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Ovarian Luteinized Thecoma Associated with Sclerosing Peritonitis

MedGen UID:
926075
•Concept ID:
C4288543
•
Neoplastic Process

Definition

A rare usually bilateral luteinized thecoma that arises from the ovary and is associated with sclerosing peritonitis. It occurs mostly in premenopausal women. The ovarian tumor is benign but patients may develop intestinal obstruction due to the sclerosing peritonitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Luteinized Thecoma Associated with Sclerosing Peritonitis

Professional guidelines

PubMed

Luteinized thecomatosis and other conditions associated with sclerosing peritonitis: a problem in causation, management, and nomenclature.
Roth LM
Expert Rev Anticancer Ther 2021 Mar;21(3):239-240. Epub 2020 Dec 8 doi: 10.1080/14737140.2021.1853530. PMID: 33290110

Recent clinical studies

Etiology

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Use of hormone suppression then oocyte freezing to preserve reproductive capability in an adolescent girl with ovarian luteinized thecoma associated with sclerosing peritonitis.
Noyes N, Perretta RC, Fino ME, Matulewicz T, Barakat R
Fertil Steril 2009 Jul;92(1):393.e11-4. Epub 2009 Mar 26 doi: 10.1016/j.fertnstert.2009.01.145. PMID: 19327766
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912

Diagnosis

Pathological discrimination between luteinized thecoma associated with sclerosing peritonitis and thecoma.
Liu J, Wei J, Yang Y, Wei J
Medicine (Baltimore) 2023 Jun 9;102(23):e33911. doi: 10.1097/MD.0000000000033911. PMID: 37335673Free PMC Article
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Selected topics in peritoneal pathology.
Baker PM, Clement PB, Young RH
Int J Gynecol Pathol 2014 Jul;33(4):393-401. doi: 10.1097/PGP.0000000000000146. PMID: 24901399
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912

Therapy

COMPLETE REMISSION OF MEDICALLY TREATED LUTEINIZED THECOMAS WITH SCLEROSING PERITONITIS.
Wehbe K, Duminil L, Bertrand A, Kianmanesh R, Graesslin O, Raimond E
J Gynecol Obstet Hum Reprod 2021 Jun;50(6):101734. Epub 2020 Apr 10 doi: 10.1016/j.jogoh.2020.101734. PMID: 32283225
Luteinized Thecomas ("Thecomatosis") with Sclerosing Peritonitis (LTSP): Report of 2 Cases and Review of an Enigmatic Syndrome Associated with a Peritoneal Proliferation of Specialized (vimentin+/keratin+/CD34+) Submesothelial Fibroblasts.
Altman AD, Bentley JR, Rittenberg PV, Murray SK
J Obstet Gynaecol Can 2016 Jan;38(1):41-50. doi: 10.1016/j.jogc.2015.10.010. PMID: 26872755
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
A case of luteinizing thecoma with sclerosing peritonitis: revisiting a link with anti-epileptic drugs.
Nauen DW, Martin A, Katz A, Cohen D, Ranganathan S
Pediatr Blood Cancer 2010 Mar;54(3):470-2. doi: 10.1002/pbc.22325. PMID: 19847882
Sclerosing peritonitis associated with bilateral luteinized thecoma, linked to anticonvulsant therapy.
Levavi H, Sabah G, Heifetz M, Feinmesser M
Eur J Gynaecol Oncol 2009;30(6):695-700. PMID: 20099509

Prognosis

Luteinized thecomas (thecomatosis) of the type typically associated with sclerosing peritonitis: a clinical, histopathologic, and immunohistochemical analysis of 27 cases.
Staats PN, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2008 Sep;32(9):1273-90. doi: 10.1097/PAS.0b013e3181666a5f. PMID: 18636018
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912

Clinical prediction guides

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537

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