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Smooth muscle cell atypia

MedGen UID:
99304
•Concept ID:
C0522598
•
Finding
Synonyms: Atypical smooth muscle cell present; Smooth Muscle Cell Atypia
SNOMED CT: Smooth muscle cell atypia (103653009); Atypical smooth muscle cell present (103653009)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmooth muscle cell atypia

Professional guidelines

PubMed

Gastroesophageal Glomus Tumors: Clinicopathologic and Molecular Genetic Analysis of 26 Cases With a Proposal for Malignancy Criteria.
Papke DJ Jr, Sholl LM, Doyle LA, Fletcher CDM, Hornick JL
Am J Surg Pathol 2022 Oct 1;46(10):1436-1446. Epub 2022 Jun 15 doi: 10.1097/PAS.0000000000001925. PMID: 35703141
Epithelioid Leiomyosarcoma of the Uterus: Modern Outcome-based Appraisal of Diagnostic Criteria in a Large Institutional Series.
Chapel DB, Nucci MR, Quade BJ, Parra-Herran C
Am J Surg Pathol 2022 Apr 1;46(4):464-475. doi: 10.1097/PAS.0000000000001795. PMID: 34419987
Fumarate Hydratase Deficiency Should be Considered in the Differential Diagnosis of Uterine and Extrauterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP).
Pors J, Weiel JJ, Devereaux KA, Folkins AK, Longacre TA
Int J Gynecol Pathol 2022 May 1;41(3):268-275. Epub 2021 Jun 9 doi: 10.1097/PGP.0000000000000797. PMID: 34108400

Recent clinical studies

Etiology

Fumarate Hydratase Deficiency Should be Considered in the Differential Diagnosis of Uterine and Extrauterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP).
Pors J, Weiel JJ, Devereaux KA, Folkins AK, Longacre TA
Int J Gynecol Pathol 2022 May 1;41(3):268-275. Epub 2021 Jun 9 doi: 10.1097/PGP.0000000000000797. PMID: 34108400
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
PEComa: morphology and genetics of a complex tumor family.
Thway K, Fisher C
Ann Diagn Pathol 2015 Oct;19(5):359-68. Epub 2015 Jun 9 doi: 10.1016/j.anndiagpath.2015.06.003. PMID: 26144278
Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.
Miettinen M
Mod Pathol 2014 Jan;27 Suppl 1(Suppl 1):S17-29. doi: 10.1038/modpathol.2013.178. PMID: 24384850Free PMC Article
Aspiration cytology of malignant intraductal myoepithelioma of the breast. A case report.
Tamai M, Nomura K, Hiyama H
Acta Cytol 1994 May-Jun;38(3):435-40. PMID: 8191838

Diagnosis

Primary cutaneous NUT carcinoma with BRD4::NUTM1 fusion.
Shah A, Box A, Brenn T, Flaman A
J Cutan Pathol 2024 Jun;51(6):424-429. Epub 2024 Mar 13 doi: 10.1111/cup.14602. PMID: 38481096
Uterine inflammatory myofibroblastic tumor.
Karpathiou G, Devouassoux-Shisheboran M, Stolnicu S, Chauleur C, Péoc'h M
Pathol Res Pract 2023 Feb;242:154335. Epub 2023 Jan 23 doi: 10.1016/j.prp.2023.154335. PMID: 36706588
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Myopericytoma - a unifying term or a unique entity?
Jairajpuri ZS, Hasan MJ, Madan GB, Jetley S
Malays J Pathol 2016 Aug;38(2):159-63. PMID: 27568674
The nested variant of urothelial carcinoma: a rare but important bladder neoplasm with aggressive behavior. Three case reports and a review of the literature.
Liedberg F, Chebil G, Davidsson T, Gadaleanu V, Grabe M, Mansson W
Urol Oncol 2003 Jan-Feb;21(1):7-9. doi: 10.1016/s1078-1439(02)00201-6. PMID: 12684120

Therapy

The incidence of occult malignancy following uterine morcellation: A ten-year single institution experience retrospective cohort study.
Mori KM, Abaid LN, Mendivil AA, Brown JV 3rd, Beck TL, Micha JP, Epstein HD, Goldstein BH
Int J Surg 2018 May;53:239-242. Epub 2018 Apr 3 doi: 10.1016/j.ijsu.2018.03.075. PMID: 29621658
Unusual morphological features of uterine leiomyomas treated with progestogens.
Boyd C, McCluggage WG
J Clin Pathol 2011 Jun;64(6):485-9. Epub 2011 Mar 11 doi: 10.1136/jcp.2011.089664. PMID: 21398323
Morphological variations of scar-related and spontaneous endometriosis of the skin and superficial soft tissue: a study of 71 cases with emphasis on atypical features and types of müllerian differentiations.
Kazakov DV, Ondic O, Zamecnik M, Shelekhova KV, Mukensnabl P, Hes O, Dvorak V, Michal M
J Am Acad Dermatol 2007 Jul;57(1):134-46. doi: 10.1016/j.jaad.2006.11.036. PMID: 17572279
Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.
Deyrup AT, Lee VK, Hill CE, Cheuk W, Toh HC, Kesavan S, Chan EW, Weiss SW
Am J Surg Pathol 2006 Jan;30(1):75-82. doi: 10.1097/01.pas.0000178088.69394.7b. PMID: 16330945
Uterine leiomyoblastoma (epithelioid leiomyoma) neoplasm of low-grade malignancy. A histopathologic study.
Kyriazis AP, Kyriazis AA
Arch Pathol Lab Med 1992 Nov;116(11):1189-91. PMID: 1444750

Prognosis

Primary cutaneous NUT carcinoma with BRD4::NUTM1 fusion.
Shah A, Box A, Brenn T, Flaman A
J Cutan Pathol 2024 Jun;51(6):424-429. Epub 2024 Mar 13 doi: 10.1111/cup.14602. PMID: 38481096
Uterine inflammatory myofibroblastic tumor.
Karpathiou G, Devouassoux-Shisheboran M, Stolnicu S, Chauleur C, Péoc'h M
Pathol Res Pract 2023 Feb;242:154335. Epub 2023 Jan 23 doi: 10.1016/j.prp.2023.154335. PMID: 36706588
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.
Miettinen M
Mod Pathol 2014 Jan;27 Suppl 1(Suppl 1):S17-29. doi: 10.1038/modpathol.2013.178. PMID: 24384850Free PMC Article
The nested variant of urothelial carcinoma: a rare but important bladder neoplasm with aggressive behavior. Three case reports and a review of the literature.
Liedberg F, Chebil G, Davidsson T, Gadaleanu V, Grabe M, Mansson W
Urol Oncol 2003 Jan-Feb;21(1):7-9. doi: 10.1016/s1078-1439(02)00201-6. PMID: 12684120

Clinical prediction guides

Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Myopericytoma - a unifying term or a unique entity?
Jairajpuri ZS, Hasan MJ, Madan GB, Jetley S
Malays J Pathol 2016 Aug;38(2):159-63. PMID: 27568674
Pleomorphic adenoma with extensive myoepithelial component (myoepithelioma) of the lower eyelid.
Huerva V, Sanchez MC, Egido RM, Matías-Guiu X
Ophthalmic Plast Reconstr Surg 2008 May-Jun;24(3):223-5. doi: 10.1097/IOP.0b013e318171a5ba. PMID: 18520841
Malignant müllerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells.
Kuroda N, Moriki T, Oguri H, Maeda N, Toi M, Miyazaki E, Hiroi M, Fukaya T, Enzan H
APMIS 2005 Sep;113(9):643-6. doi: 10.1111/j.1600-0463.2005.apm_265.x. PMID: 16218942
Aspiration cytology of malignant intraductal myoepithelioma of the breast. A case report.
Tamai M, Nomura K, Hiyama H
Acta Cytol 1994 May-Jun;38(3):435-40. PMID: 8191838

Recent systematic reviews

Prognostic significance of atypical mitotic figures in smooth muscle tumors of uncertain malignant potential (STUMP) of the uterus and uterine adnexa.
Travaglino A, Raffone A, Santoro A, Gencarelli A, Angelico G, Spadola S, Marzullo L, Zullo F, Insabato L, Zannoni GF
APMIS 2021 Apr;129(4):165-169. Epub 2021 Jan 28 doi: 10.1111/apm.13114. PMID: 33445214

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