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Cervical Yolk Sac Tumor

MedGen UID:
927339
•Concept ID:
C4289807
•
Neoplastic Process
Synonym: Cervical Endodermal Sinus Tumor

Definition

A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Yolk Sac Tumor

Professional guidelines

PubMed

The presentation and management of mandibular tumors in the pediatric population.
Benoit MM, Vargas SO, Bhattacharyya N, McGill TA, Robson CD, Ferraro N, Didas AE, Labow BI, Upton J, Taghinia A, Meara JG, Marcus KJ, Mack J, Rodriguez-Galindo C, Rahbar R
Laryngoscope 2013 Aug;123(8):2035-42. Epub 2013 May 13 doi: 10.1002/lary.24020. PMID: 23670306
Ex-utero intrapartum treatment procedure for giant neck masses--fetal and maternal outcomes.
Lazar DA, Olutoye OO, Moise KJ Jr, Ivey RT, Johnson A, Ayres N, Olutoye OA, Rodriguez MA, Cass DL
J Pediatr Surg 2011 May;46(5):817-22. doi: 10.1016/j.jpedsurg.2011.02.006. PMID: 21616233
Conservative treatment for lower gynecological tract malignancies in children and adolescents: the Institut Gustave-Roussy experience.
Gerbaulet AP, Esche BA, Haie CM, Castaigne D, Flamant F, Chassagne D
Int J Radiat Oncol Biol Phys 1989 Sep;17(3):655-8. doi: 10.1016/0360-3016(89)90119-3. PMID: 2777654

Recent clinical studies

Etiology

First results of the EORTC-SPECTA/Arcagen study exploring the genomics of rare cancers in collaboration with the European reference network EURACAN.
Morfouace M, Stevovic A, Vinches M, Golfinopoulos V, Jin DX, Holmes O, Erlich R, Fayette J, Croce S, Ray-Coquard I, Girard N, Blay JY
ESMO Open 2020 Dec;5(6):e001075. doi: 10.1136/esmoopen-2020-001075. PMID: 33262201Free PMC Article
SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features.
Shah AA, Jain D, Ababneh E, Agaimy A, Hoschar AP, Griffith CC, Magliocca KR, Wenig BM, Rooper LM, Bishop JA
Head Neck Pathol 2020 Jun;14(2):465-472. Epub 2019 Aug 29 doi: 10.1007/s12105-019-01065-7. PMID: 31468350Free PMC Article
Report on malignancies in the German juvenile idiopathic arthritis registry.
Horneff G, Foeldvari I, Minden K, Moebius D, Hospach T
Rheumatology (Oxford) 2011 Jan;50(1):230-6. doi: 10.1093/rheumatology/keq361. PMID: 21148157
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Immunodiagnosis in gynaecologic oncology: possibilities and limitations.
Bolis PF, Franchi M
Eur J Gynaecol Oncol 1984;5(1):45-52. PMID: 6698054

Diagnosis

Ex-utero intrapartum treatment procedure for giant neck masses--fetal and maternal outcomes.
Lazar DA, Olutoye OO, Moise KJ Jr, Ivey RT, Johnson A, Ayres N, Olutoye OA, Rodriguez MA, Cass DL
J Pediatr Surg 2011 May;46(5):817-22. doi: 10.1016/j.jpedsurg.2011.02.006. PMID: 21616233
Report on malignancies in the German juvenile idiopathic arthritis registry.
Horneff G, Foeldvari I, Minden K, Moebius D, Hospach T
Rheumatology (Oxford) 2011 Jan;50(1):230-6. doi: 10.1093/rheumatology/keq361. PMID: 21148157
A congenital true teratoma with cleft lip, palate, and columellar sinus.
Işken T, Alagöz MS, Günlemez A, Unal C, Sen C, Onyedi M, Işil E, Izmirli H, Yücel E
J Craniofac Surg 2007 Sep;18(5):1083-5. doi: 10.1097/scs.0b013e3181572637. PMID: 17912088
Endodermal cyst ventral to the lower brain stem.
Matsunaga S, Fujitsu K, Yagishita S, Ichikawa T, Takemoto Y, Takeda Y, Miyahara K, Niino H, Shiina T
Neurol Med Chir (Tokyo) 2006 Dec;46(12):614-8. doi: 10.2176/nmc.46.614. PMID: 17185890
Endodermal sinus tumor of the vagina and cervix.
Copeland LJ, Sneige N, Ordonez NG, Hancock KC, Gershenson DM, Saul PB, Kavanagh JJ
Cancer 1985 Jun 1;55(11):2558-65. doi: 10.1002/1097-0142(19850601)55:11<2558::aid-cncr2820551107>3.0.co;2-j. PMID: 3888365

Therapy

Nasopharyngeal yolk sac tumors: a rare pediatric occurrence.
Mantle B, Osborne RF
Ear Nose Throat J 2013 Aug;92(8):336-8. doi: 10.1177/014556131309200806. PMID: 23975485
Report on malignancies in the German juvenile idiopathic arthritis registry.
Horneff G, Foeldvari I, Minden K, Moebius D, Hospach T
Rheumatology (Oxford) 2011 Jan;50(1):230-6. doi: 10.1093/rheumatology/keq361. PMID: 21148157
Endodermal sinus tumor of the maxillary sinus.
Westerveld GJ, Quak JJ, Bresters D, Zwaan CM, van der Valk P, Leemans CR
Otolaryngol Head Neck Surg 2001 Jun;124(6):691-2. doi: 10.1177/019459980112400620. PMID: 11391265
Clear cell tumors of the female genital tract.
Matias-Guiu X, Lerma E, Prat J
Semin Diagn Pathol 1997 Nov;14(4):233-9. PMID: 9383823
Endodermal sinus tumor of the vagina and cervix.
Copeland LJ, Sneige N, Ordonez NG, Hancock KC, Gershenson DM, Saul PB, Kavanagh JJ
Cancer 1985 Jun 1;55(11):2558-65. doi: 10.1002/1097-0142(19850601)55:11<2558::aid-cncr2820551107>3.0.co;2-j. PMID: 3888365

Prognosis

Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Ozluk E, Patel S, Coppola D, Ghali G, Cotelingam JD, Kevil CG, Shackelford RE
Anticancer Res 2021 Sep;41(9):4211-4214. Epub 2021 Sep 1 doi: 10.21873/anticanres.15225. PMID: 34475040Free PMC Article
Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst.
Ligthelm LJ, Bunn BK, Raubenheimer EJ, van Heerden WFP
Head Neck 2018 May;40(5):E53-E57. Epub 2018 Feb 23 doi: 10.1002/hed.25117. PMID: 29473257
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Endodermal sinus tumor of the maxillary sinus.
Westerveld GJ, Quak JJ, Bresters D, Zwaan CM, van der Valk P, Leemans CR
Otolaryngol Head Neck Surg 2001 Jun;124(6):691-2. doi: 10.1177/019459980112400620. PMID: 11391265
Endodermal sinus tumor of the vagina and cervix.
Copeland LJ, Sneige N, Ordonez NG, Hancock KC, Gershenson DM, Saul PB, Kavanagh JJ
Cancer 1985 Jun 1;55(11):2558-65. doi: 10.1002/1097-0142(19850601)55:11<2558::aid-cncr2820551107>3.0.co;2-j. PMID: 3888365

Clinical prediction guides

"Somatic-type" malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin.
Magers MJ, Kao CS, Cole CD, Rice KR, Foster RS, Einhorn LH, Ulbright TM
Am J Surg Pathol 2014 Oct;38(10):1396-409. doi: 10.1097/PAS.0000000000000262. PMID: 24921638
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Report on malignancies in the German juvenile idiopathic arthritis registry.
Horneff G, Foeldvari I, Minden K, Moebius D, Hospach T
Rheumatology (Oxford) 2011 Jan;50(1):230-6. doi: 10.1093/rheumatology/keq361. PMID: 21148157
Tumour markers in gynaecologic oncology.
Onsrud M
Scand J Clin Lab Invest Suppl 1991;206:60-70. PMID: 1719611
Anterior mediastinal endodermal sinus (yolk sac) tumor in a female infant.
Gooneratne S, Keh P, Sreekanth S, Recant W, Talerman A
Cancer 1985 Sep 15;56(6):1430-3. doi: 10.1002/1097-0142(19850915)56:6<1430::aid-cncr2820560634>3.0.co;2-u. PMID: 2411378

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