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Abnormal dental enamel morphology

MedGen UID:: 867426
•Concept ID:: C4021800
•: Anatomical Abnormality

Synonym:	Abnormality of dental enamel

HPO:	HP:0000682

Definition

An abnormality of the dental enamel. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal dental enamel morphology

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of connective tissue
    - Abnormal odontoid tissue morphology
      - Abnormal dental enamel morphology
        Amelogenesis imperfecta
        Amelogenesis imperfecta type 1
        Amelogenesis imperfecta - hypoplastic autosomal dominant - local
        Amelogenesis imperfecta type 1A
        Amelogenesis imperfecta type 1C
        Amelogenesis imperfecta type 1F
        Amelogenesis imperfecta type 1H
        Amelogenesis imperfecta, type 1J
        Amelogenesis imperfecta type 2
        Amelogenesis imperfecta hypomaturation type 2A2
        Amelogenesis imperfecta hypomaturation type 2A3
        Amelogenesis imperfecta hypomaturation type 2A4
        Amelogenesis imperfecta hypomaturation type 2A5
        Amelogenesis imperfecta type 2A1
        Amelogenesis imperfecta, hypomaturation type, IIa6
        Amelogenesis imperfecta type 1E
        Amelogenesis imperfecta type 1G
        Amelogenesis imperfecta, hypocalcification type
        Amelogenesis imperfecta type 3B
        Amelogenesis imperfecta, type 3A
        Amelogenesis imperfecta, type 3c
        Hypomaturation-hypoplastic amelogenesis imperfecta with taurodontism
        X-linked amelogenesis imperfecta hypoplastic/hypomaturation 2
        Dental enamel pits
        Enamel agenesis
        Enamel hypomineralization
        Hypocalcification of dental enamel
        Hypomature dental enamel
        Enamel pearls
        Hypomature enamel

Conditions with this feature

Tricho-oculo-dermo-vertebral syndrome

MedGen UID:: 355714
•Concept ID:: C1866427
•: Disease or Syndrome

See: Condition Record

Tricho-oculo-dermo-vertebral syndrome

Professional guidelines

PubMed

Developmental defects of enamel and dentine: challenges for basic science research and clinical management.

Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394

Developmental enamel defects in the primary dentition: aetiology and clinical management.

Salanitri S, Seow WK
Aust Dent J 2013 Jun;58(2):133-40; quiz 266. Epub 2013 May 5 doi: 10.1111/adj.12039. PMID: 23713631

Molar incisor hypomineralization: review and recommendations for clinical management.

William V, Messer LB, Burrow MF
Pediatr Dent 2006 May-Jun;28(3):224-32. PMID: 16805354

See all (72)

Recent clinical studies

Etiology

Developmental defects of enamel and dentine: challenges for basic science research and clinical management.

Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394

Developmental enamel defects in the primary dentition: aetiology and clinical management.

Salanitri S, Seow WK
Aust Dent J 2013 Jun;58(2):133-40; quiz 266. Epub 2013 May 5 doi: 10.1111/adj.12039. PMID: 23713631

A literature review of dental erosion in children.

Taji S, Seow WK
Aust Dent J 2010 Dec;55(4):358-67; quiz 475. doi: 10.1111/j.1834-7819.2010.01255.x. PMID: 21133936

Hereditary dentine disorders: dentinogenesis imperfecta and dentine dysplasia.

Barron MJ, McDonnell ST, Mackie I, Dixon MJ
Orphanet J Rare Dis 2008 Nov 20;3:31. doi: 10.1186/1750-1172-3-31. PMID: 19021896 Free PMC Article

Amelogenesis imperfecta.

Crawford PJ, Aldred M, Bloch-Zupan A
Orphanet J Rare Dis 2007 Apr 4;2:17. doi: 10.1186/1750-1172-2-17. PMID: 17408482 Free PMC Article

See all (635)

Diagnosis

Axenfeld-Rieger syndrome: more than meets the eye.

Reis LM, Maheshwari M, Capasso J, Atilla H, Dudakova L, Thompson S, Zitano L, Lay-Son G, Lowry RB, Black J, Lee J, Shue A, Kremlikova Pourova R, Vaneckova M, Skalicka P, Jedlickova J, Trkova M, Williams B, Richard G, Bachman K, Seeley AH, Costakos D, Glaser TM, Levin AV, Liskova P, Murray JC, Semina EV
J Med Genet 2023 Apr;60(4):368-379. Epub 2022 Jul 26 doi: 10.1136/jmg-2022-108646. PMID: 35882526 Free PMC Article

Developmental defects of enamel and dentine: challenges for basic science research and clinical management.

Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394

A literature review of dental erosion in children.

Taji S, Seow WK
Aust Dent J 2010 Dec;55(4):358-67; quiz 475. doi: 10.1111/j.1834-7819.2010.01255.x. PMID: 21133936

Hereditary dentine disorders: dentinogenesis imperfecta and dentine dysplasia.

Barron MJ, McDonnell ST, Mackie I, Dixon MJ
Orphanet J Rare Dis 2008 Nov 20;3:31. doi: 10.1186/1750-1172-3-31. PMID: 19021896 Free PMC Article

Amelogenesis imperfecta.

Crawford PJ, Aldred M, Bloch-Zupan A
Orphanet J Rare Dis 2007 Apr 4;2:17. doi: 10.1186/1750-1172-2-17. PMID: 17408482 Free PMC Article

See all (557)

Therapy

The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.

Lopes LB, Machado V, Mascarenhas P, Mendes JJ, Botelho J
Sci Rep 2021 Nov 17;11(1):22405. doi: 10.1038/s41598-021-01541-7. PMID: 34789780 Free PMC Article

Gene-environment interaction in molar-incisor hypomineralization.

Bezamat M, Souza JF, Silva FMF, Corrêa EG, Fatturi AL, Brancher JA, Carvalho FM, Cavallari T, Bertolazo L, Machado-Souza C, Koruyucu M, Bayram M, Racic A, Harrison BM, Sweat YY, Letra A, Studen-Pavlovich D, Seymen F, Amendt B, Werneck RI, Costa MC, Modesto A, Vieira AR
PLoS One 2021;16(1):e0241898. Epub 2021 Jan 6 doi: 10.1371/journal.pone.0241898. PMID: 33406080 Free PMC Article

JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis.

Fragoulis GE, McInnes IB, Siebert S
Rheumatology (Oxford) 2019 Feb 1;58(Suppl 1):i43-i54. doi: 10.1093/rheumatology/key276. PMID: 30806709 Free PMC Article

Protein-mediated enamel mineralization.

Moradian-Oldak J
Front Biosci (Landmark Ed) 2012 Jun 1;17(6):1996-2023. doi: 10.2741/4034. PMID: 22652761 Free PMC Article

A literature review of dental erosion in children.

Taji S, Seow WK
Aust Dent J 2010 Dec;55(4):358-67; quiz 475. doi: 10.1111/j.1834-7819.2010.01255.x. PMID: 21133936

See all (339)

Prognosis

Hopeless tooth? Prognosis and comprehensive treatment. A case report.

Grigorie MM, Suciu I, Zaharia D, Ionescu E, Chirila M, Voiculeanu M
J Med Life 2021 Mar-Apr;14(2):287-294. doi: 10.25122/jml-2021-0080. PMID: 34104255 Free PMC Article

Mandibular metastases in neuroblastoma: Outcomes and dental sequelae.

Singh A, Modak S, Solano AK, Kushner BH, Wolden S, Huryn J, Estilo CL
Pediatr Blood Cancer 2021 Apr;68(4):e28918. Epub 2021 Jan 28 doi: 10.1002/pbc.28918. PMID: 33507629 Free PMC Article

"Pitted" lesions in dermatology.

Adya KA, Inamadar AC, Palit A
Int J Dermatol 2017 Jan;56(1):3-17. Epub 2016 Sep 9 doi: 10.1111/ijd.13358. PMID: 27613605

Molar Incisor Hypomineralization.

Rao MH, Aluru SC, Jayam C, Bandlapalli A, Patel N
J Contemp Dent Pract 2016 Jul 1;17(7):609-13. PMID: 27595731

Unilateral odontodysplasia.

Anneroth G, Ramström G
Swed Dent J 1980;4(3):93-100. PMID: 6254190

See all (250)

Clinical prediction guides

A Review of Dentinogenesis Imperfecta and Primary Dentin Disorders in Dogs.

Mack Wilson J, Bell C, Queck K, Scott K
J Vet Dent 2022 Dec;39(4):376-390. Epub 2022 Sep 15 doi: 10.1177/08987564221123419. PMID: 36113440

The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.

Lopes LB, Machado V, Mascarenhas P, Mendes JJ, Botelho J
Sci Rep 2021 Nov 17;11(1):22405. doi: 10.1038/s41598-021-01541-7. PMID: 34789780 Free PMC Article

CRAC channels in dental enamel cells.

Eckstein M, Lacruz RS
Cell Calcium 2018 Nov;75:14-20. Epub 2018 Aug 9 doi: 10.1016/j.ceca.2018.07.012. PMID: 30114531 Free PMC Article

Developmental defects of enamel and dental caries in the primary dentition: A systematic review and meta-analysis.

Costa FS, Silveira ER, Pinto GS, Nascimento GG, Thomson WM, Demarco FF
J Dent 2017 May;60:1-7. Epub 2017 Mar 24 doi: 10.1016/j.jdent.2017.03.006. PMID: 28347809

Amelogenesis imperfecta.

Crawford PJ, Aldred M, Bloch-Zupan A
Orphanet J Rare Dis 2007 Apr 4;2:17. doi: 10.1186/1750-1172-2-17. PMID: 17408482 Free PMC Article

See all (477)

Recent systematic reviews

Does primary trauma lead to developmental defects in permanent teeth?

Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286

The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.

Lopes LB, Machado V, Mascarenhas P, Mendes JJ, Botelho J
Sci Rep 2021 Nov 17;11(1):22405. doi: 10.1038/s41598-021-01541-7. PMID: 34789780 Free PMC Article

Risk Factors for Early Childhood Caries: A Systematic Review and Meta-Analysis of Case Control and Cohort Studies.

Kirthiga M, Murugan M, Saikia A, Kirubakaran R
Pediatr Dent 2019 Mar 15;41(2):95-112. PMID: 30992106 Free PMC Article

Enamel defects and aphthous stomatitis in celiac and healthy subjects: Systematic review and meta-analysis of controlled studies.

Nieri M, Tofani E, Defraia E, Giuntini V, Franchi L
J Dent 2017 Oct;65:1-10. Epub 2017 Jul 5 doi: 10.1016/j.jdent.2017.07.001. PMID: 28688949

Developmental defects of enamel and dental caries in the primary dentition: A systematic review and meta-analysis.

Costa FS, Silveira ER, Pinto GS, Nascimento GG, Thomson WM, Demarco FF
J Dent 2017 May;60:1-7. Epub 2017 Mar 24 doi: 10.1016/j.jdent.2017.03.006. PMID: 28347809

See all (18)

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Abnormal dental enamel morphology

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

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