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Mediastinitis

MedGen UID:
9921
•Concept ID:
C0025064
•
Disease or Syndrome
Synonyms: Inflammation, Mediastinum; Inflammations, Mediastinum; Mediastinitides; Mediastinum Inflammation; Mediastinum Inflammations
SNOMED CT: Inflammatory disorder of mediastinum (373409004); Mediastinitis (373409004)
 
Monarch Initiative: MONDO:0004492

Definition

An inflammatory process affecting the mediastinum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinitis

Professional guidelines

PubMed

Pathogenesis, Evaluation, and Management of Pulmonary Vein Stenosis: JACC Review Topic of the Week.
Simard T, Sarma D, Miranda WR, Jain CC, Anderson JH, Collins JD, El Sabbagh A, Jhand A, Peikert T, Reeder GS, Munger TM, Packer DL, Holmes DR
J Am Coll Cardiol 2023 Jun 20;81(24):2361-2373. doi: 10.1016/j.jacc.2023.04.016. PMID: 37316116
Deep Sternal Wound Infection: Diagnosis, Treatment and Prevention.
Phoon PHY, Hwang NC
J Cardiothorac Vasc Anesth 2020 Jun;34(6):1602-1613. Epub 2019 Sep 18 doi: 10.1053/j.jvca.2019.09.019. PMID: 31623967
Treatment of histoplasmosis.
Mocherla S, Wheat LJ
Semin Respir Infect 2001 Jun;16(2):141-8. doi: 10.1053/srin.2001.24244. PMID: 11521246

Recent clinical studies

Therapy

Mediastinitis in the intensive care unit patient: a narrative review.
Pastene B, Cassir N, Tankel J, Einav S, Fournier PE, Thomas P, Leone M
Clin Microbiol Infect 2020 Jan;26(1):26-34. Epub 2019 Jul 12 doi: 10.1016/j.cmi.2019.07.005. PMID: 31306791
Sternal reconstruction after post-sternotomy mediastinitis.
Kaul P
J Cardiothorac Surg 2017 Nov 2;12(1):94. doi: 10.1186/s13019-017-0656-7. PMID: 29096673Free PMC Article
Defining post-sternotomy mediastinitis for clinical evidence-based studies.
van Wingerden JJ, de Mol BA, van der Horst CM
Asian Cardiovasc Thorac Ann 2016 May;24(4):355-63. Epub 2016 Mar 11 doi: 10.1177/0218492316639405. PMID: 26970253
Infections of the mediastinum.
Athanassiadi KA
Thorac Surg Clin 2009 Feb;19(1):37-45, vi. doi: 10.1016/j.thorsurg.2008.09.012. PMID: 19288819
Microbiology of mediastinitis.
Brook I, Frazier EH
Arch Intern Med 1996 Feb 12;156(3):333-6. PMID: 8572845

Prognosis

Incidence and healing times of postoperative sternal wound infections: a retrospective observational single-centre study.
Ivert T, Berge A, Bratt S, Dalén M
Scand Cardiovasc J 2024 Dec;58(1):2330349. Epub 2024 Mar 18 doi: 10.1080/14017431.2024.2330349. PMID: 38500294
Post-sternotomy mediastinitis in the modern era.
Goh SSC
J Card Surg 2017 Sep;32(9):556-566. Epub 2017 Aug 22 doi: 10.1111/jocs.13189. PMID: 28833518
Surgical versus nonsurgical interventions for flail chest.
Cataneo AJ, Cataneo DC, de Oliveira FH, Arruda KA, El Dib R, de Oliveira Carvalho PE
Cochrane Database Syst Rev 2015 Jul 29;2015(7):CD009919. doi: 10.1002/14651858.CD009919.pub2. PMID: 26222250Free PMC Article
Transhiatal esophagectomy.
Lin J, Iannettoni MD
Surg Clin North Am 2005 Jun;85(3):593-610. doi: 10.1016/j.suc.2005.01.009. PMID: 15927654
Descending cervical mediastinitis.
Kiernan PD, Hernandez A, Byrne WD, Bloom R, Dicicco B, Hetrick V, Graling P, Vaughan B
Ann Thorac Surg 1998 May;65(5):1483-8. doi: 10.1016/s0003-4975(98)00142-8. PMID: 9594903

Clinical prediction guides

Classification of the oesophageal perforation.
Harrich F, Knoefel WT, Bölke E, Schauer M
Eur J Med Res 2024 Jul 1;29(1):352. doi: 10.1186/s40001-024-01910-8. PMID: 38951825Free PMC Article
Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome.
Hariri G, Genoud M, Bruckert V, Chosidow S, Guérot E, Kimmoun A, Nesseler N, Besnier E, Daviaud F, Lagier D, Imbault J, Grimaldi D, Bouglé A, Mongardon N
Crit Care 2023 Jan 6;27(1):6. doi: 10.1186/s13054-022-04277-6. PMID: 36609390Free PMC Article
Clamshell in a Heartbeat.
Vreeswijk SJM, Mommers LPW, Bergmans DCJJ, van Wageningen B
Air Med J 2020 Nov-Dec;39(6):509-511. Epub 2020 Aug 18 doi: 10.1016/j.amj.2020.08.001. PMID: 33228905
Minimally invasive Ozaki technique.
Rosseĭkin EV, Kobzev EE, Bazylev VV
Angiol Sosud Khir 2019;25(3):142-155. doi: 10.33529/ANGI02019319. PMID: 31503259
Mediastinitis following pediatric cardiac surgery.
Mangukia CV, Agarwal S, Satyarthy S, Datt V, Satsangi D
J Card Surg 2014 Jan;29(1):74-82. Epub 2013 Nov 25 doi: 10.1111/jocs.12243. PMID: 24267786

Recent systematic reviews

Pyoderma Gangrenosum after Cardiac Surgery.
Petrov A, Kappert U, Schmidt T, Matschke KE, Wilbring M
Thorac Cardiovasc Surg 2023 Jan;71(1):53-61. Epub 2021 Dec 11 doi: 10.1055/s-0041-1735960. PMID: 34894635
Pulmonary Vein Stenosis-Balloon Angioplasty Versus Stenting: A Systematic Review and Meta-Analysis.
Almakadma AH, Sarma D, Hassett L, Miranda W, Alkhouli M, Reeder GS, Munger TM, Packer DL, Simard T, Holmes DR Jr
JACC Clin Electrophysiol 2022 Oct;8(10):1323-1333. Epub 2022 Sep 16 doi: 10.1016/j.jacep.2022.08.008. PMID: 36117046
Surgical versus nonsurgical interventions for flail chest.
Cataneo AJ, Cataneo DC, de Oliveira FH, Arruda KA, El Dib R, de Oliveira Carvalho PE
Cochrane Database Syst Rev 2015 Jul 29;2015(7):CD009919. doi: 10.1002/14651858.CD009919.pub2. PMID: 26222250Free PMC Article
Systematic review on treatment of Zenker's diverticulum.
Verdonck J, Morton RP
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3095-107. Epub 2014 Sep 7 doi: 10.1007/s00405-014-3267-0. PMID: 25194579
Mediastinitis and blood transfusion in cardiac surgery: a systematic review.
Ang LB, Veloria EN, Evanina EY, Smaldone A
Heart Lung 2012 May;41(3):255-63. Epub 2011 Oct 1 doi: 10.1016/j.hrtlng.2011.07.012. PMID: 21963297

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