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Selective serotonin reuptake inhibitor response

MedGen UID:
808078
•Concept ID:
CN221268
•
Sign or Symptom
Synonyms: Selective serotonin re-uptake inhibitor response; Selective serotonin reuptake inhibitor toxicity; SSRI response
Drug:
Selective serotonin reuptake inhibitors
MedGen UID:
452467
•Concept ID:
C0360105
•
Pharmacologic Substance
Any agent that increases the extracellular level of the neurotransmitter serotonin (5-HT) by inhibiting its reuptake into the presynaptic cell. Increased level in the synaptic cleft prolongs the action of 5-HT on the postsynaptic receptor. This type of agent is typically used as an antidepressant and in the treatment of anxiety disorders and some personality disorders. They are also typically effective and used in treating some cases of insomnia. [from NCI]
Selective serotonin reuptake inhibitors
 
Genes (locations): CYP2C19 (10q23.33); CYP2D6 (22q13.2)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents.
Strawn JR, Mills JA, Poweleit EA, Ramsey LB, Croarkin PE
Pharmacotherapy 2023 Jul;43(7):675-690. Epub 2023 Jan 27 doi: 10.1002/phar.2767. PMID: 36651686Free PMC Article
Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Anxiety Disorders.
Walter HJ, Bukstein OG, Abright AR, Keable H, Ramtekkar U, Ripperger-Suhler J, Rockhill C
J Am Acad Child Adolesc Psychiatry 2020 Oct;59(10):1107-1124. Epub 2020 May 18 doi: 10.1016/j.jaac.2020.05.005. PMID: 32439401
Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review.
Strawn JR, Geracioti L, Rajdev N, Clemenza K, Levine A
Expert Opin Pharmacother 2018 Jul;19(10):1057-1070. doi: 10.1080/14656566.2018.1491966. PMID: 30056792Free PMC Article

Recent clinical studies

Etiology

Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up.
Serretti A, Zanardi R, Franchini L, Artioli P, Dotoli D, Pirovano A, Smeraldi E
Pharmacogenetics 2004 Sep;14(9):607-13. doi: 10.1097/00008571-200409000-00005. PMID: 15475734

Therapy

Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder.
Yoshimura R, Hori H, Ikenouchi-Sugita A, Umene-Nakano W, Katsuki A, Atake K, Nakamura J
Hum Psychopharmacol 2013 Sep;28(5):466-70. Epub 2013 Jun 30 doi: 10.1002/hup.2333. PMID: 23813968
P-glycoprotein (PGP) polymorphisms and sexual dysfunction in female patients with depression and SSRI-associated sexual side effects.
Bly MJ, Bishop JR, Thomas KL, Ellingrod VL
J Sex Marital Ther 2013;39(3):280-8. Epub 2013 Jan 28 doi: 10.1080/0092623X.2011.615896. PMID: 23356581Free PMC Article
Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
Abo R, Hebbring S, Ji Y, Zhu H, Zeng ZB, Batzler A, Jenkins GD, Biernacka J, Snyder K, Drews M, Fiehn O, Fridley B, Schaid D, Kamatani N, Nakamura Y, Kubo M, Mushiroda T, Kaddurah-Daouk R, Mrazek DA, Weinshilboum RM
Pharmacogenet Genomics 2012 Apr;22(4):247-53. doi: 10.1097/FPC.0b013e32835001c9. PMID: 22322242Free PMC Article
Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.
Ji Y, Biernacka J, Snyder K, Drews M, Pelleymounter LL, Colby C, Wang L, Mrazek DA, Weinshilboum RM
Pharmacogenomics J 2012 Feb;12(1):78-85. Epub 2010 Sep 28 doi: 10.1038/tpj.2010.69. PMID: 20877297Free PMC Article
Pindolol augmentation of antidepressant treatment: recent contributions from brain imaging studies.
Martinez D, Broft A, Laruelle M
Biol Psychiatry 2000 Oct 15;48(8):844-53. doi: 10.1016/s0006-3223(00)00993-8. PMID: 11063979

Prognosis

Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up.
Serretti A, Zanardi R, Franchini L, Artioli P, Dotoli D, Pirovano A, Smeraldi E
Pharmacogenetics 2004 Sep;14(9):607-13. doi: 10.1097/00008571-200409000-00005. PMID: 15475734

Clinical prediction guides

P-glycoprotein (PGP) polymorphisms and sexual dysfunction in female patients with depression and SSRI-associated sexual side effects.
Bly MJ, Bishop JR, Thomas KL, Ellingrod VL
J Sex Marital Ther 2013;39(3):280-8. Epub 2013 Jan 28 doi: 10.1080/0092623X.2011.615896. PMID: 23356581Free PMC Article
Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
Abo R, Hebbring S, Ji Y, Zhu H, Zeng ZB, Batzler A, Jenkins GD, Biernacka J, Snyder K, Drews M, Fiehn O, Fridley B, Schaid D, Kamatani N, Nakamura Y, Kubo M, Mushiroda T, Kaddurah-Daouk R, Mrazek DA, Weinshilboum RM
Pharmacogenet Genomics 2012 Apr;22(4):247-53. doi: 10.1097/FPC.0b013e32835001c9. PMID: 22322242Free PMC Article
Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up.
Serretti A, Zanardi R, Franchini L, Artioli P, Dotoli D, Pirovano A, Smeraldi E
Pharmacogenetics 2004 Sep;14(9):607-13. doi: 10.1097/00008571-200409000-00005. PMID: 15475734

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