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Malignant Melanoma in Precancerous Melanosis

MedGen UID:
96555
•Concept ID:
C0431098
•
Neoplastic Process
Synonyms: Malignant melanoma in melanosis; Malignant melanoma in precancerous melanosis
SNOMED CT: Malignant melanoma in melanosis (18450009); Malignant melanoma in precancerous melanosis (18450009)

Definition

A melanoma arising from an atypical intraepithelial melanocytic hyperplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Melanoma in Precancerous Melanosis

Professional guidelines

PubMed

Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Histological criteria for grading of atypia in melanocytic conjunctival lesions.
Maly A, Epstein D, Meir K, Pe'er J
Pathology 2008 Dec;40(7):676-81. doi: 10.1080/00313020802436428. PMID: 18985522
Congenital melanocytic nevi: treatment modalities and management options.
Marghoob AA, Borrego JP, Halpern AC
Semin Cutan Med Surg 2003 Mar;22(1):21-32. doi: 10.1053/sder.2003.50002. PMID: 12773011

Recent clinical studies

Etiology

Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Lentiginous melanoma.
King R
Arch Pathol Lab Med 2011 Mar;135(3):337-41. doi: 10.5858/2009-0538-RA.1. PMID: 21366457
Histological criteria for grading of atypia in melanocytic conjunctival lesions.
Maly A, Epstein D, Meir K, Pe'er J
Pathology 2008 Dec;40(7):676-81. doi: 10.1080/00313020802436428. PMID: 18985522
Dysplastic melanocytic nevi: a reproducible histologic definition emphasizing cellular morphology.
Rhodes AR, Mihm MC Jr, Weinstock MA
Mod Pathol 1989 Jul;2(4):306-19. PMID: 2762287

Diagnosis

Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Vulvar Neoplasms, Benign and Malignant.
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Hairy nevus spilus: a case series.
Singh S, Jain N, Khanna N, Ahuja A, Singh M
Pediatr Dermatol 2013 Jan-Feb;30(1):100-4. Epub 2012 Feb 3 doi: 10.1111/j.1525-1470.2011.01688.x. PMID: 22299593
Lentiginous melanoma.
King R
Arch Pathol Lab Med 2011 Mar;135(3):337-41. doi: 10.5858/2009-0538-RA.1. PMID: 21366457

Therapy

Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Senile lentigo--cosmetic or medical issue of the elderly population.
Situm M, Bulat V, Buljan M, Puljiz Z, Situm V, Bolanca Z
Coll Antropol 2010 Apr;34 Suppl 2:85-8. PMID: 21302707
Histological criteria for grading of atypia in melanocytic conjunctival lesions.
Maly A, Epstein D, Meir K, Pe'er J
Pathology 2008 Dec;40(7):676-81. doi: 10.1080/00313020802436428. PMID: 18985522
Atypical junctional melanocytic proliferations in benign lichenoid keratosis.
Dalton SR, Fillman EP, Altman CE, Gardner TL, Davis TL, Bastian BC, Libow LF, Elston DM
Hum Pathol 2003 Jul;34(7):706-9. doi: 10.1016/s0046-8177(03)00234-x. PMID: 12874767
External ocular pigmentation.
Henkind P, Friedman AH
Int Ophthalmol Clin 1971 Fall;11(3):87-111. PMID: 5152658

Prognosis

Treatment of Digital Melanonychia with Atypia.
Lans J, van Leeuwen W, Jupiter JB, Eberlin KR
Plast Reconstr Surg 2018 Aug;142(2):439-445. doi: 10.1097/PRS.0000000000004579. PMID: 29933293
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
Histological criteria for grading of atypia in melanocytic conjunctival lesions.
Maly A, Epstein D, Meir K, Pe'er J
Pathology 2008 Dec;40(7):676-81. doi: 10.1080/00313020802436428. PMID: 18985522
Conjunctival melanosis and melanoma.
Folberg R, McLean IW, Zimmerman LE
Ophthalmology 1984 Jun;91(6):673-8. doi: 10.1016/s0161-6420(84)34245-2. PMID: 6462625
Conjunctival melanoma.
Jakobiec FA
Arch Ophthalmol 1980 Aug;98(8):1378-84. doi: 10.1001/archopht.1980.01020040230003. PMID: 6998439

Clinical prediction guides

The Evaluation of the Malignant Characteristics of Conjunctival Lesions Based on the Dermatoscopic Algorithm.
DĘbicka-Kumela M, Romanowska-Dixon B, Karska-Basta I, Kowal J, Markiewicz A
Anticancer Res 2021 Feb;41(2):895-903. doi: 10.21873/anticanres.14842. PMID: 33517295
Unstable solar lentigo: A defined separate entity.
Byrom L, Barksdale S, Weedon D, Muir J
Australas J Dermatol 2016 Aug;57(3):229-34. Epub 2016 Feb 2 doi: 10.1111/ajd.12447. PMID: 26832231
Ophthalmic pterygium: a stem cell disorder with premalignant features.
Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D, Di Girolamo N
Am J Pathol 2011 Feb;178(2):817-27. doi: 10.1016/j.ajpath.2010.10.037. PMID: 21281814Free PMC Article
Histological criteria for grading of atypia in melanocytic conjunctival lesions.
Maly A, Epstein D, Meir K, Pe'er J
Pathology 2008 Dec;40(7):676-81. doi: 10.1080/00313020802436428. PMID: 18985522
Conjunctival melanosis and melanoma.
Folberg R, McLean IW, Zimmerman LE
Ophthalmology 1984 Jun;91(6):673-8. doi: 10.1016/s0161-6420(84)34245-2. PMID: 6462625

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