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Cervical Yolk Sac Tumor

MedGen UID:
927339
•Concept ID:
C4289807
•
Neoplastic Process
Synonym: Cervical Endodermal Sinus Tumor

Definition

A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Yolk Sac Tumor

Professional guidelines

PubMed

The presentation and management of mandibular tumors in the pediatric population.
Benoit MM, Vargas SO, Bhattacharyya N, McGill TA, Robson CD, Ferraro N, Didas AE, Labow BI, Upton J, Taghinia A, Meara JG, Marcus KJ, Mack J, Rodriguez-Galindo C, Rahbar R
Laryngoscope 2013 Aug;123(8):2035-42. Epub 2013 May 13 doi: 10.1002/lary.24020. PMID: 23670306
Ex-utero intrapartum treatment procedure for giant neck masses--fetal and maternal outcomes.
Lazar DA, Olutoye OO, Moise KJ Jr, Ivey RT, Johnson A, Ayres N, Olutoye OA, Rodriguez MA, Cass DL
J Pediatr Surg 2011 May;46(5):817-22. doi: 10.1016/j.jpedsurg.2011.02.006. PMID: 21616233
Conservative treatment for lower gynecological tract malignancies in children and adolescents: the Institut Gustave-Roussy experience.
Gerbaulet AP, Esche BA, Haie CM, Castaigne D, Flamant F, Chassagne D
Int J Radiat Oncol Biol Phys 1989 Sep;17(3):655-8. doi: 10.1016/0360-3016(89)90119-3. PMID: 2777654

Recent clinical studies

Etiology

SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features.
Shah AA, Jain D, Ababneh E, Agaimy A, Hoschar AP, Griffith CC, Magliocca KR, Wenig BM, Rooper LM, Bishop JA
Head Neck Pathol 2020 Jun;14(2):465-472. Epub 2019 Aug 29 doi: 10.1007/s12105-019-01065-7. PMID: 31468350Free PMC Article
The presentation and management of mandibular tumors in the pediatric population.
Benoit MM, Vargas SO, Bhattacharyya N, McGill TA, Robson CD, Ferraro N, Didas AE, Labow BI, Upton J, Taghinia A, Meara JG, Marcus KJ, Mack J, Rodriguez-Galindo C, Rahbar R
Laryngoscope 2013 Aug;123(8):2035-42. Epub 2013 May 13 doi: 10.1002/lary.24020. PMID: 23670306
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor.
Golbang P, Khan A, Scurry J, MacIsaac I, Planner R
Gynecol Oncol 1997 Oct;67(1):102-6. doi: 10.1006/gyno.1997.4807. PMID: 9345364
The treatment of advanced or recurrent malignant genitourinary tumors in children.
Green DM
Cancer 1987 Aug 1;60(3 Suppl):602-11. doi: 10.1002/1097-0142(19870801)60:3+<602::aid-cncr2820601527>3.0.co;2-d. PMID: 3036335

Diagnosis

The diverse morphology and immunophenotype of ovarian endometrioid carcinomas.
Talia KL, McCluggage WG
Pathology 2023 Apr;55(3):269-286. Epub 2023 Jan 21 doi: 10.1016/j.pathol.2023.01.003. PMID: 36759286
Yolk Sac Tumor in the Anterior Mediastinum Presenting as Acute Pericarditis.
Aroshidze B, Boyapati L, Pokhrel A, Gotlieb V, Khan A, Erdinc B, Cheema MA
Am J Case Rep 2022 Jan 25;23:e932616. doi: 10.12659/AJCR.932616. PMID: 35077441Free PMC Article
Yolk Sac Tumors of the Head and Neck in Aicardi Syndrome.
Epperson MV, Born HL, Wang D, Myer CM 4th
Ann Otol Rhinol Laryngol 2020 Mar;129(3):301-305. Epub 2019 Oct 22 doi: 10.1177/0003489419883660. PMID: 31640397
Mediastinal yolk sac tumor infiltrating the heart.
Imaniar R, Syahruddin E, Soepandi PZ, Putra AC, Nurwidya F
Exp Oncol 2018 Mar;40(1):82-84. PMID: 29600980
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Therapy

A primary mediastinal germ cell tumor of yolk sac type: case report.
Darif K, Benbrahim Z, Acharfi N, Khacha A, Maaroufi M, Amaadour L, Oualla K, Arifi S, Mellas N
Pan Afr Med J 2021;38:330. Epub 2021 Apr 6 doi: 10.11604/pamj.2021.38.330.23730. PMID: 34285753Free PMC Article
Yolk Sac Tumors of the Head and Neck in Aicardi Syndrome.
Epperson MV, Born HL, Wang D, Myer CM 4th
Ann Otol Rhinol Laryngol 2020 Mar;129(3):301-305. Epub 2019 Oct 22 doi: 10.1177/0003489419883660. PMID: 31640397
Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics.
Hall C, Ritz B, Cockburn M, Davidson TB, Heck JE
Cancer Epidemiol 2017 Feb;46:42-49. Epub 2016 Dec 23 doi: 10.1016/j.canep.2016.12.002. PMID: 28013088Free PMC Article
Parapharyngeal and skull base yolk sac tumor: a case report with lessons in diagnosis and management.
Hauser LJ, Chiang T, Ramakrishnan VR, Lovell MA, Kelley PE
Int J Pediatr Otorhinolaryngol 2014 Nov;78(11):2003-6. Epub 2014 Aug 28 doi: 10.1016/j.ijporl.2014.08.027. PMID: 25200853
The treatment of advanced or recurrent malignant genitourinary tumors in children.
Green DM
Cancer 1987 Aug 1;60(3 Suppl):602-11. doi: 10.1002/1097-0142(19870801)60:3+<602::aid-cncr2820601527>3.0.co;2-d. PMID: 3036335

Prognosis

Yolk Sac Tumor in the Anterior Mediastinum Presenting as Acute Pericarditis.
Aroshidze B, Boyapati L, Pokhrel A, Gotlieb V, Khan A, Erdinc B, Cheema MA
Am J Case Rep 2022 Jan 25;23:e932616. doi: 10.12659/AJCR.932616. PMID: 35077441Free PMC Article
Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options.
Hazir B, Şímșek B, Erdemír A, Gürler F, Yazici O, Kizil Y, Aydíl U
Head Neck Pathol 2022 Jun;16(2):596-601. Epub 2021 Aug 21 doi: 10.1007/s12105-021-01375-9. PMID: 34420180Free PMC Article
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Ozluk E, Patel S, Coppola D, Ghali G, Cotelingam JD, Kevil CG, Shackelford RE
Anticancer Res 2021 Sep;41(9):4211-4214. Epub 2021 Sep 1 doi: 10.21873/anticanres.15225. PMID: 34475040Free PMC Article
Mediastinal yolk sac tumor infiltrating the heart.
Imaniar R, Syahruddin E, Soepandi PZ, Putra AC, Nurwidya F
Exp Oncol 2018 Mar;40(1):82-84. PMID: 29600980
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Clinical prediction guides

Revertant mosaicism for family mutations is not observed in BRCA1/2 phenocopies.
Azzollini J, Pesenti C, Ferrari L, Fontana L, Calvello M, Peissel B, Portera G, Tabano S, Carcangiu ML, Riva P, Miozzo M, Manoukian S
PLoS One 2017;12(2):e0171663. Epub 2017 Feb 15 doi: 10.1371/journal.pone.0171663. PMID: 28199346Free PMC Article
"Somatic-type" malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin.
Magers MJ, Kao CS, Cole CD, Rice KR, Foster RS, Einhorn LH, Ulbright TM
Am J Surg Pathol 2014 Oct;38(10):1396-409. doi: 10.1097/PAS.0000000000000262. PMID: 24921638
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Germ cell tumors of the head and neck: report from the MAKEI Study Group.
Bernbeck B, Schneider DT, Bernbeck B, Koch S, Teske C, Lentrodt J, Harms D, Göbel U, Calaminus G; MAKEI-Study Group
Pediatr Blood Cancer 2009 Feb;52(2):223-6. doi: 10.1002/pbc.21752. PMID: 18937314
Anterior mediastinal endodermal sinus (yolk sac) tumor in a female infant.
Gooneratne S, Keh P, Sreekanth S, Recant W, Talerman A
Cancer 1985 Sep 15;56(6):1430-3. doi: 10.1002/1097-0142(19850915)56:6<1430::aid-cncr2820560634>3.0.co;2-u. PMID: 2411378

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