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Primary Breast Angiosarcoma

MedGen UID:
928936
•Concept ID:
C4303267
•
Neoplastic Process
Synonyms: Primary angiosarcoma of breast; Primary Angiosarcoma of the Breast
SNOMED CT: Primary angiosarcoma of breast (721576006)

Definition

An angiosarcoma that arises from the breast parenchyma and is not associated with radiation exposure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Breast Angiosarcoma

Professional guidelines

PubMed

Clinicopathological analysis and prognostic treatment study of angiosarcoma of the breast: a SEER population-based analysis.
Teng L, Yan S, Du J, Yang R, Xu P, Tao W
World J Surg Oncol 2023 May 9;21(1):144. doi: 10.1186/s12957-023-03030-9. PMID: 37158932Free PMC Article
Management of Localized Breast Angiosarcoma by North American Radiation and Medical Oncologists.
Hatfield J, McClelland S 3rd, Luo J, Degnin C, Chen Y, Maggiore RJ, Mitin T
Clin Breast Cancer 2018 Dec;18(6):498-503. Epub 2018 Sep 29 doi: 10.1016/j.clbc.2018.09.009. PMID: 30482726
Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study.
Yin M, Wang W, Drabick JJ, Harold HA
BMC Cancer 2017 Apr 27;17(1):295. doi: 10.1186/s12885-017-3292-7. PMID: 28449661Free PMC Article

Recent clinical studies

Etiology

Breast Angiosarcoma: Imaging Features With Histopathologic Correlation.
Kapoor MM, Yoon EC, Yang WT, Patel MM
J Breast Imaging 2023 May 22;5(3):329-338. doi: 10.1093/jbi/wbac098. PMID: 38416884
Angiosarcoma in the breast: a population-based cohort from Sweden.
Olander S, Wennstig AK, Garmo H, Holmberg L, Nilsson G, Blomqvist C, Karlsson F, Wickberg Å, Wärnberg F, Sund M, Wadsten C
Br J Surg 2023 Nov 9;110(12):1850-1856. doi: 10.1093/bjs/znad290. PMID: 37708086
Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast.
Li J, Li Y, Wang Y, Li Z, Zhang H, Gao Y, Tan J
Cancer Med 2023 Jun;12(12):13397-13407. Epub 2023 May 4 doi: 10.1002/cam4.6042. PMID: 37143261Free PMC Article
The Role of Imaging in the Diagnosis of Primary and Secondary Breast Angiosarcoma: Twenty-Five-Year Experience of a Provincial Cancer Institution.
Bentley H, Roberts J, Hayes M, Wilson C, Simmons C, Nichol A, Smrke A, Martin T
Clin Breast Cancer 2023 Feb;23(2):e45-e53. Epub 2022 Nov 17 doi: 10.1016/j.clbc.2022.11.003. PMID: 36575102
Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study.
Yin M, Wang W, Drabick JJ, Harold HA
BMC Cancer 2017 Apr 27;17(1):295. doi: 10.1186/s12885-017-3292-7. PMID: 28449661Free PMC Article

Diagnosis

Breast Angiosarcoma: Imaging Features With Histopathologic Correlation.
Kapoor MM, Yoon EC, Yang WT, Patel MM
J Breast Imaging 2023 May 22;5(3):329-338. doi: 10.1093/jbi/wbac098. PMID: 38416884
Angiosarcoma in the breast: a population-based cohort from Sweden.
Olander S, Wennstig AK, Garmo H, Holmberg L, Nilsson G, Blomqvist C, Karlsson F, Wickberg Å, Wärnberg F, Sund M, Wadsten C
Br J Surg 2023 Nov 9;110(12):1850-1856. doi: 10.1093/bjs/znad290. PMID: 37708086
Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast.
Li J, Li Y, Wang Y, Li Z, Zhang H, Gao Y, Tan J
Cancer Med 2023 Jun;12(12):13397-13407. Epub 2023 May 4 doi: 10.1002/cam4.6042. PMID: 37143261Free PMC Article
Primary angiosarcoma of the breast in an early adolescent female.
Lee C, Falkner N, Kamyab R, Li R
BMJ Case Rep 2023 Mar 1;16(3) doi: 10.1136/bcr-2022-254283. PMID: 36858430Free PMC Article
Primary Breast Angiosarcoma: Comparative Transcriptome Analysis.
Rincón-Riveros A, De la Peña J, Rubiano W, Olivella F, Martinez-Agüero M, Villegas VE
Int J Mol Sci 2022 Dec 16;23(24) doi: 10.3390/ijms232416032. PMID: 36555675Free PMC Article

Therapy

Complete Response of a Pleural, Hepatic, and Splenic Metastatic Primary Breast Angiosarcoma Using Gemcitabine Monotherapy.
Bender L, Gantzer J, Somme F, Weingertner N, Kurtz JE
JCO Oncol Pract 2020 Apr;16(4):181-183. Epub 2020 Feb 18 doi: 10.1200/JOP.19.00609. PMID: 32069190
Primary angiosarcoma of the breast: a case report.
Mouhoub M, Miry A, Haloui A, Karich N, Kamaoui I, Benkirane S, Bennani A
Pan Afr Med J 2019;33:134. Epub 2019 Jun 24 doi: 10.11604/pamj.2019.33.134.17414. PMID: 31558933Free PMC Article
A rare case of primary breast angiosarcoma in a male: a case report.
da Silva BB, Eulálio Filho WMN, Costa PVL, Silva RA, Junior AMC, Chagas DC, de Almeida Melo M, Neto FM, Tavares CB, de Sousa Júnior EC, Coelho EG, Campelo V, Gebrim LH, da Silva Junior RG
BMC Cancer 2018 Oct 16;18(1):978. doi: 10.1186/s12885-018-4895-3. PMID: 30326852Free PMC Article
Primary breast angiosarcoma - a single institution experience from a tertiary cancer center in South India.
Lokanatha D, Anand A, Lakshmaiah KC, Govind Babu K, Jacob LA, Suresh Babu MC, Lokesh KN, Rudresha AH, Rajeev LK, Saldanha SC, Giri GV, Koppaka D, Kumar RV
Breast Dis 2018;37(3):133-138. doi: 10.3233/BD-170291. PMID: 29286911
Angiosarcoma of the breast: a difficult surgical challenge.
Hui A, Henderson M, Speakman D, Skandarajah A
Breast 2012 Aug;21(4):584-9. Epub 2012 Feb 3 doi: 10.1016/j.breast.2012.01.001. PMID: 22305554

Prognosis

Clinicopathological analysis and prognostic treatment study of angiosarcoma of the breast: a SEER population-based analysis.
Teng L, Yan S, Du J, Yang R, Xu P, Tao W
World J Surg Oncol 2023 May 9;21(1):144. doi: 10.1186/s12957-023-03030-9. PMID: 37158932Free PMC Article
Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast.
Li J, Li Y, Wang Y, Li Z, Zhang H, Gao Y, Tan J
Cancer Med 2023 Jun;12(12):13397-13407. Epub 2023 May 4 doi: 10.1002/cam4.6042. PMID: 37143261Free PMC Article
Primary Breast Angiosarcoma: Comparative Transcriptome Analysis.
Rincón-Riveros A, De la Peña J, Rubiano W, Olivella F, Martinez-Agüero M, Villegas VE
Int J Mol Sci 2022 Dec 16;23(24) doi: 10.3390/ijms232416032. PMID: 36555675Free PMC Article
Management of Localized Breast Angiosarcoma by North American Radiation and Medical Oncologists.
Hatfield J, McClelland S 3rd, Luo J, Degnin C, Chen Y, Maggiore RJ, Mitin T
Clin Breast Cancer 2018 Dec;18(6):498-503. Epub 2018 Sep 29 doi: 10.1016/j.clbc.2018.09.009. PMID: 30482726
Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study.
Yin M, Wang W, Drabick JJ, Harold HA
BMC Cancer 2017 Apr 27;17(1):295. doi: 10.1186/s12885-017-3292-7. PMID: 28449661Free PMC Article

Clinical prediction guides

Angiosarcoma in the breast: a population-based cohort from Sweden.
Olander S, Wennstig AK, Garmo H, Holmberg L, Nilsson G, Blomqvist C, Karlsson F, Wickberg Å, Wärnberg F, Sund M, Wadsten C
Br J Surg 2023 Nov 9;110(12):1850-1856. doi: 10.1093/bjs/znad290. PMID: 37708086
The Role of Imaging in the Diagnosis of Primary and Secondary Breast Angiosarcoma: Twenty-Five-Year Experience of a Provincial Cancer Institution.
Bentley H, Roberts J, Hayes M, Wilson C, Simmons C, Nichol A, Smrke A, Martin T
Clin Breast Cancer 2023 Feb;23(2):e45-e53. Epub 2022 Nov 17 doi: 10.1016/j.clbc.2022.11.003. PMID: 36575102
Histopathologic Grading Is of Prognostic Significance in Primary Angiosarcoma of Breast: Proposal of a Simplified 2-tier Grading System.
Kuba MG, Dermawan JK, Xu B, Singer S, Plitas G, Tap WD, D'Angelo SP, Rosenbaum E, Brogi E, Antonescu CR
Am J Surg Pathol 2023 Mar 1;47(3):307-317. Epub 2022 Nov 15 doi: 10.1097/PAS.0000000000001998. PMID: 36376999Free PMC Article
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research.
Painter CA, Jain E, Tomson BN, Dunphy M, Stoddard RE, Thomas BS, Damon AL, Shah S, Kim D, Gómez Tejeda Zañudo J, Hornick JL, Chen YL, Merriam P, Raut CP, Demetri GD, Van Tine BA, Lander ES, Golub TR, Wagle N
Nat Med 2020 Feb;26(2):181-187. Epub 2020 Feb 10 doi: 10.1038/s41591-019-0749-z. PMID: 32042194
Primary breast angiosarcoma - a single institution experience from a tertiary cancer center in South India.
Lokanatha D, Anand A, Lakshmaiah KC, Govind Babu K, Jacob LA, Suresh Babu MC, Lokesh KN, Rudresha AH, Rajeev LK, Saldanha SC, Giri GV, Koppaka D, Kumar RV
Breast Dis 2018;37(3):133-138. doi: 10.3233/BD-170291. PMID: 29286911

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