U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Glioblastoma

MedGen UID:
925837
Concept ID:
C4288305
Neoplastic Process

Definition

The reemergence of glioblastoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Wang F, Huang Q, Su H, Sun M, Wang Z, Chen Z, Zheng M, Chakroun RW, Monroe MK, Chen D, Wang Z, Gorelick N, Serra R, Wang H, Guan Y, Suk JS, Tyler B, Brem H, Hanes J, Cui H
Proc Natl Acad Sci U S A 2023 May 2;120(18):e2204621120. Epub 2023 Apr 25 doi: 10.1073/pnas.2204621120. PMID: 37098055Free PMC Article
Nam JY, de Groot JF
J Oncol Pract 2017 Oct;13(10):629-638. doi: 10.1200/JOP.2017.025536. PMID: 29020535
Ellingson BM, Wen PY, Cloughesy TF
Neurotherapeutics 2017 Apr;14(2):307-320. doi: 10.1007/s13311-016-0507-6. PMID: 28108885Free PMC Article

Recent clinical studies

Etiology

Tsien CI, Pugh SL, Dicker AP, Raizer JJ, Matuszak MM, Lallana EC, Huang J, Algan O, Deb N, Portelance L, Villano JL, Hamm JT, Oh KS, Ali AN, Kim MM, Lindhorst SM, Mehta MP
J Clin Oncol 2023 Feb 20;41(6):1285-1295. Epub 2022 Oct 19 doi: 10.1200/JCO.22.00164. PMID: 36260832Free PMC Article
Minniti G, Niyazi M, Alongi F, Navarria P, Belka C
Radiat Oncol 2021 Feb 18;16(1):36. doi: 10.1186/s13014-021-01767-9. PMID: 33602305Free PMC Article
Nayak L, Molinaro AM, Peters K, Clarke JL, Jordan JT, de Groot J, Nghiemphu L, Kaley T, Colman H, McCluskey C, Gaffey S, Smith TR, Cote DJ, Severgnini M, Yearley JH, Zhao Q, Blumenschein WM, Duda DG, Muzikansky A, Jain RK, Wen PY, Reardon DA
Clin Cancer Res 2021 Feb 15;27(4):1048-1057. Epub 2020 Nov 16 doi: 10.1158/1078-0432.CCR-20-2500. PMID: 33199490Free PMC Article
Reardon DA, Brandes AA, Omuro A, Mulholland P, Lim M, Wick A, Baehring J, Ahluwalia MS, Roth P, Bähr O, Phuphanich S, Sepulveda JM, De Souza P, Sahebjam S, Carleton M, Tatsuoka K, Taitt C, Zwirtes R, Sampson J, Weller M
JAMA Oncol 2020 Jul 1;6(7):1003-1010. doi: 10.1001/jamaoncol.2020.1024. PMID: 32437507Free PMC Article
Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T
J Clin Oncol 2009 Oct 1;27(28):4733-40. Epub 2009 Aug 31 doi: 10.1200/JCO.2008.19.8721. PMID: 19720927

Diagnosis

Liau LM, Ashkan K, Brem S, Campian JL, Trusheim JE, Iwamoto FM, Tran DD, Ansstas G, Cobbs CS, Heth JA, Salacz ME, D'Andre S, Aiken RD, Moshel YA, Nam JY, Pillainayagam CP, Wagner SA, Walter KA, Chaudhary R, Goldlust SA, Lee IY, Bota DA, Elinzano H, Grewal J, Lillehei K, Mikkelsen T, Walbert T, Abram S, Brenner AJ, Ewend MG, Khagi S, Lovick DS, Portnow J, Kim L, Loudon WG, Martinez NL, Thompson RC, Avigan DE, Fink KL, Geoffroy FJ, Giglio P, Gligich O, Krex D, Lindhorst SM, Lutzky J, Meisel HJ, Nadji-Ohl M, Sanchin L, Sloan A, Taylor LP, Wu JK, Dunbar EM, Etame AB, Kesari S, Mathieu D, Piccioni DE, Baskin DS, Lacroix M, May SA, New PZ, Pluard TJ, Toms SA, Tse V, Peak S, Villano JL, Battiste JD, Mulholland PJ, Pearlman ML, Petrecca K, Schulder M, Prins RM, Boynton AL, Bosch ML
JAMA Oncol 2023 Jan 1;9(1):112-121. doi: 10.1001/jamaoncol.2022.5370. PMID: 36394838Free PMC Article
Buehler M, Yi X, Ge W, Blattmann P, Rushing E, Reifenberger G, Felsberg J, Yeh C, Corn JE, Regli L, Zhang J, Cloos A, Ravi VM, Wiestler B, Heiland DH, Aebersold R, Weller M, Guo T, Weiss T
Neuro Oncol 2023 Feb 14;25(2):290-302. doi: 10.1093/neuonc/noac169. PMID: 35802605Free PMC Article
Weller M, Le Rhun E
Cancer Treat Rev 2020 Jul;87:102029. Epub 2020 May 4 doi: 10.1016/j.ctrv.2020.102029. PMID: 32408220
Ellingson BM, Wen PY, Cloughesy TF
Neurotherapeutics 2017 Apr;14(2):307-320. doi: 10.1007/s13311-016-0507-6. PMID: 28108885Free PMC Article
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580

Therapy

Liau LM, Ashkan K, Brem S, Campian JL, Trusheim JE, Iwamoto FM, Tran DD, Ansstas G, Cobbs CS, Heth JA, Salacz ME, D'Andre S, Aiken RD, Moshel YA, Nam JY, Pillainayagam CP, Wagner SA, Walter KA, Chaudhary R, Goldlust SA, Lee IY, Bota DA, Elinzano H, Grewal J, Lillehei K, Mikkelsen T, Walbert T, Abram S, Brenner AJ, Ewend MG, Khagi S, Lovick DS, Portnow J, Kim L, Loudon WG, Martinez NL, Thompson RC, Avigan DE, Fink KL, Geoffroy FJ, Giglio P, Gligich O, Krex D, Lindhorst SM, Lutzky J, Meisel HJ, Nadji-Ohl M, Sanchin L, Sloan A, Taylor LP, Wu JK, Dunbar EM, Etame AB, Kesari S, Mathieu D, Piccioni DE, Baskin DS, Lacroix M, May SA, New PZ, Pluard TJ, Toms SA, Tse V, Peak S, Villano JL, Battiste JD, Mulholland PJ, Pearlman ML, Petrecca K, Schulder M, Prins RM, Boynton AL, Bosch ML
JAMA Oncol 2023 Jan 1;9(1):112-121. doi: 10.1001/jamaoncol.2022.5370. PMID: 36394838Free PMC Article
Tsien CI, Pugh SL, Dicker AP, Raizer JJ, Matuszak MM, Lallana EC, Huang J, Algan O, Deb N, Portelance L, Villano JL, Hamm JT, Oh KS, Ali AN, Kim MM, Lindhorst SM, Mehta MP
J Clin Oncol 2023 Feb 20;41(6):1285-1295. Epub 2022 Oct 19 doi: 10.1200/JCO.22.00164. PMID: 36260832Free PMC Article
Weller M, Le Rhun E
Cancer Treat Rev 2020 Jul;87:102029. Epub 2020 May 4 doi: 10.1016/j.ctrv.2020.102029. PMID: 32408220
Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, O'Brien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM
Nat Med 2019 Mar;25(3):477-486. Epub 2019 Feb 11 doi: 10.1038/s41591-018-0337-7. PMID: 30742122Free PMC Article
Ellingson BM, Wen PY, Cloughesy TF
Neurotherapeutics 2017 Apr;14(2):307-320. doi: 10.1007/s13311-016-0507-6. PMID: 28108885Free PMC Article

Prognosis

Minniti G, Niyazi M, Alongi F, Navarria P, Belka C
Radiat Oncol 2021 Feb 18;16(1):36. doi: 10.1186/s13014-021-01767-9. PMID: 33602305Free PMC Article
Medikonda R, Dunn G, Rahman M, Fecci P, Lim M
J Neurooncol 2021 Jan;151(1):41-53. Epub 2020 Apr 6 doi: 10.1007/s11060-020-03448-1. PMID: 32253714
Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, O'Brien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM
Nat Med 2019 Mar;25(3):477-486. Epub 2019 Feb 11 doi: 10.1038/s41591-018-0337-7. PMID: 30742122Free PMC Article
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580

Clinical prediction guides

Hoogstrate Y, Draaisma K, Ghisai SA, van Hijfte L, Barin N, de Heer I, Coppieters W, van den Bosch TPP, Bolleboom A, Gao Z, Vincent AJPE, Karim L, Deckers M, Taphoorn MJB, Kerkhof M, Weyerbrock A, Sanson M, Hoeben A, Lukacova S, Lombardi G, Leenstra S, Hanse M, Fleischeuer REM, Watts C, Angelopoulos N, Gorlia T, Golfinopoulos V, Bours V, van den Bent MJ, Robe PA, French PJ
Cancer Cell 2023 Apr 10;41(4):678-692.e7. Epub 2023 Mar 9 doi: 10.1016/j.ccell.2023.02.019. PMID: 36898379
Wu H, Guo C, Wang C, Xu J, Zheng S, Duan J, Li Y, Bai H, Xu Q, Ning F, Wang F, Yang Q
Cancer Sci 2023 Jun;114(6):2609-2621. Epub 2023 Mar 10 doi: 10.1111/cas.15773. PMID: 36853018Free PMC Article
Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, O'Brien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM
Nat Med 2019 Mar;25(3):477-486. Epub 2019 Feb 11 doi: 10.1038/s41591-018-0337-7. PMID: 30742122Free PMC Article
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580

Recent systematic reviews

Araujo Moura AW, da Silva Rodrigues S, de Oliveira TF, Lobato BM, Pereira Cerize NN, Léo P
J Oncol Pharm Pract 2023 Oct;29(7):1736-1747. Epub 2023 Jul 28 doi: 10.1177/10781552231190104. PMID: 37503551
Luo T, Feng J, Sun P
Clin Neurol Neurosurg 2023 Jun;229:107728. Epub 2023 Apr 20 doi: 10.1016/j.clineuro.2023.107728. PMID: 37105068
Li X, Jia Z, Yan Y
Acta Neurochir (Wien) 2022 Aug;164(8):1985-1993. Epub 2022 Apr 9 doi: 10.1007/s00701-022-05192-z. PMID: 35397674
Zhang T, Xin Q, Kang JM
Eur Rev Med Pharmacol Sci 2021 Nov;25(21):6480-6491. doi: 10.26355/eurrev_202111_27092. PMID: 34787852
Kazmi F, Soon YY, Leong YH, Koh WY, Vellayappan B
J Neurooncol 2019 Mar;142(1):79-90. Epub 2018 Dec 6 doi: 10.1007/s11060-018-03064-0. PMID: 30523605

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...