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Glioblastoma with Primitive Neuronal Component

MedGen UID:
926566
•Concept ID:
C4289034
•
Neoplastic Process
Synonym: Glioblastoma with PNET-Like Component

Definition

A glioblastoma characterized by the presence of well-demarcated nodules which contain primitive cells exhibiting neuronal differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlioblastoma with Primitive Neuronal Component

Recent clinical studies

Etiology

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.
Suwala AK, Stichel D, Schrimpf D, Maas SLN, Sill M, Dohmen H, Banan R, Reinhardt A, Sievers P, Hinz F, Blattner-Johnson M, Hartmann C, Schweizer L, Boldt HB, Kristensen BW, Schittenhelm J, Wood MD, Chotard G, Bjergvig R, Das A, Tabori U, Hasselblatt M, Korshunov A, Abdullaev Z, Quezado M, Aldape K, Harter PN, Snuderl M, Hench J, Frank S, Acker T, Brandner S, Winkler F, Wesseling P, Pfister SM, Reuss DE, Wick W, von Deimling A, Jones DTW, Sahm F
Acta Neuropathol 2021 Jul;142(1):179-189. Epub 2021 Apr 19 doi: 10.1007/s00401-021-02302-6. PMID: 33876327Free PMC Article

Diagnosis

Glioblastoma with primitive neuronal component: An immunohistochemical study and review of literature.
Poyuran R, Chandrasekharan K, Easwer HV, Narasimhaiah D
J Clin Neurosci 2021 Nov;93:130-136. Epub 2021 Sep 20 doi: 10.1016/j.jocn.2021.09.004. PMID: 34656236
Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.
Suwala AK, Stichel D, Schrimpf D, Maas SLN, Sill M, Dohmen H, Banan R, Reinhardt A, Sievers P, Hinz F, Blattner-Johnson M, Hartmann C, Schweizer L, Boldt HB, Kristensen BW, Schittenhelm J, Wood MD, Chotard G, Bjergvig R, Das A, Tabori U, Hasselblatt M, Korshunov A, Abdullaev Z, Quezado M, Aldape K, Harter PN, Snuderl M, Hench J, Frank S, Acker T, Brandner S, Winkler F, Wesseling P, Pfister SM, Reuss DE, Wick W, von Deimling A, Jones DTW, Sahm F
Acta Neuropathol 2021 Jul;142(1):179-189. Epub 2021 Apr 19 doi: 10.1007/s00401-021-02302-6. PMID: 33876327Free PMC Article
Case of metastatic glioblastoma with primitive neuronal component to the lung.
Tamai S, Kinoshita M, Sabit H, Furuta T, Miyashita K, Yoshimura K, Homma T, Harada K, Nakada M
Neuropathology 2019 Jun;39(3):218-223. Epub 2019 Apr 25 doi: 10.1111/neup.12553. PMID: 31025405
Glioblastoma with primitive neuronal component: Cytologic findings in intraoperative squash preparations.
Borys E, Prabhu VC, Pambuccian SE
Diagn Cytopathol 2019 Mar;47(3):234-237. Epub 2018 Nov 23 doi: 10.1002/dc.23996. PMID: 30468568

Prognosis

Case of metastatic glioblastoma with primitive neuronal component to the lung.
Tamai S, Kinoshita M, Sabit H, Furuta T, Miyashita K, Yoshimura K, Homma T, Harada K, Nakada M
Neuropathology 2019 Jun;39(3):218-223. Epub 2019 Apr 25 doi: 10.1111/neup.12553. PMID: 31025405

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