U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fibrosis

MedGen UID:
5179
•Concept ID:
C0016059
•
Pathologic Function
Synonym: Fibroses
SNOMED CT: Fibrosis (112674009); Fibrous repair (112674009); Fibrous thickening (112674009); Fibroplasia (112674009); Fibrous replacement (112674009); Fibrosis (263756000)

Definition

The formation of fibrous tissue. [from NCI]

Professional guidelines

PubMed

Progressive pulmonary fibrosis: an expert group consensus statement.
Rajan SK, Cottin V, Dhar R, Danoff S, Flaherty KR, Brown KK, Mohan A, Renzoni E, Mohan M, Udwadia Z, Shenoy P, Currow D, Devraj A, Jankharia B, Kulshrestha R, Jones S, Ravaglia C, Quadrelli S, Iyer R, Dhooria S, Kolb M, Wells AU
Eur Respir J 2023 Mar;61(3) Epub 2023 Mar 30 doi: 10.1183/13993003.03187-2021. PMID: 36517177Free PMC Article
Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline.
Daley CL, Iaccarino JM, Lange C, Cambau E, Wallace RJ Jr, Andrejak C, Böttger EC, Brozek J, Griffith DE, Guglielmetti L, Huitt GA, Knight SL, Leitman P, Marras TK, Olivier KN, Santin M, Stout JE, Tortoli E, van Ingen J, Wagner D, Winthrop KL
Eur Respir J 2020 Jul;56(1) Epub 2020 Jul 7 doi: 10.1183/13993003.00535-2020. PMID: 32636299Free PMC Article
Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper.
Lynch DA, Sverzellati N, Travis WD, Brown KK, Colby TV, Galvin JR, Goldin JG, Hansell DM, Inoue Y, Johkoh T, Nicholson AG, Knight SL, Raoof S, Richeldi L, Ryerson CJ, Ryu JH, Wells AU
Lancet Respir Med 2018 Feb;6(2):138-153. Epub 2017 Nov 15 doi: 10.1016/S2213-2600(17)30433-2. PMID: 29154106

Recent clinical studies

Etiology

Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics.
Hsieh PL, Yu CC
Int J Mol Sci 2022 May 30;23(11) doi: 10.3390/ijms23116110. PMID: 35682789Free PMC Article
Telemedicine and cystic fibrosis: Do we still need face-to-face clinics?
Dixon E, Dick K, Ollosson S, Jones D, Mattock H, Bentley S, Saunders C, Matthews J, Dobra B, King J, Edmondson C, Davies JC
Paediatr Respir Rev 2022 Jun;42:23-28. Epub 2021 May 19 doi: 10.1016/j.prrv.2021.05.002. PMID: 34215541
Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis.
Meyer KC
Expert Rev Respir Med 2017 May;11(5):343-359. Epub 2017 Apr 10 doi: 10.1080/17476348.2017.1312346. PMID: 28345383
Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report.
Collard HR, Ryerson CJ, Corte TJ, Jenkins G, Kondoh Y, Lederer DJ, Lee JS, Maher TM, Wells AU, Antoniou KM, Behr J, Brown KK, Cottin V, Flaherty KR, Fukuoka J, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kolb M, Lynch DA, Myers JL, Raghu G, Richeldi L, Taniguchi H, Martinez FJ
Am J Respir Crit Care Med 2016 Aug 1;194(3):265-75. doi: 10.1164/rccm.201604-0801CI. PMID: 27299520
CYSTIC FIBROSIS.
ASAY LD
Calif Med 1965 Apr;102(4):292-300. PMID: 14288148Free PMC Article

Diagnosis

Diagnosis of CF: An evolving and enduring challenge.
Ren CL
J Cyst Fibros 2021 Sep;20(5):727-728. Epub 2021 Jul 29 doi: 10.1016/j.jcf.2021.07.007. PMID: 34332905
Idiopathic pulmonary fibrosis.
Richeldi L, Collard HR, Jones MG
Lancet 2017 May 13;389(10082):1941-1952. Epub 2017 Mar 30 doi: 10.1016/S0140-6736(17)30866-8. PMID: 28365056
Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis.
Meyer KC
Expert Rev Respir Med 2017 May;11(5):343-359. Epub 2017 Apr 10 doi: 10.1080/17476348.2017.1312346. PMID: 28345383
Cystic Fibrosis.
Stanton BF
Pediatr Clin North Am 2016 Aug;63(4):xv. doi: 10.1016/j.pcl.2016.06.002. PMID: 27469187
Cystic fibrosis.
David TJ
Arch Dis Child 1990 Jan;65(1):152-7. doi: 10.1136/adc.65.1.152. PMID: 2405786Free PMC Article

Therapy

Drug development for cystic fibrosis.
Sanders DB, Chmiel JF
Pediatr Pulmonol 2021 Feb;56 Suppl 1:S10-S22. doi: 10.1002/ppul.25075. PMID: 32940969
Challenges in systemic sclerosis trial design.
Denton CP
Semin Arthritis Rheum 2019 Dec;49(3S):S3-S7. doi: 10.1016/j.semarthrit.2019.09.019. PMID: 31779848
End-points for drug treatment in NASH.
Adams LA
Hepatol Int 2019 May;13(3):253-258. Epub 2019 Feb 19 doi: 10.1007/s12072-019-09935-6. PMID: 30783901
Clinical applications of sonoelastography.
Yuan S, Magarik M, Lex AM, Fleischer AC
Expert Rev Med Devices 2016 Dec;13(12):1107-1117. Epub 2016 Nov 22 doi: 10.1080/17434440.2016.1257938. PMID: 27819141
Pirfenidone.
Lasky J
IDrugs 2004 Feb;7(2):166-72. PMID: 15057662

Prognosis

Lung transplantation for scleroderma: Strength in numbers.
Gelber AC
Joint Bone Spine 2018 Jan;85(1):5-7. Epub 2017 Sep 14 doi: 10.1016/j.jbspin.2017.09.002. PMID: 28917997
Respiratory manifestations of ANCA-associated vasculitis.
Greenan K, Vassallo D, Chinnadurai R, Ritchie J, Shepherd K, Green D, Ponnusamy A, Sinha S
Clin Respir J 2018 Jan;12(1):57-61. Epub 2016 May 12 doi: 10.1111/crj.12478. PMID: 27059787
Idiopathic pulmonary fibrosis: diagnosis and epidemiology.
Olson AL, Swigris JJ
Clin Chest Med 2012 Mar;33(1):41-50. doi: 10.1016/j.ccm.2011.12.001. PMID: 22365244
Forgotten cardiovascular diseases in Africa.
Sliwa K, Mocumbi AO
Clin Res Cardiol 2010 Feb;99(2):65-74. Epub 2009 Dec 11 doi: 10.1007/s00392-009-0094-1. PMID: 20012067
Pyogenic lung infections.
Mwandumba HC, Beeching NJ
Curr Opin Pulm Med 1999 May;5(3):151-6. doi: 10.1097/00063198-199905000-00005. PMID: 10228739

Clinical prediction guides

Predicting treatment response in patients with HFpEF and myocardial fibrosis. Identifying useful tools with the help of CMR.
Stoiber L, Kasiakogias A
Int J Cardiovasc Imaging 2022 Oct;38(10):2209-2211. Epub 2022 Aug 6 doi: 10.1007/s10554-022-02605-z. PMID: 37726471
Cardiac Magnetic Resonance in Nonischemic Cardiomyopathies.
Yang EY, Shah DJ
Methodist Debakey Cardiovasc J 2020 Apr-Jun;16(2):97-105. doi: 10.14797/mdcj-16-2-97. PMID: 32670469Free PMC Article
Perspectives on NASH Histology: Cellular Ballooning.
Caldwell S, Lackner C
Ann Hepatol 2017 March-April;16(2):182-184. doi: 10.5604/16652681.1231550. PMID: 28233737
Noninvasive Assessment of Liver Diseases using 2D Shear Wave Elastography.
Lupșor-Platon M, Badea R, Gersak M, Maniu A, Rusu I, Suciu A, Vicas C, Stefănescu H, Urs R, Al Hajjar N
J Gastrointestin Liver Dis 2016 Dec;25(4):525-532. doi: 10.15403/jgld.2014.1121.254.lup. PMID: 27981309
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Drug-drug interactions with CFTR modulator therapy in cystic fibrosis: Focus on Trikafta®/Kaftrio®.
Purkayastha D, Agtarap K, Wong K, Pereira O, Co J, Pakhale S, Kanji S
J Cyst Fibros 2023 May;22(3):478-483. Epub 2023 Jan 16 doi: 10.1016/j.jcf.2023.01.005. PMID: 36653239
Serum Biomarkers of Renal Fibrosis: A Systematic Review.
Barinotti A, Radin M, Cecchi I, Foddai SG, Rubini E, Roccatello D, Sciascia S
Int J Mol Sci 2022 Nov 16;23(22) doi: 10.3390/ijms232214139. PMID: 36430625Free PMC Article
Improving nutrition in cystic fibrosis: A systematic literature review.
Mielus M, Sands D, Woynarowski M
Nutrition 2022 Oct;102:111725. Epub 2022 May 6 doi: 10.1016/j.nut.2022.111725. PMID: 35816813
WITHDRAWN: Inhaled bronchodilators for cystic fibrosis.
Halfhide C, Evans HJ, Couriel J
Cochrane Database Syst Rev 2016 Feb 11;2(2):CD003428. doi: 10.1002/14651858.CD003428.pub3. PMID: 26866910Free PMC Article
Pneumothorax in cystic fibrosis.
Flume PA
Curr Opin Pulm Med 2011 Jul;17(4):220-5. doi: 10.1097/MCP.0b013e328345e1f8. PMID: 21460730

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...