, Li Z, Yi G, Wu Q, Yang C, Huang G
Clin Neurol Neurosurg 2022 Oct;221:107379. Epub 2022 Jul 21 doi: 10.1016/j.clineuro.2022.107379. PMID: 35932588
Sasaki S, Tomomasa R, Nobusawa S, Hirato J, Uchiyama T, Boku E, Miyasaka T, Hirose T, Ohbayashi C
Brain Tumor Pathol 2019 Oct;36(4):169-173. Epub 2019 Jul 26 doi: 10.1007/s10014-019-00349-8. PMID: 31350684
Wesseling P, Capper D
Neuropathol Appl Neurobiol 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. PMID: 28815663
Benjamin C, Faustin A, Snuderl M, Pacione D
J Clin Neurosci 2015 Aug;22(8):1370-3. Epub 2015 Apr 28 doi: 10.1016/j.jocn.2015.02.026. PMID: 25934112

Therapy

Schreck KC, Strowd RE, Nabors LB, Ellingson BM, Chang M, Tan SK, Abdullaev Z, Turakulov R, Aldape K, Danda N, Desideri S, Fisher J, Iacoboni M, Surakus T, Rudek MA, Bettegowda C, Grossman SA, Ye X
Clin Cancer Res 2024 May 15;30(10):2048-2056. doi: 10.1158/1078-0432.CCR-23-3241. PMID: 38446982Free PMC Article
Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM
Lancet Child Adolesc Health 2023 Jul;7(7):471-478. Epub 2023 Mar 30 doi: 10.1016/S2352-4642(23)00031-7. PMID: 37004712Free PMC Article
Kata K, Rodriguez-Quintero JC, Arevalo OD, Zhang JJ, Bhattacharjee MB, Ware C, Dono A, Riascos-Castaneda R, Tandon N, Blanco A, Esquenazi Y, Ballester LY, Amsbaugh M, Day AL, Zhu JJ
J Natl Compr Canc Netw 2022 Nov;20(11):1193-1202.e6. doi: 10.6004/jnccn.2022.7046. PMID: 36351333
Saraf AJ, Elhawary G, Finlay JL, Scott S, Olshefski R, Halverson M, Boue DR, AbdelBaki MS
Pediatr Neurol 2018 Nov;88:65-70. Epub 2018 Sep 13 doi: 10.1016/j.pediatrneurol.2018.09.004. PMID: 30322731
Brown NF, Carter T, Mulholland P
CNS Oncol 2017 Jan;6(1):5-9. Epub 2016 Oct 26 doi: 10.2217/cns-2016-0031. PMID: 27781490Free PMC Article

Prognosis

Agrawal K, Verma KK, Hussain N, Sarangi S
J Cancer Res Ther 2023 Jul-Sep;19(5):1465-1467. doi: 10.4103/jcrt.jcrt_1115_21. PMID: 37787332
Sasaki S, Tomomasa R, Nobusawa S, Hirato J, Uchiyama T, Boku E, Miyasaka T, Hirose T, Ohbayashi C
Brain Tumor Pathol 2019 Oct;36(4):169-173. Epub 2019 Jul 26 doi: 10.1007/s10014-019-00349-8. PMID: 31350684
Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA
Brain Pathol 2019 Jan;29(1):85-96. Epub 2018 Nov 6 doi: 10.1111/bpa.12639. PMID: 30051528Free PMC Article
She D, Liu J, Xing Z, Zhang Y, Cao D, Zhang Z
AJNR Am J Neuroradiol 2018 Aug;39(8):1446-1452. Epub 2018 Jun 14 doi: 10.3174/ajnr.A5701. PMID: 29903923Free PMC Article
Bayindir C, Balak N, Karasu A, Kasaroğlu D
Childs Nerv Syst 1997 Jan;13(1):50-6. doi: 10.1007/s003810050040. PMID: 9083703

Clinical prediction guides

Schreck KC, Strowd RE, Nabors LB, Ellingson BM, Chang M, Tan SK, Abdullaev Z, Turakulov R, Aldape K, Danda N, Desideri S, Fisher J, Iacoboni M, Surakus T, Rudek MA, Bettegowda C, Grossman SA, Ye X
Clin Cancer Res 2024 May 15;30(10):2048-2056. doi: 10.1158/1078-0432.CCR-23-3241. PMID: 38446982Free PMC Article
Shi ZF, Li KK, Huang QJ, Wang WW, Kwan JS, Chen H, Liu XZ, Li WC, Chan DT, Zhang ZY, Mao Y, Ng HK
Neuropathol Appl Neurobiol 2022 Jun;48(4):e12802. Epub 2022 Mar 15 doi: 10.1111/nan.12802. PMID: 35191072
Ma C, Feng R, Chen H, Hameed NUF, Aibaidula A, Song Y, Wu J
World Neurosurg 2018 Dec;120:e1225-e1233. Epub 2018 Sep 18 doi: 10.1016/j.wneu.2018.09.050. PMID: 30240866
Martínez R, Carmona FJ, Vizoso M, Rohde V, Kirsch M, Schackert G, Ropero S, Paulus W, Barrantes A, Gomez A, Esteller M
BMC Cancer 2014 Mar 20;14:213. doi: 10.1186/1471-2407-14-213. PMID: 24650279Free PMC Article
Bayindir C, Balak N, Karasu A, Kasaroğlu D
Childs Nerv Syst 1997 Jan;13(1):50-6. doi: 10.1007/s003810050040. PMID: 9083703

Recent systematic reviews

Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...