U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lichen planus

MedGen UID:
9753
Concept ID:
C0023646
Disease or Syndrome
Synonyms: Lichen Planus; Lichen Ruber Planus; Lichen Rubra Planus
SNOMED CT: LP - Lichen planus (4776004); Lichen planus (4776004); Ruber planus (4776004)
 
Monarch Initiative: MONDO:0006572

Definition

A chronic, recurrent, pruritic inflammatory disorder of unknown etiology that affects the skin and mucus membranes. It presents with rashes and papules that tend to resolve spontaneously. It may be associated with hepatitis C. Certain drugs that contain arsenic or bismuth are associated with reactions mimicking lichen planus. [from NCI]

Professional guidelines

PubMed

Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
Li Y, Li L
Clin Rev Allergy Immunol 2021 Dec;61(3):245-281. Epub 2021 Jul 15 doi: 10.1007/s12016-021-08875-0. PMID: 34264448
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S
Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Sep;122(3):332-54. Epub 2016 Jul 9 doi: 10.1016/j.oooo.2016.05.004. PMID: 27401683
Gorouhi F, Davari P, Fazel N
ScientificWorldJournal 2014;2014:742826. Epub 2014 Jan 30 doi: 10.1155/2014/742826. PMID: 24672362Free PMC Article

Diagnosis

Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Hamour AF, Klieb H, Eskander A
CMAJ 2020 Aug 4;192(31):E892. doi: 10.1503/cmaj.200309. PMID: 32753462Free PMC Article
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Alrashdan MS, Cirillo N, McCullough M
Arch Dermatol Res 2016 Oct;308(8):539-51. Epub 2016 Jun 27 doi: 10.1007/s00403-016-1667-2. PMID: 27349424

Therapy

Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:896476. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.896476. PMID: 35979355Free PMC Article
Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article

Prognosis

Solimani F, Forchhammer S, Schloegl A, Ghoreschi K, Meier K
J Dtsch Dermatol Ges 2021 Jun;19(6):864-882. Epub 2021 Jun 7 doi: 10.1111/ddg.14565. PMID: 34096678
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159

Clinical prediction guides

Hwang JK, Grover C, Iorizzo M, Lebwohl MG, Piraccini BM, Rigopoulos DG, Lipner SR
J Am Acad Dermatol 2024 Mar;90(3):585-596. Epub 2023 Nov 24 doi: 10.1016/j.jaad.2023.11.024. PMID: 38007038
Shah S, Baskaran N, Vinay K, Bishnoi A, Parsad D, Kumaran MS
Int J Dermatol 2023 Dec;62(12):1447-1457. Epub 2023 Sep 28 doi: 10.1111/ijd.16859. PMID: 37767951
Adamo D, Calabria E, Canfora F, Coppola N, Leuci S, Mignogna M, Muzio LL, Spirito F, Giuliani M, Azzi L, Dani M, Colella G, Colella C, Montebugnoli L, Gissi DB, Gabriele M, Nisi M, Sardella A, Lodi G, Varoni EM, Giudice A, Antonelli A, Gambino A, Antonucci G, Vescovi P, Meleti M, Majorana A, Bardellini E, Campisi G, Panzarella V, Spadari F, Garagiola U, Pentenero M, Sutera S, Biasotto M, Ottaviani G, Gobbo M, Nardini LG, Romeo U, Tenore G, Serpico R, Lucchese A, Lajolo C, Gioco G, Aria M, D'Aniello L, Mignogna MD; SIPMO (Italian Society of Oral Pathology, Medicine)
Clin Oral Investig 2023 Jun;27(6):3057-3069. Epub 2023 Feb 14 doi: 10.1007/s00784-023-04909-3. PMID: 36786956Free PMC Article
Schruf E, Biermann MH, Jacob J, Häckl D, Reinhardt M, Hertl M, Wohlrab J
J Dtsch Dermatol Ges 2022 Aug;20(8):1101-1110. Epub 2022 Aug 1 doi: 10.1111/ddg.14808. PMID: 35913102Free PMC Article
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article

Recent systematic reviews

Sandhu S, Klein BA, Al-Hadlaq M, Chirravur P, Bajonaid A, Xu Y, Intini R, Hussein M, Vacharotayangul P, Sroussi H, Treister N, Sonis S
BMC Oral Health 2022 May 6;22(1):161. doi: 10.1186/s12903-022-02168-4. PMID: 35524296Free PMC Article
González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, Ruiz-Ávila I, Ramos-García P
Oral Dis 2021 May;27(4):813-828. Epub 2020 Apr 2 doi: 10.1111/odi.13323. PMID: 32144836
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Vaughn AR, Branum A, Sivamani RK
Phytother Res 2016 Aug;30(8):1243-64. Epub 2016 May 23 doi: 10.1002/ptr.5640. PMID: 27213821
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...