U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gastroenteritis

MedGen UID:
8967
Concept ID:
C0017160
Disease or Syndrome
Synonyms: Gastroenteritides; Gastroenteritis
SNOMED CT: Gastroenteritis (25374005); Inflammation of stomach and intestine (25374005); GE - Gastroenteritis (25374005)
 
Monarch Initiative: MONDO:0002269

Definition

An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVgastroenteritis

Professional guidelines

PubMed

Szajewska H, Berni Canani R, Domellöf M, Guarino A, Hojsak I, Indrio F, Lo Vecchio A, Mihatsch WA, Mosca A, Orel R, Salvatore S, Shamir R, van den Akker CHP, van Goudoever JB, Vandenplas Y, Weizman Z; ESPGHAN Special Interest Group on Gut Microbiota and Modifications
J Pediatr Gastroenterol Nutr 2023 Feb 1;76(2):232-247. Epub 2022 Oct 11 doi: 10.1097/MPG.0000000000003633. PMID: 36219218
Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS
Clin Gastroenterol Hepatol 2022 Nov;20(11):2474-2484.e3. Epub 2022 Feb 16 doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570Free PMC Article
Brandt KG, Castro Antunes MM, Silva GA
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S36-43. Epub 2015 Sep 6 doi: 10.1016/j.jped.2015.06.002. PMID: 26351768

Recent clinical studies

Etiology

Guarino A, Aguilar J, Berkley J, Broekaert I, Vazquez-Frias R, Holtz L, Lo Vecchio A, Meskini T, Moore S, Rivera Medina JF, Sandhu B, Smarrazzo A, Szajewska H, Treepongkaruna S
J Pediatr Gastroenterol Nutr 2020 May;70(5):694-701. doi: 10.1097/MPG.0000000000002669. PMID: 32079974Free PMC Article
de Graaf M, Villabruna N, Koopmans MP
Curr Opin Virol 2017 Feb;22:64-70. Epub 2017 Jan 2 doi: 10.1016/j.coviro.2016.11.008. PMID: 28056379
Esona MD, Gautam R
Clin Lab Med 2015 Jun;35(2):363-91. doi: 10.1016/j.cll.2015.02.012. PMID: 26004648
Ahmed SM, Hall AJ, Robinson AE, Verhoef L, Premkumar P, Parashar UD, Koopmans M, Lopman BA
Lancet Infect Dis 2014 Aug;14(8):725-730. Epub 2014 Jun 26 doi: 10.1016/S1473-3099(14)70767-4. PMID: 24981041Free PMC Article
Pigott DC
Emerg Med Clin North Am 2008 May;26(2):475-97, x. doi: 10.1016/j.emc.2008.01.009. PMID: 18406984

Diagnosis

Meier JL
Gastroenterol Clin North Am 2021 Jun;50(2):305-322. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.003. PMID: 34024443
Fleckenstein JM, Matthew Kuhlmann F, Sheikh A
Gastroenterol Clin North Am 2021 Jun;50(2):283-304. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.002. PMID: 34024442Free PMC Article
Brady K
Pediatr Emerg Med Pract 2018 Feb;15(2):1-24. Epub 2018 Feb 1 PMID: 29369591
Zollner-Schwetz I, Krause R
Clin Microbiol Infect 2015 Aug;21(8):744-9. Epub 2015 Mar 11 doi: 10.1016/j.cmi.2015.03.002. PMID: 25769427
Graves NS
Prim Care 2013 Sep;40(3):727-41. Epub 2013 Jul 19 doi: 10.1016/j.pop.2013.05.006. PMID: 23958366Free PMC Article

Therapy

Winder N, Gohar S, Muthana M
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122811. PMID: 36560815Free PMC Article
Li Q, Zhou Q, Florez ID, Mathew JL, Shang L, Zhang G, Tian X, Fu Z, Liu E, Luo Z, Chen Y
JAMA Pediatr 2022 Dec 1;176(12):1199-1207. doi: 10.1001/jamapediatrics.2022.4123. PMID: 36374480Free PMC Article
Hirano I, Furuta GT
Gastroenterology 2020 Mar;158(4):840-851. Epub 2019 Dec 10 doi: 10.1053/j.gastro.2019.09.052. PMID: 31836530Free PMC Article
Suez J, Zmora N, Segal E, Elinav E
Nat Med 2019 May;25(5):716-729. Epub 2019 May 6 doi: 10.1038/s41591-019-0439-x. PMID: 31061539
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571

Prognosis

Shamkhali Chenar S, Deng Z
Int J Environ Health Res 2017 Feb;27(1):40-51. Epub 2016 Nov 23 doi: 10.1080/09603123.2016.1257705. PMID: 27876423
Rose MA
Hum Vaccin Immunother 2014;10(7):2112-4. doi: 10.4161/hv.29605. PMID: 25424826Free PMC Article
Dalby-Payne JR, Elliott EJ
BMJ Clin Evid 2011 Jul 26;2011 PMID: 21791124Free PMC Article
Dalby-Payne JR, Elliott EJ
BMJ Clin Evid 2009 Sep 23;2009 PMID: 21726481Free PMC Article
Mitchell DK
Pediatr Infect Dis J 2002 Nov;21(11):1067-9. doi: 10.1097/00006454-200211000-00018. PMID: 12442031

Clinical prediction guides

Guarino A, Aguilar J, Berkley J, Broekaert I, Vazquez-Frias R, Holtz L, Lo Vecchio A, Meskini T, Moore S, Rivera Medina JF, Sandhu B, Smarrazzo A, Szajewska H, Treepongkaruna S
J Pediatr Gastroenterol Nutr 2020 May;70(5):694-701. doi: 10.1097/MPG.0000000000002669. PMID: 32079974Free PMC Article
Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean JM, O'Connell KJ, Mahajan P, Levine AC, Bhatt SR, Roskind CG, Powell EC, Rogers AJ, Vance C, Sapien RE, Olsen CS, Metheney M, Dickey VP, Hall-Moore C, Freedman SB
N Engl J Med 2018 Nov 22;379(21):2002-2014. doi: 10.1056/NEJMoa1802598. PMID: 30462938Free PMC Article
Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; European Society for Pediatric Infectious Diseases
J Pediatr Gastroenterol Nutr 2014 Jul;59(1):132-52. doi: 10.1097/MPG.0000000000000375. PMID: 24739189
Dalby-Payne JR, Elliott EJ
BMJ Clin Evid 2011 Jul 26;2011 PMID: 21791124Free PMC Article
Bernstein DI
Pediatr Infect Dis J 2009 Mar;28(3 Suppl):S50-3. doi: 10.1097/INF.0b013e3181967bee. PMID: 19252423

Recent systematic reviews

Li Q, Zhou Q, Florez ID, Mathew JL, Shang L, Zhang G, Tian X, Fu Z, Liu E, Luo Z, Chen Y
JAMA Pediatr 2022 Dec 1;176(12):1199-1207. doi: 10.1001/jamapediatrics.2022.4123. PMID: 36374480Free PMC Article
Niño-Serna LF, Acosta-Reyes J, Veroniki AA, Florez ID
Pediatrics 2020 Apr;145(4) Epub 2020 Mar 4 doi: 10.1542/peds.2019-3260. PMID: 32132152
Puckrin R, Saltiel MP, Reynier P, Azoulay L, Yu OHY, Filion KB
Acta Diabetol 2018 May;55(5):503-514. Epub 2018 Feb 27 doi: 10.1007/s00592-018-1116-0. PMID: 29484489
Ahmed SM, Hall AJ, Robinson AE, Verhoef L, Premkumar P, Parashar UD, Koopmans M, Lopman BA
Lancet Infect Dis 2014 Aug;14(8):725-730. Epub 2014 Jun 26 doi: 10.1016/S1473-3099(14)70767-4. PMID: 24981041Free PMC Article
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...