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Lichen planus

MedGen UID:
9753
Concept ID:
C0023646
Disease or Syndrome
Synonyms: Lichen Planus; Lichen Ruber Planus; Lichen Rubra Planus
SNOMED CT: LP - Lichen planus (4776004); Lichen planus (4776004); Ruber planus (4776004)
 
Monarch Initiative: MONDO:0006572

Definition

A chronic, recurrent, pruritic inflammatory disorder of unknown etiology that affects the skin and mucus membranes. It presents with rashes and papules that tend to resolve spontaneously. It may be associated with hepatitis C. Certain drugs that contain arsenic or bismuth are associated with reactions mimicking lichen planus. [from NCI]

Professional guidelines

PubMed

Li Y, Li L
Clin Rev Allergy Immunol 2021 Dec;61(3):245-281. Epub 2021 Jul 15 doi: 10.1007/s12016-021-08875-0. PMID: 34264448
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048

Recent clinical studies

Etiology

Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Carrozzo M, Porter S, Mercadante V, Fedele S
Periodontol 2000 2019 Jun;80(1):105-125. doi: 10.1111/prd.12260. PMID: 31090143
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Gorouhi F, Davari P, Fazel N
ScientificWorldJournal 2014;2014:742826. Epub 2014 Jan 30 doi: 10.1155/2014/742826. PMID: 24672362Free PMC Article

Diagnosis

Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
Hamour AF, Klieb H, Eskander A
CMAJ 2020 Aug 4;192(31):E892. doi: 10.1503/cmaj.200309. PMID: 32753462Free PMC Article
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Kusari A, Ahluwalia J
N Engl J Med 2018 Aug 9;379(6):567. doi: 10.1056/NEJMicm1802078. PMID: 30089065
Alrashdan MS, Cirillo N, McCullough M
Arch Dermatol Res 2016 Oct;308(8):539-51. Epub 2016 Jun 27 doi: 10.1007/s00403-016-1667-2. PMID: 27349424

Therapy

Gupta MK, Lipner SR
Dermatol Clin 2021 Apr;39(2):221-230. Epub 2021 Feb 10 doi: 10.1016/j.det.2020.12.002. PMID: 33745635
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

Prognosis

Solimani F, Forchhammer S, Schloegl A, Ghoreschi K, Meier K
J Dtsch Dermatol Ges 2021 Jun;19(6):864-882. Epub 2021 Jun 7 doi: 10.1111/ddg.14565. PMID: 34096678
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159

Clinical prediction guides

Pakfetrat A, Delavarian Z, Mohtasham N, Mohajer Tehran F, Samiee N
Mol Biol Rep 2022 Apr;49(4):2945-2951. Epub 2022 Feb 9 doi: 10.1007/s11033-022-07115-8. PMID: 35138525
Mallah N, Ignacio Varela-Centelles P, Seoane-Romero J, Takkouche B
Oral Dis 2022 Nov;28(8):2100-2109. Epub 2021 Jun 11 doi: 10.1111/odi.13927. PMID: 34051029
Fiocco Z, Kupf S, Patzak L, Kämmerer T, Pumnea T, French LE, Reinholz M
Acta Derm Venereol 2021 Dec 14;101(12):adv00619. doi: 10.2340/actadv.v101.442. PMID: 34698356Free PMC Article
Liao H, Luo Y, Long L, Peng J, Qiu X, Yuan P, Xu H, Jiang L
Oral Dis 2021 Apr;27(3):506-514. Epub 2020 Aug 11 doi: 10.1111/odi.13569. PMID: 32697012
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article

Recent systematic reviews

Sandhu S, Klein BA, Al-Hadlaq M, Chirravur P, Bajonaid A, Xu Y, Intini R, Hussein M, Vacharotayangul P, Sroussi H, Treister N, Sonis S
BMC Oral Health 2022 May 6;22(1):161. doi: 10.1186/s12903-022-02168-4. PMID: 35524296Free PMC Article
González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, Ruiz-Ávila I, Ramos-García P
Oral Dis 2021 May;27(4):813-828. Epub 2020 Apr 2 doi: 10.1111/odi.13323. PMID: 32144836
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Vaughn AR, Branum A, Sivamani RK
Phytother Res 2016 Aug;30(8):1243-64. Epub 2016 May 23 doi: 10.1002/ptr.5640. PMID: 27213821
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

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