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Anaplastic oligoastrocytoma

MedGen UID:
96556
•Concept ID:
C0431108
•
Neoplastic Process
Synonyms: aMOA; Anaplastic Mixed Glioma; anaplastic mixed glioma; Anaplastic Oligoastrocytoma; anaplastic oligoastrocytoma; Anaplastic Oligoastrocytoma, NOS; Anaplastic Oligoastrocytoma, Not Otherwise Specified; AOAST; WHO Grade 3 Mixed Glioma; WHO Grade III Mixed Glioma; WHO grade III mixed glioma
SNOMED CT: Anaplastic oligoastrocytoma (253072003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016703
Orphanet: ORPHA251663

Definition

A rare and aggressive glial tumor of the central nervous system, that usually presents in adults with seizures, is most often located in the cerebral hemispheres and that is associated with a very poor prognosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic oligoastrocytoma
Follow this link to review classifications for Anaplastic oligoastrocytoma in Orphanet.

Professional guidelines

PubMed

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas.
Levin VA, Ictech SE, Hess KR
CNS Oncol 2018 Apr;7(2):CNS16. Epub 2018 Jan 30 doi: 10.2217/cns-2017-0031. PMID: 29378419Free PMC Article
Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Treatment updates regarding anaplastic oligodendroglioma and anaplastic oligoastrocytoma.
Khan KA, Abbasi AN, Ali N
J Coll Physicians Surg Pak 2014 Dec;24(12):935-9. PMID: 25523732

Recent clinical studies

Etiology

WHO 2016 Classification of gliomas.
Wesseling P, Capper D
Neuropathol Appl Neurobiol 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. PMID: 28815663
Treatment Outcomes in 1p19q Co-deleted/Partially Deleted Gliomas.
McNamara MG, Jiang H, Lim-Fat MJ, Sahebjam S, Kiehl TR, Karamchandani J, Coire C, Chung C, Millar BA, Laperriere N, Mason WP
Can J Neurol Sci 2017 May;44(3):288-294. doi: 10.1017/cjn.2016.420. PMID: 28488951
Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Diagnosis

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.
Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM
Lancet Child Adolesc Health 2023 Jul;7(7):471-478. Epub 2023 Mar 30 doi: 10.1016/S2352-4642(23)00031-7. PMID: 37004712
WHO 2016 Classification of gliomas.
Wesseling P, Capper D
Neuropathol Appl Neurobiol 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. PMID: 28815663
Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Therapy

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.
Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM
Lancet Child Adolesc Health 2023 Jul;7(7):471-478. Epub 2023 Mar 30 doi: 10.1016/S2352-4642(23)00031-7. PMID: 37004712
Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas.
Levin VA, Ictech SE, Hess KR
CNS Oncol 2018 Apr;7(2):CNS16. Epub 2018 Jan 30 doi: 10.2217/cns-2017-0031. PMID: 29378419Free PMC Article
Treatment updates regarding anaplastic oligodendroglioma and anaplastic oligoastrocytoma.
Khan KA, Abbasi AN, Ali N
J Coll Physicians Surg Pak 2014 Dec;24(12):935-9. PMID: 25523732
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M
J Clin Oncol 2013 Jan 20;31(3):337-43. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2674. PMID: 23071247Free PMC Article
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Prognosis

Treatment Outcomes in 1p19q Co-deleted/Partially Deleted Gliomas.
McNamara MG, Jiang H, Lim-Fat MJ, Sahebjam S, Kiehl TR, Karamchandani J, Coire C, Chung C, Millar BA, Laperriere N, Mason WP
Can J Neurol Sci 2017 May;44(3):288-294. doi: 10.1017/cjn.2016.420. PMID: 28488951
Treatment updates regarding anaplastic oligodendroglioma and anaplastic oligoastrocytoma.
Khan KA, Abbasi AN, Ali N
J Coll Physicians Surg Pak 2014 Dec;24(12):935-9. PMID: 25523732
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade.
Buckner JC, O'Fallon JR, Dinapoli RP, Schomberg PJ, Farr G, Schaefer P, Giannini C, Scheithauer BW, Ballman KV
J Neurooncol 2007 Sep;84(3):279-86. Epub 2007 Apr 13 doi: 10.1007/s11060-007-9370-y. PMID: 17431544
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Clinical prediction guides

SEOM clinical guidelines for anaplastic gliomas (2017).
Balañá C, Alonso M, Hernandez-Lain A, Hernandez A, Perez-Segura P, Pineda E, Ramos A, Sanchez AR, Teixidor P, Verger E, Benavides M
Clin Transl Oncol 2018 Jan;20(1):16-21. Epub 2017 Oct 20 doi: 10.1007/s12094-017-1762-7. PMID: 29058264Free PMC Article
Clinical discussion of the management of anaplastic oligodendroglioma/oligoastrocytoma (both codeleted and nondeleted).
Anderson MD, Gilbert MR
J Natl Compr Canc Netw 2014 May;12(5):665-72. doi: 10.6004/jnccn.2014.0070. PMID: 24812135
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
Cairncross G, Wang M, Shaw E, Jenkins R, Brachman D, Buckner J, Fink K, Souhami L, Laperriere N, Curran W, Mehta M
J Clin Oncol 2013 Jan 20;31(3):337-43. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2674. PMID: 23071247Free PMC Article
Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma.
Yi L, Zhou ZH, Ping YF, Chen JH, Yao XH, Feng H, Lu JY, Wang JM, Bian XW
Mod Pathol 2007 Oct;20(10):1061-8. Epub 2007 Jul 27 doi: 10.1038/modpathol.3800942. PMID: 17660801
Prognostic implication of clinical, radiologic, and pathologic features in patients with anaplastic gliomas.
Tortosa A, Viñolas N, Villà S, Verger E, Gil JM, Brell M, Caral L, Pujol T, Acebes JJ, Ribalta T, Ferrer I, Graus F
Cancer 2003 Feb 15;97(4):1063-71. doi: 10.1002/cncr.11120. PMID: 12569607

Recent systematic reviews

Chemotherapy plus radiotherapy versus radiotherapy alone in patients with anaplastic glioma: a systematic review and meta-analysis.
Zhang L, Wu X, Xu T, Luo C, Qian J, Lu Y
J Cancer Res Clin Oncol 2013 May;139(5):719-26. Epub 2013 Feb 10 doi: 10.1007/s00432-013-1387-3. PMID: 23397358

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