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Abnormal brainstem MRI signal intensity

MedGen UID:
868355
•Concept ID:
C4022749
•
Finding
HPO: HP:0012747

Definition

A deviation from normal signal on magnetic resonance imaging (MRI) of the brainstem. [from HPO]

Professional guidelines

PubMed

Neuro-behçet's disease in South Korea: clinical characteristics and treatment response.
Yoon DL, Kim YJ, Koo BS, Kim YG, Lee CK, Yoo B
Int J Rheum Dis 2014 May;17(4):453-8. Epub 2014 Feb 8 doi: 10.1111/1756-185X.12265. PMID: 24506839
The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.
O'Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS; Children's Cancer and Leukaemia Group
Br J Neurosurg 2007 Dec;21(6):539-49. doi: 10.1080/02688690701594817. PMID: 18071981
Fragile X-associated tremor/ataxia syndrome: clinical features, genetics, and testing guidelines.
Berry-Kravis E, Abrams L, Coffey SM, Hall DA, Greco C, Gane LW, Grigsby J, Bourgeois JA, Finucane B, Jacquemont S, Brunberg JA, Zhang L, Lin J, Tassone F, Hagerman PJ, Hagerman RJ, Leehey MA
Mov Disord 2007 Oct 31;22(14):2018-30, quiz 2140. doi: 10.1002/mds.21493. PMID: 17618523

Recent clinical studies

Etiology

MRI detection of brain gadolinium retention in multiple sclerosis: Magnetization transfer vs. T1-weighted imaging.
Cananau C, Forslin Y, Bergendal Å, Sjöström H, Fink K, Ouellette R, Wiberg MK, Fredrikson S, Granberg T
J Neuroimaging 2023 Mar;33(2):247-255. Epub 2023 Jan 4 doi: 10.1111/jon.13079. PMID: 36599653
Focal Areas of High Signal Intensity in Children with Neurofibromatosis Type 1: Expected Evolution on MRI.
Calvez S, Levy R, Calvez R, Roux CJ, Grévent D, Purcell Y, Beccaria K, Blauwblomme T, Grill J, Dufour C, Bourdeaut F, Doz F, Robert MP, Boddaert N, Dangouloff-Ros V
AJNR Am J Neuroradiol 2020 Sep;41(9):1733-1739. Epub 2020 Aug 13 doi: 10.3174/ajnr.A6740. PMID: 32816766Free PMC Article
3D-Flair sequence at 3T in cochlear otosclerosis.
Lombardo F, De Cori S, Aghakhanyan G, Montanaro D, De Marchi D, Frijia F, Fortunato S, Forli F, Chiappino D, Berrettini S, Canapicchi R
Eur Radiol 2016 Oct;26(10):3744-51. Epub 2016 Jan 8 doi: 10.1007/s00330-015-4170-9. PMID: 26747254
Neurological complications of Anderson-Fabry disease.
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
MR of Zellweger syndrome.
Barkovich AJ, Peck WW
AJNR Am J Neuroradiol 1997 Jun-Jul;18(6):1163-70. PMID: 9194444Free PMC Article

Diagnosis

Neonatal maple syrup urine disease case report and literature review.
Liu Q, Li F, Zhou J, Liu X, Peng J, Gong L
Medicine (Baltimore) 2022 Dec 16;101(50):e32174. doi: 10.1097/MD.0000000000032174. PMID: 36550798Free PMC Article
Adult Leukodystrophies: A Step-by-Step Diagnostic Approach.
Resende LL, de Paiva ARB, Kok F, da Costa Leite C, Lucato LT
Radiographics 2019 Jan-Feb;39(1):153-168. doi: 10.1148/rg.2019180081. PMID: 30620693
Neurological complications of Anderson-Fabry disease.
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
Neuroimaging of Dandy-Walker malformation: new concepts.
Correa GG, Amaral LF, Vedolin LM
Top Magn Reson Imaging 2011 Dec;22(6):303-12. doi: 10.1097/RMR.0b013e3182a2ca77. PMID: 24132069
Neuroimaging in rabies.
Laothamatas J, Sungkarat W, Hemachudha T
Adv Virus Res 2011;79:309-27. doi: 10.1016/B978-0-12-387040-7.00014-7. PMID: 21601052

Therapy

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes.
Eide PK, Vatnehol SAS, Emblem KE, Ringstad G
Sci Rep 2018 May 8;8(1):7194. doi: 10.1038/s41598-018-25666-4. PMID: 29740121Free PMC Article
New Findings, Classification and Long-Term Follow-Up Study Based on MRI Characterization of Brainstem Encephalitis Induced by Enterovirus 71.
Zeng H, Wen F, Huang W, Gan Y, Zeng W, Chen R, He Y, Wang Y, Liu Z, Liang C, Wong KK
PLoS One 2016;11(10):e0162877. Epub 2016 Oct 31 doi: 10.1371/journal.pone.0162877. PMID: 27798639Free PMC Article
The magnetic resonance imaging spectrum of Pelizaeus-Merzbacher disease: A multicenter study of 19 patients.
Sumida K, Inoue K, Takanashi J, Sasaki M, Watanabe K, Suzuki M, Kurahashi H, Omata T, Tanaka M, Yokochi K, Iio J, Iyoda K, Kurokawa T, Matsuo M, Sato T, Iwaki A, Osaka H, Kurosawa K, Yamamoto T, Matsumoto N, Maikusa N, Matsuda H, Sato N
Brain Dev 2016 Jun;38(6):571-80. Epub 2016 Jan 13 doi: 10.1016/j.braindev.2015.12.007. PMID: 26774704
Vigabatrin-associated reversible MRI signal changes in patients with infantile spasms.
Dracopoulos A, Widjaja E, Raybaud C, Westall CA, Snead OC 3rd
Epilepsia 2010 Jul;51(7):1297-304. Epub 2010 Apr 2 doi: 10.1111/j.1528-1167.2010.02564.x. PMID: 20384718
Electroencephalography, evoked potentials and MRI brain scans in saturation divers. An epidemiological study.
Todnem K, Skeidsvoll H, Svihus R, Rinck P, Riise T, Kambestad BK, Aarli JA
Electroencephalogr Clin Neurophysiol 1991 Oct;79(4):322-9. doi: 10.1016/0013-4694(91)90127-p. PMID: 1717236

Prognosis

High-resolution MRI demonstrates signal abnormalities of the 3rd cranial nerve in giant cell arteritis patients with 3rd cranial nerve impairment.
Mournet S, Sené T, Charbonneau F, Poillon G, Vignal C, Clavel G, Zuber K, Savatovsky J, Lecler A
Eur Radiol 2021 Jul;31(7):4472-4480. Epub 2021 Jan 13 doi: 10.1007/s00330-020-07595-x. PMID: 33439314
Focal Areas of High Signal Intensity in Children with Neurofibromatosis Type 1: Expected Evolution on MRI.
Calvez S, Levy R, Calvez R, Roux CJ, Grévent D, Purcell Y, Beccaria K, Blauwblomme T, Grill J, Dufour C, Bourdeaut F, Doz F, Robert MP, Boddaert N, Dangouloff-Ros V
AJNR Am J Neuroradiol 2020 Sep;41(9):1733-1739. Epub 2020 Aug 13 doi: 10.3174/ajnr.A6740. PMID: 32816766Free PMC Article
Neurological complications of Anderson-Fabry disease.
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
Neuroimaging in rabies.
Laothamatas J, Sungkarat W, Hemachudha T
Adv Virus Res 2011;79:309-27. doi: 10.1016/B978-0-12-387040-7.00014-7. PMID: 21601052
MRI of the fetal posterior fossa.
Adamsbaum C, Moutard ML, André C, Merzoug V, Ferey S, Quéré MP, Lewin F, Fallet-Bianco C
Pediatr Radiol 2005 Feb;35(2):124-40. Epub 2004 Nov 23 doi: 10.1007/s00247-004-1316-3. PMID: 15565345

Clinical prediction guides

Associations of Brain Atrophy and Cerebral Iron Accumulation at MRI with Clinical Severity in Wilson Disease.
Dusek P, Lescinskij A, Ruzicka F, Acosta-Cabronero J, Bruha R, Sieger T, Hajek M, Dezortova M
Radiology 2021 Jun;299(3):662-672. Epub 2021 Mar 23 doi: 10.1148/radiol.2021202846. PMID: 33754827
White matter alteration and cerebellar atrophy are hallmarks of brain MRI in alpha-mannosidosis.
Majovska J, Nestrasil I, Paulson A, Nascene D, Jurickova K, Hlavata A, Lund T, Orchard PJ, Vaneckova M, Zeman J, Magner M, Dusek P
Mol Genet Metab 2021 Mar;132(3):189-197. Epub 2020 Dec 3 doi: 10.1016/j.ymgme.2020.11.008. PMID: 33317989
Focal Areas of High Signal Intensity in Children with Neurofibromatosis Type 1: Expected Evolution on MRI.
Calvez S, Levy R, Calvez R, Roux CJ, Grévent D, Purcell Y, Beccaria K, Blauwblomme T, Grill J, Dufour C, Bourdeaut F, Doz F, Robert MP, Boddaert N, Dangouloff-Ros V
AJNR Am J Neuroradiol 2020 Sep;41(9):1733-1739. Epub 2020 Aug 13 doi: 10.3174/ajnr.A6740. PMID: 32816766Free PMC Article
Adult Leukodystrophies: A Step-by-Step Diagnostic Approach.
Resende LL, de Paiva ARB, Kok F, da Costa Leite C, Lucato LT
Radiographics 2019 Jan-Feb;39(1):153-168. doi: 10.1148/rg.2019180081. PMID: 30620693
Parkinson's disease related signal change in the nigrosomes 1-5 and the substantia nigra using T2* weighted 7T MRI.
Schwarz ST, Mougin O, Xing Y, Blazejewska A, Bajaj N, Auer DP, Gowland P
Neuroimage Clin 2018;19:683-689. Epub 2018 May 24 doi: 10.1016/j.nicl.2018.05.027. PMID: 29872633Free PMC Article

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