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gastroenteritis

MedGen UID:
8967
Concept ID:
C0017160
Disease or Syndrome
Synonyms: Gastroenteritides; Gastroenteritis
SNOMED CT: Gastroenteritis (25374005); Inflammation of stomach and intestine (25374005); GE - Gastroenteritis (25374005)
 
Monarch Initiative: MONDO:0002269

Definition

An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVgastroenteritis

Professional guidelines

PubMed

Szajewska H, Berni Canani R, Domellöf M, Guarino A, Hojsak I, Indrio F, Lo Vecchio A, Mihatsch WA, Mosca A, Orel R, Salvatore S, Shamir R, van den Akker CHP, van Goudoever JB, Vandenplas Y, Weizman Z; ESPGHAN Special Interest Group on Gut Microbiota and Modifications
J Pediatr Gastroenterol Nutr 2023 Feb 1;76(2):232-247. Epub 2022 Oct 11 doi: 10.1097/MPG.0000000000003633. PMID: 36219218
Brady K
Pediatr Emerg Med Pract 2018 Feb;15(2):1-24. Epub 2018 Feb 1 PMID: 29369591
Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; European Society for Pediatric Infectious Diseases
J Pediatr Gastroenterol Nutr 2014 Jul;59(1):132-52. doi: 10.1097/MPG.0000000000000375. PMID: 24739189

Recent clinical studies

Etiology

Non LR, Ince D
Gastroenterol Clin North Am 2021 Jun;50(2):415-430. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.013. PMID: 34024449
Guarino A, Aguilar J, Berkley J, Broekaert I, Vazquez-Frias R, Holtz L, Lo Vecchio A, Meskini T, Moore S, Rivera Medina JF, Sandhu B, Smarrazzo A, Szajewska H, Treepongkaruna S
J Pediatr Gastroenterol Nutr 2020 May;70(5):694-701. doi: 10.1097/MPG.0000000000002669. PMID: 32079974Free PMC Article
Esona MD, Gautam R
Clin Lab Med 2015 Jun;35(2):363-91. doi: 10.1016/j.cll.2015.02.012. PMID: 26004648
Daneshjoo R, J Talley N
Curr Gastroenterol Rep 2002 Oct;4(5):366-72. doi: 10.1007/s11894-002-0006-2. PMID: 12228038
Christensen ML
Clin Microbiol Rev 1989 Jan;2(1):51-89. doi: 10.1128/CMR.2.1.51. PMID: 2644024Free PMC Article

Diagnosis

Meier JL
Gastroenterol Clin North Am 2021 Jun;50(2):305-322. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.003. PMID: 34024443
Fleckenstein JM, Matthew Kuhlmann F, Sheikh A
Gastroenterol Clin North Am 2021 Jun;50(2):283-304. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.002. PMID: 34024442Free PMC Article
Brady K
Pediatr Emerg Med Pract 2018 Feb;15(2):1-24. Epub 2018 Feb 1 PMID: 29369591
Zollner-Schwetz I, Krause R
Clin Microbiol Infect 2015 Aug;21(8):744-9. Epub 2015 Mar 11 doi: 10.1016/j.cmi.2015.03.002. PMID: 25769427
Graves NS
Prim Care 2013 Sep;40(3):727-41. Epub 2013 Jul 19 doi: 10.1016/j.pop.2013.05.006. PMID: 23958366Free PMC Article

Therapy

Winder N, Gohar S, Muthana M
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122811. PMID: 36560815Free PMC Article
Li Q, Zhou Q, Florez ID, Mathew JL, Shang L, Zhang G, Tian X, Fu Z, Liu E, Luo Z, Chen Y
JAMA Pediatr 2022 Dec 1;176(12):1199-1207. doi: 10.1001/jamapediatrics.2022.4123. PMID: 36374480Free PMC Article
Hirano I, Furuta GT
Gastroenterology 2020 Mar;158(4):840-851. Epub 2019 Dec 10 doi: 10.1053/j.gastro.2019.09.052. PMID: 31836530Free PMC Article
Suez J, Zmora N, Segal E, Elinav E
Nat Med 2019 May;25(5):716-729. Epub 2019 May 6 doi: 10.1038/s41591-019-0439-x. PMID: 31061539
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571

Prognosis

Brumfield KD, Usmani M, Chen KM, Gangwar M, Jutla AS, Huq A, Colwell RR
Environ Microbiol 2021 Dec;23(12):7314-7340. Epub 2021 Aug 25 doi: 10.1111/1462-2920.15716. PMID: 34390611
Shamkhali Chenar S, Deng Z
Int J Environ Health Res 2017 Feb;27(1):40-51. Epub 2016 Nov 23 doi: 10.1080/09603123.2016.1257705. PMID: 27876423
Dalby-Payne JR, Elliott EJ
BMJ Clin Evid 2011 Jul 26;2011 PMID: 21791124Free PMC Article
Dalby-Payne JR, Elliott EJ
BMJ Clin Evid 2009 Sep 23;2009 PMID: 21726481Free PMC Article
Wyndham CH, Fellingham SA
S Afr Med J 1978 Jun 24;53(26):1051-61. PMID: 694679

Clinical prediction guides

Freedman SB, Finkelstein Y, Pang XL, Chui L, Tarr PI, VanBuren JM, Olsen C, Lee BE, Hall-Moore CA, Sapien R, O'Connell K, Levine AC, Poonai N, Roskind C, Schuh S, Rogers A, Bhatt S, Gouin S, Mahajan P, Vance C, Hurley K, Powell EC, Farion KJ, Schnadower D
Clin Infect Dis 2022 Aug 24;75(1):55-64. doi: 10.1093/cid/ciab876. PMID: 34596225Free PMC Article
Guarino A, Aguilar J, Berkley J, Broekaert I, Vazquez-Frias R, Holtz L, Lo Vecchio A, Meskini T, Moore S, Rivera Medina JF, Sandhu B, Smarrazzo A, Szajewska H, Treepongkaruna S
J Pediatr Gastroenterol Nutr 2020 May;70(5):694-701. doi: 10.1097/MPG.0000000000002669. PMID: 32079974Free PMC Article
Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean JM, O'Connell KJ, Mahajan P, Levine AC, Bhatt SR, Roskind CG, Powell EC, Rogers AJ, Vance C, Sapien RE, Olsen CS, Metheney M, Dickey VP, Hall-Moore C, Freedman SB
N Engl J Med 2018 Nov 22;379(21):2002-2014. doi: 10.1056/NEJMoa1802598. PMID: 30462938Free PMC Article
Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; European Society for Pediatric Infectious Diseases
J Pediatr Gastroenterol Nutr 2014 Jul;59(1):132-52. doi: 10.1097/MPG.0000000000000375. PMID: 24739189
Bernstein DI
Pediatr Infect Dis J 2009 Mar;28(3 Suppl):S50-3. doi: 10.1097/INF.0b013e3181967bee. PMID: 19252423

Recent systematic reviews

Visaggi P, Ghisa M, Barberio B, Maniero D, Greco E, Savarino V, Black CJ, Ford AC, de Bortoli N, Savarino E
Dig Liver Dis 2023 Feb;55(2):208-222. Epub 2022 May 30 doi: 10.1016/j.dld.2022.05.004. PMID: 35654734
Li Q, Zhou Q, Florez ID, Mathew JL, Shang L, Zhang G, Tian X, Fu Z, Liu E, Luo Z, Chen Y
JAMA Pediatr 2022 Dec 1;176(12):1199-1207. doi: 10.1001/jamapediatrics.2022.4123. PMID: 36374480Free PMC Article
Zia JK, Lenhart A, Yang PL, Heitkemper MM, Baker J, Keefer L, Saps M, Cuff C, Hungria G, Videlock EJ, Chang L
Gastroenterology 2022 Oct;163(4):995-1023.e3. Epub 2022 Jun 16 doi: 10.1053/j.gastro.2022.06.028. PMID: 35716771Free PMC Article
Niño-Serna LF, Acosta-Reyes J, Veroniki AA, Florez ID
Pediatrics 2020 Apr;145(4) Epub 2020 Mar 4 doi: 10.1542/peds.2019-3260. PMID: 32132152
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571

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