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Cap polyposis

MedGen UID:
929640
•Concept ID:
C4303971
•
Neoplastic Process
Synonyms: Cap inflammatory polyposis; cap polyposis; Eroded polypoid hyperplasia; eroded polypoid hyperplasia; Inflammatory myoglandular polyps; inflammatory myoglandular polyps; Polypoid prolapsing folds; polypoid prolapsing folds
SNOMED CT: Cap polyposis (720604008); Cap inflammatory polyposis (720604008); Polypoid prolapsing folds (720604008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015565
Orphanet: ORPHA160148

Definition

Cap polyposis (CP) is characterised by multiple inflammatory polyps that predominantly affect the rectosigmoid area and manifest primarily as rectal bleeding with abnormal transit, constipation or diarrhoea. To date, around 67 cases have been described in the world literature. The aetiology of CP is still unclear but some causes such as lower colonic mucosal prolapse, mucosal ischaemia, inflammation, abnormal colonic motility, repeated trauma to the colonic mucosa caused by straining, infection and immune disorders have been proposed. CP is not a premalignant condition. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCap polyposis

Professional guidelines

PubMed

Genotype-Phenotype Correlations in Autosomal Dominant and Recessive APC Mutation-Negative Colorectal Adenomatous Polyposis.
Zhu LH, Dong J, Li WL, Kou ZY, Yang J
Dig Dis Sci 2023 Jul;68(7):2799-2810. Epub 2023 Mar 2 doi: 10.1007/s10620-023-07890-9. PMID: 36862359Free PMC Article
Endoscopic mucosal resection for cap poliposis treatment.
Monsalve Alonso S, Miranda García P, Santander Vaquero C
Rev Esp Enferm Dig 2020 Feb;112(2):155. doi: 10.17235/reed.2020.6537/2019. PMID: 31960689

Recent clinical studies

Etiology

Cap polyposis: a rare cause of rectal bleeding in children.
Li JH, Leong MY, Phua KB, Low Y, Kader A, Logarajah V, Ong LY, Chua JH, Ong C
World J Gastroenterol 2013 Jul 14;19(26):4185-91. doi: 10.3748/wjg.v19.i26.4185. PMID: 23864782Free PMC Article
Nine-year follow-up from onset to spontaneous complete remission of cap polyposis.
Sasaki Y, Takeda H, Fujishima S, Sato T, Nishise S, Abe Y, Ajioka Y, Kawata S, Ueno Y
Intern Med 2013;52(3):351-4. Epub 2013 Feb 1 doi: 10.2169/internalmedicine.52.8536. PMID: 23370743
Long-term outcome of cap polyposis, with special reference to the effects of steroid therapy.
Chang HS, Yang SK, Kim MJ, Ye BD, Byeon JS, Myung SJ, Kim JH
Gastrointest Endosc 2012 Jan;75(1):211-6. Epub 2011 Nov 10 doi: 10.1016/j.gie.2011.08.027. PMID: 22078102
Cap polyposis: further experience and review.
Ng KH, Mathur P, Kumarasinghe MP, Eu KW, Seow-Choen F
Dis Colon Rectum 2004 Jul;47(7):1208-15. Epub 2004 Jun 3 doi: 10.1007/s10350-004-0561-8. PMID: 15164251
Features of cap polyposis by magnifying colonoscopy.
Kajihara H, Uno Y, Ying H, Tanaka M, Munakata A
Gastrointest Endosc 2000 Dec;52(6):775-8. doi: 10.1067/mge.2000.109874. PMID: 11115917

Diagnosis

Cap Polyposis: A Case Report.
Khadka T, Giri GK, Sherpa P, Shrestha N, Poudyal S
JNMA J Nepal Med Assoc 2023 Jun 1;61(262):555-558. doi: 10.31729/jnma.8177. PMID: 37464856Free PMC Article
Cap Polyposis.
Wang X, Ding Y, Li H, Huang WF
Dig Liver Dis 2023 Sep;55(9):1295-1296. Epub 2023 Jul 14 doi: 10.1016/j.dld.2023.07.003. PMID: 37455157
Endoscopic mucosal resection for cap poliposis treatment.
Monsalve Alonso S, Miranda García P, Santander Vaquero C
Rev Esp Enferm Dig 2020 Feb;112(2):155. doi: 10.17235/reed.2020.6537/2019. PMID: 31960689
Cap polyposis in children: case report and literature review.
Brunner M, Agaimy A, Atreya R, Grützmann R, Matzel KE
Int J Colorectal Dis 2019 Feb;34(2):363-368. Epub 2018 Nov 13 doi: 10.1007/s00384-018-3192-6. PMID: 30426196
Cap polyposis mistaken for Crohn's disease: case report and review of literature.
Kini GP, Murray I, Champion-Young J, Lau M, Katta V, Thorn M, Schultz MP
J Crohns Colitis 2013 Apr;7(3):e108-11. Epub 2012 Jul 4 doi: 10.1016/j.crohns.2012.06.005. PMID: 22766527

Therapy

Dysbiosis-Associated Polyposis of the Colon-Cap Polyposis.
Okamoto K, Watanabe T, Komeda Y, Okamoto A, Minaga K, Kamata K, Yamao K, Takenaka M, Hagiwara S, Sakurai T, Tanaka T, Sakamoto H, Fujimoto K, Nishida N, Kudo M
Front Immunol 2018;9:918. Epub 2018 May 7 doi: 10.3389/fimmu.2018.00918. PMID: 29867933Free PMC Article
A Case of Cap Polyposis with Epidermal Nevus in an Infant.
Kim SC, Kang MJ, Jeong YJ, Hwang PH
J Korean Med Sci 2017 May;32(5):880-884. doi: 10.3346/jkms.2017.32.5.880. PMID: 28378565Free PMC Article
A case of cap polyposis remission by betamethasone enema after antibiotics therapy including Helicobacter pylori eradication.
Suzuki H, Sato M, Akutsu D, Sugiyama H, Sato T, Mizokami Y
J Gastrointestin Liver Dis 2014 Jun;23(2):203-6. doi: 10.15403/jgld.2014.1121.232.hs1. PMID: 24949613
Cap polyposis: a rare cause of rectal bleeding in children.
Li JH, Leong MY, Phua KB, Low Y, Kader A, Logarajah V, Ong LY, Chua JH, Ong C
World J Gastroenterol 2013 Jul 14;19(26):4185-91. doi: 10.3748/wjg.v19.i26.4185. PMID: 23864782Free PMC Article
Cap polyposis (CP) which relapsed after remission by avoiding straining at defecation, and was cured by Helicobacter pylori eradication therapy.
Nakagawa Y, Nagai T, Okawara H, Nakashima H, Tasaki T, Soma W, Hisamatsu A, Watada M, Murakami K, Fujioka T
Intern Med 2009;48(23):2009-13. Epub 2009 Dec 1 doi: 10.2169/internalmedicine.48.2547. PMID: 19952483

Prognosis

Endoscopic mucosal resection for cap poliposis treatment.
Monsalve Alonso S, Miranda García P, Santander Vaquero C
Rev Esp Enferm Dig 2020 Feb;112(2):155. doi: 10.17235/reed.2020.6537/2019. PMID: 31960689
Cap polyposis: a rare cause of rectal bleeding in children.
Li JH, Leong MY, Phua KB, Low Y, Kader A, Logarajah V, Ong LY, Chua JH, Ong C
World J Gastroenterol 2013 Jul 14;19(26):4185-91. doi: 10.3748/wjg.v19.i26.4185. PMID: 23864782Free PMC Article
Long-term outcome of cap polyposis, with special reference to the effects of steroid therapy.
Chang HS, Yang SK, Kim MJ, Ye BD, Byeon JS, Myung SJ, Kim JH
Gastrointest Endosc 2012 Jan;75(1):211-6. Epub 2011 Nov 10 doi: 10.1016/j.gie.2011.08.027. PMID: 22078102
Unusual colon polyps. Diagnosis: Cap polyposis.
da Cunha Araújo RN, Castanheira A, Silva A
Gastroenterology 2011 Oct;141(4):e1-2. Epub 2011 Aug 29 doi: 10.1053/j.gastro.2010.07.066. PMID: 21878333
Cap polyposis: further experience and review.
Ng KH, Mathur P, Kumarasinghe MP, Eu KW, Seow-Choen F
Dis Colon Rectum 2004 Jul;47(7):1208-15. Epub 2004 Jun 3 doi: 10.1007/s10350-004-0561-8. PMID: 15164251

Clinical prediction guides

Dysbiosis-Associated Polyposis of the Colon-Cap Polyposis.
Okamoto K, Watanabe T, Komeda Y, Okamoto A, Minaga K, Kamata K, Yamao K, Takenaka M, Hagiwara S, Sakurai T, Tanaka T, Sakamoto H, Fujimoto K, Nishida N, Kudo M
Front Immunol 2018;9:918. Epub 2018 May 7 doi: 10.3389/fimmu.2018.00918. PMID: 29867933Free PMC Article
A case of cap polyposis remission by betamethasone enema after antibiotics therapy including Helicobacter pylori eradication.
Suzuki H, Sato M, Akutsu D, Sugiyama H, Sato T, Mizokami Y
J Gastrointestin Liver Dis 2014 Jun;23(2):203-6. doi: 10.15403/jgld.2014.1121.232.hs1. PMID: 24949613
Possible relationship between Helicobacter pylori infection and cap polyposis of the colon.
Akamatsu T, Nakamura N, Kawamura Y, Shinji A, Tateiwa N, Ochi Y, Katsuyama T, Kiyosawa K
Helicobacter 2004 Dec;9(6):651-6. doi: 10.1111/j.1083-4389.2004.00273.x. PMID: 15610079
Cap polyposis of the colon and rectum: an analysis of endoscopic findings.
Esaki M, Matsumoto T, Kobayashi H, Yao T, Nakamura S, Mizuno M, Iida M, Fujishima M
Endoscopy 2001 Mar;33(3):262-6. doi: 10.1055/s-2001-12797. PMID: 11293761
Abnormal mucus in cap polyposis.
Buisine MP, Colombel JF, Lecomte-Houcke M, Gower P, Aubert JP, Porchet N, Janin A
Gut 1998 Jan;42(1):135-8. doi: 10.1136/gut.42.1.135. PMID: 9518233Free PMC Article

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