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Benign reproductive system neoplasm

MedGen UID:: 234034
•Concept ID:: C1332536
•: Neoplastic Process

Synonyms:	Benign Reproductive System Neoplasm; benign reproductive system neoplasm; reproductive organ benign neoplasm

Monarch Initiative:	MONDO:0000383

Definition

A neoplasm that arises from the male or female reproductive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign reproductive system neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Benign Genitourinary System Neoplasm
        Benign reproductive system neoplasm
        Adrenal rest tumor
        Benign female reproductive system neoplasm
        Adenomyoma
        Adenomyoma of uterine corpus
        Atypical polypoid adenomyoma
        Cervical adenomyoma
        Uterine Ligament Adenomyoma
        Benign neoplasm of placenta
        Chorangioma
        Placental polyp
        Benign uterine ligament neoplasm
        Benign Broad Ligament Neoplasm
        Uterine Ligament Leiomyoma
        Uterine Ligament Papillary Cystadenoma
        Benign vaginal neoplasm
        Benign Vaginal Melanocytic Nevus
        Benign vaginal mixed epithelial and mesenchymal neoplasm
        Vaginal Angiomyofibroblastoma
        Vaginal Deep (Aggressive) Angiomyxoma
        Vaginal Dermoid Cyst
        Vaginal leiomyoma
        Vaginal mullerian papilloma
        Vaginal Rhabdomyoma
        Vaginal squamous papilloma
        Vaginal Superficial Myofibroblastoma
        Fallopian tube benign neoplasm
        Fallopian tube adenomatoid tumor
        Fallopian tube leiomyoma
        Fallopian Tube Metaplastic Papillary Tumor
        Fallopian tube papilloma
        Fallopian tube serous adenofibroma
        Genital Rhabdomyoma
        Cervical Rhabdomyoma
        Vulvar Rhabdomyoma
        Mucinous cystadenofibroma
        Ovarian mucinous cystadenofibroma
        Ovarian benign neoplasm
        Benign Ovarian Epithelial Tumor
        Benign Ovarian Germ Cell Tumor
        Benign ovarian sex cord-stromal tumor
        Ovarian Adenomatoid Tumor
        Ovarian Leiomyoma
        Ovarian Myxoma
        Rete ovarii adenoma
        Uterine benign neoplasm
        Benign neoplasm of corpus uteri
        Cervical benign neoplasm
        Vulvar benign neoplasm
        Bartholin gland benign neoplasm
        Benign mixed tumor of the vulva
        Benign Vulvar Phyllodes Tumor
        Minor vestibular glands adenoma
        Vestibular papilloma
        Vulvar Acquired Melanocytic Nevus
        Vulvar Angiomyofibroblastoma
        Vulvar Angiomyxoma
        Vulvar Blue Nevus
        Vulvar Cellular Angiofibroma
        Vulvar Composite Hidradenoma Papilliferum and Fibroadenoma
        Vulvar Congenital Melanocytic Nevus
        Vulvar Fibroadenoma
        Vulvar Hidradenoma Papilliferum
        Vulvar leiomyoma
        Vulvar Lipoblastoma-Like Tumor
        Vulvar Lipoma
        Vulvar nodular hidradenoma
        Vulvar Prepubertal Fibroma
        Vulvar seborrheic keratosis
        Vulvar Superficial Myofibroblastoma
        Vulvar syringoma
        Vulvar trichoepithelioma
        Benign male reproductive system neoplasm
        Benign neoplasm of epididymis
        Epididymal adenomatoid tumor
        Epididymal Cystadenoma
        Benign neoplasm of penis
        Penile Hemangioma
        Penile Leiomyoma
        Penile Lymphangioma
        Penile Myointimoma
        Penile Neurofibroma
        Penile Schwannoma
        Benign neoplasm of prostate
        Benign prostate phyllodes tumor
        Fibroma of prostate
        Prostate Cystadenoma
        Prostate Hemangioma
        Prostate leiomyoma
        Prostatic adenoma
        Benign neoplasm of testis
        Benign testicular sertoli cell tumor
        Testicular fibroma
        Testicular Mature Teratoma
        Benign Seminal Vesicle Neoplasm
        Seminal vesicle cystadenoma
        Seminal Vesicle Leiomyoma
        Seminal Vesicle Mammary-Type Myofibroblastoma
        Seminal Vesicle Schwannoma
        Paratesticular Adenomatoid Tumor
        Paratesticular Cellular Angiofibroma
        Paratesticular Deep (Aggressive) Angiomyxoma
        Paratesticular Hemangioma
        Paratesticular Leiomyoma
        Paratesticular lipoma
        Lipoma of spermatic cord
        Paratesticular Mammary-Type Myofibroblastoma
        Paratesticular Rhabdomyoma
        Paratesticular Schwannoma
        Rete testis adenoma
        Benign sertoli cell tumor
        Fibroadenoma of Anogenital Mammary-Type Glands
        Anal Fibroadenoma

Professional guidelines

PubMed

Diagnosis and management of uterine fibroids: current trends and future strategies.

Ahmad A, Kumar M, Bhoi NR, Badruddeen, Akhtar J, Khan MI, Ajmal M, Ahmad M
J Basic Clin Physiol Pharmacol 2023 May 1;34(3):291-310. Epub 2023 Mar 30 doi: 10.1515/jbcpp-2022-0219. PMID: 36989026

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.

Yang Q, Ciebiera M, Bariani MV, Ali M, Elkafas H, Boyer TG, Al-Hendy A
Endocr Rev 2022 Jul 13;43(4):678-719. doi: 10.1210/endrev/bnab039. PMID: 34741454 Free PMC Article

EAA clinical practice guidelines-gynecomastia evaluation and management.

Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

See all (219)

Recent clinical studies

Etiology

FIGO statement: Fertility preservation.

Henry L, Berek JS, Diaz I, Feldberg D, Mocanu E, Niederberger CC, Ohlander S, Purandare N, Rosenwaks Z, Tulandi T, Wasson M, Wilailak S, Malhotra J
Int J Gynaecol Obstet 2023 Dec;163(3):790-794. Epub 2023 Oct 9 doi: 10.1002/ijgo.15187. PMID: 37807831

Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.

Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364 Free PMC Article

Toward automation of germline variant curation in clinical cancer genetics.

Ravichandran V, Shameer Z, Kemel Y, Walsh M, Cadoo K, Lipkin S, Mandelker D, Zhang L, Stadler Z, Robson M, Offit K, Vijai J
Genet Med 2019 Sep;21(9):2116-2125. Epub 2019 Feb 21 doi: 10.1038/s41436-019-0463-8. PMID: 30787465 Free PMC Article

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.

Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587 Free PMC Article

See all (2780)

Diagnosis

Mimics of cancer in pregnancy.

Olinger K, Maheshwari E, Shenoy-Bhangle AS, Adejolu M, McGettigan M, Mathew H, Lee KS, Nicola R
Abdom Radiol (NY) 2023 May;48(5):1752-1773. Epub 2022 Dec 29 doi: 10.1007/s00261-022-03783-z. PMID: 36577923

Uterine Adenosarcoma.

Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

Vulvar Neoplasms, Benign and Malignant.

Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635

Cervical tumors.

Sahdev A
Semin Ultrasound CT MR 2010 Oct;31(5):399-413. doi: 10.1053/j.sult.2010.07.004. PMID: 20974359

See all (3902)

Therapy

Detection of endometrial cancer using tampon-based collection and methylated DNA markers.

Bakkum-Gamez JN, Sherman ME, Slettedahl SW, Mahoney DW, Lemens MA, Laughlin-Tommaso SK, Hopkins MR, VanOosten A, Shridhar V, Staub JK, Cao X, Foote PH, Clarke MA, Burger KN, Berger CK, O'Connell MC, Doering KA, Podratz KC, DeStephano CC, Schoolmeester JK, Kerr SE, Wentzensen N, Taylor WR, Kisiel JB
Gynecol Oncol 2023 Jul;174:11-20. Epub 2023 May 2 doi: 10.1016/j.ygyno.2023.04.014. PMID: 37141817 Free PMC Article

Endometrial hyperplasia as a risk factor of endometrial cancer.

Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185 Free PMC Article

Guideline No. 403: Initial Investigation and Management of Adnexal Masses.

Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853

Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.

Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364 Free PMC Article

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

See all (893)

Prognosis

FIGO statement: Fertility preservation.

Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.

Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364 Free PMC Article

Malignant transformation of adenomyosis: literature review and meta-analysis.

Yuan H, Zhang S
Arch Gynecol Obstet 2019 Jan;299(1):47-53. Epub 2018 Dec 5 doi: 10.1007/s00404-018-4991-2. PMID: 30519753

Uterine Adenosarcoma.

Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

See all (1828)

Clinical prediction guides

O-RADS US: A Systematic Review and Meta-Analysis of Category-specific Malignancy Rates.

Lee S, Lee JE, Hwang JA, Shin H
Radiology 2023 Aug;308(2):e223269. doi: 10.1148/radiol.223269. PMID: 37642566

Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.

Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612

Toward automation of germline variant curation in clinical cancer genetics.

Uterine Leiomyosarcoma.

Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869

Simple ultrasound-based rules for the diagnosis of ovarian cancer.

Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L
Ultrasound Obstet Gynecol 2008 Jun;31(6):681-90. doi: 10.1002/uog.5365. PMID: 18504770

See all (2294)

Recent systematic reviews

O-RADS US: A Systematic Review and Meta-Analysis of Category-specific Malignancy Rates.

Lee S, Lee JE, Hwang JA, Shin H
Radiology 2023 Aug;308(2):e223269. doi: 10.1148/radiol.223269. PMID: 37642566

A systematic review and meta-analysis of artificial intelligence diagnostic accuracy in prostate cancer histology identification and grading.

Morozov A, Taratkin M, Bazarkin A, Rivas JG, Puliatti S, Checcucci E, Belenchon IR, Kowalewski KF, Shpikina A, Singla N, Teoh JYC, Kozlov V, Rodler S, Piazza P, Fajkovic H, Yakimov M, Abreu AL, Cacciamani GE, Enikeev D; Young Academic Urologists (YAU) Working Group in Uro-technology of the European Association of Urology
Prostate Cancer Prostatic Dis 2023 Dec;26(4):681-692. Epub 2023 Apr 25 doi: 10.1038/s41391-023-00673-3. PMID: 37185992

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.

Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127 Free PMC Article

Endometrial hyperplasia as a risk factor of endometrial cancer.

What is the influence of cyclooxygenase-2 on postmenopausal endometrial polyps?

Pereira AK, Garcia MT, Pinheiro W, Ejzenberg D, Soares JM Jr, Baracat EC
Climacteric 2015;18(4):498-502. Epub 2014 Nov 19 doi: 10.3109/13697137.2014.966240. PMID: 25242379

See all (72)

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Benign reproductive system neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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