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Hypertrophic lichen planus

MedGen UID:
9756
•Concept ID:
C0023649
•
Disease or Syndrome
Synonyms: Hypertrophic Lichen Planus; hypertrophic lichen planus; Lichen planus hypertrophicus; lichen planus hypertrophicus
SNOMED CT: Hypertrophic lichen planus (68266006); Lichen planus hypertrophicus (68266006)
 
Monarch Initiative: MONDO:0021377

Definition

A form of lichen planus that is characterized by plaques of markedly thickened skin that is often extremely pruritic and localized to the lower legs. It can result in permanent pigmentation and scarring. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypertrophic lichen planus

Professional guidelines

PubMed

Concomitant hypertrophic lichen planus and squamous cell carcinoma: Clinical features and treatment outcomes.
Idriss MH, Barbosa N, Chang MB, Gibson L, Baum CL, Vidal NY
Int J Dermatol 2022 Dec;61(12):1527-1531. Epub 2022 Jun 29 doi: 10.1111/ijd.16321. PMID: 35766459
Eruptive squamous atypia (also known as eruptive keratoacanthoma): Definition of the disease entity and successful management via intralesional 5-fluorouracil.
Que SKT, Compton LA, Schmults CD
J Am Acad Dermatol 2019 Jul;81(1):111-122. Epub 2019 May 15 doi: 10.1016/j.jaad.2018.10.014. PMID: 31103317
Fractional carbon dioxide laser in combination with topical corticosteroid: An innovative treatment for hypertrophic lichen planus.
Majid I
J Am Acad Dermatol 2017 Sep;77(3):e67-e68. doi: 10.1016/j.jaad.2017.05.005. PMID: 28807121

Recent clinical studies

Etiology

Eosinophils in Traditionally Noneosinophil-Rich Dermatoses.
Sanchez I, Ibraheim MK, Lee BA, Kraus CN, Elsensohn A
Am J Dermatopathol 2023 Dec 1;45(12):820-821. doi: 10.1097/DAD.0000000000002550. PMID: 37883982
Concomitant hypertrophic lichen planus and squamous cell carcinoma: Clinical features and treatment outcomes.
Idriss MH, Barbosa N, Chang MB, Gibson L, Baum CL, Vidal NY
Int J Dermatol 2022 Dec;61(12):1527-1531. Epub 2022 Jun 29 doi: 10.1111/ijd.16321. PMID: 35766459
Distinction Between Hypertrophic Lichen Planus and Squamous Cell Carcinoma Requires Clinicopathologic Correlation in Difficult Cases.
Astudillo MG, Hoang MP, Nazarian RM, Foreman RK
Am J Dermatopathol 2021 May 1;43(5):349-355. doi: 10.1097/DAD.0000000000001776. PMID: 33395040
Squamous Cell Carcinoma Arising in Hypertrophic Lichen Planus: A Review and Analysis of 38 Cases.
Knackstedt TJ, Collins LK, Li Z, Yan S, Samie FH
Dermatol Surg 2015 Dec;41(12):1411-8. doi: 10.1097/DSS.0000000000000565. PMID: 26551772
The significance of eosinophils in hypertrophic lichen planus.
Alomari A, McNiff JM
J Cutan Pathol 2014 Apr;41(4):347-52. Epub 2014 Jan 31 doi: 10.1111/cup.12275. PMID: 24325780

Diagnosis

Eosinophils in Traditionally Noneosinophil-Rich Dermatoses.
Sanchez I, Ibraheim MK, Lee BA, Kraus CN, Elsensohn A
Am J Dermatopathol 2023 Dec 1;45(12):820-821. doi: 10.1097/DAD.0000000000002550. PMID: 37883982
Concomitant hypertrophic lichen planus and squamous cell carcinoma: Clinical features and treatment outcomes.
Idriss MH, Barbosa N, Chang MB, Gibson L, Baum CL, Vidal NY
Int J Dermatol 2022 Dec;61(12):1527-1531. Epub 2022 Jun 29 doi: 10.1111/ijd.16321. PMID: 35766459
Hypertrophic lichen planus-like eruption following pembrolizumab.
Chapman S, Ashack K, Dapprich DC
Cutis 2021 Jan;107(1):E10-E11. doi: 10.12788/cutis.0160. PMID: 33651868
Tofacitinib in Hypertrophic Lichen Planus.
Seiringer P, Lauffer F, Pilz AC, Boehmer D, Biedermann T, Eyerich K
Acta Derm Venereol 2020 Jul 28;100(14):adv00220. doi: 10.2340/00015555-3585. PMID: 32618349Free PMC Article
The practical usefulness of dermoscopy in general dermatology.
Errichetti E, Stinco G
G Ital Dermatol Venereol 2015 Oct;150(5):533-46. Epub 2015 Jun 18 PMID: 26086412

Therapy

Concomitant hypertrophic lichen planus and squamous cell carcinoma: Clinical features and treatment outcomes.
Idriss MH, Barbosa N, Chang MB, Gibson L, Baum CL, Vidal NY
Int J Dermatol 2022 Dec;61(12):1527-1531. Epub 2022 Jun 29 doi: 10.1111/ijd.16321. PMID: 35766459
Hypertrophic lichen planus-like eruption following pembrolizumab.
Chapman S, Ashack K, Dapprich DC
Cutis 2021 Jan;107(1):E10-E11. doi: 10.12788/cutis.0160. PMID: 33651868
Pembrolizumab-induced pseudoepitheliomatous eruption consistent with hypertrophic lichen planus.
Coscarart A, Martel J, Lee MP, Wang AR
J Cutan Pathol 2020 Mar;47(3):275-279. Epub 2019 Oct 20 doi: 10.1111/cup.13587. PMID: 31589773
Nivolumab reactivation of hypertrophic lichen planus, a case report and review of published literature.
Maarouf M, Alexander C, Shi VY
Dermatol Online J 2018 Jan 15;24(1) PMID: 29469765
Successful treatment of hypertrophic lichen planus with betamethasone under occlusion and TCA-peelings.
Theodosiou G, Papageorgiou M, Vakirlis E, Mandekou-Lefaki I
Dermatol Ther 2016 Sep;29(5):338-340. Epub 2016 Jun 30 doi: 10.1111/dth.12372. PMID: 27357021

Prognosis

Hypertrophic Lichen Planus: Importance of Follow-Up and Clinicopathologic Correlation.
Guillen-Climent S, Porcar Saura S, Monteagudo C, Ramón Quiles MD
Actas Dermosifiliogr (Engl Ed) 2021 Feb;112(2):184-185. Epub 2020 Sep 28 doi: 10.1016/j.ad.2019.04.020. PMID: 33002453
Eruptive squamous atypia (also known as eruptive keratoacanthoma): Definition of the disease entity and successful management via intralesional 5-fluorouracil.
Que SKT, Compton LA, Schmults CD
J Am Acad Dermatol 2019 Jul;81(1):111-122. Epub 2019 May 15 doi: 10.1016/j.jaad.2018.10.014. PMID: 31103317
Using Stratum Corneum Thickness and Configuration to Distinguish Lichenoid Dermatoses.
Marsch AF
Am J Dermatopathol 2018 Sep;40(9):655-660. doi: 10.1097/DAD.0000000000001166. PMID: 29697423
Perforating elastic fibers ('elastic fiber trapping') in the differentiation of keratoacanthoma, conventional squamous cell carcinoma and pseudocarcinomatous epithelial hyperplasia.
Shah K, Kazlouskaya V, Lal K, Molina D, Elston DM
J Cutan Pathol 2014 Feb;41(2):108-12. Epub 2013 Nov 5 doi: 10.1111/cup.12247. PMID: 24138600
Giant keratoacanthoma arising in hypertrophic lichen planus.
Giesecke LM, Reid CM, James CL, Huilgol SC
Australas J Dermatol 2003 Nov;44(4):267-9. doi: 10.1046/j.1440-0960.2003.00006.x. PMID: 14616493

Clinical prediction guides

Distinction Between Hypertrophic Lichen Planus and Squamous Cell Carcinoma Requires Clinicopathologic Correlation in Difficult Cases.
Astudillo MG, Hoang MP, Nazarian RM, Foreman RK
Am J Dermatopathol 2021 May 1;43(5):349-355. doi: 10.1097/DAD.0000000000001776. PMID: 33395040
Using Stratum Corneum Thickness and Configuration to Distinguish Lichenoid Dermatoses.
Marsch AF
Am J Dermatopathol 2018 Sep;40(9):655-660. doi: 10.1097/DAD.0000000000001166. PMID: 29697423
Extensive hypertrophic lichen planus in an HIV positive patient.
Emadi SN, Akhavan-Mogaddam J, Yousefi M, Sobhani B, Moshkforoush A, Emadi SE
Dermatol Online J 2010 Jun 15;16(6):8. PMID: 20579463
Hypertrophic lichen planus-like reactions combined with infundibulocystic hyperplasia: pathway to neoplasia.
Kossard S, Thompson C, Duncan GM
Arch Dermatol 2004 Oct;140(10):1262-7. doi: 10.1001/archderm.140.10.1262. PMID: 15492191
Evolution, maturation, and regression of lesions of lichen planus. New observations and correlations of clinical and histologic findings.
Ragaz A, Ackerman AB
Am J Dermatopathol 1981 Spring;3(1):5-25. doi: 10.1097/00000372-198100310-00002. PMID: 7235199

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