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Focal fibrosis

MedGen UID:
99264
•Concept ID:
C0521195
•
Pathologic Function
Synonym: Focal Fibrosis
SNOMED CT: Focal fibrosis (45559001)

Definition

Localized formation of fibrous tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal fibrosis

Professional guidelines

PubMed

Management of Lung Cancer in the Patient with Interstitial Lung Disease.
Frank AJ, Dagogo-Jack I, Dobre IA, Tait S, Schumacher L, Fintelmann FJ, Fingerman LM, Keane FK, Montesi SB
Oncologist 2023 Jan 18;28(1):12-22. doi: 10.1093/oncolo/oyac226. PMID: 36426803Free PMC Article
Early diagnosis of cardiomyopathies by cardiac magnetic resonance. Overview of the main criteria.
Sozzi FB, Iacuzio L, Belmonte M, Schiavone M, Bursi F, Gherbesi E, Levy F, Canetta C, Carugo S
Monaldi Arch Chest Dis 2022 Apr 11;92(4) doi: 10.4081/monaldi.2022.2151. PMID: 35416001
Incidental, subsolid pulmonary nodules at CT: etiology and management.
Seidelman JL, Myers JL, Quint LE
Cancer Imaging 2013 Sep 23;13(3):365-73. doi: 10.1102/1470-7330.2013.9025. PMID: 24061063Free PMC Article

Recent clinical studies

Etiology

Understanding and managing cardiac involvement in systemic sclerosis.
Moysidou GS, Dara A, Arvanitaki A, Skalkou A, Pagkopoulou E, Daoussis D, Kitas GD, Dimitroulas T
Expert Rev Clin Immunol 2023 Mar;19(3):293-304. Epub 2023 Feb 9 doi: 10.1080/1744666X.2023.2171988. PMID: 36690592
Management of Lung Cancer in the Patient with Interstitial Lung Disease.
Frank AJ, Dagogo-Jack I, Dobre IA, Tait S, Schumacher L, Fintelmann FJ, Fingerman LM, Keane FK, Montesi SB
Oncologist 2023 Jan 18;28(1):12-22. doi: 10.1093/oncolo/oyac226. PMID: 36426803Free PMC Article
Myocardial fibrosis and arrhythmic burden in systemic sclerosis.
Ross L, Costello B, Brown Z, Hansen D, Lindqvist A, Stevens W, Burns A, Prior D, Nikpour M, La Gerche A
Rheumatology (Oxford) 2022 Nov 2;61(11):4497-4502. doi: 10.1093/rheumatology/keac065. PMID: 35136975Free PMC Article
Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.
Kanagala P, Cheng ASH, Singh A, Khan JN, Gulsin GS, Patel P, Gupta P, Arnold JR, Squire IB, Ng LL, McCann GP
JACC Cardiovasc Imaging 2019 Nov;12(11 Pt 2):2291-2301. Epub 2019 Feb 13 doi: 10.1016/j.jcmg.2018.11.031. PMID: 30772227
Focal fibrosis and diffuse fibrosis are predictors of reversed left ventricular remodeling in patients with non-ischemic cardiomyopathy.
Yingchoncharoen T, Jellis C, Popovic ZB, Wang L, Gai N, Levy WC, Tang WH, Flamm S, Kwon DH
Int J Cardiol 2016 Oct 15;221:498-504. Epub 2016 Jun 23 doi: 10.1016/j.ijcard.2016.06.095. PMID: 27414729

Diagnosis

Management of Lung Cancer in the Patient with Interstitial Lung Disease.
Frank AJ, Dagogo-Jack I, Dobre IA, Tait S, Schumacher L, Fintelmann FJ, Fingerman LM, Keane FK, Montesi SB
Oncologist 2023 Jan 18;28(1):12-22. doi: 10.1093/oncolo/oyac226. PMID: 36426803Free PMC Article
Energy drink-induced cardiomyopathy.
Fisk G, Hammond-Haley M, D'Silva A
BMJ Case Rep 2021 Apr 15;14(4) doi: 10.1136/bcr-2020-239370. PMID: 33858880Free PMC Article
Chagas Disease: Chronic Chagas Cardiomyopathy.
Echavarría NG, Echeverría LE, Stewart M, Gallego C, Saldarriaga C
Curr Probl Cardiol 2021 Mar;46(3):100507. Epub 2019 Dec 1 doi: 10.1016/j.cpcardiol.2019.100507. PMID: 31983471
Focal lesions in cirrhosis: Not always HCC.
Ronot M, Dioguardi Burgio M, Purcell Y, Pommier R, Brancatelli G, Vilgrain V
Eur J Radiol 2017 Aug;93:157-168. Epub 2017 Jun 3 doi: 10.1016/j.ejrad.2017.05.040. PMID: 28668410
Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review.
Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S
J Cardiovasc Magn Reson 2016 Nov 30;18(1):89. doi: 10.1186/s12968-016-0308-4. PMID: 27899132Free PMC Article

Therapy

Energy drink-induced cardiomyopathy.
Fisk G, Hammond-Haley M, D'Silva A
BMJ Case Rep 2021 Apr 15;14(4) doi: 10.1136/bcr-2020-239370. PMID: 33858880Free PMC Article
Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.
Kanagala P, Cheng ASH, Singh A, Khan JN, Gulsin GS, Patel P, Gupta P, Arnold JR, Squire IB, Ng LL, McCann GP
JACC Cardiovasc Imaging 2019 Nov;12(11 Pt 2):2291-2301. Epub 2019 Feb 13 doi: 10.1016/j.jcmg.2018.11.031. PMID: 30772227
Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review.
Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S
J Cardiovasc Magn Reson 2016 Nov 30;18(1):89. doi: 10.1186/s12968-016-0308-4. PMID: 27899132Free PMC Article
Cardiac MRI evaluation of myocardial disease.
Captur G, Manisty C, Moon JC
Heart 2016 Sep 15;102(18):1429-35. Epub 2016 Jun 27 doi: 10.1136/heartjnl-2015-309077. PMID: 27354273
Sirolimus-associated pulmonary toxicity.
Pham PT, Pham PC, Danovitch GM, Ross DJ, Gritsch HA, Kendrick EA, Singer J, Shah T, Wilkinson AH
Transplantation 2004 Apr 27;77(8):1215-20. doi: 10.1097/01.tp.0000118413.92211.b6. PMID: 15114088

Prognosis

Understanding and managing cardiac involvement in systemic sclerosis.
Moysidou GS, Dara A, Arvanitaki A, Skalkou A, Pagkopoulou E, Daoussis D, Kitas GD, Dimitroulas T
Expert Rev Clin Immunol 2023 Mar;19(3):293-304. Epub 2023 Feb 9 doi: 10.1080/1744666X.2023.2171988. PMID: 36690592
Myocardial fibrosis and arrhythmic burden in systemic sclerosis.
Ross L, Costello B, Brown Z, Hansen D, Lindqvist A, Stevens W, Burns A, Prior D, Nikpour M, La Gerche A
Rheumatology (Oxford) 2022 Nov 2;61(11):4497-4502. doi: 10.1093/rheumatology/keac065. PMID: 35136975Free PMC Article
Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review.
Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S
J Cardiovasc Magn Reson 2016 Nov 30;18(1):89. doi: 10.1186/s12968-016-0308-4. PMID: 27899132Free PMC Article
Cardiac MRI evaluation of myocardial disease.
Captur G, Manisty C, Moon JC
Heart 2016 Sep 15;102(18):1429-35. Epub 2016 Jun 27 doi: 10.1136/heartjnl-2015-309077. PMID: 27354273
Myocardial T1 mapping.
Bulluck H, Maestrini V, Rosmini S, Abdel-Gadir A, Treibel TA, Castelletti S, Bucciarelli-Ducci C, Manisty C, Moon JC
Circ J 2015;79(3):487-94. Epub 2015 Feb 6 doi: 10.1253/circj.CJ-15-0054. PMID: 25746524

Clinical prediction guides

Myocardial fibrosis and arrhythmic burden in systemic sclerosis.
Ross L, Costello B, Brown Z, Hansen D, Lindqvist A, Stevens W, Burns A, Prior D, Nikpour M, La Gerche A
Rheumatology (Oxford) 2022 Nov 2;61(11):4497-4502. doi: 10.1093/rheumatology/keac065. PMID: 35136975Free PMC Article
Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.
Kanagala P, Cheng ASH, Singh A, Khan JN, Gulsin GS, Patel P, Gupta P, Arnold JR, Squire IB, Ng LL, McCann GP
JACC Cardiovasc Imaging 2019 Nov;12(11 Pt 2):2291-2301. Epub 2019 Feb 13 doi: 10.1016/j.jcmg.2018.11.031. PMID: 30772227
Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review.
Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S
J Cardiovasc Magn Reson 2016 Nov 30;18(1):89. doi: 10.1186/s12968-016-0308-4. PMID: 27899132Free PMC Article
Focal fibrosis and diffuse fibrosis are predictors of reversed left ventricular remodeling in patients with non-ischemic cardiomyopathy.
Yingchoncharoen T, Jellis C, Popovic ZB, Wang L, Gai N, Levy WC, Tang WH, Flamm S, Kwon DH
Int J Cardiol 2016 Oct 15;221:498-504. Epub 2016 Jun 23 doi: 10.1016/j.ijcard.2016.06.095. PMID: 27414729
Cardiac MRI evaluation of myocardial disease.
Captur G, Manisty C, Moon JC
Heart 2016 Sep 15;102(18):1429-35. Epub 2016 Jun 27 doi: 10.1136/heartjnl-2015-309077. PMID: 27354273

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